Зопиклон

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Зопиклон

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Treatment option: Insomnia

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Overview of Зопиклон

Quick Facts

Property Description
Active ingredient Zopiclone (racemic compound)
Form Oral film-coated tablet
Pharmacological class Sedative-Hypnotic, Cyclopyrrolone Derivative (Z-drug)
Common use Short-term relief of insomnia
Origin Synthetic

What is Zopiclone (Зопиклон) and What Type of Drug is It?

Zopiclone is a synthetic, prescription-only medication clinically recognized for its role as a sedative-hypnotic agent, used for the short-term management of sleep disorders. The drug is chemically classified as a cyclopyrrolone derivative, distinguishing it from older compounds. Its inclusion in the group of Z-drugs highlights its focused action profile geared toward promoting sleep. The drug is synthesized as a racemic compound, meaning it contains two mirror-image forms of the molecule.

Zopiclone's primary purpose is to provide pharmacological support to help adults achieve a restful state, promoting both sleep initiation and maintenance. The medication is positioned as a temporary solution for individuals experiencing difficulty falling or staying asleep. The drug's mechanism involves enhancing the effect of the brain's main calming messenger, GABA (gamma-aminobutyric acid), to slow down neurological activity and promote sleep.

Zopiclone's Composition and General Purpose

Zopiclone is typically provided as an oral, film-coated tablet, which is the standard, measurable format for its systemic delivery following ingestion. As a single-component product, it consists solely of the Zopiclone racemic compound combined with solid tablet excipients. This formulation is distinctive from the purified S-isomer, which is marketed separately as Eszopiclone.

The general therapeutic aim is the effective, temporary relief of insomnia symptoms, such as the frequent nocturnal awakenings that disturb sleep continuity. Zopiclone is indicated for the improvement of sleep parameters in patients with insomnia. The drug is a well-established option for improving sleep quality and duration.

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What side effects are possible with Зопиклон?

Possible Side Effects and Safety Information

The safety profile of Zopiclone ( Зопиклон) is organized in regulatory documents by the frequency of reported adverse reactions and the system-organ class (SOC) affected, based on clinical data and post-marketing surveillance. This framework moves from very common, expected experiences to rare, serious safety events.

Frequency-Classified Adverse Reactions

The most frequently reported effects, officially classified as Common, include dysgeusia (a bitter or metallic taste), residual somnolence (daytime sleepiness), and dry mouth. Uncommon effects listed include headache, dizziness, nausea, vomiting, agitation, nightmare, and fatigue. Rare documented reactions span multiple systems, such as anterograde amnesia, dyspnoea (difficulty breathing), rash, and falls, particularly in older adults.

Serious Adverse Reactions

Official labeling highlights several serious safety concerns. These include Anaphylactic reaction and Angioedema (swelling of the face, tongue, or throat, which can cause airway obstruction). Other serious events reported are Complex Sleep Behaviours, such as sleepwalking or “sleep-driving” with subsequent amnesia for the event, and Respiratory Depression (slowed or shallow breathing), which is a key risk when Zopiclone is used with opioids.

Safety Patterns and Restrictions

Regulatory sources specify safety patterns tied to exposure. The risk of developing dependence and withdrawal syndrome is officially documented to increase with higher doses and treatment duration, particularly beyond four weeks, and may result in rebound insomnia upon discontinuation. Safety information also advises that psychomotor skills and alertness may be impaired into the day following evening use. Population-specific considerations are noted for older adults and individuals with severe hepatic impairment, for whom a lower starting dosage is recommended due to altered metabolism and increased risk of CNS-related effects like falls.

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Overdose and Emergency Response

Overdose and When to Seek Help

If an overdose of Zopiclone is suspected, immediate emergency medical attention is required, even if the person does not feel unwell.

Overdose with Zopiclone, whether alone or in combination with other substances, can present as a spectrum of severity, ranging from profound drowsiness to life-threatening conditions. In healthy individuals, overdose is generally not fatal but may lead to serious central nervous system (CNS) depression.

Documented Overdose Manifestations

Official regulatory information describes the clinical signs of Zopiclone overdose as including exaggerations of its primary effects:

  • Mild to Moderate: Prolonged sleep, lethargy, confusion, somnolence, and slurred speech.
  • Severe: Hypotonia (muscle weakness), ataxia (loss of coordination), severe hypotension, respiratory depression (shallow/slow breathing), and coma. Fatal outcomes have been reported, particularly in mixed drug overdoses.

