Антигриппин

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Method of action: Analgesic, Antiallergic, Anti-Inflammatory, Antipyretic

Treatment option:

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Антигриппин

Property	Description
Active Ingredients	Acetaminophen, Chlorpheniramine, Ascorbic Acid
Forms	Effervescent tablets, Powder for oral solution
Pharmacological Class	Analgesic, Antipyretic, Antihistamine, Vitamin
Common Use	Symptomatic relief of cold and flu manifestations
Type	Combination Product (Synthetic and Derived)

Антигриппин (Antigrippin) is a combined pharmacological preparation designed for the symptomatic treatment of common colds, influenza, and related acute respiratory viral infections (ARVI). This multi-component agent is widely available as an Over-The-Counter (OTC) medicine. Its primary purpose is to address several simultaneous manifestations of illness, thereby controlling bothersome symptoms and making the acute stage of a viral infection more tolerable.

Core Components and Classification

Антигриппин is a combination product that belongs to the pharmacological classes of a non-narcotic analgesic, an antipyretic, an H1-histamine receptor blocker, and a vitamin. The product's composition involves the combination of these agents for broad symptomatic relief. This blend of Acetaminophen for fever control, Chlorpheniramine for mucosal irritation, and Ascorbic Acid for supportive action differentiates this product from single-ingredient analgesics.

The formulation relies on the synergy of three key active ingredients. Combination products containing Acetaminophen and antihistamines like Chlorpheniramine are used for reducing discomfort associated with common colds. This mechanism of action helps to suppress both fever/pain and the allergic-type symptoms often seen during a cold. It is typically administered via the oral route and often appears as effervescent tablets or powder for oral solution.

General Therapeutic Purpose

The general therapeutic purpose of Антигриппин is to achieve multi-target symptomatic control over the temporary discomforts associated with colds and flu. The coordinated action of the ingredients provides relief that helps mitigate the most disruptive effects, such as a fever, headache, and pronounced rhinorrhea (runny nose), during the acute phase of illness. The inclusion of Ascorbic Acid is intended to provide general supportive action, a feature common in multi-component formulas targeting ARVI symptoms. This approach is particularly suited for individuals experiencing multiple concurrent cold symptoms.

What side effects are possible with Антигриппин?

Possible side effects and safety information for Антигриппин

Adverse reaction scope

The regulatory safety profile of Antigrippin is primarily defined by the known risks of its active ingredients, which typically include acetaminophen (paracetamol), ascorbic acid (vitamin C), and antihistamines.

Key adverse reaction categories: The most commonly documented adverse effects involve the gastrointestinal system (e.g., dyspepsia, nausea), nervous system (e.g., drowsiness, dizziness from the antihistamine component), and skin/allergic reactions.
System-organ classes involved: Primary System Organ Classes (SOC) include Gastrointestinal Disorders, Nervous System Disorders, and Immune System Disorders (allergic reactions).
Serious adverse reactions: Rare but serious adverse reactions documented for its components include severe hepatotoxicity (liver damage) associated with the acetaminophen component, especially following high doses or prolonged use, and severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome, which require immediate medical attention.
Population-specific safety considerations: Caution is officially advised for patients with hepatic or renal impairment due to the risk of accumulation and toxicity, particularly of acetaminophen. Use during pregnancy or breastfeeding is typically subject to specific regulatory limitations and medical consultation.

Safety-related restrictions or limitations

Safety labeling mandates strict adherence to dose limits to mitigate the risk of severe liver damage. The product is contraindicated in cases of hypersensitivity to any of its components. Caution must be exercised in patients with certain pre-existing conditions, such as angle-closure glaucoma or prostatic hypertrophy, due to the anticholinergic effects of the antihistamine component.

Safety classifications (high-level)

Regulatory frequency framework used: Adverse reactions are typically classified using a standard frequency framework (e.g., CIOMS or ICH frequency bands) ranging from Very Common to Not Known, though specific frequencies are label-dependent.
Context-of-use safety notes: Official documents emphasize that concomitant use with other acetaminophen-containing products or alcohol significantly increases the risk of hepatotoxicity. Prolonged use without medical supervision is formally discouraged.

