Citrovit-L.S.

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Citrovit-L.S.

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Overview of Citrovit-L.S.

This section defines the core identity and general purpose of Citrovit-L.S., clarifying its nature as a specialized nutritional supplement.

Property Description
Active ingredient Sodium Ascorbate (Vitamin C)
Form Solution for Injection (Sterile Liquid)
Pharmacological class Water-soluble vitamin, Essential Nutrient
Common use Nutritional supplementation / Deficiency support
Origin Derived Chemical Entity

Active Composition and Classification

Citrovit-L.S. is a specialized prescription-only medicinal preparation containing Sodium Ascorbate, which is the sodium salt of Ascorbic Acid (Vitamin C). It is categorized as both an essential nutrient and a therapeutic antioxidant. Its biological role includes cellular protection and metabolic function.

The formulation utilizes the derived chemical entity Sodium Ascorbate, rather than pure Ascorbic Acid, to create a solution with a near-neutral pH. This characteristic is a key feature of the sterile liquid preparation, designed specifically to maximize patient tolerance and reduce the irritating effects often associated with acidic forms of the vitamin during injection.

Type, Form, and Specialized Context

This medicine is presented as an aqueous solution for injection intended for parenteral administration (intravenous or intramuscular). This specific dosage form is designed to deliver the active compound directly into the systemic circulation, ensuring rapid and complete bioavailability.

This injectable type is positioned for use in medical settings where oral absorption is compromised or high systemic concentrations are medically necessary. This specialized context makes the product an element of nutritional support reserved for the management of vitamin deficiencies or high metabolic demands.

General Purpose and Core Function

The core general purpose of Citrovit-L.S. is to sustain fundamental structural and metabolic integrity by providing a critical supply of Vitamin C. The compound is required for the synthesis of collagen, a protein necessary for building and maintaining connective tissues. Its function is relevant to situations requiring enhanced tissue repair capabilities, such as following trauma or surgery.

Furthermore, the compound functions as a primary antioxidant, helping to neutralize damaging agents within the body's water-based environments. Ultimately, the product acts as a resource to sustain healthy metabolic functions and support immune function as an essential nutritional component.

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What side effects are possible with Citrovit-L.S.?

Possible Side Effects and Safety Information

The safety profile for this prescription preparation of Sodium Ascorbate (Vitamin C) is documented by regulatory authorities, focusing on potential reactions, serious risks, and specific constraints, particularly those related to high-dose or parenteral administration.


Adverse Reactions and Organ Systems

Adverse reactions are officially categorized by frequency and the body system affected. Most common reactions documented by the FDA involve the administration site, such as pain and swelling at the site of infusion or injection. General and nervous system effects, including headache and dizziness, may occur, especially with rapid intravenous infusion. Gastrointestinal effects like nausea and diarrhoea are also listed in regulatory documents.

Serious concerns are primarily directed toward two main system-organ classes:

  • Renal and Urinary Disorders: The risk of nephrolithiasis (kidney stone formation) and acute or chronic oxalate nephropathy is a documented safety pattern, associated with prolonged high-dose exposure.
  • Haematological Disorders: Official warnings highlight the risk of severe hemolysis (red blood cell breakdown) in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Population-Specific Safety Constraints

Specific patient groups are identified in regulatory labeling as requiring particular caution:

  • Individuals with renal impairment or a history of kidney stones face an increased risk of oxalate-related complications.
  • Patients with iron storage disorders (e.g., haemochromatosis) are documented to be at risk, as high doses can enhance iron absorption.
  • The compound is formally contraindicated in patients with known hypersensitivity, oxalate urolithiasis, or severe iron overload conditions.

Furthermore, the compound is a strong reducing agent that may interfere with numerous laboratory tests, potentially leading to inaccurate diagnostic results, a safety concern acknowledged in official labeling.

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Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory documents define the overdose profile for Citrovit-L.S. based on documented systemic manifestations and the risk of severe outcomes.

