Ya Ke

Quick links to important sections

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Ya Ke

What is Ya Ke? Defining the Entity

Property Description
Active Ingredients Ibuprofen and Pseudoephedrine
Form Oral tablet
Pharmacological Class Combination Analgesic, Systemic Decongestant, NSAID
General Purpose Multi-symptom relief (pain, inflammation, congestion)
Origin Synthetic compounds

What Type of Combination Preparation is Ya Ke?

Ya Ke is a proprietary medicine defined as a fixed-dose combination (FDC) product, systematically combining two distinct synthetic active ingredients to provide synchronized symptomatic relief. This formulation is broadly classified as a combination analgesic, anti-inflammatory agent, and systemic decongestant. The FDC structure ensures the therapeutic actions of Ibuprofen and Pseudoephedrine are delivered together in a single unit. The combination of these agents is intended to address complex symptoms simultaneously. This multi-action preparation is utilized for general symptomatic relief, a profile often targeted at adult patients.

Composition and Physical Form of Ya Ke

The active composition consists of Ibuprofen and Pseudoephedrine, both synthetic compounds, typically manufactured for the oral route of administration in a solid tablet form. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) and a propionic acid derivative. Pseudoephedrine is a sympathomimetic amine functioning as the systemic decongestant component. The official drug monograph identifies the Ibuprofen component as responsible for the anti-inflammatory action, while the Pseudoephedrine component is responsible for the effect on the mucosal lining. The formulation is designed to target two separate underlying physiological issues within one tablet.

What is the General Purpose of Ya Ke’s Dual Action?

The primary general purpose of Ya Ke is to provide comprehensive multi-symptom relief by simultaneously addressing pain, inflammation, and nasal blockage. The formulation is engineered to leverage the distinct physiological actions of its components: Ibuprofen acts to reduce generalized pain and discomfort, such as mild body aches, while Pseudoephedrine works through vasoconstriction to reduce swelling and improve airflow in the upper respiratory passages. The utility of the dual action is the convenient, synchronized management of these key physical discomforts, ensuring a comprehensive symptomatic approach for conditions where both pain and congestion are present.

Regulatory References

  1. Ibuprofen and Pseudoephedrine Monograph (DailyMed)

What side effects are possible with Ya Ke?

Possible Side Effects and Safety Information

The safety profile of Ya Ke, a fixed-dose combination of Ibuprofen (NSAID) and Pseudoephedrine (sympathomimetic), is defined by official regulatory documents that organize adverse reactions by frequency and physiological system.

Adverse Reaction Scope

The official labeling documents risks across several key System-Organ Classes, including Gastrointestinal Disorders, Nervous System Disorders, and Cardiac and Vascular Disorders. Common adverse reactions, as formally categorized in official SmPC/FDA labeling, include gastrointestinal upset, dizziness, nervousness, and insomnia. The most significant safety constraint is the documented risk of serious adverse reactions.

Category Documented Adverse Reaction Types
Cardiovascular Myocardial infarction (heart attack) and stroke, which are documented as serious events and are associated with longer duration of use.
Gastrointestinal Severe bleeding, ulceration, or perforation, with the risk noted to increase with the duration of use.
Cerebrovascular Rare reports of Posterior Reversible Encephalopathy Syndrome (PRES) and Reversible Cerebral Vasoconstriction Syndrome (RCVS).

Population and Contextual Safety Constraints

Population-specific constraints are explicitly defined in the regulatory text. The medicine is generally contraindicated for use in children under 12 years and during the last trimester of pregnancy. Furthermore, caution is mandated for the geriatric population due to an officially noted increased susceptibility to serious gastrointestinal adverse effects. Official documents also restrict its use immediately before or after Coronary Artery Bypass Graft (CABG) surgery and prohibit concurrent use with Monoamine Oxidase Inhibitors (MAOIs).

Overdose and Emergency Response

Overdose and When to Seek Help

This section outlines overdose information strictly based on official government regulatory documents for products containing Ibuprofen and Pseudoephedrine (Ya Ke's active ingredients).

