Citalo

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Citalo

Property Description
Active ingredient Escitalopram (typically as the oxalate salt)
Form Film-coated tablet and oral solution
Pharmacological class Selective Serotonin Reuptake Inhibitor (SSRI)
Common purpose Aiding in the stabilization of mood and reduction of excessive worry
Origin Synthetic compound (pure S-enantiomer)

1. What Type of Medication is Citalo? (Identity and Classification)

Citalo is a specific pharmaceutical preparation containing the active ingredient Escitalopram, which places it within the drug class known as Selective Serotonin Reuptake Inhibitors (SSRIs). This class is primarily utilized as an antidepressant, and its efficacy is clinically recognized for managing conditions involving persistent negative emotional states and severe anxiety. The designation "selective" confirms that Escitalopram is specifically engineered to target and modulate the activity of the neurotransmitter serotonin, exhibiting minimal effect on other brain chemical messengers. The medication is a prescription-only item, underscoring the necessity of medical supervision for its use.

2. Composition, Origin, and Form (Substance and Origin Intents)

The core substance, Escitalopram, is a fully synthetic compound, manufactured as the oxalate salt. It is chemically significant as the purified S-enantiomer—or single isomer—of the related compound citalopram. Escitalopram is the active S-enantiomer, a key differentiating factor that focuses the drug's activity on the most therapeutically potent molecular structure. Citalo is prepared for oral administration and is supplied primarily as a film-coated tablet or, less commonly, as an oral solution, providing flexibility for specific patient groups, such as those who have difficulty swallowing tablets.

3. General Purpose of this SSRI (High-Level Benefit Intents)

The overall purpose of Citalo is to promote a beneficial shift in the brain's neurochemical environment by augmenting the action of serotonin. This is achieved by the drug's mechanism of inhibiting the reabsorption (reuptake) of serotonin by nerve cells. This sustained action on serotonergic activity is the core principle that allows the medication to aid in the gradual restoration of stable neurochemical balance. For patients, the general use scenario involves mitigating symptoms such as pervasive sadness or continuous, uncontrollable worry, thereby stabilizing overall emotional function.

Regulatory References

  1. MedlinePlus: Escitalopram

What side effects are possible with Citalo?

Possible Side Effects and Safety Information

Citalo (Escitalopram), as a Selective Serotonin Reuptake Inhibitor, has an official safety profile categorized by the frequency and physiological system of adverse reactions, as documented by regulatory bodies.

Commonly Documented Adverse Reactions

According to official regulatory labeling, reactions classified as Very Common (ge 1/10) include Nausea and Headache. Side effects classified as Common (ge 1/100 to < 1/10) often affect the Nervous System (e.g., Insomnia, Somnolence, Dizziness), the Gastrointestinal System (e.g., Diarrhoea, Dry mouth, Constipation), and may involve Increased sweating, Fatigue, and various forms of Sexual dysfunction.

Serious Adverse Reactions and Specific Warnings

The regulatory profile highlights several serious adverse events, including the documented risk of Suicidal Thoughts and Behaviors, particularly in young adults and upon initiating treatment or changing the dose, as emphasized in FDA warnings. Other serious but rare documented risks involve Serotonin Syndrome, a potentially life-threatening reaction, and the possibility of QT Prolongation and a specific type of ventricular arrhythmia called Torsade de Pointes. Seizures and severe electrolyte disturbances, such as Hyponatraemia (low sodium), are also officially documented.

Population and Exposure-Related Safety Notes

Official labels note specific safety considerations for certain groups: Older adults may be at an increased risk for Hyponatraemia. Use in children and adolescents (under 18) is generally not recommended due to the observed increased risk of suicide-related behaviors. The risk of discontinuation symptoms, such as sensory disturbances and anxiety, requires a gradual dose reduction upon stopping the medicine. Furthermore, safety is restricted by contraindications with certain medicines, including Monoamine Oxidase Inhibitors (MAOIs) and Pimozide.

Overdose and Emergency Response

Overdose and when to seek help

Suspected overdosage of Citalo (Escitalopram) is considered a medical emergency and requires immediate medical attention. The officially documented clinical manifestations of overdose primarily involve the Central Nervous System (CNS) and the cardiovascular system, as reported in regulatory documents.