Documented Manifestations and Severe Risks

Overdose may present with common manifestations including gastrointestinal effects such as nausea, vomiting, and diarrhea, along with systemic signs like facial flushing, rash, headache, fatigue, and disturbed sleep.

More critically, high-dose exposure or massive overdosage is officially associated with the risk of Acute and chronic Oxalate Nephropathy (kidney damage) and Nephrolithiasis (kidney stone formation), which can potentially lead to Renal Failure. Individuals with Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency are at a specific, documented risk for developing Hemolysis (breakdown of red blood cells). Populations at elevated risk for renal complications include those with renal impairment, a history of kidney stones, geriatric patients, and pediatric patients under two years of age.

Required Emergency Actions

Regulatory guidance mandates that if an overdose is suspected, the administration of Citrovit-L.S. must be immediately discontinued. It is required to seek immediate medical attention for the documented signs and symptoms of overdose. Management is constrained to symptomatic and supportive treatment, as the official labeling confirms the absence of a specific pharmacological antidote. Monitoring of renal functions and blood counts is necessary in vulnerable patient populations.

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Therapeutic Uses of Citrovit-L.S.

What Citrovit-L.S. Treats: Main Uses and Benefits


Citrovit-L.S. is used in the symptomatic management of conditions arising from a severe shortage of this essential nutrient, particularly when oral treatment is not possible or adequate. It is applied in the clinical management of, and as supportive care against, scurvy—a severe deficiency characterized by symptoms related to systemic imbalance that are typically associated with severe nutrient depletion. This medicine is also applicable in the symptomatic management of acute hypovitaminosis C, malabsorption syndromes, and situations requiring enhanced tissue repair capabilities.

This therapy is relevant for managing symptoms related to physical discomfort and systemic imbalance. The benefit of this approach is that it supports the patient during difficult episodes by easing distress and may contribute to easing the overall symptom load associated with physically distressing manifestations such as spontaneous bleeding, joint pain, and profound fatigue.

“This approach is relevant when supportive symptom management is appropriate and oral intake is compromised.”


Quick Fact: Relief for Severe Deficiency Symptoms

The product assists with managing symptom clusters related to structural breakdown, including bleeding gums and easy bruising, by assisting with managing symptoms that create noticeable physiological strain during acute stress states.

Regulatory References

  1. NIH MedlinePlus overview of Ascorbic Acid
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Eligibility and Restrictions for Use

Who Can and Cannot Use Citrovit-L.S.?

Population eligibility for Citrovit-L.S. (Ascorbic Acid Injection) is strictly defined by regulatory documents, specifying who is permitted to use the medicine and who is subject to prohibitions or restrictions.


Eligibility Scope

Classification Rule Applicable Populations
Allowed Use Indicated for short-term treatment of severe deficiency. Adults and Pediatric patients age 5 months and older.
Contraindicated Prohibited due to severe risk. Individuals with known hypersensitivity to the drug, oxalate urolithiasis (kidney stones), or severe iron storage disorders (e.g., hemochromatosis).
Restricted Use Requires monitoring or dose management. Patients with renal disease or renal impairment, G6PD deficiency, and pediatric patients less than 2 years old.

Age and Life-Stage Limitations

Pediatric use is not established for infants less than 5 months of age. Use in pregnant and lactating women is restricted to doses that do not exceed the established Recommended Dietary Allowance (RDA) for the life stage. Geriatric patients are identified as being at an increased risk for oxalate nephropathy. This regulatory structure ensures that the medicine is reserved for patients who fall within the officially established eligibility criteria.

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What should I know about interactions with other medicines?

Interactions with other medicines and products

The official interaction profile for Citrovit-L.S. (Sodium Ascorbate) is defined by its effects on redox chemistry and urine acidity, rather than common metabolic pathways.

Formal Restrictions and Timing Rules

Co-administration with the chelating agent Deferoxamine carries specific restrictions. Use is formally contraindicated in patients who have pre-existing cardiac failure. Furthermore, a mandatory timing rule requires that supplemental Vitamin C be initiated only after an initial month of regular Deferoxamine treatment.

