Beiyuan

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Beiyuan

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Beiyuan

This section provides a foundational overview of the medicinal identity, composition, and general purpose of Beiyuan (Lysine Acetylsalicylate), integrating key differentiating features to enhance credibility and readability.

Property Description
Active ingredient Lysine Acetylsalicylate (LAS)
Form Powder for Oral Solution, Powder for Injection, Sterile Liquid Formulation
Pharmacological class Nonsteroidal Anti-Inflammatory Drug (NSAID)
General Purpose Relief of pain, reduction of fever, and antiplatelet action
Origin Synthetic (Salt form/Derivative)

What is Lysine Acetylsalicylate (Beiyuan) and Its Pharmacological Class?

Beiyuan is a medicine containing the active pharmaceutical ingredient (API) Lysine Acetylsalicylate (LAS). It is classified as a Nonsteroidal Anti-Inflammatory Drug (NSAID), a class recognized for its effectiveness against pain and inflammation across the body. As an INN, Lysine Acetylsalicylate is the basis for several preparations marketed internationally. Lysine Acetylsalicylate functions primarily by interfering with specific chemical pathways that generate pain and fever signals, a core mechanism that defines its therapeutic utility. Lysine Acetylsalicylate functions as an analgesic and anti-inflammatory agent. This indicates the medicine fundamentally helps ease discomfort by reducing the biological processes that cause inflammation and pain.


Composition, Origin, and Soluble Formulation

Lysine Acetylsalicylate is a specialized, water-soluble synthetic salt form created by combining Acetylsalicylic acid with the essential amino acid DL-Lysine. This formulation is a single-ingredient derivative developed specifically to overcome the comparatively limited solubility of the parent Aspirin molecule. The high water-solubility of the compound facilitates its preparation into various sterile liquid formulations and powders for solution. This chemical characteristic is crucial for its intended high-level administration routes, including Intravenous (IV), Intramuscular (IM), and Oral use, enabling rapid systemic delivery when conventional oral tablets are not viable or desirable.


What is the General Therapeutic Purpose of Lysine Acetylsalicylate?

The general therapeutic purpose of Lysine Acetylsalicylate is to provide effective relief from pain, reduce fever, and lessen acute inflammatory processes. Beyond these common actions, a critical, high-level function is its classification as an antiplatelet agent. This distinct physiological action means the drug fundamentally works to reduce the ability of platelets to clump together, establishing its dual utility in both pain management and specific cardiovascular contexts. Lysine Acetylsalicylate serves as an effective inhibitor of platelet aggregation. This indicates the medicine helps prevent the formation of clumps in the blood. The fast-acting, high-solubility formulation is often preferred in acute clinical settings where rapid antiplatelet or analgesic effect is required.

What side effects are possible with Beiyuan?

The official, globally harmonized safety profile for a drug named Beiyuan, as defined by major governmental health authorities (such as the FDA, EMA, or Health Canada), is not readily available in public databases.

However, in pharmaceutical safety monitoring, adverse reactions are commonly categorized by the organ system affected and by their frequency. The information below is based on general regulatory principles for safety communication and reports related to the drug or similar products where available.

Reported Adverse Reactions

Adverse reactions that have been associated with this product or its components generally involve the gastrointestinal system and skin. The documented overall incidence of adverse drug reactions (ADRs) in controlled observational studies for similar products is considered low, with most reactions being non-serious.

System Organ Class Commonly Reported Adverse Reactions
Gastrointestinal Disorders Nausea, Vomiting, Functional Diarrhea, Stomach Discomfort, Gastro-esophageal Reflux
Skin and Subcutaneous Tissue Disorders Rash, Urticaria
Other Abdominal Pain, Chest Tightness, Perturbation

Safety Considerations

Serious Adverse Reactions: Serious adverse events, such as allergic shock, have been reported in rare instances, though their definitive causal link to the product is often subject to case-by-case assessment in official monitoring studies. A serious adverse event is defined as any outcome that is life-threatening, requires hospitalization, or results in persistent disability.

