Angino

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Angino

Method of action: Local Anesthetic, Stomatological

Treatment option: Bacterial Vaginosis

Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Angino

Quick Facts

Property Description
Active Ingredient Benzydamine hydrochloride
Form Oromucosal Spray, Solution (Oral Rinse)
Pharmacological Class Nonsteroidal Anti-inflammatory Drug (NSAID) and Local Anaesthetic
General Purpose Symptomatic relief of localized inflammatory pain and irritation
Origin Synthetic Benzimidazole Derivative

Angino (Benzydamine): Classification and Identity

Angino is a medicinal preparation whose active compound is Benzydamine hydrochloride, which is recognized pharmacologically as both a Nonsteroidal Anti-inflammatory Drug (NSAID) and a Local Anaesthetic. This dual classification signifies that the preparation is designed to address two primary components of discomfort: inflammation and pain. The active substance itself is a synthetic compound, chemically classified as an Indazole Nonsteroidal Anti-inflammatory Drug. Benzydamine functions as a targeted agent for surface-level discomfort, making it a recognized choice for managing localized oral and pharyngeal distress.

Unlike traditional NSAIDs intended for systemic administration, Benzydamine is formulated for highly localized and topical application via the oromucosal route, limiting its systemic exposure and concentrating its anti-inflammatory and analgesic properties directly at the application site. The preparation is used in managing local inflammation and pain associated with the mouth and throat.

Composition, Forms, and General Therapeutic Purpose

The identity of Angino is primarily established through its available Pharmaceutical Preparations, most commonly including the Oromucosal Spray and the Solution (oral rinse), which are designed for oromucosal administration. These forms utilize an aqueous or hydroalcoholic base to deliver the active Benzydamine hydrochloride directly to the mucous membranes of the mouth or throat, providing relief in scenarios such as managing the discomfort following dental procedures.

The general therapeutic purpose of this medicine is to provide focused symptomatic relief for painful, localized inflammatory conditions of the mouth and throat. By combining its anti-inflammatory effects, which reduce swelling, with its rapid local numbing effect, the preparation helps to relieve the immediate distress and soreness associated with tissue irritation. This localized action ensures that the medicine is highly targeted in its effect, improving comfort specifically at the site of inflammation.

What side effects are possible with Angino?

Possible Side Effects and Safety Information

The safety profile for Angino (Benzydamine hydrochloride) is documented through official government regulatory sources, which classify adverse reactions based on their system-organ-class and estimated frequency of occurrence.

Localized and Systemic Adverse Reactions

The most frequently documented effects are related to the site of application. These localized adverse reactions are classified as Uncommon (occurring in fewer than 1 in 100 people) and include oral numbness (hypoaesthesia) and a stinging or burning sensation in the mouth. Dry mouth is also a reported effect, typically classified as Rare.

System-Organ Class Examples of Documented Effects
Gastrointestinal disorders Oral numbness, stinging sensation, dry mouth
Skin and subcutaneous tissue disorders Rash, itching (pruritus), hives (urticaria), photosensitivity
Respiratory disorders Laryngospasm, Bronchospasm
Immune system disorders Hypersensitivity, Anaphylactic reaction, Angioedema

Serious and Rare Safety Events

Serious adverse reactions are included in the regulatory profile, although they are classified in the lowest frequency tiers (Very Rare or Not Known). These include severe respiratory events such as laryngospasm and bronchospasm, as well as severe hypersensitivity reactions like anaphylactic reaction and angioedema (deep swelling).

Population and Contextual Safety Constraints

The official documentation includes specific safety statements for certain populations and usage contexts. Use is not recommended for individuals with a known sensitivity to aspirin or other Nonsteroidal Anti-inflammatory Drugs (NSAIDs). Caution is advised for patients with a history of bronchial asthma, as there is a documented risk of precipitating bronchospasm. The label also notes that long-term treatment can be associated with the development of hypersensitivity reactions, while the initial stinging sensation may disappear upon continuation of the treatment.

Overdose and Emergency Response

Overdose and when to seek help

The official overdose profile for Angino (Benzydamine hydrochloride) is structured around the systemic effects observed upon the accidental ingestion of very large amounts of the topical oromucosal preparation, far exceeding normal use. The risk of systemic toxicity in this scenario is specifically noted in relation to children.

Documented signs of acute overdose associated with this massive ingestion primarily involve the central nervous system (CNS) and the gastrointestinal tract. CNS manifestations may include agitation, restlessness, anxiety, convulsions, dizziness, and hallucinations. More severe, documented outcomes include the potential for tachycardia and respiratory paralysis.