Critical Risk Factors and Management

Risk of severe outcomes is significantly increased by the co-ingestion of Zopiclone with other CNS depressants, notably alcohol. This combination elevates the likelihood of severe respiratory compromise and coma.

Treatment is primarily supportive and symptomatic, with close monitoring of vital signs (cardiac and respiratory function) until the patient is stable. Gastric lavage may be performed shortly after ingestion. The use of the specific GABA receptor antagonist, Flumazenil, may be considered by medical professionals, though its use requires caution due to the risk of inducing seizures.

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Therapeutic Uses of Зопиклон

What Зопиклон treats: Main Uses and Benefits

Zopiclone (Зопиклон) is generally used for the short-term treatment and symptomatic relief of insomnia in adults. The medication is applied across domains where additional symptomatic support is needed, primarily when symptoms that interfere with daily functioning become noticeable.

It is commonly used across conditions characterized by periods of heightened symptoms, helping to manage symptom clusters that may become intense or disruptive, such as difficulty initiating sleep, frequent nocturnal awakenings, and early morning waking. This provides support that contributes to easing the overall symptom load during episodes of sudden symptom escalation.

This supportive benefit assists with supporting general well-being when symptoms interfere with routine activities.

Quick Fact: Relief for Sleep Initiation and Maintenance

Zopiclone is applied in clinical settings that involve acute or unstable symptom patterns, supporting patients during difficult episodes by easing distress and assisting with symptom management.

Regulatory References

  1. Health Canada Drug Product Details
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Eligibility and Restrictions for Use

Zopiclone is officially approved for the short-term treatment of insomnia in adults (aged 18 years and over). Regulatory bodies define specific populations who are restricted or absolutely prohibited from using the medicine.

Contraindicated Populations

The medicine is formally contraindicated and must not be used in patients with the following severe conditions or histories, as stated in regulatory prescribing information:

  • Myasthenia Gravis
  • Severe Respiratory Insufficiency or Respiratory Failure
  • Severe Sleep Apnoea Syndrome
  • Severe Hepatic Insufficiency
  • Hypersensitivity to the drug
  • History of Complex Sleep Behaviours (e.g., sleep-driving) after previous Zopiclone intake
  • Children and adolescents under 18 years of age (safety and efficacy not established).

Restricted or Conditional Use

Use is subject to conditional consideration by regulatory authorities in patient groups where elimination may be reduced or sensitivity is increased:

  • Elderly Patients: Explicitly designated as a population for whom a reduced initial dose is recommended.
  • Hepatic or Renal Impairment: Patients with non-severe liver or kidney dysfunction are designated as populations where a reduced starting dose is advised.
  • History of Alcohol or Drug Abuse: Use requires extreme caution due to the greater risk of developing physical and psychological dependence.

Reproductive Status

Zopiclone use is generally not recommended during pregnancy (especially the third trimester) and while lactating, as the drug is known to be excreted in breast milk.

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What should I know about interactions with other medicines?

The official regulatory profile for Zopiclone interactions is governed by two main patterns: metabolic clearance modification and central nervous system (CNS) depressant additivity.

Pharmacokinetic Interactions (Metabolic Clearance)

Classification Interacting Agents Official Interaction Outcome
Reduced Clearance Potent CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin, Ritonavir, Itraconazole) Increases Zopiclone plasma concentration and systemic exposure.
Increased Clearance CYP450 Inducers (e.g., Rifampicin, Carbamazepine, Phenytoin) Decreases Zopiclone plasma concentration, potentially reducing effectiveness.

Zopiclone metabolism involves Cytochrome P450 enzymes, primarily CYP3A4 and CYP2C8. Co-administration with potent enzyme inhibitors reduces clearance, leading to an increase in Zopiclone exposure. Conversely, enzyme inducers accelerate clearance, resulting in decreased exposure. The herbal product St. John's Wort is also documented as an inducer that can reduce effectiveness.