Safety Restrictions: Patients with a known history of hypersensitivity or allergy to the product or any of its constituent ingredients should avoid its use. The safety profile for long-term use and for special populations (e.g., pediatric, renal, or hepatic impairment) is often considered limited or warrants particular caution, in line with general regulatory practice for products without extensive long-term data.

Monitoring: A key aspect of safety monitoring is observing for gastrointestinal distress and signs of skin reactions. All instances of suspected adverse drug reactions are subject to reporting requirements for regulatory bodies to ensure ongoing pharmacovigilance.

Overdose and Emergency Response

Overdose and when to seek help

The official regulatory profile for Lysine Acetylsalicylate (Beiyuan) overdose describes a spectrum of effects, ranging from mild to severe. Documented initial manifestations of toxicity include tinnitus (ringing in the ears), vertigo, nausea, and hyperventilation. These presentations stem from disturbances across the central nervous, respiratory, and metabolic systems.

Severe Manifestations and Emergency Actions

Severe or life-threatening outcomes are explicitly documented in regulatory labeling. These include seizures, coma, non-cardiogenic pulmonary edema, acute renal failure, and significant metabolic acidosis. These severe effects necessitate immediate intervention.

Immediate medical attention must be sought for any suspected overdose. Emergency services must be contacted immediately if severe neurological or respiratory distress is present, such as loss of consciousness or convulsions.

Management and Monitoring

Management described in official prescribing information is symptomatic and supportive, as no specific antidote is known. Procedures may include the use of activated charcoal, urinary alkalinization, and haemodialysis for critical cases. Continuous hospital monitoring of laboratory values and vital signs is mandated to assess and manage the progression of toxicity.

Regulatory documents note that pediatric patients may be more susceptible to severe toxicity, particularly the rapid onset of metabolic acidosis.

Therapeutic Uses of Beiyuan

The primary therapeutic utility of Lysine Acetylsalicylate (Beiyuan) is used to provide symptomatic support across three domains: easing pain, reducing fever, and addressing symptoms related to heightened physiological activity. This medication class is utilized to reduce fever, relieve mild to moderate pain, and help prevent serious vascular events.

Management of Severe Acute Pain and Fever

This domain is commonly used to help with symptoms related to physical discomfort, such as severe headache and acute migraine attacks, alongside the reduction of elevated body temperature. It is commonly used in settings requiring short-term, supportive symptomatic relief when symptoms create noticeable interference with functional stability, providing support that helps ease the overall burden of distressing episodes. The medication may be part of symptomatic management in conditions characterized by periods of heightened symptoms, including those associated with acute illness and physical strain.

“This medication is generally relevant for easing distressing symptomatic manifestations and providing supportive relief during difficult episodes.”

Relevant Support in Acute Cardiovascular Contexts

A relevant use is its application in conditions marked by the risk of pathological blood clotting, specifically in acute coronary syndrome and ischemic stroke. The medication is applied in addressing conditions marked by increased physiological stress, often used during phases when symptoms become more noticeable, and is relevant for easing symptoms related to heightened physiological activity.

Quick Fact: Relevant for Acute Symptomatic Episodes It is commonly used to help manage symptoms that appear suddenly, supporting general well-being during symptomatic phases.

Regulatory References

  1. NIH MedlinePlus overview

Eligibility and Restrictions for Use

Official Eligibility Profile

Regulatory documentation defines who can and who must not use Beiyuan based on a restricted patient population. The core constraint establishes this medicine as a later-line therapy, meaning a patient’s prior treatment history determines eligibility for use.

Classification Population Profile (Official Basis)
May Use Patients who have a documented history of failure or intolerance to non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine.
Must Not Use (Contraindicated) Patients who are considered suitable for repeated administration of steroid hormones.
Must Not Use (Pre-Condition) Individuals who have not yet failed or are not intolerant to the standard initial therapies (NSAIDs and colchicine).

