Comfora

The total for the two dosage forms

osteochondrosis.

Solution for intramuscular administration complete with solvent

primary and secondary osteoarthritis,

spondyloarthrosis.

Powder for the preparation of a solution for oral administration

osteoarthritis of the peripheral joints, joints of the spine, osteochondrosis.

Osteoarthritis of the peripheral joints and joints of the spine.

Osteoarthritis of the peripheral joints and spine.

Osteoarthritis of the peripheral joints and spine.

The drug stimulates the regeneration of cartilage tissue, has an anabolic, anti-catabolic, chondroprotective, anti-inflammatory, analgesic effect.

Glucosamine sulfate, the active component of the drug, is a salt of the natural aminomonosaccharide glucosamine, which is found in the body. Glucosamine stimulates the synthesis of proteoglycans (glucosaminoglycans and hyaluronic acid) by chondrocytes in the synovial fluid, inhibits enzymes (including collagenase, phospholipase A₂), which cause the destruction of cartilage tissue, prevents the formation of superoxide radicals, suppresses the activity of lysosomal enzymes, initiates the process of sulfur fixation in the synthesis of chondroitinseric acid and promotes the normal deposition of calcium in bone tissue, prevents the damaging effect of corticosteroids on chondrocytes and disruption of the synthesis of glucosaminoglycans induced by NSAIDs.

Sulfonate groups are also involved in the synthesis of glycosaminoglycans in the metabolism of cartilaginous tissue, and solitairy side chains composed of proteoglycans, contributing to water retention, preserving the ductility of the matrix of cartilage.

Glucosamine sulfate stops the destruction of cartilage and reduces the symptoms of osteoarthritis. The decrease in clinical symptoms usually occurs 2 weeks after the start of treatment, with the preservation of clinical improvement for 8 weeks after discontinuation of the drug.

Symptoms^® The maximum makes up for endogenous glucosamine deficiency, stimulates the synthesis of proteoglycans and hyaluronic acid. Restores the enzymatic processes in the cells of the synovial membrane and articular cartilage, promotes the restoration of the cartilaginous surfaces of the peripheral joints and joints of the spine.

It has chondroprotective and anti-inflammatory properties. Reduces pain and the need for NSAIDs, inhibits the formation of superoxide radicals and enzymes that damage cartilage (collagenases and phospholipases).

To improve the supply of glucosamine to the joint tissues, a transdermal glucosamine complex was used — a complex of glucosamine and natural triglycerides.