Calcicare

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Calcicare

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Calcicare

Property Description
Active ingredients Calcium Carbonate, Calcium Glubionate, Colecalciferol (Vitamin D3)
Form Tablet, Oral Liquid, Granules, Chewable Tablet
Pharmacological class Calcium Preparations and Vitamin D Analogs
Common use Nutritional supplementation for bone health
Origin Combination of inorganic salt, organic salt, and vitamin derivative

Calcicare is classified as a combination medicine and a nutritional supplement formulated to provide essential micronutrients required for skeletal system maintenance and mineral balance. It operates within the pharmacological class of Calcium Preparations and Vitamin D Analogs, acting as an Agent Affecting Bone Metabolism. A key differentiating feature is its availability in multiple dosage forms, including the Tablet, Oral Liquid, Granules, and Chewable Tablet, intended for Oral delivery, which caters to patient groups such as growing children and the elderly.

Calcicare's Composition: Elemental Calcium and Vitamin D3

Calcicare is a Combination Product that incorporates two distinct forms of Elemental Calcium—the inorganic salt Calcium Carbonate and the organic salt Calcium Glubionate—alongside the crucial co-factor, Colecalciferol (Vitamin D3). Vitamin D is essential for regulating calcium absorption and maintaining phosphate levels. This means the formulation is designed to improve the body's ability to take in and utilize the mineral effectively. The use of a blend of calcium salts and a vitamin derivative is a distinctive compositional feature, clinically recognized for supporting bioavailability.

What is the General Purpose of Calcicare?

The general purpose of Calcicare is to aid in the prevention and correction of nutritional deficiencies of calcium and Vitamin D, which are critical for maintaining bone structure and strength. Combined supplementation is utilized to support optimal bone mineral density and reduce risk factors associated with deficiencies. This indicates the combination is generally recognized for its role in long-term bone health support. The Colecalciferol component facilitates the physiological action of enhancing calcium absorption from the intestine, ensuring that the mineral is effectively utilized for processes like bone mineralisation in individuals with inadequate sun exposure or high nutritional requirements.

Regulatory References

  1. Source: NCBI Bookshelf

What side effects are possible with Calcicare?

Possible Side Effects and Safety Information

This section outlines the officially documented adverse reactions and regulatory safety characteristics of Calcicare (Calcium Carbonate, Calcium Glubionate, and Colecalciferol combination), based strictly on government regulatory documents.


Documented Adverse Reactions

Adverse effects are classified by frequency according to regulatory standards (e.g., EMA/ICH):

Frequency Affected System Documented Effects
Uncommon Metabolism & Nutrition Hypercalcaemia (high blood calcium), Hypercalciuria (high urinary calcium).
Rare Gastrointestinal Constipation, Flatulence, Dyspepsia, Nausea, Abdominal pain, Diarrhoea.
Rare Skin & Subcutaneous Tissue Pruritus (itching), Rash, Urticaria (hives).
Very Rare Systemic Milk-alkali syndrome (Hypercalcaemia, alkalosis, and renal impairment).

Serious adverse effects documented in regulatory labeling include the potential for irreversible renal damage and soft tissue calcification resulting from severe or prolonged Hypercalcaemia.


Safety Constraints and Special Populations

Official labeling defines specific situations where Calcicare should not be used or requires particular caution:

  • Contraindications: Use is strictly forbidden for individuals with Severe Renal Failure, pre-existing Hypercalcaemia from any cause, or hypersensitivity to any component.
  • Population-Specific Caution: Caution and specific monitoring of calcium levels are required for patients with renal impairment, sarcoidosis, and immobilized patients with osteoporosis.
  • Exposure Patterns: Hypercalcaemia and Hypercalciuria are specifically noted as effects seen with long-term treatment at high dosages.

Regulatory documentation emphasizes the need to consider the total intake of calcium and Vitamin D from all sources (including food and other supplements) to mitigate the risk of Hypercalcaemia.

Overdose and Emergency Response

Overdose and when to seek help — Official Regulatory Information for Calcicare

Overdose Scope

Property Regulatory Statement
Documented Overdose Presentations Symptoms include nausea, vomiting, anorexia, excessive thirst (polydipsia), increased urination (polyuria), fatigue, and mental disturbances. Laboratory findings consistently show Hypercalcaemia and Hypercalciuria.
Severe Outcomes Overdose may result in severe hypercalcaemia, which carries the documented risk of cardiac arrhythmias, irreversible renal damage (nephrocalcinosis), and potential escalation to coma or death.
Emergency Actions Required Seek immediate medical attention or contact a poison control center or emergency room at once if an overdose is suspected. Immediate discontinuation of the product is required.