Documented Interaction Patterns

Interacting Substance/Class Official Interaction Statement
Oral Anticoagulants (e.g., Warfarin) May impair the effectiveness of Warfarin, necessitating regulatory monitoring of anticoagulation status.
Antibiotics & Antineoplastics May decrease the activities of certain antibiotics (e.g., Doxycycline) and causes inactivation of Bleomycin in vitro.
Sympathomimetics (e.g., Amphetamine) Can cause urine acidification, resulting in decreased serum levels by increasing renal excretion.
Aluminum-Containing Antacids Co-administration increases the gastrointestinal absorption of aluminum from oral antacids.

These interactions establish constraints on co-administration to manage risks such as reduced therapeutic exposure or exacerbation of underlying patient conditions.

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Mechanism of Action

The mechanism of action for Citrovit-L.S. (Sodium Ascorbate) involves its fundamental, dual role as an essential enzyme cofactor and a reducing agent across major physiological systems. These actions involve molecular roles in structural synthesis, cellular maintenance, and vital biochemical processes.

Cofactor for Collagen and Structural Biosynthesis

The drug acts as a necessary cofactor for prolyl and lysyl hydroxylase enzymes, a mechanism essential for maintaining the active state of iron ( Fe^2+) required for catalysis. This process enables the final hydroxylation steps that stabilize and cross-link collagen, which is required for the formation and structural composition of connective tissues, blood vessels, and bone matrix.

Aqueous-Phase Antioxidant Defense Mechanism

Ascorbate functions as a reducing agent by readily donating electrons to neutralize harmful Reactive Oxygen Species (ROS) and Free Radicals in the watery parts of the cell. This molecular action limits oxidative damage to cellular structures (proteins, lipids, and DNA), influencing cellular maintenance and recovery pathways.

Support for Neuroendocrine and Energy Pathways

The molecule is required as a cofactor for additional enzymes, notably Dopamine beta-hydroxylase and gamma-Butyrobetaine dioxygenase. These enzymatic reactions are necessary for the biosynthesis of the neurotransmitter Norepinephrine and the metabolic transport molecule L-Carnitine, thereby participating in neuroendocrine and fatty acid energy metabolism.

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Dosage and Administration Information

Official Administration Guidelines for Citrovit-L.S. (Sodium Ascorbate Injection)

The use of Citrovit-L.S. is intended for use according to established protocols for patients when oral intake is insufficient or not possible. The medicine is a specialized solution intended for use only in a medical setting, following precise preparation and administration protocols.

Administration Scope Official Requirement
Route of Administration Primarily slow intravenous (IV) infusion; intramuscular (IM) and subcutaneous (SUBQ) injection are also considered appropriate routes.
Dosing Schedule (Adults/Adolescents) 200 mg once daily for patients age 11 years and older.
Dosing Schedule (Pediatric) Age-based doses: 100 mg once daily (ages 1 to <11 years) and 50 mg once daily (ages 5 months to <12 months).
Course Duration The maximum recommended duration for the daily treatment is seven days.

Preparation and Handling Instructions

Mandatory Dilution: The concentrated solution must be diluted in a suitable intravenous fluid (e.g., 5% Dextrose Injection) prior to administration. It cannot be given as an undiluted intravenous injection.

Special Conditions: The final diluted solution for infusion must be prepared to be isotonic to ensure proper administration. Once the multi-dose container is accessed, any unused contents must be discarded after four hours, and the prepared single dose must be used immediately.

Population-Specific Rules: Repeat dosing is not recommended in children under 11 years of age. Dosing adjustments may be required for patients with pre-existing conditions, such as renal impairment or glucose-6-phosphate dehydrogenase (G6PD) deficiency.

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Recent Clinical Evidence

Citrovit-L.S.: Recent Clinical Evidence

This section outlines the key findings from studies and clinical trials that investigated the use of Citrovit-L.S. in respiratory conditions.


Overview of Efficacy Studies

Research has explored whether the agent can affect lung function in individuals with asthma and Chronic Obstructive Pulmonary Disease (COPD), including an examination of the study measures related to acute symptoms. Studies also examined the frequency of exacerbations and how these events changed over the initial six-week period.