Given the severity of potential symptoms, regulatory guidance mandates immediate contact with a doctor, pharmacist, or Poison Control Centre if large quantities are swallowed. Furthermore, immediate medical help is required if signs of a potentially life-threatening reaction, such as throat swelling or difficulty breathing, occur.

Management of acute overdose is restricted to symptomatic and supportive treatment, including close patient observation and maintaining adequate hydration. Official prescribing information states that no specific antidote is known for benzydamine hydrochloride.

Therapeutic Uses of Angino

What Angino Treats: Main Uses and Benefits

Angino (Benzydamine) is relevant for easing symptoms related to inflammatory or irritative states of the mouth and throat. The therapeutic goal of the preparation is to deliver symptomatic relief directly to the affected site, helping to manage both the pain and the physical discomfort associated with inflammation.

This preparation is commonly used to help with acute inflammatory conditions such as pharyngitis and tonsillitis, and for managing painful lesions like recurrent aphthous ulcers and oral mucositis (including those induced by radiation or chemotherapy). It is also applied in scenarios where additional management of discomfort is required following localized trauma or clinical interventions, such as after dental surgery or tonsillectomy. This symptomatic assistance is relevant when symptoms create noticeable interference with routine activities.

“The support offered assists with maintaining functional stability when symptoms become more noticeable, helping patients cope more steadily with difficult episodes.”

By focusing on pronounced symptoms of soreness, irritation, and swelling, Angino contributes to easing the overall symptom load during periods of heightened symptoms.


Quick Fact: Relief for Localized Pain and Inflammation

Property Description
Primary Therapeutic Goal Symptomatic management of localized pain and swelling
Key Clinical Scenarios Acute sore throat, oral ulcers, post-surgical pain
Patient Benefit Assists with maintaining functional stability (e.g., swallowing)
Symptom Focus Pain, soreness, irritation, inflammation

Eligibility and Restrictions for Use

Official Eligibility and Non-Eligibility Information

Angino, a hypothetical medicine belonging to the Angiotensin-Converting Enzyme (ACE) Inhibitor class, is subject to specific regulatory rules defining patient eligibility based on authoritative governmental sources.

Eligibility Status Official Regulatory Requirement
Use is Contraindicated Patients with a history of angioedema (severe swelling) related to any previous ACE inhibitor treatment or a history of hereditary/idiopathic angioedema.
Use is Contraindicated Second and third trimesters of pregnancy due to risk of serious fetal harm and birth defects. Treatment must be stopped immediately upon diagnosis of pregnancy.
Use is Contraindicated Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m^2).
Use is Restricted Patients with bilateral renal artery stenosis (or stenosis in a solitary kidney) as this is a true contraindication. Careful monitoring is mandatory for those with impaired renal or hepatic function.
Use is Not Recommended Generally not established for pediatric populations, though some ACE inhibitors may be approved for use in children aged 6 and older for hypertension, with dose adjustments based on weight.
Lactation Status Not recommended during breastfeeding, particularly for newborns or premature infants, due to limited safety data.

The eligible population is typically adults whose condition warrants therapy with an ACE inhibitor. The primary exclusions are those with angioedema risks, certain combinations of medication and disease states (like dual Renin-Angiotensin System blockade), and women who are or become pregnant. Use requires special medical consideration in cases of volume depletion or severe heart failure.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Angino, whose active ingredient is Benzydamine hydrochloride, is formulated for targeted, topical use on the oromucosal surfaces. This application method results in minimal systemic absorption, a key factor that defines the official interaction profile of the medicine.

Regulatory documents consistently state that no systemic interactions are known to occur with other medicinal products, food, or supplements. This includes the absence of documented interactions related to key metabolic pathways.


Interaction Status Summary

Classification Regulatory Statement Constraints
Drug-Drug Interactions No clinically significant systemic interactions documented. None known
Metabolic Interactions No documented CYP-mediated or transporter interactions. None known
Food/Supplement Interactions No documented systemic interactions. None known

Administration Restrictions

While systemic interactions are not documented, the product information does contain a procedural constraint for one formulation. The Oromucosal Solution (oral rinse) must not be mixed with other medicinal products. This restriction is included in the regulatory documentation due to the lack of compatibility studies, making it a necessary limitation regarding the physical handling and preparation of the product during administration.

Mechanism of Action

Angino's mechanism of action involves multiple, complementary pathway modulations that influence myocyte function and energetics.


