Components:
Method of action:
Treatment option:
Medically reviewed by Fedorchenko Olga Valeryevna, PharmD. Last updated on 07.06.2023
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2 World Cefazolin
Cefazolin
Bacterial infections of the upper and lower respiratory tract, urinary and biliary tracts, pelvic organs, skin and soft tissues, bones and joints
Sepsis, peritonitis, infectious endocarditis, infections of the respiratory tract, genitourinary system (including syphilis, gonorrhea), bones and joints. Prevention of postoperative complications.
Infections of the upper and lower respiratory tract (bronchitis, pneumonia), genitourinary system, biliary tract, pelvic organs, skin, soft tissues, bones, joints, wound, burn and postoperative endocarditis, sepsis, prevention of surgical infections in the pre - and postoperative period.
In/in (bolus and infusion), in/m. 0.5 g 2 times a day (maximum-12 g)
Hypersensitivity. Do not administer to children under 1 month of age and premature infants.
Anorexia, abdominal pain, nausea, vomiting, diarrhea, changes in liver tests, neutropenia, leukopenia, thrombocytopenia, thrombocytosis, pseudomembranous colitis, candidiasis, skin rash, itching of the skin, genitals and anal, drug fever, eosinophilia, Stevens-Johnson syndrome, phlebitis.
It has a wide range of antimicrobial action. active against gram-positive (Staphylococcus spp., Staphylococcus aureus (non - producing and producing penicillinase
With the intravenous administration of 500 mg, the average concentration of the drug in the blood serum after 1 hour is 37 mcg/ml, after 8 hours-3 mcg/ml. When administered intravenously at a dose of 1 g Cmax-185 mcg / ml, after 8 h-4 mcg/ml. The half-life of 1.8 hours with intravenous administration. It is excreted unchanged in the urine: during the first 6 hours — about 60% of the dose, after 24 hours-70-80%. In peritoneal dialysis (2 l / h) using a solution containing ancef at a concentration of 50 mg / l and 150 mg/l, after 24 hours, the average concentration of the drug in the blood serum is 10 and 30 mcg/ml, respectively.
- Cephalosporins
Probenecid may reduce the allocation ancefa.
However, we will provide data for each active ingredient