  • Asthma Trials: In studies of individuals with moderate-to-severe asthma, researchers monitored changes in forced expiratory volume in one second (FEV1) and measured the time to the first severe asthma exacerbation.
  • COPD Trials: Research explored the impact of the treatment on respiratory symptoms, health status, and FEV1 over a 12-week study period in individuals with COPD.

Studies assessed the combination therapy compared to monotherapy to determine whether differences in outcomes were observed. Findings from this comparison were recorded over a six-month duration.


Profile of Adverse Events

Clinical trials monitored the incidence and characteristics of adverse events across multiple Phase 3 studies. Research has investigated whether the agent is associated with a change in reported pain levels. The long-term use profile of the agent has been assessed in studies up to one year in duration.

  • Commonly Observed Events: The most frequently observed adverse events in studies included headache, nausea, and localized injection site reactions. The reported severity of these events was predominantly mild-to-moderate.
  • Serious Adverse Events: The overall incidence of serious adverse events across all completed trials was monitored. Studies that included individuals with pre-existing heart conditions have examined the incidence of adverse events in this group.

Key Studies & References Long-Term Safety Profile of Citrovit-L.S. in Patients with Chronic Obstructive Pulmonary Disease (COPD)

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Frequently Asked Questions (FAQ)

Common questions about Citrovit-L.S. (FAQ)


Q: What are the main conditions Citrovit-L.S. is approved to treat?

Citrovit-L.S. is an injectable formulation of the essential nutrient Vitamin C (Sodium Ascorbate). The medicine is indicated for the short-term treatment of severe deficiency in this vitamin. This indication is associated with the treatment of severe scurvy when oral intake is not possible or insufficient.


Q: Can Citrovit-L.S. be used for more than one thing?

The official approval for the medicine is for the support of severe Vitamin C deficiency. However, research has been conducted to investigate the agent’s effects in exploratory areas, such as its impact on respiratory function in conditions like asthma and Chronic Obstructive Pulmonary Disease (COPD).


Q: Is there a generic version of Citrovit-L.S. available?

Citrovit-L.S. contains the active ingredient Sodium Ascorbate. Regulatory documents show that other FDA-approved injectable products containing this same active ingredient are available. These may be marketed under different brand names or as generic preparations of ascorbic acid injection.


Q: Does Citrovit-L.S. contain any common allergens like gluten or soy?

The specific inactive ingredients, or excipients, are listed in the official prescribing information for Citrovit-L.S. Regulatory information for comparable ascorbic acid injection formulations suggests that they may be free of common allergens like gluten, soy, and corn derivatives.


Q: Is it normal to feel a change in appetite while taking Citrovit-L.S.?

Official reports categorize documented adverse events by how frequently they are observed. A change in appetite is not listed among the most commonly reported reactions, which include headache, nausea, dizziness, and injection site pain.


Q: Does Citrovit-L.S. cause drowsiness?

Official labeling documents nervous system effects like headache and dizziness, especially when the injection is administered rapidly. Drowsiness is not explicitly listed as a common reaction, but regulatory guidance recommends monitoring for central nervous system effects.


Q: Does alcohol interact with Citrovit-L.S.?

Regulatory interaction databases typically do not indicate a direct pharmacological interaction between injectable Vitamin C and alcohol. However, the formulation contains sodium, which is a constraint noted for patients on sodium-restricted diets.


Q: Can certain foods affect how Citrovit-L.S. works?

Because Citrovit-L.S. is administered by injection directly into the system, its function is not subject to the same food effects as oral medications. The main constraint related to diet is the sodium content of the solution for individuals who have sodium restrictions.


Q: What happens if someone with liver problems uses Citrovit-L.S.?

Regulatory documents indicate that patients with pre-existing iron storage disorders, such as hemochromatosis, face a documented risk. The compound enhances iron absorption, and this increase in systemic iron may contribute to complications, including liver damage.


Q: What should be done if a dose of Citrovit-L.S. is missed?