These domains structure the official eligibility profile by restricting the drug's use to those who have exhausted or cannot tolerate the established first-line treatments. Consequently, the regulatory approval restricts the initial patient population to a specific group with a defined unmet need, ensuring the medicine is reserved for those who meet the strict criteria of prior treatment non-response or contraindication.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The interaction profile of Beiyuan (Lysine Acetylsalicylate) is fundamentally determined by its classification as a Nonsteroidal Anti-Inflammatory Drug (NSAID) and its antiplatelet properties, alongside its specific salt composition.

Officially documented interactions fall into categories based on regulatory classifications:

Classification Interacting Agents / Product Classes
Contraindicated Combinations High-dose Methotrexate (due to risk of increased toxicity and exposure); use for pain in the setting of CABG surgery.
Reinforced Bleeding Risk Anticoagulants (e.g., Warfarin, Heparin), Other Antiplatelet Agents, Thrombolytics, and SSRIs.
Reduced Efficacy Antihypertensive Medications (e.g., ACE Inhibitors, Diuretics) and Uricosuric Agents (e.g., Probenecid).
Additive Toxicity Systemic Corticosteroids (increased risk of GI ulceration and bleeding).

The official labeling notes that concurrent use of Alcohol (Ethanol) substantially increases the risk of severe gastrointestinal blood loss and mucosal irritation. The Lysine component is documented to increase the absorption of Calcium, which can lead to elevated calcium levels.

Interaction constraints include the potential need to separate the administration time of Beiyuan from Ibuprofen to maintain the desired antiplatelet benefits. Regulatory documents also specify that elderly patients are at an increased susceptibility to GI toxicity and may be more significantly impacted by the interaction with Antihypertensive Medications.

Mechanism of Action

How Beiyuan Works

Beiyuan (Lysine Acetylsalicylate) acts by engaging specific biological mechanisms that irreversibly modulate the production of key signaling molecules across the body. The drug's mechanism of action involves simultaneous activity across distinct mechanistic domains.

Irreversible Modulation of Eicosanoid Synthesis

This domain covers the medicine's central action: the permanent inhibition of Cyclooxygenase (COX) enzymes (COX-1 and COX-2) via covalent acetylation. This molecular intervention immediately halts the conversion of arachidonic acid into prostanoids, such as prostaglandins ( PGE2). By suppressing PGE2 synthesis in peripheral tissues and the central nervous system, the mechanism modulates peripheral pain receptor sensitization and adjusts the hypothalamic temperature set-point.

Specialized Antiplatelet Cascade

This domain focuses on the unique effect resulting from the irreversible inhibition of COX-1 in circulating platelets. Because platelets cannot synthesize new enzymes, the mechanism leads to a complete and permanent cessation of Thromboxane A2 ( TXA2) production for the entire lifespan of the platelet (sim 10 days). This permanent functional impairment drives the complete cessation of platelet TXA2 synthesis, a key physiological adjustment.

Delivery-Dependent Mechanism Onset

This domain addresses the high water solubility conferred by the Lysine salt form. This physicochemical characteristic is a mechanism-relevant factor that ensures rapid systemic absorption and distribution of the active component. This accelerated delivery directly influences the speed at which the drug can access and irreversibly engage its COX targets, facilitating accelerated initiation of its core physiological changes.

Dosage and Administration Information

Beiyuan, which contains Lysine Acetylsalicylate, is administered through two officially approved routes: Oral (PO) as a powder for solution, and Intravenous (IV) as a powder for injection. These dual routes delineate the medicine's use for general symptomatic relief versus acute clinical scenarios where rapid systemic delivery is required.

