Corodil (ANTIANGINAL)

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Corodil (ANTIANGINAL)

Corodil is a synthetic prescription medication whose active ingredient is Isosorbide Dinitrate (ISDN), classifying it as an antianginal drug used to influence the cardiovascular system. It is a single-ingredient product belonging to the chemical class of organic nitrates, whose function is centered on promoting the relaxation of blood vessels.


Quick Facts: Corodil (Isosorbide Dinitrate)

Property Description
Active ingredient Isosorbide Dinitrate (ISDN)
Form Tablet, Sublingual Tablet, Solution
Pharmacological class Antianginal Drug, Vasodilator
Origin Synthetic (Organic Nitrate)

What Type of Medicine is Corodil (Isosorbide Dinitrate)?

Corodil is defined as an organic nitrate vasodilator, a specialized antianginal drug that acts directly on the vascular system. Its active component, Isosorbide Dinitrate, is a synthetic compound typically formulated as a tablet, a sublingual tablet designed for rapid absorption, or a sustained-release form. ISDN is classified as a coronary vasodilator. This confirms that the medicine's core function is to relax the blood vessels supplying the heart. The drug's identity is based on its primary function as a systemic reliever of vascular tension, which places it in the essential category of cardiovascular medicine.

What is the General Purpose of an Antianginal Vasodilator?

The general purpose of this type of medicine is to reduce the workload on the heart by promoting efficient blood flow and optimizing the heart's oxygen supply. Corodil achieves this by acting as a nitric oxide precursor to relax vascular smooth muscle. This mechanism provides systemic circulatory relief. The drug helps ease the strain on the heart by making the blood vessels wider, which results in the dilation of both the veins and, to a lesser extent, the coronary arteries. The general benefit is the maintenance of circulatory support to balance the heart muscle's needs.

Regulatory References

  1. MedlinePlus: Nitrates and Nitrites

What side effects are possible with Corodil (ANTIANGINAL)?

Possible Side Effects and Safety Information

Corodil (Isosorbide Dinitrate) safety information is formally documented in government regulatory materials and is primarily structured around effects related to its action as a vasodilator.

Frequency-Classified Adverse Reactions

The adverse reactions are categorized based on their documented frequency in clinical use, according to regulatory standards (e.g., SmPC):

  • Very Common (Affecting more than 1 in 10 people): Headache.
  • Common (Affecting 1 to 10 in 100 people): Hypotension (low blood pressure, including when standing up), Dizziness, Reflex Tachycardia (increased heart rate), and Flushing.
  • Uncommon (Affecting 1 to 10 in 1,000 people): Nausea, Vomiting, and Allergic Skin Reactions.

Time-Related Patterns and Safety Constraints

The Very Common headache is noted in regulatory documents to be most prominent at the start of therapy and generally diminishes with continued use. Both hypotension and dizziness are also more likely to occur upon initiation of treatment or during dose increases. Tolerance, where the effects of the drug lessen over time, may also develop with continued exposure.

Safety is formally restricted in certain situations. The medicine is contraindicated (should not be used) with specific medications, such as Phosphodiesterase-5 (PDE-5) inhibitors (e.g., sildenafil) and Soluble Guanylate Cyclase (sGC) Stimulators, due to the high risk of a severe drop in blood pressure. Use is also restricted in patients with severe anemia.

Serious Adverse Reactions and Special Populations

Documented serious adverse reactions include severe hypotensive responses that may lead to syncope (fainting). Rare but severe allergic events, such as Stevens-Johnson syndrome, are also listed.

For Older Adults, cautious dose selection is advised due to the greater likelihood of reduced organ function. The safety and effectiveness of Corodil have not been established in pediatric patients.

Overdose and Emergency Response

Overdose and when to seek help

Overdose with Corodil (Isosorbide Dinitrate) is officially documented to result from an exaggerated vasodilatory effect, which may lead to a severe hypotensive response. Individuals must seek emergency medical help immediately if an overdose is suspected or if any symptoms of overdose occur, as mandated by regulatory authorities.

Documented Manifestations and Severe Outcomes

Overdose symptoms typically reflect a prompt fall in blood pressure to le 90 mmHg, which can progress to circulatory collapse. Other clinical signs listed in regulatory documents include severe and throbbing headache, dizziness, syncope, tachycardia or paradoxical bradycardia, nausea, vomiting, and visual disturbances. The most serious life-threatening outcomes include the risk of Methemoglobinemia and resultant cyanosis, a condition that may lead to anxiety, loss of consciousness, and cardiac arrest. Increased intracranial pressure is also a documented concern. In infants, a bulge in the soft spot on the head is a noted sign.