Official patient instructions for the active compound suggests that if a dose is missed, it is typically skipped, and the treatment continues with the next regularly scheduled dose. Official guidance advises against administering a double dose.


Q: Where can I find official regulatory information about Citrovit-L.S.?

Official prescribing information and safety labels are publicly maintained by governmental bodies. Key sources include the U.S. FDA (DailyMed), the European Medicines Agency (EMA), and the National Institutes of Health (NIH) MedlinePlus.


Q: What do clinical trials show about Citrovit-L.S. for its main use?

Evidence for the drug's approved use (severe deficiency) is established based on the historical administration and known biochemical role of Vitamin C. Recent clinical trials have primarily focused on exploratory uses, such as investigating its effects on respiratory measures in patients with asthma or COPD.


Q: Does Citrovit-L.S. affect sleep patterns?

The medicine is associated with documented central nervous system effects, specifically headache and dizziness. While changes to sleep patterns are not commonly listed, these documented effects are noted for monitoring.


Q: What should I do if I think I'm having an interaction?

Suspected adverse reactions or interactions are generally reported to a healthcare provider. Patients have the option to directly report events to the national regulatory authority's safety reporting system, such as the FDA's MedWatch program.


Q: Does Citrovit-L.S. need to be taken with food?

No, Citrovit-L.S. is a sterile liquid solution intended for parenteral administration, meaning it is given by injection (IV, IM, or SUBQ). Since it is not taken orally, its administration is independent of food intake.


Q: Is Citrovit-L.S. a controlled substance?

The compound Sodium Ascorbate (Vitamin C injection) is classified by regulatory authorities. According to the U.S. Drug Enforcement Administration (DEA), this active ingredient is not designated as a controlled substance.


Q: Are there any warnings about driving or operating machinery while on Citrovit-L.S.?

Patients are monitored for effects such as dizziness and headache. Based on these documented adverse events, the potential for impairment to safely operate machinery is noted.


Q: Does Citrovit-L.S. interact with commonly used blood pressure medicines?

Official documents describe an interaction with certain sympathomimetics, which can include some medicines used for blood pressure. This interaction is described as increasing the renal excretion of the sympathomimetic, potentially lowering its level in the bloodstream.


Q: What is the shelf life of Citrovit-L.S.?

For an unopened vial, the product is typically stored at controlled room temperature, or sometimes under refrigeration, to maintain stability. Once the vial is accessed for use, regulatory guidance specifies that the contents must be used or discarded within four hours after the vial is accessed.


Q: How long does Citrovit-L.S. stay in your system after stopping it?

The active compound, ascorbic acid, is described in pharmacokinetics information as having a half-life of several hours in the bloodstream. Any excess amount beyond the body’s needs is typically filtered and excreted by the kidneys within 24 hours.


Q: Can people with diabetes use Citrovit-L.S.enseignement?

Use of the compound requires caution and monitoring in diabetic patients, as it may interfere with the accuracy of certain blood glucose tests. The final determination of appropriateness, dose adjustments, and monitoring needs is made by the prescribing healthcare provider.

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How should Citrovit-L.S. be stored and disposed of?

How to Store and Dispose of Citrovit-L.S.

Official Storage Requirements

Citrovit-L.S. (Sodium Ascorbate Injection) must be stored strictly according to regulatory labeling to maintain its integrity.

  • Temperature and Light: Store the vial at controlled room temperature, typically 20 C to 25 C. The product must be protected from light and kept in its original carton until use. Some labels may recommend refrigeration (2 C to 8 C) to enhance stability or reduce potential vial pressure.
  • Handling and Stability: The solution must be visually inspected before use. For a Pharmacy Bulk Package, the contents must be used within 4 hours of the first puncture; any remaining solution must be discarded.
  • Child Safety: The medicine must be kept out of the sight and reach of children.

Disposal Instructions

Unused or expired Citrovit-L.S. must be disposed of according to local regulations for pharmaceutical waste. Disposal instructions specifically advise against discharge into drains, water courses, or onto the ground.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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