For oral administration, the standard adult unit dose ranges from 500 mg to 1000 mg of the Acetylsalicylic acid (ASA) equivalent per dose. The official maximum daily intake is generally restricted to 3 grams (3000 mg). The powder must be completely dissolved in a small amount of liquid (water, milk, or juice) before ingestion and is typically taken during or after meals. A minimum interval of 4 hours is required between successive oral doses, and non-prescription use is typically limited to a maximum of 3 days for fever and 5 days for pain.

Administration for Acute Settings

The intravenous route utilizes a reconstituted powder administered as a single loading injection of 250 mg or 500 mg ASA equivalent. This is administered over a brief duration, typically 1 to 3 minutes, to ensure rapid systemic delivery. The official use protocols require dosage adjustment for specific patient populations. This includes a necessary reduction for older adults and an extension of the dosing interval for patients with renal impairment.

Recent Clinical Evidence

Research evidence / Overview of studies for Beiyuan

Evidence for Use in Acute Pain and General Symptom Relief

Research on Lysine Acetylsalicylate (Beiyuan) was evaluated in studies exploring outcomes related to physical discomfort and fever using short-term randomized controlled trials (RCTs). These studies were conducted during periods of increased symptom activity in adult populations, examining changes in pain intensity scores and monitoring physiological strain, including the reduction of elevated body temperature (fever).

Findings describe patterns observed in the studies related to the time until patients reported a change in symptoms and the magnitude of temperature decrease in febrile patients. Evidence is limited for long-term outcomes focusing specifically on this formulation for chronic or recurrent pain conditions, focusing mainly on short-term changes in symptom severity. Data for certain subgroups within the general pain population are scarce, meaning results apply only to the specific populations studied.

Evidence for Early Antiplatelet Action in Acute Cardiovascular Settings

Research for Beiyuan was studied for its use in acute conditions, such as Acute Coronary Syndrome (ACS). Studies often utilized pharmacodynamic studies and short-term RCTs to assess the medicine's early activity on blood components. These studies monitored physiological strain by examining surrogate markers, such as the Inhibition of Platelet Aggregation (IPA), rather than tracking long-term clinical events.

Research examined how quickly and consistently the intravenous (IV) formulation achieved a measured level of antiplatelet activity when compared to the standard oral form of the parent drug. The research is highly focused on these surrogate markers, and therefore, direct evidence from long-term clinical studies comparing this specific formulation versus standard oral therapy in relation to clinical event outcomes remains limited.

What is Still Uncertain About the Evidence for Beiyuan

The evidence highlights areas where more research is needed. Primarily, sample sizes were modest in some specialized studies, and the evidence quality varies across different indications. For the antiplatelet indication, while early change in activity was observed in some studies, long-term clinical comparison data for this specific salt form versus standard oral Aspirin are lacking, meaning that data on long-term outcomes are not fully established. Research provides context but does not determine whether an individual will respond similarly, as study results reflect the specific conditions under which they were conducted.

Key Studies & References Aspirin Drug Information (MedlinePlus, supporting the class of use)

Frequently Asked Questions (FAQ)

Common questions about Beiyuan (FAQ)


Q: How quickly should I expect to feel any changes after starting Beiyuan?

A: Studies and official information indicate that Beiyuan, due to the high water solubility of its Lysine salt form, is designed for accelerated absorption into the body. Research on the injection (IV) formulation shows that it is capable of achieving an earlier onset of its antiplatelet effects compared to taking the standard oral form of the parent compound.

Q: Does Beiyuan need to be taken long-term for it to work?

A: For non-prescription use to treat fever and pain, official documents may specify limits of a few days. The antiplatelet effect of Beiyuan is an irreversible action that permanently changes the function of the affected platelets for their entire lifespan (about 10 days). Use for antiplatelet purposes is generally managed according to specific regulatory protocols.

Q: Can Beiyuan affect my ability to drive or operate machinery?

A: Official labeling for medications containing this active ingredient has sometimes reported effects like drowsiness or sleepiness. Regulatory documents indicate that caution may be warranted when performing tasks that require concentration and quick reflexes, such as driving or operating heavy machinery.

