Aurorix

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Aurorix

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Aurorix

What is Aurorix? Defining the Drug's Identity

Property Description
Active ingredient Moclobemide
Form Film-coated tablet (Oral)
Pharmacological class Reversible Inhibitor of Monoamine Oxidase A (RIMA)
Common use Management of depressive and anxiety syndromes
Origin Synthetic organic compound (Benzamide derivative)

The medication Aurorix contains the active ingredient Moclobemide, which belongs to the category of psychoanaleptics and antidepressants. The fundamental purpose of this drug is the management and alleviation of symptoms associated with major depressive syndromes and specific anxiety-related disorders. Moclobemide is an approved, single-component medicine derived from the Benzamide derivative group of synthetic organic compounds. It is administered as an oral dosage form, specifically a film-coated tablet, which is designed for reliable and standardized systemic delivery of the active substance. Aurorix is typically a prescription-only medication, indicating regulatory control over its use and reinforcing its pharmacological potency.

Moclobemide’s Classification as a Synthetic RIMA

Moclobemide is formally categorized as a Reversible Inhibitor of Monoamine Oxidase A (RIMA), establishing its identity within the broader class of Monoamine Oxidase Inhibitors (MAOIs). This classification is defined by its targeted action: it selectively blocks the enzyme Monoamine Oxidase A (MAO-A) in the brain. By temporarily inhibiting the action of MAO-A, the medicine prevents the premature metabolic degradation of key monoamine neurotransmitters, including Serotonin, Noradrenaline, and Dopamine, causing their concentrations to increase in the neural synapses. Moclobemide functions as a selective and reversible MAO-A inhibitor. The action is unique because the inhibition of the enzyme is reversible, differentiating it from older, irreversible MAOIs and contributing to its comparatively flexible profile. This targeted and temporary modulation of brain chemistry is the defining mechanism through which the drug supports mood stabilization and emotional balance.

What side effects are possible with Aurorix?

Possible Side Effects and Safety Information

The safety profile for Aurorix (Moclobemide) is classified by regulatory authorities using System-Organ Classes (SOC) and frequency categories based on clinical and post-marketing data. These classifications define the spectrum of expected and clinically significant adverse events.

Frequency and System-Organ Classifications

Adverse reactions are documented using standard frequency terms:

  • Very Common (ge 1/10): Includes sleep disorders, headache, dizziness, nausea, and dry mouth.
  • Common (ge 1/100 to <1/10): Includes agitation, anxiety, restlessness, diarrhoea, and rash.
  • Uncommon (ge 1/1,000 to <1/100): Includes confusional state, pruritus (itching), urticaria (hives), and increases in liver enzyme levels.

Adverse events are often grouped into SOCs, such as Nervous System disorders, Gastrointestinal disorders, and Psychiatric disorders.

Serious Safety Considerations

Regulatory documentation highlights specific, clinically important adverse reactions:

  • Suicidality: Antidepressant treatment carries an associated risk of suicidal thoughts and behaviors, which persists until significant clinical remission is achieved, particularly in the early phases of treatment.
  • Serotonin Syndrome: A potentially severe reaction, its risk is noted to increase significantly when Moclobemide is used alongside other serotonergic agents.
  • Hepatic Reactions: Rare but serious events, including hepatitis, are documented under Hepatobiliary disorders.

Safety Restrictions and Special Populations

Official labels define high-level constraints for the use of Aurorix:

  • Contraindications: Use is prohibited in individuals with acute confusional states or phaeochromocytoma.
  • Hepatic Impairment: Patients with severe hepatic impairment require close clinical oversight due to potential changes in the medicine's removal from the body.
  • Paediatric Use: Use in children and adolescents under 18 years is generally not established and therefore not recommended in standard regulatory documents.

Overdose and Emergency Response

Any suspected overdose with Aurorix (Moclobemide) requires immediately seeking medical attention. The official labeling describes overdose manifestations primarily affecting the central nervous system and cardiovascular system. Documented signs include somnolence, drowsiness, disorientation, and tachycardia, often accompanied by a mild increase in blood pressure.

While Moclobemide monotherapy overdose is generally less severe than with older MAOIs, high-dose ingestion, especially when combined with other psychoactive drugs, significantly increases the risk of severe outcomes. These critical manifestations may include convulsions, respiratory depression, and coma. Regulatory guidance emphasizes the severe danger of mixed overdose, which heightens the risk of fatalities and the development of Serotonin Syndrome if taken with other serotonergic agents.

When severe symptoms are present, emergency services must be contacted immediately. The officially described management is primarily symptomatic and supportive treatment, as no specific antidote is known. Hospitalization and intensive monitoring are required to manage symptoms and stabilize the individual following an overdose event.