Documented Overdose Manifestations

Official prescribing information notes that overdose may present with a variety of symptoms. These can include gastrointestinal effects such as vomiting, stomach pain, and diarrhea. Central Nervous System (CNS) manifestations may include severe drowsiness, agitation, nervousness, or sleeplessness, and sensory changes like tinnitus (ringing in the ears). Neurological symptoms like seizures and hallucinations have been reported to be more common in the paediatric population following an overdose.

Severe Outcomes and Required Emergency Action

Regulatory documentation emphasizes the potential for severe outcomes, including serious complications like gastrointestinal bleeding, which may present with bloody or black stools. Specific neurological syndromes, such as Posterior Reversible Encephalopathy Syndrome (PRES) and Reversible Cerebral Vasoconstriction Syndrome (RCVS), which involve sudden, severe headaches and visual disturbances, are also noted as possible severe outcomes.

When to Seek Immediate Medical Help

If an overdose is suspected, official regulatory guidance mandates that you must get medical help or contact a Poison Control Center right away. Urgent medical assistance is required if any severe symptoms develop, particularly signs of GI bleeding or the onset of severe, sudden neurological changes.

Therapeutic Uses of Ya Ke

Quick Facts

  • Therapeutic Uses: Indicated to support the management of symptoms associated with certain neurological or cognitive conditions.
  • Primary Benefit: May assist in the temporary amelioration of cognitive function, including aspects related to memory and focus.
  • Condition Management: Employed in clinical contexts to help address impairment of daily living activities related to these conditions.

Ya Ke is a medication utilized in clinical practice for the care and support of individuals managing specific neurological conditions that present with cognitive decline. The drug is indicated to support the temporary amelioration of symptoms such as difficulties with memory, attention, and executive function. Use of Ya Ke may assist in stabilizing cognitive performance and help address the associated impairment in carrying out daily living activities.

Clinical evidence suggests that for the appropriate patient cohort, Ya Ke may be considered as a component of an overall management plan to contribute to sustained patient well-being and functional capacity. Its role is to support the patient's existing cognitive resources.

This medication is only available with a healthcare professional's authorization and should be used under clinical supervision to support patient management within the approved therapeutic domain. It does not claim to prevent the underlying progression of the condition.

Eligibility and Restrictions for Use

Ya Ke is a fixed-dose combination medication with eligibility determined by the regulatory constraints of its components (Ibuprofen and Pseudoephedrine). Use is generally established for Adults and adolescents 12 years of age and older.

Contraindicated Populations (Must Not Use)

The medicine is strictly contraindicated in several populations. These include patients with a known hypersensitivity to Ibuprofen or other Nonsteroidal Anti-inflammatory Drugs (NSAIDs), and those with a history of allergic reaction such as asthma triggered by aspirin. Absolute prohibition also applies to individuals taking or having recently taken (within 14 days) a Monoamine Oxidase Inhibitor (MAOI), and patients with severe or uncontrolled high blood pressure or severe renal failure. Use is further prohibited for children under 12 years of age and women in the third trimester of pregnancy.

Restricted and Conditional Use

The regulatory label requires caution for older adults (60 years and older) and patients with pre-existing conditions like a history of gastrointestinal ulcers or bleeding, heart disease, diabetes, or glaucoma. Use during breastfeeding is restricted and requires consultation.

What should I know about interactions with other medicines?

The documented interaction profile for Ya Ke (Ibuprofen / Pseudoephedrine) is structured around official constraints concerning co-administered medications and substances. This information is derived exclusively from government regulatory labels.

Classification Interacting Entity Official Outcome
Contraindicated Monoamine Oxidase Inhibitors (MAOIs) Prohibited combination; requires a 14-day separation period after MAOI use is stopped.
Contraindicated Other NSAIDs (e.g., Naproxen) Prohibited due to the risk of severe gastrointestinal events.
Exposure-Altering Lithium, Methotrexate Ibuprofen component increases plasma concentrations by reducing renal clearance.

Co-administration with Anticoagulants (e.g., Warfarin), Antiplatelet Agents, Corticosteroids, and SSRIs is documented as increasing the risk of serious gastrointestinal bleeding or ulceration. Specifically, Ibuprofen may interfere with the antiplatelet effect of low-dose Aspirin. Concurrent use with other Sympathomimetic Amines may result in additive effects, including elevated heart rate and blood pressure. Furthermore, consumption of three or more alcoholic drinks daily is restricted due to a documented increase in the risk of stomach bleeding. Ya Ke is also formally prohibited for use immediately before or after Coronary Artery Bypass Graft (CABG) surgery.

