Levina

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Levina

Property Description
Active ingredients Ethinyl Estradiol (EE) and Levonorgestrel (LNG)
Form Oral tablet
Pharmacological class Hormonal Contraceptive
Common use Pregnancy prevention
Origin Synthetic

What Type of Medicine is Levina?

Levina is a prescription-only pharmaceutical product classified as a hormonal contraceptive and delivered as an oral tablet. It belongs to the high-level pharmacological category of Estrogen-Progestin Combinations, specifically functioning as a combined oral contraceptive (COC). This medication represents a combination product because its formulation requires two distinct synthetic hormones to achieve its intended effect: an estrogen and a progestin. Being an oral preparation, the tablets are designed to be taken by mouth to deliver these exogenous hormones systematically, enabling the reliable control of reproductive function.

Composition: Ethinyl Estradiol and Levonorgestrel

The active compounds in Levina are Ethinyl Estradiol (EE) and Levonorgestrel (LNG), two synthetic hormones that govern the drug’s properties. Ethinyl Estradiol serves as the estrogen component, and Levonorgestrel is the progestin component. The product is structurally identified as a monophasic formulation, meaning the dosage of both the Ethinyl Estradiol and the Levonorgestrel remains fixed and constant in every active tablet within the cycle. This type of fixed-dose regimen is clinically recognized for providing a steady hormonal level throughout the active period. This consistent composition is achieved using solid excipients, which form the base and structure of the oral tablet.

General Purpose: How Levina Prevents Pregnancy

The general purpose of Levina is pregnancy prevention in women of reproductive potential. The medication achieves this through a high-level, multi-faceted strategy that suppresses the hormonal cascade necessary for conception. By introducing exogenous hormones, Levina establishes conditions that inhibit key biological events, primarily working by preventing the release of an egg (ovulation) and thickening the cervical mucus to impede sperm passage. This results in a comprehensive, reversible biological barrier designed to minimize the likelihood of conception, representing a typical use scenario for individuals seeking long-term reversible contraception.

What side effects are possible with Levina?

Possible Side Effects and Safety Information

The safety profile of Levina, a combined oral contraceptive containing Ethinyl Estradiol and Levonorgestrel, is defined by official regulatory documents, which classify documented adverse reactions by frequency and affected body system. This information is strictly non-advisory and focuses on the high-level safety characteristics of the medicine.

Adverse reactions that are classified as very common in regulatory labeling include headache and intermenstrual bleeding (spotting). Common effects frequently involve the gastrointestinal system (nausea, vomiting), reproductive system (breast pain or tenderness), and psychological status (mood changes, including depression).

Serious adverse reactions are specifically documented in official labeling, most notably the risk of venous thromboembolism (VTE) and arterial thromboembolism (ATE), which may manifest as deep vein thrombosis, pulmonary embolism, stroke, or myocardial infarction. The regulatory basis for this concern notes that the risk for thromboembolism is highest during the first year of use.

Official documents define specific safety restrictions. Levina is contraindicated in individuals with a history of VTE or ATE, severe hepatic impairment, or undiagnosed abnormal uterine bleeding. Furthermore, a specific safety note emphasizes that the medicine should not be used in women over the age of 35 who smoke, due to a significantly increased risk of serious cardiovascular events. Regulatory texts also specify that the product must be discontinued prior to elective major surgery or prolonged immobilization.

Overdose and Emergency Response

Levina Overdose and when to seek help

The official regulatory documentation for combined oral contraceptives containing Ethinyl Estradiol and Levonorgestrel defines the overdose profile as low-risk, primarily resulting in self-limiting effects.

Overdose Scope: Documented Presentations

The documented clinical manifestations of acute overdosage are typically confined to the gastrointestinal and reproductive systems. The officially reported symptoms include nausea and vomiting. In females, withdrawal bleeding or spotting is a common physiological manifestation following the ingestion of an excessive quantity. Accidental ingestion by young children is generally noted as not resulting in serious adverse consequences.

Official Severity and Mandated Action

Regulatory agencies classify an overdose as generally not life-threatening, and serious adverse effects are not commonly reported, even following the acute ingestion of large doses.

Immediate Medical Attention is Required: Individuals who have confirmed or suspected an overdose must seek immediate medical attention or contact a Poison Control Center immediately.

Supportive Treatment Only: Overdose management is explicitly defined as symptomatic and supportive treatment because no specific antidote is known. Hospital monitoring may be required for supportive care based on medical necessity following the initial consultation to manage any manifestations that arise.

Therapeutic Uses of Levina

What Levina Treats: Main Uses and Benefits

The primary function of Levina is providing effective, reversible pregnancy prevention in women of reproductive potential. The medication serves as a systemic method of birth control. Beyond this core use, Levina is applied across domains where additional symptomatic support is needed.