Documented signs often include CNS effects such as somnolence, dizziness, tremor, insomnia, and confusion, alongside gastrointestinal effects like nausea and vomiting. Physiologically, overdose may result in sinus tachycardia (fast heart rate) and QT prolongation, which is a potentially serious change in heart rhythm.

Regulators emphasize that severe outcomes may include convulsions (seizures), coma, and life-threatening conditions such as Serotonin Syndrome and Torsades de pointes (TdP). The risk of severe toxicity is heightened when Escitalopram is co-ingested with other medicinal products or alcohol. Furthermore, hyponatremia (low sodium levels) has been observed, a specific concern in older patients.

Emergency Action

Given the high risk of serious cardiac and neurological complications, immediate emergency medical attention must be sought for any suspected overdose. Official regulatory guidance confirms that no specific antidote is known for Escitalopram. Therefore, management is symptomatic and supportive, and requires mandatory monitoring of cardiac rhythm (ECG monitoring) and vital signs. Medical procedures, such as the use of activated charcoal, may be employed under supervision.

Therapeutic Uses of Citalo

What Citalo treats: main uses and benefits

The therapeutic role of Citalo (Escitalopram) is relevant for symptomatic relief across key domains involving persistent mood and anxiety disturbances. The medication is commonly used to help with symptoms associated with Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD). It may be part of symptomatic management for conditions like Panic Disorder, Social Anxiety Disorder, and Obsessive-Compulsive Disorder (OCD).

“This use supports the patient during difficult episodes by easing distress, and contributes to maintaining a sense of stability when symptoms are more noticeable.”

The medication is generally applied in settings where supportive symptom management is appropriate, targeting clusters of symptoms that may become intense or disruptive, such as pervasive sadness, significant loss of interest, excessive worry, and chronic tension. This use may assist with maintaining functional stability and contributes to improved comfort during periods of heightened symptoms.


Quick Fact: Support for Excessive Worry

Citalo is relevant for easing the symptoms of chronic excessive worry and associated restlessness, which may help patients cope more steadily with symptom fluctuations.

Eligibility and Restrictions for Use

Who Can and Cannot Use Citalo?

Citalo (Citalopram) eligibility is determined by regulatory bodies based on mandatory health and co-medication constraints, primarily to manage the risk of cardiac electrical abnormalities.

Population Status Official Classification
Contraindicated Patients currently taking Monoamine Oxidase Inhibitors (MAOIs) or the drug Pimozide. Also strictly prohibited for individuals with known Hypersensitivity to Citalopram or those with Congenital Long QT Syndrome.
Restricted Use Older adults (age ge 60) and patients with Hepatic Impairment. The maximum recommended dose for these specific populations is officially limited to 20 mg per day.

Age and Conditional Eligibility

The standard approved population consists of adults (18–60 years). Use is generally not approved for pediatric patients (under 18) by the U.S. FDA. For those with Severe Renal Impairment, caution is required as official data on drug clearance in this group are not fully established. Use during pregnancy or lactation is conditional, permitted only when the potential benefits are officially deemed to justify the potential risks to the fetus or infant.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documents identify several drug categories and substances that require strict management when used with Citalopram, based on documented pharmacokinetic and pharmacodynamic effects.

Interaction Type Interacting Agents/Classes Restriction Summary
Contraindicated Monoamine Oxidase Inhibitors (MAOIs), Pimozide, other drugs that prolong the QT interval (e.g., certain antiarrhythmics). Co-administration is forbidden. A 14-day separation period is required when switching to or from MAOIs.
Serotonergic Risk Triptans, Tricyclic Antidepressants, Fentanyl, Tramadol, Lithium, St. John's Wort. Concomitant use increases the documented risk of Serotonin Syndrome.
Bleeding Risk Nonsteroidal Anti-inflammatory Drugs (NSAIDs), Aspirin, Warfarin, other anticoagulants. Use with caution; these combinations are documented to increase the risk of abnormal bleeding events.
Exposure Modifiers Potent inhibitors of the CYP2C19 or CYP3A4 enzymes (e.g., Omeprazole, Cimetidine, Ketoconazole). Inhibitors decrease Citalopram clearance, increasing systemic exposure and the risk of QTc prolongation. Dosage constraints are specified in the labeling for co-administration.