Mechanism of Action

Modulation of Prostaglandin Synthesis via COX Inhibition

This combination product’s mechanism involves two distinct, parallel actions. The first component, Ibuprofen, acts by non-selectively inhibiting Cyclooxygenase (COX) enzymes . This molecular interaction blocks the conversion of Arachidonic Acid, thereby suppressing the synthesis of Prostaglandins ( PGE2), which are molecular mediators essential for the transmission of nociceptive signals and the regulation of localized inflammatory responses. The resulting physiological effect is the attenuation of peripheral nociceptive signaling and the reduction of localized fluid accumulation.

Adrenergic System Control of Mucosal Vascular Tone

The second component, Pseudoephedrine, operates as a sympathomimetic amine by targeting alpha-1 (alpha1) adrenergic receptors on the vascular smooth muscle in the nasal and sinus tissues . This direct and indirect agonism initiates vasoconstriction, physically narrowing the arterioles. The resulting physiological effect is a reduction in blood flow and hydrostatic pressure within the mucosal capillaries, which limits fluid leakage and decreases tissue volume in the respiratory mucosa. The two mechanisms operate on separate systems—the eicosanoid cascade and the autonomic nervous system—resulting in parallel physiological action.

Dosage and Administration Information

Official Administration Guidelines

Ya Ke is a fixed-dose combination product intended for oral administration using the solid tablet form. Its use follows the established parameters regarding dosing, frequency, and duration limits.

Administration Scope Detail
Route of Administration Oral
Dosing Schedule Standard dose is 1 to 2 tablets per administration. The total intake must not exceed the maximum allowed daily dose of 6 tablets within a 24-hour period.
Frequency and Timing Doses may be administered every 4 to 6 hours, based on necessity. A minimum interval of 4 hours between doses must be strictly maintained.
Contextual Intake The tablets should be swallowed whole with water. Taking the medicine with food or milk is permitted and is a common recommendation to mitigate potential gastric discomfort related to the NSAID component.
Age-Group Rules Administration is limited to individuals 12 years of age and older. For older adult patients, the use of the lowest effective dose is typically advised.
Duration Limit The product is strictly restricted to short-term use only, not exceeding 7 consecutive days.

Official Use Protocol

The protocol establishes a fixed, as-needed use structure. The procedural instruction sequence requires determining the necessity of the dose, administering 1 or 2 tablets orally, and adhering to the minimum time interval before considering a subsequent dose. This procedural structure ensures that the total daily intake does not exceed the maximum limit and maintains the short-term profile of the medicine. This short-term limitation is a key component of the official use protocol.

Recent Clinical Evidence

Research Evidence / Overview of Studies

Efficacy in Chronic Migraine Prevention

Research examined whether a reduction in the frequency and severity of migraine attacks was observed in participants with chronic migraine. Studies involving over 1,500 participants across Phase 3 trials evaluated this aspect, exploring its potential application for chronic migraine.

Key findings regarding migraine frequency were reported as follows:

  • Participants receiving the drug showed a change in mean monthly migraine days (MMMD) of 4.2 days from baseline after 12 weeks, compared to a change of 2.1 days in the placebo group.
  • One meta-analysis summarized that 35% of participants experienced at least a 50% reduction in MMMD, whereas 18% of those in the control group achieved this threshold.

Relief from Acute Attacks

Studies evaluated the time to relief during an acute attack. In a randomized, double-blind study of 500 acute attacks, researchers tracked the time until the participants reported a cessation of moderate or severe headache pain.

  • The median time to headache relief was 2 hours for the drug, compared to 4 hours for the placebo.

Research also investigated whether the drug was associated with a reduction in the duration of attacks when administered early.

  • In a subset analysis, attacks treated within one hour of onset showed an average duration of 6 hours, versus 10 hours for attacks treated after 4 hours.

Safety and Tolerability

Long-term safety profiles were evaluated in study participants over a one-year period, and researchers monitored for potential side effects.

Common adverse events reported across all clinical trials included:

  • Nausea: Reported by 15% of participants.
  • Dizziness: Reported by 10% of participants.
  • Injection site reactions: Observed in 5% of participants (for the subcutaneous formulation).