The non-contraceptive benefits are relevant for easing distressing manifestations, including excessive menstrual bleeding (menorrhagia), severe, chronic menstrual pain (dysmenorrhea), and discomfort associated with conditions like endometriosis. It may also assist in managing certain hormonal skin manifestations, such as moderate acne. The medication generally supports patients during symptomatic periods and may assist with maintaining functional stability.

“The use of this medication provides support that helps ease the overall symptom burden, especially when monthly discomfort interferes with daily life.”

Quick Fact: Relief for Menstrual Symptoms

Levina is used to help address symptom clusters that may become intense or disruptive, providing support that helps ease the overall symptom burden related to the menstrual cycle.

Regulatory References

  1. NIH MedlinePlus overview

Eligibility and Restrictions for Use

Official Eligibility and Contraindications for Levina

The combined oral contraceptive Levina (Ethinyl Estradiol and Levonorgestrel) is officially indicated for use by females of reproductive potential (post-menarcheal) to prevent pregnancy. Regulatory documents define eligibility strictly by excluding populations with specific health conditions and physiological states.

Absolute Contraindications (Must Not Use)

The medicine is contraindicated in women with a high risk of arterial or venous thrombotic diseases. This includes women over 35 years old who smoke, or those with a history of deep vein thrombosis, pulmonary embolism, stroke, or myocardial infarction. Use is also prohibited in individuals with known thrombogenic mutations, severe uncontrolled hypertension, or diabetes with vascular involvement.

Furthermore, Levina is contraindicated in patients with current or history of breast cancer or other hormone-sensitive cancers, liver tumors, or active liver disease (including decompensated cirrhosis).

Restrictions and Conditional Use

Population Group Official Regulatory Status
Pregnancy Contraindicated (must be discontinued if pregnancy is suspected)
Lactation (Breastfeeding) Not Recommended (may reduce milk production)
Postpartum Restricted; initiation is generally not recommended until at least four weeks after delivery in non-breastfeeding women.
Surgery/Immobilization Use must be stopped at least four weeks before and through two weeks after major surgery.
Geriatric Use Not Indicated for post-menopausal women; safety and efficacy are not established.
Pediatric Use Not Indicated before the start of menstruation (menarche).

Official eligibility is defined by the absence of these high-risk conditions, ensuring the drug is used only within the medically appropriate patient population.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Levina's official interaction profile is structured around defined pharmacokinetic alterations and formal regulatory prohibitions. Interacting substances include certain anticonvulsants and the antibiotic Rifampicin, which are documented as CYP3A inducers that significantly decrease the systemic exposure of the Ethinyl Estradiol and Levonorgestrel components.

Interaction-Related Restrictions

A formal contraindication exists for co-administration with specific Hepatitis C antiviral regimens. These include combinations containing Ombitasvir/Paritaprevir/Ritonavir and Elbasvir/Grazoprevir, a prohibition based on the documented risk of significant ALT enzyme elevations.

Official Interaction Statements

  • Strong CYP3A inhibitors may lead to an increase in the plasma concentration of Levina's hormones.
  • The herbal product St. John's Wort is explicitly listed as a substance that reduces contraceptive efficacy via enzyme induction.
  • The bile acid sequestrant Colesevelam requires a timing separation rule: Levina must be administered at least four hours prior to Colesevelam to mitigate its documented effect of decreasing Ethinyl Estradiol absorption.
  • Levina is documented to cause a decrease in the plasma concentration of certain co-administered drugs, such as Lamotrigine.
  • Gastrointestinal events like vomiting or severe diarrhea that occur within three to four hours after administration are noted as conditions that may reduce the absorption of the active hormonal components.

Mechanism of Action

Modulating Specific Receptor Systems

Levina initiates its action by engaging defined biological targets—specifically, a subtype of receptor within regulatory pathways. This direct molecular interaction serves to initiate or suppress signaling events, which is relevant where rapid adjustment of receptor activity is needed to modulate signal transmission within the targeted pathway.

Targeted Interference in Signal Transduction

The drug acts within well-characterized molecular cascades, altering signaling dynamics in defined neural or humoral pathways. This targeted interference is applied in contexts involving heightened pathway activation, influencing the regulation of processes driven by distinct signaling patterns.

Influence on Physiological Activity Patterns

By influencing these core mechanisms, Levina influences the level or duration of specific signals. This modifies activity patterns within the targeted physiological system and alters signaling dynamics to promote pathway regulation, influencing subsequent physiological adjustments resulting from this mechanism of action.

Dosage and Administration Information

How Levina is Used: Dosing and Administration

Levina is a monophasic combined oral contraceptive (COC) that is administered according to a fixed dosing schedule. The instructions below describe the administration protocols for this oral tablet formulation.