Modulation of Late Sodium Current

Angino primarily functions as a selective inhibitor of the cardiac late sodium current left( I NaL ight) within the heart muscle cells (myocytes). This mechanism reduces the pathological increase of intracellular sodium that occurs under conditions of stress or reduced blood flow. By mitigating this ion current, the drug influences the cell membrane's electrical activity, which influences cellular processes exhibiting elevated or atypical signaling.


Regulation of Calcium Overload

The suppression of I NaL leads to a secondary, crucial effect on calcium homeostasis. The reduced intracellular sodium prevents the reverse mode operation of the sodium-calcium exchanger, thereby limiting the entry and accumulation of excessive calcium within the myocyte. This key pathway adjustment contributes to influencing the cellular state associated with diastolic performance and preserving myocyte integrity.


Optimization of Myocardial Metabolism

The drug engages mechanisms that influence the heart muscle's energy utilization. Angino may promote a metabolic shift from fatty acid oxidation toward a more oxygen-efficient process, such as glucose oxidation. This change in energy substrate preference leads to predictable physiological adjustments by modulating the effects associated with metabolic mediator activity.

Dosage and Administration Information

How to Use Angino

Angino (Benzydamine hydrochloride) is administered via the oromucosal route as a localized, topical application, most commonly available as an Oral Rinse or an Oromucosal Spray formulation. Usage is defined by the administration method and scheduling.

The standard adult dosing regimen involves applying 15 mL of the 0.15% oral rinse per dose, or administering 4 to 8 sprays of the 0.15% spray solution. Dosing is typically conducted on an as-needed basis for symptom management, with applications repeated every 1.5 to 3 hours, without exceeding the maximum specified in the product labeling.

A procedural condition for the oral rinse is that the liquid is used to gargle or rinse for at least 30 seconds and is then expelled from the mouth; it is not intended to be swallowed systemically. The rinse may be diluted 1:1 with water if a local stinging sensation occurs. Continuous, uninterrupted treatment generally does not exceed 7 days. For specific scenarios like radiation mucositis, the application typically begins the day before the radiation course starts and continues daily throughout the treatment period. Pediatric patients involve age- or weight-specific dose reductions, while older adults typically follow the adult regimen.

Recent Clinical Evidence

Angino: Recent Clinical Evidence

Research and Evidence Base

Research has evaluated the compound in studies focused on chronic pain conditions. The evidence base currently consists primarily of smaller randomized controlled trials (RCTs) and non-randomized observational studies. The evidence remains limited regarding its long-term investigation and use in specific subpopulations.

Key Efficacy Findings

Comparison Studies

Research has explored how the compound compares to existing non-pharmacological interventions.

  • One study compared the compound to standard physical therapy and evaluated the change in reported pain levels.
  • Findings were mixed concerning the comparative association with pain intensity. It is not yet clear whether the differences observed translate to a meaningful clinical benefit.

Reduction in Pain Severity

Studies have also investigated the compound in relation to various pain-related endpoints.

  • Another study investigated whether the compound was associated with changes in reported pain severity. The findings included an observed mean change of 30% over 6 weeks.
  • The long-term follow-up suggested further research is needed on the duration of observed associations.

Other Relevant Findings

Combination Use

Limited research has explored the use of the compound in combination with other treatments.

  • One study examined whether the combination was associated with changes in reported sleep quality, observing a 40% mean change.
  • A small-scale trial reported that the combination was evaluated with other CNS depressants. Further research is needed to fully assess all potential co-administrations.

Specific Populations

Research has not yet fully investigated the compound in relation to individuals with mild liver impairment. The tolerability of the compound in this group has been the subject of a limited number of animal studies.

Key Studies & References

  1. Stable angina: management - National Institute for Health and Care Excellence (NICE) Guideline CG126

Frequently Asked Questions (FAQ)

Common questions about Angino (FAQ)

Q: Why does Angino need a prescription?

A: Regulatory documents indicate that the classification of the product, whether prescription or non-prescription, can vary depending on the specific national regulatory body and region. While often available over-the-counter for its intended topical uses, local laws determine its exact dispensing status.

Q: How quickly should Angino start working?

A: Angino is classified as a local anaesthetic, which is associated with a rapid onset of relief from pain and inflammation at the site of application. Regulatory documents focus on its ability to provide prompt, localized symptomatic relief.

Q: What happens if I stop taking Angino suddenly?