Mandated Emergency Actions

The required immediate actions for nitrate-related hypotension include laying the patient down with the head lowered and legs raised (Trendelenburg position), supplying oxygen, and expanding plasma volume with I.V. fluids. Hospital monitoring of blood pressure and pulse is required, and patients should be observed for a period of at least 12 hours. While no specific antagonist to the drug’s primary effect is known, Methylene Blue is the specific treatment documented for the complication of Methemoglobinemia.

Therapeutic Uses of Corodil (ANTIANGINAL)

What Corodil (ANTIANGINAL) Treats: Main Uses and Benefits

Corodil is a medication commonly used to help with conditions characterized by periods of heightened symptoms, specifically those related to physical discomfort in the chest. It is applied in addressing symptom clusters that may become intense or disruptive. This product is primarily used for the management of conditions presenting with systemic or localized discomfort (such as angina pectoris) and is also relevant in contexts involving heightened systemic burden (such as left ventricular failure).

In clinical settings involving acute or unstable symptom patterns, the therapy is often used when short-term symptomatic assistance is needed. It supports patients during episodes of heightened discomfort that interfere with daily comfort. It contributes to easing the overall symptom load, helping patients cope more steadily with symptom fluctuations. It assists with maintaining functional stability when symptoms are more noticeable, contributing to improved comfort.


Quick Fact: Relief for Physical Discomfort

Regulatory References

  1. official FDA-mandated product labeling

Eligibility and Restrictions for Use

Who Can and Cannot Use Corodil (ANTIANGINAL)?

Official regulatory documents define strict population eligibility for Corodil (Isosorbide Dinitrate). Use is generally established for adults but is restricted or prohibited in several populations due to safety concerns.

Absolute Contraindications

Corodil must not be used by individuals with a known hypersensitivity to any organic nitrate or by patients concurrently taking Phosphodiesterase Type 5 (PDE5) inhibitors (e.g., sildenafil, tadalafil) or the Soluble Guanylate Cyclase (sGC) stimulator riociguat. The medication is also contraindicated in specific circulatory states, including marked anaemia, circulatory collapse, and conditions that increase intracranial pressure (e.g., cerebral hemorrhage).

Age and Condition Restrictions

The safety and effectiveness have not been established in pediatric patients (children). While use is permitted in older adults, caution is advised due to the greater frequency of decreased organ function. Use is restricted during pregnancy (FDA Category C) and lactation, where caution should be exercised. Additionally, use requires careful supervision in patients with severe hypotension, volume depletion, or significant renal or hepatic impairment.

What should I know about interactions with other medicines?

Corodil (Isosorbide Dinitrate) interactions are primarily defined by its potent vasodilatory effect, as documented in official government labeling. The interaction structure is dominated by combinations that are formally contraindicated.

Interaction Classifications and Restrictions

The medicine is contraindicated for co-administration with all Phosphodiesterase-5 (PDE5) Inhibitors (such as sildenafil and tadalafil) and Soluble Guanylate Cyclase (sGC) Stimulators (such as riociguat). This regulatory restriction is due to the potential for severe hypotension, syncope, or myocardial ischemia resulting from amplified vasodilatory effects.

Regulatory documents consistently describe pharmacodynamic reinforcement with other medications. Concurrent administration of antihypertensive drugs, neuroleptics, or tricyclic antidepressants may potentiate the hypotensive effect of Corodil, as the vasodilating effects are additive. This potentiation of low blood pressure may also be enhanced by the consumption of alcohol.

Exposure and Population Notes

Regarding co-administered drugs, official labeling indicates that Isosorbide Dinitrate may increase the blood level and hypertensive effect of Dihydroergotamine. The interaction profile includes a population-specific note: use of the product should proceed with caution in patients who have severe hepatic or renal impairment.

Mechanism of Action

The action of Corodil (Isosorbide Dinitrate) is rooted in its ability to be converted into Nitric Oxide (NO), a signaling molecule that modulates systemic vascular tone. Corodil functions as a prodrug that undergoes enzymatic conversion to release NO within the vascular smooth muscle cells. This NO activates the enzyme Soluble Guanylyl Cyclase (sGC), leading to an increase in the secondary messenger cGMP. This cascade triggers the dephosphorylation of the myosin light chain, leading to vascular smooth muscle relaxation and vasodilation. The resulting relaxation is most pronounced in the peripheral venous system, achieving venodilation. This increase in venous capacity results in the redistribution of blood volume, which decreases the volume of blood returning to the heart (reducing preload). The reduction in preload decreases cardiac wall tension, thereby reducing myocardial oxygen consumption. A key constraint is nitrate tolerance, where continuous exposure causes efficacy to diminish, hypothesized to involve the depletion of necessary co-factors for the initial bioactivation into NO.