Administration Protocol

The route of administration for Levina is oral (by mouth). The medication is indicated for use in postmenarchal females of reproductive potential.

Dosing Principle Instruction
Route & Form One oral tablet taken once daily. Tablets may be taken with or without food.
Standard Regimen One active tablet is taken daily at the same time every day for 21 consecutive days, followed by 7 days of either inactive (placebo) tablets or no tablets.
Cycle Timing The medication is taken cyclically, completing a 28-day course (21 active / 7 inactive). A new tablet pack must be started immediately following the completion of the prior cycle.
Dose Initiation The first pack is typically initiated on the first day of the menstrual period (Day 1 Start) or on the first Sunday after the period begins (Sunday Start).

Procedural Instructions for Use

Adherence to the 24-hour interval and the correct sequence of tablets is critical. Specific protocols exist for managing missed active tablets, which vary depending on the number of pills missed and the week of the cycle they were missed. These instructions define the actions required to maintain the controlled hormonal regimen and ensure consistent use.

Recent Clinical Evidence

Levina is an established combined oral contraceptive (COC) containing levonorgestrel and ethinyl estradiol. Clinical evidence has consistently focused on its high contraceptive efficacy, safety profile, and impact on menstrual cycle control.

Contraceptive Efficacy

When used as directed (perfect use), the combination of levonorgestrel and ethinyl estradiol is observed to have a pregnancy prevention rate greater than 99%. Under real-world conditions (typical use), which accounts for missed doses, the effectiveness rate is generally reported to be around 91%.

Large-scale studies, including those for formulations similar to Levina, calculate the efficacy using the Pearl Index, which reflects the number of pregnancies per 100 women over one year of use. Clinical trials often report a low Pearl Index for the method failure rate of this hormone combination, which aligns with its classification as a highly effective form of reversible contraception.

Cycle Control and Bleeding Patterns

Clinical investigations of low-dose formulations of levonorgestrel and ethinyl estradiol, such as those in Levina, have evaluated their effect on menstrual patterns. Key findings indicate that:

  • Cycle Regularity: The medication promotes regular withdrawal bleeding, which typically occurs during the inactive (placebo) pill phase.
  • Unscheduled Bleeding: The incidence of intermenstrual bleeding or spotting is generally highest in the initial cycles of use and tends to decrease substantially after the first few months of continuous use. One trial involving a similar low-dose formulation reported that unscheduled spotting and bleeding decreased over six treatment cycles.

Tolerability and Safety Profile

In clinical trials, combined oral contraceptives containing levonorgestrel and ethinyl estradiol are generally reported as being tolerable. The most frequently observed adverse events are typical of hormonal contraceptives and include headaches, breast tenderness, and nausea. These events are often mild and tend to resolve after the first few cycles.

Key Studies & References

  1. The Pearl Index: Efficacy of Contraceptive Methods

Frequently Asked Questions (FAQ)

Common questions about Levina (FAQ)


Q: How quickly can I expect to notice Levina working?

A: Official guidelines explain how quickly the medicine is considered effective based on the day you start taking the first tablet. If the cycle is started on the first day of your period, no additional contraception is generally not considered necessary. However, if initiated later, regulatory guidance defines the required use of a back-up barrier method for the first seven days of active pills.

Q: Does Levina interact with birth control pills?

A: Levina itself is classified as a combined oral contraceptive (COC) because it already contains the necessary two hormonal ingredients for pregnancy prevention. Therefore, official documents state that Levina is classified as a comprehensive method of contraception and is not intended to be used with other hormonal birth control pills or methods.

Q: Does taking Levina affect laboratory blood tests?

A: Official prescribing information indicates that hormonal contraceptives may influence the results of certain medical laboratory tests. This interference can sometimes be observed with tests that measure thyroid function and blood clotting (coagulation) parameters.

Q: Can Levina be split or crushed?

A: The approved administration protocol specifies swallowing one entire oral tablet once daily. Regulatory documents do not contain instructions or information supporting the practice of splitting or crushing the tablets, and ensuring the correct dose is delivered is a required part of the established administration protocol.

Q: If I miss a dose of Levina, what does the official document say I should do?

A: Official guidance outlines specific, detailed protocols for managing missed active tablets. These instructions vary significantly based on how many pills were missed and during which week of the cycle the miss occurred. These instructions are defined to maintain the controlled hormonal regimen.

Q: Does Levina cause weight gain?

A: The official product documentation lists common adverse events such as headache, nausea, and breast tenderness. Regulatory documents do not classify weight gain as a very common or common side effect associated with the medicine.

Q: Is it common to have mild headaches when first starting Levina?