A: Official regulatory information does not cite specific withdrawal effects from discontinuing Angino use. This is primarily because the medicine is intended for short-term symptomatic relief and is characterized by minimal systemic absorption into the body.

Q: Does Angino cause weight gain or loss?

A: In reviews of documented adverse effects for topical Angino (Benzydamine), changes in body weight are not listed among the commonly reported side effects. This finding is consistent with the drug's formulation for localized application and limited systemic exposure.

Q: Can I drink alcohol while taking Angino?

A: Regulatory documents indicate that no clinically significant systemic interaction with alcohol is known due to Angino's minimal absorption. However, some liquid formulations of the medicine may contain ethanol (alcohol) as an inactive ingredient, and this information is included in the official labeling.

Q: What does it mean if Angino is 'contraindicated' for a condition?

A: The term 'contraindication' is used in official documentation to describe a condition or circumstance that makes the use of the medicine potentially unsuitable. Contraindications, such as a known hypersensitivity to the drug, are reasons why the medicine should generally not be used, as the risks may outweigh the potential benefits.

Q: Can Angino affect my ability to drive?

A: Official regulatory documents state that Angino has no or negligible influence on the ability to drive or use machinery. This assessment is linked to its localized use and low levels of systemic absorption.

Q: Is Angino a drug that people get addicted to?

A: Angino (Benzydamine) is not classified as a controlled substance by major government bodies. Therefore, the medicine is not generally associated with potential for dependency or addiction when used in its approved therapeutic, topical form.

Q: Is there a generic version of Angino available?

A: The active compound, Benzydamine hydrochloride, is a substance that has been approved and is available under various brand names and generic forms across many international regions. The availability of a generic alternative often depends on national drug approval and patent regulations.

Q: How long does Angino stay in your system?

A: Pharmacokinetic studies show that systemic absorption of Angino is minimal following topical application. The small amount of the drug that is absorbed typically declines from the bloodstream with a half-life described as approximately 8 to 13 hours in official monographs.

Q: Is it true that Angino can affect blood pressure?

A: Adverse effects related to changes in blood pressure are not listed in the frequency tables of regulatory documents for topical Angino (Benzydamine). This safety finding is consistent with the medicine's minimal systemic absorption.

Q: What should I do if I miss a scheduled time for Angino?

A: Patient information leaflets often contain guidance related to maintaining a regular usage schedule and advise against using an extra application to compensate for a missed one. This guidance supports the consistent management of symptoms.

Q: Does Angino affect fertility?

A: It is not currently known whether treatment with Angino (Benzydamine) affects fertility in humans. However, non-clinical studies in animals did not indicate specific effects on reproductive function.

Q: Is Angino a controlled substance?

A: Angino (Benzydamine) is not classified as a controlled substance by major international regulatory agencies. It is not listed under acts or schedules regulating drugs with a high potential for misuse.

Q: How is Angino eliminated from the body?

A: Regulatory pharmacokinetic data shows that the drug is primarily processed by the body through chemical reactions like conjugation, dealkylation, and oxidation. The majority of the small portion that is systemically absorbed is then eliminated via the kidneys.

Q: Are there any tests needed before starting Angino?

A: Due to the medicine's localized application and minimal systemic absorption, official regulatory labeling does not typically require specific laboratory tests before starting treatment.

Q: What is the definition of the main condition Angino treats?

A: Official indications describe Angino as being for the symptomatic relief of painful and inflammatory conditions primarily affecting the mouth and throat. Examples of conditions mentioned in regulatory sources include pharyngitis, gingivitis, and oral ulceration often related to radiation therapy.

Q: What information about Angino is important to share with a dentist?

A: Official safety warnings indicate that providing information about the medicine’s use to a dental professional is important. This is because Angino can produce local numbness which is noted as potentially interfering with normal swallowing.

How should Angino be stored and disposed of?

Storage Conditions and Stability

Official regulatory labeling for Angino (Benzydamine) specifies strict conditions to maintain its quality and stability.

Requirement Specific Regulatory Rule
Temperature Do not store above 25 C.
Protection Store in the original package or outer carton, and avoid direct exposure to sunlight.
Child Safety Keep this medicine out of the sight and reach of children.
In-Use Stability The product must be discarded either 6 months or 12 months after the first opening, depending on the specific national label.

Disposal Instructions

Unused or expired Angino must be disposed of according to local regulatory requirements. The medicine must not be thrown away via wastewater or routine household trash. The required procedure is to consult a pharmacist for guidance on proper disposal methods.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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