Dosage and Administration Information

Corodil, which contains the active substance Isosorbide Dinitrate, is administered via multiple routes as determined by the clinical need. For long-term management, the medicine is typically taken via the oral route as immediate-release or extended-release forms, while acute symptom relief relies on the sublingual route. The intravenous route is reserved for controlled infusion in critical care settings.

Oral dosing schedules require adherence to a mandatory regimen defined by a daily drug-free interval of approximately 10 to 14 hours. This constraint is a critical procedural condition required to prevent the development of pharmacological tolerance and maintain the medicine’s long-term effectiveness. Prophylactic oral doses are typically in the range of 10 mg to 40 mg administered two to three times daily. If chronic therapy is to be stopped, the dosage is advised to be gradually reduced over one to two weeks.

Administration is strictly defined by the dosage form. Sublingual tablets must be dissolved completely under the tongue and must not be swallowed, while extended-release forms must be swallowed whole to preserve their intended sustained release profile. Oral forms are preferably taken on an empty stomach. Furthermore, for older adults, dose selection should commence at the lower end of the established therapeutic range, while pediatric use remains not established.

Recent Clinical Evidence

Corodil (ANTIANGINAL): Recent Clinical Evidence

Clinical research involving Corodil, a compound that inhibits the cardiac late sodium current (INa, late), has focused on its role in managing chronic stable angina pectoris. The compound is often studied as an add-on therapy for patients whose symptoms are not fully controlled by traditional first-line antianginal medications such as beta-blockers or calcium channel blockers.

Core Efficacy Findings

Major randomized controlled trials (RCTs) have investigated the compound's effect on key metrics of angina control:

  • Exercise Tolerance: Studies evaluating exercise testing demonstrated that participants receiving the compound experienced a greater duration of exercise and increased time to the onset of both angina symptoms and specific changes on an electrocardiogram (ECG) compared to placebo.
  • Symptom Frequency: In patients with stable angina, adding the compound to existing therapy was associated with fewer reported angina attacks per week and a reduction in the required weekly consumption of short-acting nitrates (e.g., nitroglycerin) compared to placebo groups.

These effects were generally observed to be independent of clinically significant changes in the participant's heart rate or blood pressure, which distinguishes its studied action from that of many conventional antianginal agents.

Safety and Other Observations

Research has also explored the long-term safety profile. A large-scale trial in patients with acute coronary syndromes (MERLIN-TIMI 36) investigated the compound's safety over one year. The study found no significant difference in the incidence of all-cause mortality or sudden cardiac death between the compound and placebo groups.

Furthermore, researchers have examined the compound's potential influence on arrhythmias and glycemic control (HbA1c levels) in various study populations, suggesting areas for further investigation beyond its primary antianginal indication.

Key Studies & References

  1. Effects of Ranolazine on Recurrent Cardiovascular Events in Patients With Non–ST-Elevation Acute Coronary Syndromes: The MERLIN-TIMI 36 Randomized Trial

Frequently Asked Questions (FAQ)

Common questions about Corodil (ANTIANGINAL) (FAQ)


Q: What is the typical timeframe before Corodil might start to have an effect?

Official product information suggests that for the oral immediate-release tablets, the anti-anginal effects are generally present about one hour after the dose is taken. The sublingual form is generally used when a more rapid onset of action is desired; this route is often associated with the management of immediate symptoms.


Q: What happens if I forget to take my Corodil dose?

If a dose is missed, regulatory patient information often advises taking it as soon as remembered. If it is almost time for the next scheduled dose, the common guidance is to skip the missed dose and return to the regular schedule. Official instructions consistently advise against taking a double dose to compensate for a missed one.


Q: Are there any long-term side effects associated with Corodil use?

One key consideration for long-term use, as noted in authoritative sources, is the potential development of nitrate tolerance. This means the medicine's effectiveness may lessen over time. This is generally managed by adhering to a dosing schedule that includes a daily drug-free period to maintain the drug’s intended anti-anginal effects.


Q: Can taking cold or flu medications affect how Corodil works?

Official patient guidance cautions against using certain over-the-counter medicines for symptoms like coughs, colds, or pain, as they may contain ingredients that could interact with Corodil. Some ingredients, for example, can potentially increase blood pressure, which may interfere with the medicine’s primary function.


Q: Is Corodil typically prescribed to patients with low heart rate?

Corodil is indicated for angina prevention and works primarily by widening blood vessels. Although its effects are generally independent of clinically significant heart rate changes, it is noted that use may require careful monitoring of heart rate and blood pressure, particularly where a low heart rate is a factor.


Q: Why would a doctor switch me from one antianginal to Corodil?

Corodil is approved for the prevention of angina (chest pain). Research studies often describe its use in patients whose angina symptoms are not adequately controlled by traditional first-line antianginal medications. This research context provides insight into its role as an add-on or alternative therapy.