A: Official documents classify headache as a very common adverse reaction when using Levina. Clinical findings documented in studies indicate that the incidence of many frequently reported adverse events, including headaches, is often observed to decrease after the first few months of continuous use.

Q: Does Levina lose its effectiveness over time?

A: Regulatory documentation bases the drug’s effectiveness classification on continuous use data. Long-term effectiveness is typically assessed using the Pearl Index, a measure calculated in clinical trials, which is an indicator used to assess the consistency of efficacy during the recommended duration of use.

Q: How is Levina different from other drugs that treat the same condition?

A: Levina is officially classified as a combined oral contraceptive (COC) because its formulation requires both an estrogen and a progestin component to prevent pregnancy. This is distinct from other contraceptive methods, which may rely only on progestin or non-hormonal strategies.

Q: Is Levina safe for people with liver problems?

A: Levina is contraindicated (must not be used) in patients with current or a history of liver tumors or active liver disease, including decompensated cirrhosis. Official documents do not contain information regarding use for individuals with mild or non-active liver impairment.

Q: What happens if I stop taking Levina suddenly?

A: Regulatory data on combined oral contraceptives indicate that the contraceptive effect ceases upon discontinuation of the medicine. The return to a normal ovulatory menstrual cycle is generally described as rapid, and the post-discontinuation resumption of fertility is observed to be similar to other reversible contraceptives.

Q: Are there any specific foods I should avoid while using Levina?

A: Official interaction statements primarily focus on prescription drugs, over-the-counter medicines, and herbal products like St. John's Wort. Regulatory documents do not contain information regarding specific food prohibitions.

Q: Does alcohol interact negatively with Levina?

A: Official regulatory documents do not list a specific drug-to-drug chemical interaction between Levina and alcohol. However, alcohol consumption may worsen common reported adverse events like headache or nausea, and may present a risk that affects adherence to the required daily dosing schedule.

Q: Can Levina be purchased over-the-counter in some countries?

A: Levina is classified as a prescription-only pharmaceutical product by the governing health authority for this territory. Its availability status in other countries is subject to the independent regulations and classifications of their specific regulatory bodies.

Q: How long after stopping Levina does it stay in my system?

A: The active hormonal ingredients are systematically processed by the body following the final dose. Regulatory documents that describe this clearance process indicate the elimination half-life for the hormonal components is generally in the range of several hours.

Q: What is the purpose of the 'inactive' ingredients in Levina tablets?

A: Regulatory labeling lists inactive ingredients, also called excipients, which are necessary components. Their purpose is to form the physical structure of the oral tablet, stabilize the medicine, and assist in its dissolution and proper absorption within the body.

Q: Does Levina affect fertility?

A: Clinical evidence indicates that the contraceptive effect of Levina is completely reversible. Its use is not documented to cause a decrease in the rate of conception following discontinuation when compared to other non-hormonal methods.

Q: Is it normal to feel a bit nauseous after starting Levina?

A: Nausea is classified in official documents as a common adverse event associated with the use of Levina. As with many commonly reported side effects when starting a new medication, its occurrence is often highest during the initial cycles of use.

Q: What are the known severe or rare side effects of Levina?

A: Official labeling documents the risk of serious adverse reactions, most notably venous and arterial thromboembolism (blood clots). Other serious events described in regulatory texts include certain liver problems, changes in blood pressure, and potential links to specific cancers.

Q: What is the difference between Levina and a placebo in clinical trials?

A: In clinical trials, the primary difference observed is the successful demonstration of contraceptive efficacy. Levina exhibits a very high rate of pregnancy prevention, which contrasts significantly with the expected high pregnancy rates observed in non-treatment (placebo) groups.

Q: Can people with high blood pressure use Levina?

A: Levina is contraindicated (must not be used) in women with severe uncontrolled hypertension, as specified in regulatory documents. The decision for use in individuals with controlled or mild blood pressure is based on a full evaluation of other cardiovascular risk factors.

How should Levina be stored and disposed of?

How to Store and Dispose of Levina?

Levina tablets must be stored according to the requirements specified in the official regulatory labeling to maintain product stability and potency.

Storage Conditions

Requirement Official Specification
Temperature Range Store at 20 C to 25 C (68 F to 77 F).
Protection Protect from moisture and heat.
Container Rule Keep in the original container and ensure it is tightly closed.
Safety Keep this medication out of the sight and reach of children.

Disposal Instructions

Unused or expired Levina should be disposed of through a dedicated drug take-back program. If an official program is unavailable, follow the specific household disposal guidelines recommended by the FDA, which generally involve mixing the medication with an undesirable substance and sealing it before discarding. The tablets must not be flushed down the toilet or poured into a drain.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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