Official Overdose Profile

The primary risk of Calcicare overdose is the resulting state of Hypercalcaemia and Hypervitaminosis D, which dictates the severity and required action. Regulatory documents mandate that any suspected overdose requires the user to seek urgent medical help due to the explicitly documented risks to the renal and cardiovascular systems. The profile notes that overdose must be avoided during pregnancy due to documented risks of developmental harm to the child, and patients with impaired renal function require special monitoring. Management is described as supportive and symptomatic treatment, involving monitoring serum calcium and renal function, as no specific antidote is known. Specialized procedures, such as fluid administration or the use of specific anti-hypercalcaemic medications, may be required for severe cases.

Therapeutic Uses of Calcicare

What Calcicare Treats: Main Uses and Benefits

Calcicare is generally used to help address diagnosed deficiencies of calcium and Vitamin D, providing supportive nutritional assistance. This approach is relevant for conditions characterized by decreased bone density (such as osteoporosis) and for muscle function issues related to mineral imbalances. This application includes the prevention and treatment of vitamin D and calcium deficiency, particularly in the elderly.

The medication is commonly applied in clinical settings when supportive management of these deficiencies is needed, such as during phases of increased physiological stress or to supplement specific treatments for osteoporosis. By helping to replenish these key nutrients, Calcicare may assist with easing symptoms that arise from these foundational systemic imbalances.

“This supportive therapy contributes to the maintenance of structural strength and functional stability across key physiological domains.”

Indications: The main symptomatic domains Calcicare is used to help manage include low nutritional levels, weakened bones and teeth, and mineral-related muscle discomfort. This support is relevant in contexts marked by increased discomfort or tension caused by deficiency.

Quick Fact: Relief for Muscle Discomfort The supportive role of Calcicare may assist with easing muscle aches and discomfort that are linked to imbalances in calcium and Vitamin D levels.

Eligibility and Restrictions for Use

Calcicare, often containing calcium carbonate and sometimes Vitamin D, is primarily indicated for individuals experiencing conditions related to low calcium levels in the blood (hypocalcemia). This includes those with osteoporosis, osteomalacia (rickets), hypoparathyroidism, and during periods of high calcium demand, such as pregnancy and lactation. It may also be used as a phosphate binder in patients with chronic kidney disease (CKD) to control high phosphate levels, or as an antacid for symptomatic relief of heartburn and acid indigestion.


Contraindications and Precautions

Calcicare should not be used by individuals who have hypercalcemia (high calcium levels in the blood) or hypercalciuria (excess calcium in the urine), which can contribute to kidney stones (nephrolithiasis). It is also contraindicated in those with a known allergy to calcium carbonate, Vitamin D, or any other components of the product.

Considerations Condition/Medication
**Use with Caution** Sarcoidosis, severe renal impairment, history of kidney stones, and patients taking cardiac glycosides (like digoxin).
**Drug Interactions** Tetracycline and quinolone antibiotics, thyroid hormone (levothyroxine), bisphosphonates, and certain medications for fungal infections. Dosing should be spaced apart to prevent decreased absorption.

Consultation with a healthcare provider is essential to determine appropriate use and to manage potential interactions or underlying health conditions.

What should I know about interactions with other medicines?

Calcicare Interactions with other medicines and products

The interaction profile of Calcicare, a combination of Calcium and Colecalciferol ( Vitamin D3), is based on two primary regulatory concerns: altered absorption of co-administered medicines and additive effects on mineral balance.


Interactions Affecting Drug Absorption

Calcium salts can reduce the absorption of several oral medications by forming complexes in the gut. To prevent this, regulatory guidance requires a separation window, typically 2 to 4 hours, when co-administering Calcicare with:

  • Antibiotics: Such as tetracyclines and quinolones.
  • Thyroid Hormones: Including levothyroxine.
  • Bone Health Agents: Such as bisphosphonates.

Interactions Affecting Vitamin D and Calcium Levels

Other medicines can increase the risk of hypercalcaemia (high calcium levels) or reduce the effectiveness of the Colecalciferol component.