Therapeutic Uses of Aurorix

What Aurorix Treats: Main Uses and Benefits

Aurorix (Moclobemide) is commonly used across conditions presenting with significant affective symptoms, primarily serving as a relevant tool in the management of Major Depressive Disorder (MDD) and persistent forms of low mood (Dysthymia). The medication is also relevant for specific anxiety syndromes, most notably Social Phobia (Social Anxiety Disorder).

It is applied in clinical settings marked by patient distress associated with core symptoms like pervasive low mood, emotional imbalance, and pronounced anhedonia (loss of pleasure). The medication helps address groups of symptoms that can lead to temporary functional strain, which may include debilitating fatigue, lack of energy, or psychomotor disturbances.

This therapeutic domain aims to provide supportive relief that assists with maintaining functional stability in their social and professional life. The primary therapeutic uses generally involve managing mood disorders, chronic depression, and specific anxiety presentations.


“The medication may support patients during difficult episodes, assisting with easing distress and helping them cope more steadily with symptom fluctuations.”

Quick Fact: Support for Atypical Depressive Symptoms

Aurorix is commonly used to help with symptom clusters that include features like leaden paralysis, mood reactivity, and hypersomnia, providing support when symptoms interfere with routine activities.

Regulatory References

  1. Medsafe Data Sheet – Aurorix

Eligibility and Restrictions for Use

Eligibility and Contraindications for Aurorix

The eligibility profile for Aurorix (Moclobemide) is defined by official regulatory documentation, outlining who may use the medicine and under what conditions.


Absolute Contraindications

Aurorix must not be used by patients with:

  • Acute confusional states or phaeochromocytoma (a rare tumor) [Source 1.5, 3.1].
  • Known hypersensitivity to moclobemide or any excipients [Source 1.5, 3.1].
  • Co-administration with several other medications is contraindicated, including SSRIs, Linezolid, Selegiline, Pethidine, Tramadol, and Triptans [Source 1.5, 3.1].

Population and Organ-Function Restrictions

Population Group Regulatory Status Restriction/Limitation
Children/Adolescents (under 18) Not Recommended Safety and efficacy have not been established [Source 1.5, 3.2].
Pregnant/Lactating Women Not Recommended Safety is not established; use requires careful benefit-risk evaluation [Source 2.5, 3.3].
Impaired Hepatic Function Conditional Use The daily dose must be reduced to one-half or one-third [Source 1.5, 4.3].
Renal Function Allowed No special dose adjustment is required [Source 1.5, 4.3].

The standard approved population for Aurorix use consists of adults (18 years and older) [Source 1.5, 2.2]. Caution is also advised for patients with excitable or agitated features, thyrotoxicosis, or schizophrenia [Source 1.7, 3.6].

What should I know about interactions with other medicines?

Interactions with other medicines and products

Aurorix (moclobemide) is a reversible inhibitor of monoamine oxidase A (RIMA), and its co-administration with other medications must be carefully managed to avoid serious drug-drug interactions. The most significant risk is the development of Serotonin Syndrome.

Contraindicated Combinations

The following products are contraindicated due to the increased risk of Serotonin Syndrome or hypertensive crisis:

  • Other Antidepressants: Selective Serotonin Reuptake Inhibitors (SSRIs), Tricyclic Antidepressants (TCAs, e.g., clomipramine), and Bupropion.
  • Other Agents: Selegiline, linezolid, pethidine, tramadol, and dextromethorphan (a common cough suppressant).
  • Triptans: Medicines used to treat migraine, such as zolmitriptan, due to enhanced serotonergic activity.

Other Significant Interactions

Cimetidine, a medicine that inhibits liver enzymes, reduces the metabolism of Aurorix. Co-administration requires a dose reduction for Aurorix, typically to half or one third of the standard dose, to prevent elevated drug levels in the bloodstream. Other agents that are known to increase serotonin concentration, such as St. John's wort (Hypericum), should also be used with caution. Aurorix may also cause an additional drop in blood pressure when combined with certain antihypertensives, such as metoprolol. Patients with pre-existing severe hepatic impairment require similar dose adjustments as with cimetidine.

Mechanism of Action

Aurorix is a reversible and selective inhibitor of the enzyme monoamine oxidase-A ( MAO-A). MAO-A is an integral enzyme located on the outer mitochondrial membrane of neurons and glial cells, where it functions to metabolize monoamines.

Inhibition occurs when Aurorix binds non-covalently to the active site of MAO-A, preventing the enzymatic degradation of the monoamine neurotransmitters norepinephrine ( NE) and serotonin ( 5-HT). The rapid and reversible nature of this binding allows the drug to quickly dissociate from the enzyme, restoring MAO-A function shortly after plasma concentrations decline.