Regulatory safety summary

The established safety structure for Antigrippin focuses on managing dose-related risks, particularly acetaminophen-induced hepatotoxicity, while also identifying potential allergic and central nervous system effects from the combination of active substances. The official safety data provides the mandatory framework for risk identification and harm reduction as defined by the authorizing regulatory body.

Overdose and Emergency Response

Overdose and When to Seek Help

Overdose with Антигриппин, a combination product, is primarily defined by the risks associated with its main components: Acetaminophen and Chlorpheniramine. Regulatory documents classify overdose as potentially severe and life-threatening.

Documented Overdose Manifestations

Official labeling describes initial symptoms of overdose including Nausea, Vomiting, Abdominal Pain, Diaphoresis (sweating), and general malaise. These may progress to more serious outcomes.

System	Documented Symptoms / Signs
Hepatic	Jaundice, Severe Liver Damage (Fatal Hepatic Necrosis)
CNS / Anticholinergic	Sedation, Delirium, Hallucinations, Convulsions, Dilated Pupils
Cardiovascular	Cardiac Arrhythmias, QRS Prolongation, Cardiovascular Collapse

Required Emergency Actions

The most critical instruction in official regulatory documents is to seek immediate medical attention or contact a Poison Control Center right away, even if no signs or symptoms are immediately noticeable. Prompt medical attention is critical because severe consequences, particularly Acute Liver Failure from the Acetaminophen component, can progress rapidly. The antidote N-acetylcysteine is documented for Acetaminophen toxicity, but its efficacy is constrained by the time elapsed since ingestion. Management involves Continuous Cardiac Monitoring and Symptomatic and Supportive Treatment. Individuals with pre-existing liver disease or chronic alcoholism are officially noted to have a greater hazard of severe toxicity.

Therapeutic Uses of Антигриппин

What Антигриппин treats: Main Uses and Benefits

Антигриппин (Antigrippin) is a multi-component preparation generally used for the symptomatic relief of discomfort associated with conditions characterized by periods of heightened symptoms, specifically the common cold, influenza, and related acute respiratory viral infections (ARVI). Its core therapeutic purpose is to help temporarily relieve minor aches and pains, headache, runny nose, sneezing, and fever due to a cold or flu. It is used for managing symptom clusters of mild to moderate intensity, which generally helps patients manage the acute phase of illness.

Symptom Domains and Therapeutic Support

The medicine helps address symptom clusters that interfere with daily functioning, specifically addressing systemic discomfort (fever, headache, muscle aches) and mucosal irritation (runny nose, sneezing). This combination of actions is applied in contexts where short-term symptomatic assistance is needed for simultaneous relief from these manifestations.

“This symptomatic support is often used when discomfort arises from temporary physiological imbalance, which requires comprehensive relief across multiple domains.”

The product supports the patient during difficult episodes by easing the overall symptom load.

Quick Fact: Relief for Fever and Nasal Symptoms

Indications at a Glance

The preparation is used for managing manifestations associated with the common cold, influenza, and acute respiratory viral infections, including fever, headache, muscle aches, joint discomfort, runny nose, and sneezing.

Regulatory References

NIH DailyMed Drug Label

Eligibility and Restrictions for Use

Eligibility for Using Антигриппин (Official Regulatory Information)

Official regulatory documentation strictly defines the populations permitted or prohibited from using this medicine (Acetaminophen, Chlorpheniramine, and Ascorbic Acid combination). Use is generally permitted for adults and adolescents 12 years of age and older who do not have contraindications.

Absolute Contraindications

Антигриппин is formally contraindicated in several groups due to the risk associated with its components:

Patients with documented hypersensitivity or allergy to any active ingredient.
Individuals concurrently taking any other product containing Acetaminophen (to prevent overdose).
Patients with severe hepatic impairment or severe renal impairment.
Patients with angle-closure glaucoma or difficulty urinating due to conditions like prostatic enlargement.

Restricted and Non-Recommended Use

Use is not recommended in children under 12 years of age for the adult-strength formulation. Older adults are advised to use with caution due to increased sensitivity to the effects of Chlorpheniramine. For pregnant and breastfeeding individuals, a health professional must be consulted before use, as the medicine's status is either restricted or not established for these states.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Contraindicated Combinations and Restrictions

Co-administration with Monoamine Oxidase Inhibitors (MAOIs) is restricted due to the potential for severe adverse reactions. The product is not to be co-administered with Alcohol / Ethanol, as this combination significantly increases the documented risk of hepatotoxicity from Acetaminophen and additive central nervous system (CNS) depression from Chlorpheniramine. Herbal supplements like St. John's Wort are noted to carry a risk of pharmacokinetic interaction through enzyme induction.