  • Cardiac Glycosides (e.g., Digoxin): Co-administration may potentiate the risk of cardiac arrhythmias and necessitates close monitoring.
  • Thiazide Diuretics: These drugs decrease calcium excretion, increasing the risk of hypercalcaemia.
  • Enzyme Inducers: Medicines like phenytoin and barbiturates can reduce the effect of Vitamin D through increased metabolism.

Food and Population Considerations

Foods high in oxalic acid (spinach, rhubarb) or phytic acid (whole grains) can interfere with calcium absorption. Additionally, patients with impaired renal function are at a heightened risk for hypercalcaemia and hyperphosphatemia during treatment.

Mechanism of Action

How Calcicare Works: Mechanistic Domains


Selective Modulation of Voltage-Gated Calcium Channels

Calcicare functions by engaging voltage-gated L-type calcium channels primarily on vascular smooth muscle cells (VSMCs), inhibiting the influx of extracellular calcium ions ( Ca^2+). This action directly reduces the contractility of the muscle, which initiates a change in peripheral vascular resistance.


Induction of Peripheral Vasodilation

The resulting effect of calcium channel blockade is the direct relaxation of VSMCs throughout the arterial system. This mechanism is primarily relevant in systems where targeted pathway adjustment is required to decrease the resistance to blood flow, resulting in physiological changes that define the modulation of resistance to blood flow.


Modulation of Systemic Vascular Resistance

By promoting arterial relaxation, Calcicare acts within domains involving the regulation of systemic vascular tone. This cascade modifies early molecular steps that result in reduced afterload on the heart, which contributes to the modulation of cardiovascular resistance without significantly altering the heart's electrophysiology.

Dosage and Administration Information

Calcicare is designated exclusively for Oral administration, a usage pattern consistent across all approved forms, including tablets, chewable tablets, and granules. The administration is typically defined by a standardized daily dosing regimen, which is based on the quantity of elemental calcium and Colecalciferol (Vitamin D3) required. The total daily intake typically involves a range between 1000 mg and 1200 mg of elemental calcium.

The required dosing frequency is established as either a once-daily regimen or a divided-dose twice daily schedule to optimize utilization of the mineral components. Instructions regarding intake conditions specify that the medicine may be taken with or without food, though it is frequently taken alongside the main meal of the day.

Proper usage procedures dictate that chewable tablets must be completely chewed or sucked prior to swallowing, while film-coated tablets should be swallowed whole. A critical procedural rule is the requirement for drug separation: the dose must be administered separately from certain co-administered medications, such as some antibiotics and thyroid treatments, with an interval of two to six hours to prevent reduced absorption of the co-administered drug. This separation is a crucial constraint.

Usage patterns over time establish the medicine as suitable for long-term therapy or ongoing supplementation. Population boundaries restrict its use, noting that the medicine is not recommended for patients with severe renal impairment (e.g., GFR < 30 mL/min) due to the constraints associated with mineral metabolism.

Recent Clinical Evidence

Research Evidence / Overview of studies for Calcicare

Evidence for Addressing Nutritional Deficiency

Research has examined Calcicare for conditions characterized by functional imbalance, such as calcium and Vitamin D deficiencies, primarily through Randomized Controlled Trials (RCTs) and Systematic Reviews. These studies focused on measuring changes in key blood biomarkers (like Vitamin D and calcium levels) and Bone Mineral Density (BMD) as endpoints. Studies explored supplementation in the elderly, children and adolescents, and patients in institutionalized settings over defined time intervals, typically six months to one year.

Researchers reported measurements indicating shifts toward normal ranges for key biomarkers in the observed populations. While evidence contributes to understanding these systemic patterns, certainty remains low for some aspects due to heterogeneity in participants' baseline deficiency severity and variability in laboratory methods.


Research exploring conditions marked by functional limitations and decreased bone density

Research has explored the use of Calcicare in individuals with decreased bone density. This evidence is drawn from long-term RCTs and meta-analyses that examined clinical outcomes such as fracture incidence (non-vertebral and hip) and longitudinal BMD changes in populations like post-menopausal women and the elderly.

Long-term trial data reported mixed measurements regarding the incidence of major fractures in the observed cohorts. Findings indicate that studies documented small or stable changes in BMD measurements over one-to-two year periods. A key uncertainty is the difficulty in isolating the specific contribution of the supplement when patients are concurrently utilizing other drug therapies for bone density conditions.