Population-Specific Constraint: Patients identified as CYP2C19 Poor Metabolizers, those with hepatic impairment, or elderly patients (age 65 or older) have an official, interaction-related maximum daily dose restriction due to the heightened risk of QTc prolongation at higher plasma concentrations.

Mechanism of Action

Citalopram's action focuses on influencing a key signaling pathway in the brain, which leads to long-term changes in serotonergic signaling and associated physiological responses.

Selective Serotonin Transporter Inhibition

This mechanistic domain covers the drug's immediate molecular action: it selectively inhibits the serotonin transporter (SERT) protein, preventing the reabsorption of serotonin (5-HT) back into presynaptic nerve terminals. This interaction increases the concentration of serotonin available to signal across the synaptic cleft, immediately modulating transmission within the serotonergic system.

Time-Dependent Neuroplastic Modulation

The subsequent domain involves the long-term physiological consequences of sustained serotonin elevation, which drive adaptive changes in the brain's circuitry over a period of weeks. This leads to the modulation of neural signaling activity and the promotion of neuroplasticity (changes in nerve cell connections). This cascade contributes to the long-term modulation of central nervous system pathways that receive serotonergic input.

Dosage and Administration Information

Citalo (Escitalopram) is administered exclusively through the oral route, available as both film-coated tablets and an oral solution (1 mg/ mL). The tablets are often scored, allowing for division into equal doses for precise administration. The general principle of use follows a once-daily schedule, which can be maintained in the morning or evening, and the medicine may be taken with or without food.

The initiation of use typically begins with a daily dose of 10 mg for most adult patients. This regimen may be increased up to the maximum recommended dose of 20 mg once daily, but this adjustment must only occur after a minimum of one week of treatment to allow for proper dose assessment. Specific populations are subject to lower daily limits; for instance, the recommended dose for older adults and patients with hepatic impairment is generally limited to 10 mg once daily.

Citalo is used as part of a long-term plan, involving both initial acute treatment and sustained maintenance periods, and requires periodic re-evaluation to determine the need for continued therapy. Should a dose be missed, the instruction is to skip that dose entirely and resume the regular schedule the next day; the dose must not be doubled. Upon the conclusion of use, the medicine is not stopped abruptly; instead, a gradual dose reduction (tapering) is prescribed to follow the official protocol for cessation.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Citalo


Evidence for Major Depressive Disorder (MDD)

The research into the use of Citalo (Escitalopram) for Major Depressive Disorder (MDD) has primarily relied on randomized controlled trials (RCTs). These short-term studies, often lasting 6 to 8 weeks, compare the outcomes measured in individuals receiving Citalo against outcomes measured in individuals receiving an inactive substance, or placebo, and sometimes against other existing medications. Studies conducted during periods of increased symptom activity reported measured patterns of change in average depression severity scores, which were contrasted with the inactive control. Evidence also includes longer maintenance trials that explore short-term symptom changes over 24 to 76 weeks.


Evidence for Generalized Anxiety Disorder (GAD)

Research exploring Citalo for Generalized Anxiety Disorder (GAD) also relied heavily on placebo-controlled RCTs, with a standard follow-up duration of approximately 8 to 12 weeks. These studies monitored outcomes linked to physical discomfort or tension and outcomes reflecting daily functioning. Studies focusing on episodes where symptoms become more noticeable reported measurements that showed patterns of change in anxiety severity scores, which were contrasted with the placebo groups. The evidence base describes research focused on short-term changes over the standard 8 to 12-week time interval. The study results apply most directly to the specific populations studied in the trials, as many early trials systematically excluded individuals with certain significant psychiatric conditions.


Evidence for Panic Disorder (PD)

The evidence base for Panic Disorder (PD) was evaluated in both placebo-controlled trials and other observational study types. Research examined outcomes related to episodic or acute changes, primarily focusing on the frequency and intensity of panic attacks over short-term intervals. Research describes patterns observed in these studies, indicating that the use of the drug was studied for its relationship with measured changes in panic attack frequency. However, the volume of dedicated, rigorous placebo-controlled RCTs for PD is noted to be lower than the research volume for MDD and GAD.


Long-Term Studies and Follow-up Durations

Studies conducted to understand outcomes over a longer period, including the rate of symptom recurrence, have follow-up durations ranging from six months up to approximately one year. These extended studies are applied research that contributes to understanding symptom patterns related to the measured rate of depression or anxiety symptoms returning. However, long-term effects beyond these defined study intervals are not fully established.