Pharmacodynamic and Substance Restrictions

Co-administration with alcohol (ethanol) is officially not recommended due to the severe enhancement of sedative effects, which increases the risk of respiratory depression and severe outcomes. The use of Zopiclone with other CNS depressants (including antipsychotics, antidepressants, and narcotic analgesics like opioids) leads to an additive CNS-depressant effect. The label imposes a timing-based restriction, requiring a mandatory minimum of 12 hours to pass between Zopiclone administration and performing activities that require full mental alertness. In patients with severe hepatic impairment, reduced clearance exaggerates drug effects and increases the clinical significance of interactions that boost Zopiclone exposure.

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Mechanism of Action

How Зопиклон Works: Mechanism of Action

The mechanism of action of Zopiclone is rooted in its selective modulation of the brain's main inhibitory signaling pathway.


Molecular Interaction with the GABA A Receptor

Zopiclone acts as a Positive Allosteric Modulator (PAM), binding to a specific recognition site (omega site) on the Gamma-aminobutyric acid type A ( GABA A) receptor complex. This interaction does not activate the receptor directly but enhances the effectiveness of the endogenous neurotransmitter, GABA, thereby amplifying its natural inhibitory signal.


Mechanistic Cascade of Inhibitory Signaling

The modulation of the GABA A receptor leads to an increased frequency of opening of the receptor's central chloride ( Cl^-) ion channel. The rapid influx of negative Cl^- ions into the nerve cell causes it to become hyperpolarized, which establishes an inhibitory potential and makes the neuron significantly less likely to fire or transmit an excitatory signal.


Resulting Systemic Central Nervous System (CNS) Dampening

The widespread reduction in neuronal excitability throughout key arousal and vigilance centers of the brain constitutes a generalized CNS depression. This physiological state of dampening and suppression of active neurological transmission is the underlying mechanism that results in a physiological state of reduced arousal.

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Dosage and Administration Information

Administration Map: How to Use Zopiclone

Zopiclone is administered strictly via the oral route as a film-coated tablet, following a precise, time-bound protocol for its short-term use.

Administration Scope

Instruction Entity Standard Parameters
Route of administration Oral route only, via film-coated tablets.
Dosing schedule The standard adult dose is a single intake of 7.5 mg. The lowest effective dose should always be used, and the dosage regimen must not be re-administered during the same night.
Timing in relation to meals (if applicable) Must be taken immediately before bedtime or just before retiring, independent of meal intake.
Preparation requirements (if applicable) The tablet must be swallowed whole with a drink of water and must not be crushed or chewed.
Age-group administration rules A reduced starting dose of 3.75 mg is generally recommended for older adults (geriatric patients) and is also advised for those with hepatic, renal, or chronic respiratory insufficiency. Use is not authorized for individuals under 18 years of age.

Instruction Classifications (High-Level)

Classification Parameter
Administration method type Oral (tablet form).
Frequency pattern Once daily, as a single dose.
Use-context constraints Treatment is intended for short-term use only. The total duration, including any tapering period, should not exceed four weeks.

Resulting Procedural Structure

Step sequence:

  • Take the Zopiclone tablet once daily immediately prior to retiring.
  • Swallow the tablet whole with water.
  • Ensure a full 7 to 8 hours of sleep is possible before awakening.

Connection to the overall use protocol: The instructions establish a structured, time-specific protocol by mandating the single, nightly oral intake of a defined dose immediately before retiring, while simultaneously imposing a strict limit on the total course duration. This procedural structure defines the standardized manner of administration.

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Recent Clinical Evidence

Research evidence / Overview of studies for Zopiclone (Зопиклон)

Evidence for Use in Short-Term Symptomatic Relief of Insomnia

Zopiclone was studied for the short-term symptomatic management of insomnia in adults. These studies usually take the form of randomized controlled trials (RCTs), where zopiclone is compared directly against an inactive substance (a placebo) or sometimes against other older sedative-hypnotic medications. This research design is relevant in trials assessing short-term or episodic symptom patterns and helps explore how symptoms change over time.

Studies monitored various outcomes related to sleep quality, including patient-reported outcomes describing perceived discomfort from lack of sleep. Studies reported measurements of changes in sleep onset latency and total sleep time in the zopiclone group when compared to the placebo group within the context of the trials. Research describes the changes measured during the study period for these specific sleep metrics.

The evidence primarily contributes to understanding symptom patterns observed during acute or short-term use. The core RCT data research examined is typically limited to periods of four weeks or less. The follow-up durations were limited, meaning there is limited information for long-term outcomes or how the reported patterns might be maintained over many months. Research provides insight into short-term changes, but does not determine whether an individual will respond similarly over longer periods.