This inhibitory action leads to a net increase in the synaptic concentration of NE and 5-HT within the central nervous system. The cumulative effect of MAO-A inhibition is the maintenance of higher concentrations of monoamines within the synapse, representing the system-level physiological consequence of this targeted enzyme interaction.

Dosage and Administration Information

How to Use Aurorix: Administration Guidelines

Aurorix (Moclobemide) is administered via the oral route as a film-coated tablet, which is designed to be easily divisible for dose flexibility. The standard usage protocol is structured around specific timing, dosing ranges, and population adjustments.

Standard Dosing and Administration

The medicine is typically taken in divided doses, two or three times daily, and should be ingested with or immediately following meals. This meal-time requirement is a key instruction for proper administration.

Usage Parameter Instruction
Initial Daily Dose Generally 300 mg per day for Major Depressive Disorder (MDD).
Effective Dose Range Typically 300 mg to 600 mg per day, adjusted according to individual response.
Maximum Daily Dose 600 mg; higher doses are often used for Social Anxiety Disorder.
Missed Dose Rule If a dose is missed, take it as soon as possible, but do not double the dose to make up for the omission.

Duration and Special Conditions

Treatment begins with the standard initial dose, and this dose should not be increased during the first seven days of therapy. Assessment of efficacy requires a duration of at least four to six weeks at the therapeutic dose before conclusions can be drawn. Following symptom remission, treatment is generally continued for four to six months to help prevent recurrence, and discontinuation should be gradual.

Population Adjustments: While no special adjustment is required for older adults or patients with renal impairment, the daily dose must be reduced to one half or one third for those with severe hepatic impairment. Use in individuals under 18 years is not recommended due to limited data.

Recent Clinical Evidence

Aurorix: Recent Clinical Evidence

Clinical research on Aurorix (moclobemide), a reversible inhibitor of monoamine oxidase-A (RIMA), has focused primarily on its effectiveness in the management of major depressive disorder and its safety profile compared to older antidepressants.


Efficacy Findings

  • Acute Treatment: Multiple meta-analyses and randomized controlled trials (RCTs) examining the short-term (4 to 6 weeks) treatment of depression reported that moclobemide resulted in significantly greater improvements in depression rating scale scores compared to placebo.
  • Comparative Studies: Several trials have compared moclobemide to other antidepressant classes, including tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs). These studies generally indicated that moclobemide demonstrated similar efficacy to these comparator drugs in the acute management of depression.
  • Long-Term Effect: Follow-up studies of 6 to 12 months' duration suggest that the difference in therapeutic effect seen in the short term is maintained during continuation treatment.

Tolerability and Safety Profile

Moclobemide's safety profile is a key focus of the research, particularly in comparison to older MAO inhibitors and TCAs.

Comparison Group Primary Finding Clinical Relevance Focus
Tricyclic Antidepressants (TCAs) Demonstrated a better overall tolerability Relative absence of anticholinergic and cardiovascular effects.
Irreversible MAO Inhibitors Showed significantly reduced risk of severe hypertensive reaction Reversibility of MAO-A inhibition minimizes the risk of the 'cheese reaction' associated with tyramine-rich foods.
SSRIs Overall tolerability was similar Tended to cause fewer reports of gastrointestinal side effects and sexual dysfunction compared to SSRIs.

Commonly reported adverse events in clinical trials include insomnia, nausea, and dizziness. Studies also suggest that renal function does not significantly alter moclobemide elimination, which is relevant for patient subpopulations with kidney impairment.

Frequently Asked Questions (FAQ)

Common questions about Aurorix (FAQ)

Q: How quickly does Aurorix typically start to work?

Official information indicates that initial improvements in symptoms such as sleep, appetite, and energy may be observed within one to two weeks after treatment begins. Full clinical assessment of the medicine's effect is generally conducted after four to six weeks of treatment.

Q: Is it common to feel sleepy when starting Aurorix?

Regulatory documents note that the medicine may cause sleep disturbances or insomnia. Official product information suggests that caution is used when driving or operating heavy machinery if drowsiness or feeling slowed down occurs.

Q: Does Aurorix have sexual side effects?

The official product labeling does not list sexual dysfunction in the most common side effect categories. Studies comparing Aurorix to other antidepressant types suggest that the medicine tends to be associated with fewer reports of sexual dysfunction.

Q: How is Aurorix different from SSRIs?

Aurorix (Moclobemide) is formally categorized as a Reversible Inhibitor of Monoamine Oxidase A (RIMA). This is a targeted mechanism of action that works by temporarily blocking an enzyme called MAO-A, which is distinct from the mechanism of Selective Serotonin Reuptake Inhibitors (SSRIs).