Q: What should I do if my angina symptoms seem to get worse while on Corodil?

Authoritative patient resources clearly advise that if symptoms such as chest pain or pressure are new, unusual, or worsening after starting the medicine, emergency medical care should be obtained.


Q: How often is Corodil typically taken per day?

Official drug information describes that the immediate-release tablet is generally taken two or three times daily, and the extended-release tablet is usually taken once daily. These schedules are part of a regimen that must include a daily drug-free interval.


Q: Is Corodil sometimes used for conditions other than heart-related chest pain?

The medication’s primary formal indication is the prevention of angina pectoris (chest pain). However, it is also formally indicated for the treatment of heart failure in combination with certain other medications, according to regulatory labeling.


Q: How is Corodil different from other types of heart medication?

Corodil belongs to the drug class of organic nitrates. Unlike some other heart medicines, its primary action is to cause the relaxation of vascular smooth muscle and dilatation of blood vessels by converting into nitric oxide. This process helps reduce the workload on the heart.


Q: How do I know if Corodil is actually working for me?

Official patient resources suggest that experiencing a headache, especially at the start of treatment, can be an expected sign that the medicine is causing vasodilation. The primary clinical indicator that the medicine is working as intended is described as a reduction in the frequency or severity of angina symptoms.


Q: Can Corodil cause ankle swelling or fluid retention?

Swelling in areas such as the ankles, face, hands, or lower legs is described in patient information as a possible side effect of this drug, though its frequency may be considered less common. This symptom is generally associated with effects on the circulatory system.


Q: Does Corodil affect a patient's cholesterol levels?

According to official drug information, Corodil may potentially interfere with certain laboratory tests, including those measuring blood cholesterol levels, which could result in inaccurate readings. It is recommended that patients ensure the laboratory staff are aware they are taking this medication before testing.


Q: Will Corodil help prevent a heart attack?

Corodil is formally indicated for the prevention of angina pectoris, which is chest pain caused by heart disease. However, government labeling does not explicitly state that the medicine prevents a heart attack or cures coronary artery disease.


Q: Is Corodil effective for all types of angina (stable, unstable, or variant)?

Official labeling specifically indicates Corodil for the prevention of angina pectoris due to coronary artery disease. Information concerning its effectiveness for every specific form of angina, such as unstable or variant (Prinzmetal’s) angina, is often not included in the primary regulatory documentation.


Q: Does Corodil have any known effects on mood or sleep?

The drug’s official list of adverse reactions includes mood or mental changes and potential trouble sleeping (insomnia) as effects that may occur. These reactions are typically considered less common or their frequency is not fully established.


Q: Can Corodil affect driving or operating machinery?

Official warnings state that because the medicine can cause side effects such as dizziness, lightheadedness, or fainting, caution is required when driving, operating machinery, or performing tasks that require mental alertness.


Q: Does Corodil commonly cause digestive issues like nausea or constipation?

Official regulatory documents list nausea and vomiting as common to less common side effects. Constipation is also noted in patient information as a possible side effect associated with the use of the drug.


Q: Is Corodil used to manage heart rate as well as chest pain?

Corodil is indicated for angina prevention, and its effects on the heart are primarily through vasodilation. Studies have noted that the anti-anginal effects are generally observed to be independent of clinically significant changes in the patient’s heart rate.


Q: Are there different strengths or forms of Corodil available?

Yes, official drug references confirm that Corodil (Isosorbide Dinitrate) is available in several forms, including oral tablets in different strengths, as well as extended-release tablets and sublingual tablets for different usage needs.


Q: Is Corodil related to nitroglycerin or nitrate-type medicines?

Yes, Corodil (Isosorbide Dinitrate) is classified as an organic nitrate. It belongs to the same class of medicines as nitroglycerin and works by a similar process, involving the conversion into nitric oxide to relax blood vessels.

How should Corodil (ANTIANGINAL) be stored and disposed of?

How to Store and Dispose of Corodil (Isosorbide Dinitrate)

Corodil (Isosorbide Dinitrate) must be stored and handled according to specific conditions defined by regulatory labeling to maintain its chemical stability and ensure safety.


Storage Requirements

Condition Official Requirement
Temperature Store at Controlled Room Temperature, typically below 30 C.
Protection The medicine must be protected from light, excess heat, and moisture.
Handling The product must not be frozen.
Packaging Keep the medicine in its original container, tightly closed, and light-resistant.
Child Safety Store the product out of the reach and sight of children.

Disposal Instructions

Unused or expired Corodil should not be kept. The official instruction is to ask a healthcare professional or pharmacist for guidance on proper disposal. Unless specifically instructed to do so by the labeling, the medicine should not be flushed down a toilet or poured into a drain.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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