Pharmacokinetic and Exposure Modifiers

Several substances are documented to alter the absorption or clearance of Acetaminophen, a pharmacokinetic interaction. Probenecid reduces clearance, leading to increased plasma exposure. Metoclopramide increases the rate of absorption, while Cholestyramine reduces it; co-administration with Cholestyramine requires a mandatory time separation (typically one hour). Enzyme Inducers (e.g., Rifampicin, Carbamazepine) may reduce Acetaminophen exposure and increase toxic metabolite formation.

Pharmacodynamic and Additive Effects

Co-administration with CNS Depressants (including sedatives and opioids) is documented to cause additive sedation and drowsiness via Chlorpheniramine. Anticholinergic Agents may reinforce effects such as dry mouth or urinary retention. Consistent, high-dose use of Acetaminophen with Warfarin may increase INR/Prothrombin Time.

Population-Specific Notes

Interactions that affect Acetaminophen metabolism are officially noted as more clinically significant in patients with Hepatic Impairment. Elderly patients show increased susceptibility to the reinforced CNS depressant effects of Chlorpheniramine's pharmacodynamic interactions.

Mechanism of Action

Антигриппин is a combination product whose pharmacodynamic activity is defined by the independent mechanisms of its three components. Paracetamol acts primarily within the central nervous system (CNS) by selectively inhibiting prostaglandin synthesis, functioning as a weak inhibitor of cyclooxygenase (COX) enzymes, particularly in low-peroxidase environments. This reduces the concentration of PGE2 in the hypothalamus, which subsequently resets the thermoregulatory center to a lower set point, increasing heat dissipation.

Chlorphenamine Maleate is a first-generation H1-receptor antagonist. It competitively binds to the H1 receptor, stabilizing its inactive conformation. This action blocks the binding and downstream activity of endogenous histamine released by mast cells. The blockade modulates cellular processes regulated by H1 signaling, including capillary permeability and glandular secretion.

Ascorbic Acid is incorporated into numerous intracellular oxidation-reduction reactions, acting as a reducing agent and essential cofactor. It maintains the reduced state of metal ions required for key enzymatic biosynthesis pathways, including those for collagen and certain neurotransmitters, supporting cellular response to oxidative stress.

Dosage and Administration Information

How to use Антигриппин

Usage of this combined pharmacological preparation follows an administration protocol for Over-The-Counter (OTC) symptomatic cold and flu products. The medicine is intended exclusively for oral administration and requires a specific preparation step to ensure proper intake.

Standard Dosing and Frequency

The standard single dose for adults and adolescents (typically those 15 years and older) is one unit (one effervescent tablet or one sachet of powder). Dosing is structured around a required interval of four to six hours between administrations. Total daily intake is limited; administration must not exceed a maximum of four units in any 24-hour period. This limitation exists to prevent exceeding the recommended limits for the Acetaminophen component.

Preparation and Administration Conditions

Prior to ingestion, the unit dose must be fully dissolved in a glass of water, forming a homogeneous solution that must be consumed immediately. The preparation may be taken with or without food. The intended pattern of use is short-term; for instance, administration for fever should not exceed three days and use for general symptomatic relief should not exceed five days without further clinical review.

Procedural Restriction

To maintain safety and ensure accurate dosing, the protocol includes a crucial restriction: this product must not be taken concurrently with any other preparation that contains Acetaminophen or other identical active ingredients found in this combination.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Антигриппин

Evidence for Use in Symptomatic Management of the Common Cold

The research examined common cold symptoms through Randomized Controlled Trials (RCTs) and comprehensive Systematic Reviews. These studies explored combination products that include both an analgesic, such as Acetaminophen, and an antihistamine, like Chlorpheniramine. Researchers studied how symptoms evolved in adult and older child populations presenting with conditions characterized by periods of heightened symptoms of mild to moderate intensity.