What Remains Uncertain or Requires Further Research

One key limitation is that follow-up durations were limited in the initial efficacy trials, meaning that long-term outcomes are not fully established. The results apply only to the specific populations studied, and caution is warranted when generalizing findings. Findings were also mixed in some of the smaller patient subgroups, and evidence quality varies across studies, especially for long-term data derived from less rigorous, open-label designs.

Key Studies & References

  1. Escitalopram (Lexapro) - MedlinePlus Drug Information
  2. Guidance on the use of computerised cognitive behavioural therapy for mild to moderate depression and generalised anxiety disorder (NICE Guideline Reference)

Frequently Asked Questions (FAQ)

Common questions about Citalo (FAQ)

Q: Is it safe to drive after taking Citalo?

Official labeling contains a warning about the drug’s potential to Interfere with Cognitive and Motor Performance. Because of this, caution is advised regarding activities such as operating machinery or driving. Patients are advised to be aware of how the medicine affects them before engaging in activities that require full mental alertness.

Q: How long until Citalo starts working for depression?

According to official product information, it may take up to 4 weeks before a patient begins to notice an improvement in symptoms. Full therapeutic benefit may take longer, typically developing over 6 to 8 weeks. The clinical studies and product information are based on consistent, daily use of the medication.

Q: Can Citalo be taken with NSAIDs like ibuprofen for pain?

Official labeling advises caution when combining this medication with Nonsteroidal Anti-inflammatory Drugs (NSAIDs), aspirin, or other drugs that affect blood clotting. Regulatory documents state that these combinations are documented to increase the risk of abnormal bleeding events. The decision to combine Citalo with any pain reliever should be made by a healthcare professional.

Q: What happens if I suddenly stop taking Citalo?

Regulatory documents indicate that abrupt cessation of the medicine is generally avoided. A gradual reduction in dose (tapering) is instead performed to minimize the risk of discontinuation symptoms. These symptoms may include sensory disturbances, sleep difficulties, agitation, nausea, dizziness, and headache.

Q: Can I drink alcohol while I am taking Citalo?

Official patient information states that alcohol use is generally discouraged during treatment. While the drug does not appear to enhance the effects of alcohol, concomitant use may worsen side effects such as drowsiness and impaired coordination, and is associated with other potential risks.

Q: How long does Citalo stay in your system?

Regulatory documents state that the mean terminal half-life of the active ingredient, Escitalopram, is approximately 27 to 32 hours. The half-life is the time it takes for the drug's concentration in the body to be reduced by half. Steady-state concentrations are typically reached within about one week of once-daily dosing.

Q: Does Citalo cause weight gain?

Official adverse event data from clinical trials identifies both weight gain and weight decrease as reported side effects. Neither outcome is classified as a common adverse reaction, but they were reported in a small percentage of patients during the studies. Further details are available in the full section on possible side effects.

Q: Is Citalo addictive?

Official regulatory documents do not classify Citalo as having an abuse potential or being addictive. However, a gradual dose reduction is mandated upon stopping treatment to manage the risk of discontinuation symptoms, which are sometimes mistakenly referred to as withdrawal.

Q: How should I dispose of the oral solution?

Unused or expired medication should be disposed of via an official drug take-back program if one is available. If a program is unavailable, non-flushable medication may be mixed with an undesirable substance (such as dirt or used coffee grounds), sealed in a plastic bag, and discarded with household trash. Disposal procedures are subject to local requirements.

How should Citalo be stored and disposed of?

How to Store and Dispose of Citalopram / Escitalopram

The official storage requirements for Citalopram and Escitalopram (Citalo) are defined by regulatory authorities to maintain product quality and safety.


Storage Requirements

Condition Requirement
Temperature Store at Controlled Room Temperature, ideally 25 C (77 F), with excursions permitted up to 30 C (86 F).
Protection Keep the medication, especially the oral solution, in its original, tightly closed container and protect it from moisture and light.
Child Safety The medication must be kept out of the reach and sight of children.

Disposal Instructions

Unused or expired product should be disposed of via an official drug take-back program. If a program is unavailable, non-flushable medication may be mixed with an undesirable substance (e.g., dirt, used coffee grounds), sealed in a bag, and discarded with household trash. Disposal must always follow local requirements.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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