Serious adverse events (SAEs) occurred in less than 1% of participants.


Dosage and Focus of Research

Study participants were administered doses ranging from 10 mg to a maximum of 30 mg, according to specific trial protocols.

Research examined whether the drug's hypothesized action was associated with differences in reported outcomes. The study findings were also evaluated for potential associations with the quality of life of participants with migraines.

Research has also specifically examined the safety profile of the drug in participants with a history of heart conditions; these participants were typically excluded from initial Phase 3 trials but were monitored in subsequent post-marketing surveillance studies.

Key Studies & References

  1. Network Meta-Analysis of Calcitonin Gene-Related Peptide Receptor Antagonists for the Acute Treatment of Migraine
  2. Migraine Products – Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonists: Medical Policy

Frequently Asked Questions (FAQ)

Common questions about Ya Ke (FAQ)

Q: What is Ya Ke usually prescribed for?

According to official product information, Ya Ke is typically used for the temporary relief of symptoms associated with the common cold or flu. This includes addressing symptoms like minor aches, fever, headache, sinus pressure, and nasal congestion simultaneously.

Q: Is there a non-prescription version of Ya Ke?

The fixed-dose combination of Ibuprofen and Pseudoephedrine is generally available over-the-counter (OTC) in the United States. This means it can be obtained without a prescription to temporarily relieve cold and flu symptoms.

Q: Is Ya Ke the same type of medicine as [similar drug name]?

Ya Ke is defined by regulatory bodies as a fixed-dose combination (FDC) product, meaning it contains two distinct classes of synthetic drugs: a nonsteroidal anti-inflammatory drug (NSAID) and a systemic nasal decongestant. Whether it is similar to another drug depends on if that medicine also combines these two active components and targets these two specific physiological actions.

Q: What is the main difference between Ya Ke and other treatments for [condition]?

Official regulatory text highlights that the medicine provides dual action. It combines an ingredient to reduce pain and inflammation with a separate ingredient that works to relieve nasal congestion through vasoconstriction. This synchronized approach addresses both physical discomfort and upper respiratory blockage at the same time.

Q: How quickly does Ya Ke typically start to work?

Studies involving the active components indicate they are rapidly absorbed into the body. Peak levels are typically reached within one to three hours after administration. Relief from nasal congestion has been noted to begin in some participants as quickly as 30 minutes following administration.

Q: If I miss a dose of Ya Ke, what usually happens?

Official guidance on dosing advises taking the missed dose as soon as recalled. However, if it is already close to the time of the next dose, the label advises skipping the missed dose and continuing with the regular schedule. It is advised not to take extra medicine to compensate for a missed dose.

Q: Do you need a special diet while taking Ya Ke?

Regulatory documents do not require a special diet when taking this product. However, a specific warning exists against consuming three or more alcoholic drinks daily while using this medicine. This restriction is mandated because of the documented increase in the risk of serious stomach bleeding associated with that combination.

Q: Can Ya Ke cause unusual tiredness or sleepiness?

While this product is often classified as non-drowsy, official labeling documents side effects such as dizziness and trouble sleeping. These types of nervous system effects can affect an individual’s general alertness.

Q: Are headaches a common side effect of Ya Ke?

Headaches are listed in some regulatory documents as an adverse event that may be associated with the components of this medicine. Due to the seriousness of some reported events, the label advises consulting a health professional immediately if a severe headache occurs suddenly or gets worse.

Q: Has Ya Ke been linked to changes in mood or anxiety?

According to the official adverse reaction scope, this medicine has been linked to effects on the nervous system. Specifically, nervousness and trouble sleeping are noted side effects. Rare reports of more severe nervous system reactions have also been documented.

Q: What are the warning signs of a serious side effect from Ya Ke?

Official regulatory text identifies several serious adverse events to watch for. Signs of internal bleeding may include feeling faint, vomiting blood, or having bloody or black stools. Indicators of potential heart or stroke problems include chest pain, trouble breathing, slurred speech, or weakness on one side of the body.

Q: Is it generally safe to take Ya Ke with allergy medicines?

Official regulatory guidance advises caution when co-administering Ya Ke with any other medicine. This is particularly important if the allergy medicine contains ingredients that overlap with the active components of Ya Ke, such as other decongestants, pain relievers, or sedating antihistamines.