What Remains Uncertain About Calcicare Research

A primary limitation across the research is that many findings for bone maintenance are based on endpoints such as BMD and bone turnover markers, and not always on hard clinical outcomes like fracture reduction. The evidence quality varies across studies, with findings sometimes being mixed regarding fracture outcomes. Furthermore, certain symptomatic axes, such as mineral-related muscle discomfort, rely heavily on subjective patient-reported outcomes from small-scale studies. Research is ongoing to better characterize long-term effects beyond several years, as currently, follow-up durations were limited in key areas.

Key Studies & References

  1. Calcium and Vitamin D Supplementation for Bone Health (Inferred NCBI Bookshelf Review)

Frequently Asked Questions (FAQ)

Common questions about Calcicare (FAQ)


Q: What is the main reason doctors prescribe Calcicare?

According to official regulatory labels, the medicine is used to prevent or treat conditions associated with low blood calcium levels (calcium deficiency). This includes managing or preventing associated conditions such as osteoporosis (bone loss) and rickets.


Q: Is Calcicare a type of supplement or a prescription drug?

The regulatory status of the calcium and Vitamin D3 combination product often allows it to be sold Over the Counter (OTC) for general supplementation. However, the doses used to treat specific diagnosed deficiencies or conditions are typically regulated as prescription-grade medicines.


Q: What happens if I forget to take Calcicare for a day?

Regulatory information advises that if a dose is missed, it should be taken as soon as it is remembered. However, if it is nearly time for your next scheduled dose, you should skip the missed dose entirely. Regulatory documents state that users should not double the dose to try and make up for a missed one.


Q: What are the most commonly reported mild side effects of Calcicare?

According to official regulatory summaries, the most commonly reported mild side effects of this medicine are constipation and upset stomach. These effects are commonly reported as mild.


Q: Can Calcicare cause weight changes?

Regulatory summaries list unusual or sudden weight loss as a potential serious side effect. This type of change is generally considered a sign of a more significant problem, such as hypercalcaemia. Regulatory information advises consulting a healthcare professional if this occurs.


Q: Does Calcicare affect sleep or cause drowsiness?

Regulatory information lists sudden confusion or drowsiness as signs of a potentially serious problem. If these effects are noted, regulatory information indicates that these signs may be linked to a serious safety concern.


Q: Can I take Calcicare if I have kidney issues?

Official product information states that Calcicare is generally not recommended for people with severe kidney disease (severe renal impairment) due to concerns about mineral metabolism. Use for individuals with non-severe kidney issues requires the guidance of a healthcare professional.


Q: Is Calcicare okay for people with a history of heart problems?

Regulatory summaries indicate that conditions such as heart disease or an irregular heartbeat (arrhythmia) are listed as precautions for use. This is especially relevant if you are taking specific heart medicines like cardiac glycosides. An individual assessment by a healthcare professional is necessary to evaluate the risk.


Q: Is Calcicare similar to other common medicines for the same condition?

Calcicare is primarily classified as a calcium supplement that contains calcium and Vitamin D3. Its components are often studied and compared with other medicines and agents used to improve bone health and mineral balance.


Q: Are there any reported interactions between Calcicare and herbal supplements?

Regulatory documents mention that a healthcare provider should be informed about the use of herbal supplements while taking Calcicare. This is due to the potential for certain herbs to interfere with the absorption or metabolism of the medicine's components.


Q: Does alcohol consumption affect how Calcicare works?

Official regulatory information suggests that if patients experience headaches while taking the medicine, they may need to consider limiting their consumption of alcohol. This information relates to managing specific side effects.


Q: Why do some people experience stomach upset with Calcicare?

Upset stomach and nausea are listed as possible side effects in the official product information. These common effects may occur due to the presence of calcium salts in the medicine.


Q: Is Calcicare a steroid?

Calcicare is a calcium and Vitamin D combination product. While the Vitamin D3 component (Colecalciferol) is structurally related to a class of compounds called secosteroids, the product itself is generally classified as a calcium supplement.


Q: Can I crush or split my Calcicare tablets?

According to the official product information, how you take the tablet depends on its type. Chewable tablets are meant to be fully chewed or sucked before swallowing. However, film-coated or extended-release tablets are generally not intended to be chewed or crushed; doing so can cause the medicine to be released too quickly and increase the risk of side effects.


Q: Is it normal to feel a bit nauseous when first starting Calcicare?