Evidence in Special Populations and Uncertainties

Zopiclone was studied for research involving a specific, specialized group: adult patients with advanced cancer who are also experiencing insomnia. These studies monitored outcomes related to physical discomfort over ultra-short-term periods, such as six consecutive nights. Research reports patterns observed during this limited duration, but long-term effects are not fully established.

Research has explored zopiclone use across different age groups, including older adults (typically aged 55 to 65 years and up). Research examined zopiclone in patients whose insomnia was associated with comorbid conditions, such as anxiety or depression. Findings indicate some observed patterns related to sleep parameters, but research also describes potential differences observed between older and younger adults.

One of the main research limitations is the limited information for long-term outcomes, particularly the consequences of use extending beyond the recommended short duration. Furthermore, comparative evidence is lacking against every other established sleep medication. Research provides context on group patterns, not personal outcomes, and evidence highlights what is known—and what is still uncertain—regarding its profile.

Key Studies & References

  1. Health Canada Drug and Health Product Register: ZOPICLONE (Regulatory document on approved use/duration)
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Frequently Asked Questions (FAQ)

Common questions about Зопиклон (FAQ)

Q: Для чего вообще назначают Зопиклон? (What is Zopiclone prescribed for?)

Official documents state that Zopiclone is indicated for the short-term treatment of insomnia in adults. This includes difficulties with falling asleep, frequent nighttime awakenings, and waking up too early in the morning.


Q: Какая продолжительность действия Зопиклон? (What is the duration of Zopiclone's effect?)

The drug's profile indicates a relatively short duration of effect. The half-life of Zopiclone is approximately 5 hours, meaning it takes about this much time for half of the dose to be eliminated from the body. Peak levels in the bloodstream are typically reached about 1.5 to 2 hours after the dose is taken.


Q: Сколько по времени можно принимать Зопиклон без перерыва? (How long can Zopiclone be taken without a break?)

Official instructions specify that treatment should be as brief as possible and generally must not exceed four weeks, including any period required for gradual dose reduction. The duration is kept short because the risk of dependence and tolerance increases with prolonged use.


Q: Какие побочные эффекты Зопиклона самые распространенные? (What are the most common side effects of Zopiclone?)

The most frequently reported side effects in official product information are residual drowsiness, which may persist the next day, and dysgeusia, which is a bitter or metallic taste in the mouth.


Q: Почему после Зопиклона остается горький привкус во рту? (Why does Zopiclone leave a bitter taste in the mouth?)

A bitter or metallic taste (dysgeusia) is a common side effect of Zopiclone that is documented in official drug information. It is considered a characteristic, though non-serious, adverse reaction.


Q: Может ли Зопиклон вызывать проблемы с памятью? (Can Zopiclone cause memory problems?)

Official sources describe cases of anterograde amnesia, which is difficulty recalling new events that occurred after taking the medication. The official recommendation is to take the dose immediately before going to bed and ensure the possibility of 7 to 8 hours of uninterrupted sleep.


Q: Правда ли, что Зопиклон может вызвать зависимость? (Is it true that Zopiclone can cause dependence?)

Yes, regulatory warnings indicate that Zopiclone has the potential to cause physical and psychological dependence. The risk of developing dependence increases with higher doses, longer duration of use (over four weeks), and in individuals with a history of substance abuse or alcoholism.


Q: Что происходит, если резко прекратить прием Зопиклона? (What happens if Zopiclone is stopped suddenly?)

Upon sudden cessation of use, particularly after prolonged treatment, a withdrawal syndrome may develop, which includes symptoms like muscle aches, agitation, and nervousness. There is also the potential for rebound insomnia, where the original sleep problem may temporarily return or worsen.


Q: Можно ли принимать Зопиклон, если я принимаю антидепрессанты? (Can Zopiclone be taken if I am taking antidepressants?)

Official documents caution that Zopiclone can enhance the depressant effects on the central nervous system when combined with other sedating medications, including certain antidepressants. Regulatory documents state that using these medications together requires caution due to the potential for enhanced sedative effects.


Q: Влияет ли Зопиклон на способность управлять автомобилем? (Does Zopiclone affect the ability to drive?)