Studies conducted during periods of increased symptom activity measured patient-reported outcomes describing perceived discomfort and focused on changes in the Total Symptom Score (TSS). Findings describe patterns observed in the studies related to overall symptom intensity during the brief follow-up periods. The evidence contributes to the broader research landscape regarding symptom patterns, but long-term effects are not fully established.

Evidence for Use in Flu-Like Syndromes and ARVI

Research related to conditions associated with acute or disruptive episodes, such as flu-like syndromes and Acute Respiratory Viral Infections (ARVI), was evaluated in a similar research structure. Studies primarily examined outcomes related to systemic or functional imbalance, particularly the monitoring of physiological strain related to fever and headache. Researchers also assessed outcomes reflecting daily functioning, such as the time needed for individuals to resume their usual routines.

Findings indicate patterns related to changes in systemic discomfort during the acute phase of illness. The data show patterns related to symptom changes, but the evidence base is subject to heterogeneity across different studies, and the short duration of the trials means there is limited information for long-term outcomes or sustained relief after the acute episode passes.

Evidence in Special Populations: Children and Adults

The research evidence for these combination products focuses most consistently on adults and older children presenting with typical cold and flu symptoms. However, the evidence concerning the symptom patterns observed in younger children is limited. Regulatory and scientific reviews describe that data for this group remain insufficient to draw clear conclusions about observed symptom patterns.

Key Studies & References

Frequently Asked Questions (FAQ)

Common questions about Антигриппин (FAQ)

Q: Does Антигриппин help with a runny nose?

A: Yes, official product information confirms that the antihistamine component, Chlorphenamine, is documented to help relieve symptoms associated with a common cold, specifically including a runny nose (rhinorrhea) and watery eyes.

Q: Can children take Антигриппин?

A: Regulatory documents specify that the adult-strength formulation is generally intended for use by adults and adolescents aged 12 years and older. Use in children under 12 is usually not recommended and is subject to specific regulatory limitations.

Q: Is Антигриппин safe for elderly people?

A: Official labeling advises caution for older adults. This is because this population may have increased sensitivity to the effects of the antihistamine component, which can lead to enhanced central nervous system (CNS) effects, such as increased drowsiness.

Q: Can Антигриппин cause drowsiness?

A: Yes, the product contains a sedating antihistamine (Chlorphenamine Maleate). According to the official safety profile, adverse reactions including drowsiness and somnolence (sleepiness) are documented.

Q: Is it normal to feel a little dizzy after taking Антигриппин?

A: Official documents list dizziness as a possible adverse reaction associated with the use of this medicine. If individuals experience dizziness, the manufacturer's guidance suggests avoiding activities like driving. If the dizziness is severe or concerning, individuals should consult a healthcare professional.

Q: What should I avoid eating or drinking while taking Антигриппин?

A: It is crucial to avoid consuming alcohol/ethanol while taking this medication. This combination significantly increases the risk of severe liver damage (hepatotoxicity) from the Acetaminophen component and can cause additive central nervous system (CNS) depression.

Q: Does Антигриппин interact with blood pressure medication?

A: Official labeling contraindicates co-administration with Monoamine Oxidase Inhibitors (MAOIs), which are sometimes used for blood pressure or other conditions. Antihistamines can also sometimes interact with certain medications for cardiovascular conditions, so checking for specific interactions is recommended, ideally with a healthcare professional.

Q: What pain relievers can I safely take with Антигриппин?

A: The most important safety restriction is that the product must not be taken concurrently with any other medicine that contains Acetaminophen (Paracetamol). This constraint is in place to prevent accidental overdose. For guidance on alternatives, individuals should consult a healthcare professional or pharmacist.

Q: Is Антигриппин suitable for people with a sensitive stomach?

A: Regulatory safety documents list gastrointestinal disorders, such as nausea and dyspepsia (indigestion), as commonly documented adverse effects. Individuals with a pre-existing sensitive stomach should be aware of this potential side effect.

Q: Does Антигриппин contain a stimulant?

A: No, the combination of active ingredients does not include a known stimulant. The formula contains an antihistamine (Chlorphenamine), which actually has documented sedating effects, often leading to drowsiness.

Q: What should I do if I miss a dose of Антигриппин?

A: Patient information leaflets often advise that a missed dose may be taken as soon as it is remembered. However, if the time for the next scheduled dose is approaching, it is generally recommended to skip the missed dose and return to the regular schedule. A double dose should never be taken to compensate for a forgotten one.