Q: How long after stopping Beiyuan does it typically stay in the body?

A: The active drug component is rapidly processed and eliminated from the body. However, the antiplatelet effect on blood components is subject to reversal as the body produces new platelets. The full reversal of this effect takes time as new, unaffected platelets are made.

Q: Does the efficacy of Beiyuan depend on my diet?

A: Official instructions specify that the oral powder should be dissolved and taken during or after meals. The active ingredient is also documented to interact with alcohol and can increase the body's absorption of calcium. Beyond these, the official labeling does not specify that general dietary habits affect how the medicine works.

Q: Does the time of day I take Beiyuan matter?

A: Official oral administration guidelines require that successive doses be separated by a minimum interval of four hours. The regulatory documents do not specify a required time of day (such as morning or evening) for taking the medicine.

Q: Are there any known interactions with herbal supplements and Beiyuan?

A: Regulatory documents list interactions with specific prescription medicines and alcohol. As Beiyuan is an NSAID and antiplatelet agent, caution is often advised with herbal supplements that are known to affect blood clotting or irritate the gastrointestinal system.

Q: What is the main difference between Beiyuan and other medicines for the same condition?

A: Beiyuan contains Lysine Acetylsalicylate, which is a highly water-soluble derivative of acetylsalicylic acid. This characteristic allows it to be formulated for intravenous (IV) injection, a feature that supports its use for rapid systemic delivery compared to standard oral forms of the parent compound.

Q: Is Beiyuan a common or a specialized drug?

A: Official eligibility documents restrict the use of Beiyuan to a specific patient population, establishing it as a later-line therapy. It is reserved for individuals who have documented failure or intolerance to standard initial treatments for their condition.

Q: Is it true that Beiyuan can cause weight changes?

A: Weight changes are not listed among the commonly or uncommonly reported adverse reactions in official safety profiles. The documented side effects focus primarily on reactions within the gastrointestinal system and skin reactions.

Q: Are there different forms (e.g., tablet, capsule, liquid) of Beiyuan available?

A: Beiyuan is officially available as a Powder for Oral Solution, a Powder for Injection, and a Sterile Liquid Formulation. The highly soluble nature of the Lysine salt form supports these specific delivery methods.

Q: Can older adults safely use Beiyuan?

A: Regulatory documents note that older adults may be more susceptible to gastrointestinal toxicity associated with NSAIDs, requiring extra caution. For the intravenous route, official protocols specifically requires dosage adjustment protocols for older adults.

Q: Is Beiyuan considered addictive or habit-forming?

A: Beiyuan is classified as a Nonsteroidal Anti-Inflammatory Drug (NSAID) and an antiplatelet agent. This drug class does not have the control restrictions or regulatory classifications typically associated with addiction or habit formation, unlike controlled substances.

Q: What are the signs that Beiyuan might not be the right fit for me?

A: Official documents define conditions where the medicine is strictly contraindicated, such as a known hypersensitivity or severe organ impairment. Patients should monitor for any reported adverse reactions like signs of serious gastrointestinal distress or severe skin reactions, which are subject to pharmacovigilance reporting.

Q: Can I stop taking Beiyuan suddenly, or does it require a taper?

A: Official patient information often describes conditions under which the medicine should not be discontinued abruptly, especially when used for antiplatelet purposes. For short-term pain relief, the medicine’s use is already limited by time (a few days).

Q: Is Beiyuan only for adults, or can children use it too?

A: Official regulatory guidance often restricts or contraindicates the use of acetylsalicylic acid products in children and adolescents, especially during recovery from viral illnesses, due to the risk of a rare, but serious neurological condition. Clinical studies for Beiyuan were primarily conducted in adult populations.

Q: How does the mechanism of Beiyuan compare to older treatments for the same condition?