Q: Are there any common foods to avoid when using Aurorix?

Official documentation advises caution and the avoidance of certain tyramine-containing foods, such as fermented cheese, cold cuts, beer, shrimp, organ meats, and red wine. These dietary cautions are noted in regulatory information to minimize the potential for an adverse reaction.

Q: Are there any research studies focusing on Aurorix for non-depression uses?

Official regulatory documents support the use of Aurorix for Social Anxiety Disorder (also called Social Phobia), in addition to its use in major depressive disorder. Studies have also examined its potential for other applications, such as smoking cessation.

Q: Can Aurorix affect blood pressure?

Regulatory warnings indicate a potential for a severe reaction known as a hypertensive crisis (rapid increase in blood pressure) if the medicine is combined with high-tyramine foods. The medicine is associated with this risk related to the context of food and other interactions.

Q: What is the official purpose of the black box warning on Aurorix packaging (if applicable)?

As an antidepressant, the most serious warnings associated with this drug class relate to the risk of suicidal thoughts and behaviors, particularly during the initial period of therapy. Some regulatory regions also subject the medicine to additional monitoring to enhance the reporting of potential adverse effects.

Q: What happens if I take Aurorix with cold or flu medicine?

The official product label explicitly prohibits taking Aurorix with the ingredient dextromethorphan. Dextromethorphan is a common component in many cough and cold medicines, and the combination carries an increased risk of Serotonin Syndrome.

Q: Does taking Aurorix require regular blood tests?

Official labeling states that laboratory tests may be done periodically while taking this medication. Periodic laboratory tests are noted in regulatory documents as a requirement for monitoring the patient during treatment.

Q: Can Aurorix be taken with stomach acid reducers?

Official documentation notes a significant interaction with Cimetidine, which is a type of stomach acid reducer. Because Cimetidine can inhibit liver enzymes and increase the level of Aurorix in the blood, regulatory guidance states that the dose of Aurorix must be reduced if the two are taken together.

Q: Are there any known allergic reactions to Aurorix?

Yes, a known hypersensitivity to the drug or its components is listed as an absolute contraindication for use. Allergic reactions may involve symptoms such as cough, shortness of breath, swelling of the face, rash, itching, or hives.

Q: Does Aurorix cause weight gain for most people?

In comparison to many other antidepressants, published data suggests that in short-term treatment, Aurorix has generally shown a tendency toward weight-neutrality or slight weight reduction. Long-term data regarding the incidence of weight changes has produced mixed results.

Q: Is Aurorix known to interact with caffeine or alcohol?

Official documents state that this drug may increase the effects of alcohol, which could result in increased sleepiness, dizziness, or lightheadedness. Core regulatory labels do not explicitly address an interaction with caffeine.

Q: Do I need to follow a special diet while taking Aurorix?

Dietary caution is advised in official product information regarding the avoidance of certain foods high in tyramine to prevent a severe reaction. Additionally, some regulatory documents state that if a dose is higher than 600 mg per day, special diet restrictions may be needed.

Q: What is the experience like when discontinuing Aurorix?

Withdrawal effects may occur within five days of stopping treatment, especially if discontinued suddenly. Reported symptoms may include effects such as muscle cramps, shivering, headache, nausea, and hot flushes. Regulatory instructions state that discontinuation should be gradual to minimize these effects.

Q: Does Aurorix require special monitoring by a doctor?

Yes, treatment with this medicine requires regular monitoring by a doctor and includes periodic laboratory tests to monitor effects.

Q: How does the half-life of Aurorix influence its use?

Aurorix has a short elimination half-life, typically around 2 to 4 hours. This characteristic is important because the enzyme inhibition it causes is rapidly reversible, meaning drug-drug interactions are considered unlikely to occur 24 hours after the medicine has been stopped.

Q: What should I know about driving while taking Aurorix?

Official information advises users to be careful when driving or operating machinery until they are certain of how the medicine affects them. This caution is advised because the medicine can potentially cause side effects such as dizziness or tiredness in some people.

How should Aurorix be stored and disposed of?

How to Store and Dispose of Aurorix (Moclobemide)

Aurorix tablets must be stored in a cool, dry place at room temperature, ensuring the storage area remains below 30 C (86 F). The medicine must be protected from heat, moisture, and direct light, and should not be frozen as per official regulatory instructions. To maintain product stability, the tablets must be kept in their original container or blister pack and should not be used past the labeled expiry date (EXP).

Disposal and Child Safety

All Aurorix tablets must be kept out of the sight and reach of children, often requiring storage in a locked cupboard. For unused, expired, or damaged medication, official disposal instructions require the product to be returned to a pharmacist for safe disposal. It must not be discarded by flushing down the toilet or placing in household waste bins.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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