Q: Is Антигриппин recommended for just a common cold?

A: Yes, the medicine is officially indicated for the symptomatic treatment of several conditions, including the common cold, influenza, and related acute respiratory viral infections (ARVI).

Q: Can Антигриппин cause allergic reactions?

A: Yes, regulatory documentation lists Immune System Disorders as a category of adverse reactions. The product is formally contraindicated in patients with a known hypersensitivity or allergy to any of its active components, indicating that allergic reactions are a possibility.

Q: Is there a sugar-free version of Антигриппин?

A: The exact excipients (inactive ingredients) can vary between different formulations. To confirm the presence or absence of sugar (like sucrose or glucose), it is necessary to check the specific excipient list on the product's packaging or regulatory label.

Q: What is the role of vitamin C in the Антигриппин formula?

A: The Ascorbic Acid (Vitamin C) component is included to provide general supportive action. It acts as an essential cofactor in oxidation-reduction reactions, which helps support the body's cellular response to oxidative stress during illness.

Q: What distinguishes the 'Day' and 'Night' versions of Антигриппин?

A: When 'Day' and 'Night' versions of cold medicine exist, regulatory documents usually show a difference in the active ingredients. The 'Night' formulation typically contains the sedating antihistamine (Chlorphenamine), while the 'Day' formula generally excludes it to prevent drowsiness during the day.

Q: Are there any known issues with taking Антигриппин and driving?

A: Yes. Due to the presence of the antihistamine component, the official label advises against engaging in hazardous activities such as driving or operating machinery. This is because side effects like drowsiness and dizziness can impair mental and physical performance.

Q: Can Антигриппин be taken on an empty stomach?

A: The preparation is generally intended for oral administration and the official regulatory label permits it to be taken with or without food.

Q: Is it possible to become dependent on Антигриппин?

A: The active ingredients in this combination product (Acetaminophen, Chlorphenamine, and Ascorbic Acid) are not generally associated with the risk of physical dependence that requires a specific regulatory warning.

Q: What ingredients in Антигриппин help with congestion?

A: The Chlorphenamine component acts as an antihistamine, which helps modulate symptoms like excessive mucus production and a runny nose (rhinorrhea). The product is a multi-symptom formula but does not contain a dedicated decongestant agent like Pseudoephedrine or Phenylephrine.

Q: What happens if I take more Антигриппин than recommended?

A: Taking more than the stated recommended dose is very dangerous. It carries a significant risk of severe hepatotoxicity (liver damage) primarily due to the Acetaminophen component, and this situation requires immediate emergency medical attention.

Q: Can I take Антигриппин if I have asthma?

A: Official cold product labels often advise caution for patients with certain respiratory conditions. This is because the antihistamine component may have effects, such as thickened secretions, that could be a concern for individuals with pre-existing conditions like severe asthma.

Q: Can Антигриппин interact with oral contraceptives?

A: The official documentation does not typically issue a specific warning for an interaction between the product's main active ingredients (Acetaminophen and Chlorphenamine) and oral contraceptives, implying no known major regulatory concern.

Q: What kind of research supports the combination of ingredients in Антигриппин?

A: Official rationale indicates that research confirms the utility of combination products. Specifically, studies show that combining an analgesic (Acetaminophen) and an antihistamine (Chlorphenamine) is clinically recognized for reducing the overall discomfort associated with colds and flu-like symptoms.

How should Антигриппин be stored and disposed of?

How to Store and Dispose of Антигриппин

Storage and disposal of Antigrippin, a combination product, must strictly follow regulatory guidance to maintain product stability and ensure environmental safety.

Official Storage Requirements

Condition	Regulatory Rule
Temperature	Store at a temperature typically below 25 C; avoid excessive heat above 40 C.
Protection	Keep in a dry place, protected from light and moisture.
Packaging	Store in the original package and keep out of the sight and reach of children.

Shelf-Life and Disposal

The product should not be used after the expiration date, which is typically tied to a three-year shelf life. Unused or expired Antigrippin must not be disposed of via household waste or wastewater. Disposal must be carried out in accordance with local regulations, often by consulting a pharmacist for guidance on take-back programs.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Russia

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