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Components:
Sodium Ascorbate
Method of action:
Antioxidant, Metabolic, Nutritive Agent, Regulating Redox Processes, Replenishing Vitamin C Deficiency, Vitamins
Available in countries
Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 2019.11.22

Therapeutic indications

The information provided in Therapeutic indications of C-500 is based on data of another medicine with exactly the same composition as the C-500 of the medicine (Sodium Ascorbate). Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug C-500 directly from the package or from the pharmacist at the pharmacy.
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The prevention and treatment of scurvy, or other conditions requiring vitamin C supplementation, where the deficiency is acute or oral administration is difficult.

Dosage (Posology) and method of administration

The information provided in Dosage (Posology) and method of administration of C-500 is based on data of another medicine with exactly the same composition as the C-500 of the medicine (Sodium Ascorbate). Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug C-500 directly from the package or from the pharmacist at the pharmacy.
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Route of Administration: Parenteral

Adults

0.5 to 1g daily for scurvy, 200 to 500mg daily for preventative therapy.

Children

100 to 300mg daily for curative purposes, or 30mg daily for protective treatment.

Elderly

No special dosage requirements have been suggested.

Contraindications

The information provided in Contraindications of C-500 is based on data of another medicine with exactly the same composition as the C-500 of the medicine (Sodium Ascorbate). Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug C-500 directly from the package or from the pharmacist at the pharmacy.
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Hyperoxaluria

Special warnings and precautions for use

The information provided in Special warnings and precautions for use of C-500 is based on data of another medicine with exactly the same composition as the C-500 of the medicine (Sodium Ascorbate). Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug C-500 directly from the package or from the pharmacist at the pharmacy.
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C-500 should be given with care to patients with underlying renal failure due to the risk of formation of renal oxalate calculi. Tolerance may be induced in patients taking high doses.

Large doses of C-500 have resulted in haemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Effects on ability to drive and use machines

The information provided in Effects on ability to drive and use machines of C-500 is based on data of another medicine with exactly the same composition as the C-500 of the medicine (Sodium Ascorbate). Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug C-500 directly from the package or from the pharmacist at the pharmacy.
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C-500 injection is unlikely to affect the patient's ability to drive or use machinery.

Undesirable effects

The information provided in Undesirable effects of C-500 is based on data of another medicine with exactly the same composition as the C-500 of the medicine (Sodium Ascorbate). Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug C-500 directly from the package or from the pharmacist at the pharmacy.
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Large doses may cause gastrointestinal disorders including diarrhoea. Large doses may also result in hyperoxaluria and renal oxalate calculi may form if the urine becomes acidic. Doses of 600mg or more daily have a diuretic action. Induced tolerance with prolonged use of large doses can result in symptoms of deficiency when intake is reduced to normal.

Overdose

The information provided in Overdose of C-500 is based on data of another medicine with exactly the same composition as the C-500 of the medicine (Sodium Ascorbate). Be careful and be sure to specify the information on the section Overdose in the instructions to the drug C-500 directly from the package or from the pharmacist at the pharmacy.
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Large doses may cause gastrointestinal disorders including diarrhoea. Large doses may also result in hyperoxaluria and renal oxalate calculi may form if urine is acidic. Doses of 600mg or more daily have a diuretic action. Stop treatment and treat symptomatically.

Pharmacodynamic properties

The information provided in Pharmacodynamic properties of C-500 is based on data of another medicine with exactly the same composition as the C-500 of the medicine (Sodium Ascorbate). Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug C-500 directly from the package or from the pharmacist at the pharmacy.
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ATC Code: A11G A01

C-500, a water-soluble vitamin, is essential for formation of collagen and intercellular material, and therefore necessary for the development of cartilage, bone, teeth and for the healing of wounds. It is also essential for the conversion from folic acid to folinic acid, facilitates iron absorption from the gastro-intestinal tract and influences haemoglobin formation and erythrocyte maturation.

Pharmacokinetic properties

The information provided in Pharmacokinetic properties of C-500 is based on data of another medicine with exactly the same composition as the C-500 of the medicine (Sodium Ascorbate). Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug C-500 directly from the package or from the pharmacist at the pharmacy.
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Distribution - widely distributed in body tissues with about 25% bound to plasma proteins. Large amounts are present in leucocytes and platelets. C-500 crosses the placenta.

Metabolism - readily oxidised to dehydroC-500 where some is metabolised to oxalic acid and the inactive ascorbate - 2 - sulphate. Metabolic turnover appears to be greater in females than males.

Excretion - large doses are rapidly excreted in the urine when in excess of the requirements of the body and after an intravenous dose, about 40% is excreted in 8 hours, which is increased to about 70% after tissue saturation. The amount of unchanged drug is dose dependent; in women the excretion of C-500 appears to vary with the stage of the menstrual cycle and it is decreased when taking oral contraceptives.

C-500 is excreted in breast milk.

Oxalic acid and ascorbate - 2 - sulphate are excreted in the urine.

Preclinical safety data

The information provided in Preclinical safety data of C-500 is based on data of another medicine with exactly the same composition as the C-500 of the medicine (Sodium Ascorbate). Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug C-500 directly from the package or from the pharmacist at the pharmacy.
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None stated

Incompatibilities

The information provided in Incompatibilities of C-500 is based on data of another medicine with exactly the same composition as the C-500 of the medicine (Sodium Ascorbate). Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug C-500 directly from the package or from the pharmacist at the pharmacy.
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Incompatible with ferric salts, oxidising agents, and salts of heavy metals, particularly copper.

Injections of C-500 have been reported to be incompatible with aminophylline, bleomycin sulphate, erythromycin lactobionate, nafcillin sodium, nitrofurantoin sodium, conjugated oestrogens, sodium bicarbonate and sulphafurazole diethanolamine. Occasional incompatibility, depending on pH or concentration, has occurred with chloramphenicol sodium succinate.

Special precautions for disposal and other handling

The information provided in Special precautions for disposal and other handling of C-500 is based on data of another medicine with exactly the same composition as the C-500 of the medicine (Sodium Ascorbate). Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug C-500 directly from the package or from the pharmacist at the pharmacy.
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None stated

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