Nausea is listed in the official product information as a possible side effect of the drug. If this occurs, it is generally mild, but persistent or severe nausea is a symptom that may warrant a consultation with a healthcare provider.


Q: How does Calcicare affect blood sugar?

Studies have examined calcium and Vitamin D supplementation and its association with blood sugar levels. Evidence indicates that this type of supplementation has been associated with attenuated increases in blood sugar in non-diabetic adults who have impaired fasting glucose.


Q: What is the shelf life of Calcicare tablets?

Regulatory guidance instructs patients on proper storage, such as keeping the drug at room temperature and away from light and moisture. While it provides instructions for optimal storage, regulatory guidance does not typically provide a specific shelf-life duration once the packaging is opened.


Q: Is Calcicare affected by hot or cold weather?

Official storage guidelines advise keeping the drug at room temperature and away from excessive light and moisture. This is why regulatory guidance states that the medicine should not be stored in places like the bathroom.


Q: What official warnings or precautions are listed for Calcicare?

Official documents list specific precautions for using this medication. These include having a history of kidney disease, kidney stones, or a known high level of calcium or Vitamin D in the blood (hypercalcaemia).


Q: Does Calcicare contain any common allergens like gluten or lactose?

Regulatory summaries note that some forms, particularly chewable tablets, may contain ingredients like sugar or aspartame. This requires caution for patients with conditions like diabetes or phenylketonuria (PKU). Information on general allergens is not typically consolidated in these warnings.


Q: If I am pregnant, what are the safety considerations for Calcicare?

Official guidance indicates that the components of the drug are generally acceptable for use during pregnancy, but suggests a cautious approach. Doses of Vitamin D above the recommended dietary allowance should only be used when clearly necessary. High calcium levels in the mother have been associated with adverse fetal events.


Q: Do I need special monitoring or blood tests while on Calcicare?

Regulatory information advises that for patients taking Calcicare for an extended period, a doctor will typically arrange a blood test to check calcium levels. This monitoring is done to prevent a condition called hypercalcaemia, which is when calcium levels in the blood become too high.


Q: What are some of the less common but important side effects of Calcicare?

Official regulatory summaries list signs of a potentially serious side effect called hypercalcaemia (too much calcium). These signs include unusual weight loss, mental or mood changes, increased thirst or urination, and headaches.


Q: Can Calcicare cause skin rashes or sensitivity to the sun?

Regulatory information indicates that taking too much of the Vitamin D3 component over a long period can cause a skin rash. Rashes, hives, and swelling are also listed as signs of a serious allergic reaction.


Q: What happens if I take Calcicare twice by accident?

Regulatory guidance states that users should not double the dose to make up for a missed one. Taking two doses too close together can increase the risk of experiencing side effects.


Q: How is Calcicare different from an antibiotic?

Calcicare is classified as a calcium channel modulator or a calcium/ Vitamin D supplement. It works to manage mineral levels in the body, which is fundamentally different from antibiotics, which are used to fight bacterial infections. Official documents specify that Calcicare can interfere with the absorption of certain antibiotics.


Q: Is there a version of Calcicare available for children?

Official regulatory documents indicate that the use and specific dose of Calcicare for children must be determined by a healthcare professional.


Q: Can men and women use Calcicare equally?

The medicine is indicated for general calcium deficiency in adults. However, regulatory information specifically mentions its use for certain populations with known deficiency risks, such as pregnant, nursing, or postmenopausal women.


Q: Has Calcicare been studied in people from different ethnic backgrounds?

Studies on the Vitamin D component of Calcicare have examined its use in diverse groups. Research summaries note that studies have included individuals from various ethnic backgrounds in the clinical analyses.


How should Calcicare be stored and disposed of?

How to Store and Dispose of Calcicare?

The storage and disposal of Calcicare (Calcium/Vitamin D3) must adhere to official regulatory requirements to maintain product stability.

Storage Conditions

Temperature: Store the product below 25 C or 30 C, as indicated on the label, and never above the specified maximum. It must be protected from light and moisture; therefore, keep the medicine in its original container and ensure the cap or closure is tightly closed.

Child Safety: It is mandatory to keep Calcicare out of the sight and reach of children.

Stability: Do not use the medicine past the expiry date. Liquid formulations may have a limited use period after first opening the bottle.

Disposal

Unused or expired product must be disposed of according to local requirements. Do not throw away any medicines via household waste or by flushing them down the toilet or sink (wastewater).

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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