Yes, official safety warnings state that Zopiclone has a significant negative impact on the ability to drive and operate machinery. The risk is elevated if the medication is taken less than 12 hours before performing such activities.


Q: Можно ли принимать Зопиклон пожилым людям? (Can elderly people take Zopiclone?)

Yes, Zopiclone can be prescribed to elderly patients. However, regulatory guidelines indicate that a reduced starting dose is generally recommended for older patients, as this population may be more sensitive to the effects of the medication.


Q: Безопасно ли использовать Зопиклон при беременности? (Is it safe to use Zopiclone during pregnancy?)

Official sources generally advise against the use of Zopiclone during pregnancy, especially during the third trimester. Official prescribing information states that the use of this medication during pregnancy is generally not recommended.


Q: Можно ли принимать Зопиклон во время кормления грудью? (Can Zopiclone be taken while breastfeeding?)

In alignment with official documents, Zopiclone should not be used during breastfeeding. The active substance has been shown to pass into breast milk.


Q: Какие существуют исследования о долгосрочном использовании Зопиклона? (What research exists on the long-term use of Zopiclone?)

Official documents emphasize that the drug is approved and recommended only for short-term use, generally not exceeding four weeks. Long-term use is not advised because it is associated with an increased risk of tolerance and dependence.


Q: Почему врачи назначают Зопиклон только на короткий срок? (Why do doctors prescribe Zopiclone only for a short period?)

The treatment course is restricted to a short duration (a maximum of four weeks) in official documents. This limitation exists because increasing the length of treatment increases the likelihood of developing tolerance (decreased effectiveness) and physical dependence.


Q: Вызывает ли Зопиклон дневную сонливость? (Does Zopiclone cause daytime sleepiness?)

Yes, residual drowsiness is explicitly listed in regulatory documents as a common side effect of Zopiclone. Regulatory information notes that ensuring adequate sleep time (7–8 hours) is recommended to help minimize this residual effect.


Q: Какие ощущения могут возникнуть при пробуждении после приема Зопиклона? (What feelings might occur upon waking up after taking Zopiclone?)

Commonly reported residual effects include daytime drowsiness, dizziness, and the characteristic bitter taste in the mouth. Where insufficient sleep time occurs (less than 7–8 hours), there is a possibility of disturbances in memory or coordination.


Q: Правда ли, что на Зопиклон нужен специальный рецепт? (Is it true that a special prescription is required for Zopiclone?)

In many countries, Zopiclone is included in lists of controlled or closely monitored substances due to its potential for dependence. This classification means that it is generally only dispensed with a special prescription that is subject to regulatory accountability.


Q: Может ли Зопиклон влиять на настроение или вызывать тревожность? (Can Zopiclone affect mood or cause anxiety?)

Official documentation describes changes in mood, increased anxiety, irritability, and agitation as possible, though less common, side effects, sometimes referred to as paradoxical reactions. The official warning also includes the potential for the worsening of depression.


Q: Какие меры предосторожности нужно соблюдать при приеме Зопиклона? (What precautions should be observed when taking Zopiclone?)

Official sources indicate that caution is necessary for individuals with severe respiratory, liver, or kidney impairment. It is also important to ensure that the patient can commit to 7 to 8 hours of uninterrupted sleep after taking the dose.


Q: Какие необычные сны могут быть связаны с приемом Зопиклона? (What unusual dreams might be associated with taking Zopiclone?)

Nightmares and hallucinations are included in the official drug documentation as rare or paradoxical reactions that have been reported with the use of Zopiclone.


Q: Как Зопиклон влияет на качество сна? (How does Zopiclone affect the quality of sleep?)

Pharmacological properties described in official documents indicate that Zopiclone is intended to rapidly induce sleep, decrease the number of awakenings throughout the night, and help sustain the stages of deep, slow-wave sleep.


Q: Влияет ли прием пищи на действие Зопиклона? (Does food intake affect the action of Zopiclone?)

According to pharmacokinetic data, the absorption of Zopiclone is generally not affected by food intake. However, official regulatory instructions require the tablet to be taken immediately before going to sleep.


Q: Что такое 'парадоксальные реакции' на Зопиклон? (What are 'paradoxical reactions' to Zopiclone?)

Paradoxical reactions are unusual responses to the drug that have been documented in official safety information. These effects are opposite to the intended sedative effect and can include increased insomnia, agitation, nervousness, aggression, and hallucinations.


