Coltab

this medicine is indicated for symptomatic control of all allergic conditions responsive to antihistamines, including hay fever, vasomotor rhinitis, urticaria, angioneurotic oedema, food allergy, drug and serum reactions, insect bites.

Also indicated for the symptomatic relief of itch associated with chickenpox in addition to that it ca treat the allergic cough.

Coltab contains a combination of acetaminophen and chlorpheniramine. Acetaminophen is a pain reliever and a fever reducer. Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Coltab is used to treat headache, runny nose, sneezing, watery eyes, and pain or fever caused by allergies, the common cold, or the flu.

Coltab may also be used for other purposes not listed in this medication guide.

Adult 0.5-1 g 4-6 hrly to max: 4 g daily. Childn 6-12 yr 250-500 mg, 1-5 yr 125-250 mg, up to 1 yr 60-120 mg. To be taken 4-6 hrly to a max of 4 doses in 24 hr.

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What is the most important information I should know about Coltab?

Hypersensitivity to any component. - Must be used with caution in patients with a history of coronary disease, peripheral vascular disease, severe hypertension, advanced hepatic or renal.- It is contraindicated in patients with active peptic ulcer or gastrointestinal bleeding. -

No association with macrolide antibiotics or beta blockers

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What other drugs will affect Coltab?

Acetaminophen is metabolized (eliminated by conversion to other chemicals) by the liver. Therefore drugs that increase the action of liver enzymes that metabolize acetaminophen [for example, carbamazepine (Tegretol), isoniazid (INH, Nydrazid, Laniazid), rifampin (Rifamate, Rifadin, Rimactane)] reduce the levels of acetaminophen and may decrease the action of acetaminophen. Doses of acetaminophen greater than the recommended doses are toxic to the liver and may result in severe liver damage. The potential for acetaminophen to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.

Cholestyramine (Questran) reduces the effect of acetaminophen by decreasing its absorption into the body from the intestine. Therefore, acetaminophen should be administered 3 to 4 hours after cholestyramine or one hour before cholestyramine.

Acetaminophen doses greater than 2275 mg per day may increase the blood thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore, prolonged administration or large doses of acetaminophen should be avoided during warfarin therapy

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What are the possible side effects of Coltab?

CNS depression, sedation, drowsiness, lassitude, dizziness. GI upsets, anorexia, or increased appetite, epigastric pain, blurring of vision, dysuria, dryness of mouth, tightness in chest, hypotension, muscular weakness, tinnitus, euphoria, headache, paradoxical CNS stimulation.

Potentially Fatal: CV collapse and respiratory failure and there is also the side effects of corticosteroids if included.