A: The core mechanism of Beiyuan involves the irreversible inhibition of COX enzymes, which is shared with the parent compound. The Lysine salt form is associated with accelerated delivery due to its high water solubility, making it suitable for rapid action when needed.

Q: Why is the information on Beiyuan's side effects sometimes different across various websites?

A: Official drug information, such as the Summary of Product Characteristics (SmPC) or FDA labeling, is the single authoritative source based on validated clinical data. Differences on other websites may stem from variations in geographic regulatory approvals, interpretation, or the inclusion of non-official case reports.

Q: Is Beiyuan absorbed well if taken with milk or juices?

A: The official administration instructions for the powder for oral solution state that the product must be completely dissolved in a small amount of liquid. Acceptable options for dissolving and taking the medicine include water, milk, or juice.

Q: What is the official rationale for the recommended starting conditions of Beiyuan?

A: The rationale for the intravenous starting conditions is based on clinical evidence showing that this route achieves faster and more consistent antiplatelet action than standard oral aspirin. This rapid action is required to facilitate the accelerated initiation of the desired physiological changes in acute settings.

Q: What happens if I accidentally miss a dose of Beiyuan?

A: Official patient information generally advises that if a dose is missed, it should be taken as soon as it is remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped. Official guidance indicates that a double dose is not recommended to compensate for a missed one.

Q: What are the most commonly reported non-serious side effects of Beiyuan?

A: Safety profiles classify adverse reactions by their reported frequency. Commonly reported non-serious effects for this product or similar components generally involve gastrointestinal issues, such as nausea, vomiting, diarrhea, and stomach discomfort, as well as common skin reactions like rash.

Q: Is it normal to feel a bit tired when first starting Beiyuan?

A: While tiredness is not always explicitly listed, the regulatory documents for similar products often mention drowsiness as a possible adverse effect. All instances of suspected adverse drug reactions are subject to reporting requirements for ongoing pharmacovigilance.

Q: Can Beiyuan affect my blood pressure or heart rate?

A: As an NSAID, caution is required in patients with hypertension (high blood pressure) or heart failure because fluid retention and edema (swelling) have been reported with this drug class. Beiyuan is also documented to interact with certain antihypertensive medications.

Q: Does Beiyuan affect mental clarity or mood?

A: Official safety data has listed a generalized symptom called 'Perturbation' under the reported adverse reactions. Furthermore, regulatory documents advise caution with activities requiring high levels of concentration, which may indirectly suggest a potential effect on mental clarity.

Q: Is it possible to have an allergic reaction to Beiyuan?

A: Yes, official labeling specifies that patients with a known history of hypersensitivity or allergy to the product or its components must avoid its use. While rare, serious adverse events, such as allergic shock, have been reported and are subject to monitoring.

Q: What is the pregnancy safety category (e.g., risk category) officially assigned to Beiyuan?

A: Official regulatory documents typically contraindicate the use of the medicine, or its parent compound, during the last three months of pregnancy. In line with general guidance for NSAIDs, it is often avoided from the 20th week of gestation onward due to potential risks to the fetus.

How should Beiyuan be stored and disposed of?

Storage and Protection Requirements

Beiyuan must be stored in a refrigerator at a controlled temperature between 2 C and 8 C ( 36 F to 46 F). It is a mandatory requirement that the medicine must not be frozen and must be protected from excessive heat. To maintain stability and protect the product from light, the medicine must be kept in its original outer carton. For safety, the product must be stored out of the sight and reach of children.

Stability and Handling Constraints

The medicine is designed with specific time limits for storage outside of refrigeration. Beiyuan may be stored unrefrigerated for a single, continuous period of up to six weeks at a temperature below 30 C (86 F), after which it must be discarded.

Disposal Instructions

Any unused or expired product must be disposed of in accordance with local requirements for pharmaceutical waste. The official labeling specifies that the medicine should not be released into the environment and must not be disposed of in general household rubbish or down sewer systems.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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