Q: Может ли Зопиклон изменить результаты анализов крови? (Can Zopiclone change blood test results?)

Official documentation mentions rare occurrences of changes in certain laboratory values, such as an increase in liver enzyme activity. These changes may be detectable in blood test results.


Q: Какие симптомы могут указывать на передозировку Зопиклоном? (What symptoms might indicate an overdose of Zopiclone?)

Symptoms of overdose are directly related to the dose and result in central nervous system depression. Manifestations can range from severe drowsiness and confusion to coma. In serious cases, respiratory depression (slow, shallow breathing) may occur.


Q: Можно ли принимать Зопиклон, если у меня проблемы с печенью? (Can Zopiclone be taken if I have liver problems?)

In cases of severe liver insufficiency, Zopiclone is contraindicated and must not be used. For other less severe liver function issues, official guidelines advise a lower dose is used.


Q: Можно ли принимать Зопиклон, если у меня проблемы с почками? (Can Zopiclone be taken if I have kidney problems?)

For patients with impaired kidney function, regulatory recommendations suggest starting treatment at a reduced dose. Official data indicate that accumulation of the active substance has not generally been observed during short-term treatment in this patient group.


Q: Можно ли принимать Зопиклон, если у меня астма или ХОБЛ? (Can Zopiclone be taken if I have asthma or COPD?)

Zopiclone is contraindicated in patients experiencing severe respiratory failure. Patients with chronic respiratory insufficiency (such as severe asthma or COPD) are advised in official guidelines to start with a reduced dose due to the known risk of respiratory depression.


Q: Есть ли известные случаи взаимодействия Зопиклона с травами или БАДами? (Are there known interactions between Zopiclone and herbs or supplements?)

Official documentation does not typically list every specific herb or supplement, but it advises caution with products that inhibit the CYP3A4 enzyme. Official documentation advises caution with products that may enhance CNS depression, such as St. John's Wort.


Q: Зопиклон: можно ли принимать его 'по необходимости'? (Zopiclone: Can it be taken 'as needed'?)

Official prescribing information directs that Zopiclone should be taken as a single dose once per night, immediately before bed. The treatment course is strictly intended to be short-term and is not designed for prolonged or unsupervised 'as-needed' use.


Q: Какое максимальное время между приемом и сном должно быть? (What is the maximum time between taking the dose and going to sleep?)

Official regulatory instructions emphasize that the tablet should be taken 'immediately before retiring' or 'just before sleep.' This timing is critical to ensure enough time for a full 7 to 8 hours of sleep and minimize the risk of developing memory problems.


Q: Как долго нужно ждать улучшения сна при приеме Зопиклона? (How long does it take to see an improvement in sleep when taking Zopiclone?)

Zopiclone is classified in official documents as a rapid-acting medication. Its pharmacological properties indicate that the sedative effect usually begins quickly, often within 30 minutes of taking the dose.


Q: Почему в разных странах разные правила отпуска Зопиклона? (Why are the rules for dispensing Zopiclone different in various countries?)

Differences in dispensing regulations (such as the requirement for a special prescription and strict accountability) are due to variations in national legislation and international scheduling of psychoactive substances. Each country assesses the risk of abuse and classifies the drug accordingly.


Q: Может ли Зопиклон влиять на аппетит или вес? (Can Zopiclone affect appetite or weight?)

Gastrointestinal disturbances, such as nausea and dry mouth, are infrequently mentioned in official documents. Direct or frequent effects on appetite or body weight are not commonly described as a widespread side effect of this medication.

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How should Зопиклон be stored and disposed of?

How to Store and Dispose of Zopiclone

Zopiclone requires specific handling to maintain stability and prevent misuse. Store the tablets securely in a dry place, at room temperature (generally below 25 C or 30 C), and protect from light. The medication must be kept out of the sight and reach of children due to the risk of accidental ingestion.

Always keep the medicine in its original container until the expiry date. Do not use expired medication.

For disposal of unused or expired Zopiclone, patients are generally advised to return it to a pharmacist or a drug take-back program. The medicine should not be disposed of by flushing down a toilet or pouring down a sink. If a take-back program is unavailable, follow specific government guidelines for home disposal, such as mixing the tablets with an undesirable substance before sealing and placing them in the household trash.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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