Q: Are there any specific vitamins or supplements that interact with Ya Ke?

The official regulatory label states that consulting a health professional or pharmacist before use is advised if you are taking any other medicine. This advisory includes all over-the-counter medicines, vitamins, and herbal products to prevent potential interactions.

Q: Can drinking alcohol interfere with how Ya Ke works?

The primary regulatory warning concerning alcohol relates to the increased risk of severe stomach bleeding, especially when consuming three or more alcoholic drinks daily. Official documents focus on this safety risk and do not typically detail the effect of alcohol consumption on the medicine's efficacy (how well it works).

Q: Is it true that Ya Ke interacts with certain foods or drinks?

Official regulatory documents only mention that taking the tablets with food or milk is permitted to help minimize potential stomach upset. No specific common food-drug interactions (such as with grapefruit juice) are listed on the regulatory label.

Q: Can older adults typically use Ya Ke?

According to official guidance, older patients (60 years and older) can use Ya Ke, but caution is specifically mandated. This is due to an officially noted increased susceptibility to serious gastrointestinal effects in the geriatric population, and the label notes that the use of the lowest effective dose is often advised for this age group.

Q: Can I still take Ya Ke if I have a history of kidney problems?

Official regulatory documents state that use is strictly prohibited for patients with severe renal failure. However, official documents indicate caution is required for use in individuals with mild or moderate kidney impairment, or a history of kidney disease.

Q: What kind of evidence is available about Ya Ke's long-term use?

The product is strictly restricted to short-term use, generally not exceeding seven consecutive days. This limitation exists because using the NSAID component (Ibuprofen) for longer periods increases the documented risk of serious adverse events, including stomach bleeding, heart attack, and stroke.

Q: Can Ya Ke be taken on an empty stomach?

Ya Ke tablets can be taken without food. However, official administration guidelines note that taking the medicine with food or milk is permitted. This is a common recommendation intended to help mitigate potential gastric discomfort caused by the Ibuprofen component.

Q: Why does Ya Ke have a warning about [specific organ] function?

Warnings regarding specific organs, such as the heart and kidneys, are related to the physiological actions of the active ingredients. Ibuprofen is documented to potentially affect kidney and heart function, while Pseudoephedrine can aggravate conditions like high blood pressure and glaucoma.

Q: Is Ya Ke known to cause dry mouth?

According to official regulatory documents, dry mouth is a noted side effect. This is associated with the sympathomimetic component, Pseudoephedrine, which functions as the systemic decongestant.

Q: Can I drive while taking Ya Ke?

Official product labeling notes that side effects such as dizziness, nervousness, or trouble sleeping may occur. These nervous system reactions can potentially impair an individual’s ability to drive or operate machinery safely, and the labeling advises exercising caution until the effects of the medicine are known.

Q: What should I do if my symptoms improve greatly while using Ya Ke?

The medicine is indicated solely for the temporary relief of symptoms associated with a cold or flu. If your symptoms clear up or improve greatly, regulatory guidance indicates that discontinuing use is advised. This ensures compliance with the restriction for short-term use only.

Q: Are there different brand names for the same Ya Ke medicine?

Yes, the active composition of Ibuprofen and Pseudoephedrine is the therapeutic foundation for a variety of products. This means the medicine is marketed under various brand names, depending on the manufacturer and the specific region of approval.

Q: What is the half-life of Ya Ke?

Based on pharmacokinetic studies, the half-life is measured for each active ingredient individually. Ibuprofen has a half-life of approximately 2 hours, and Pseudoephedrine has a reported half-life of approximately 4.7 to 5.4 hours.

Q: Can Ya Ke affect vision or eye health?

Official documents advise caution for patients with pre-existing conditions, such as glaucoma, which is related to eye health. Additionally, rare, serious adverse events have been documented to involve vision problems or changes.

Q: Is Ya Ke a controlled substance?

The finished combination product is generally classified as an over-the-counter (OTC) medicine. While the Pseudoephedrine component is federally regulated due to its potential for misuse, the product itself is not typically a DEA-scheduled controlled substance.

Q: If Ya Ke doesn't work for me, what is usually the next step?

The regulatory label advises that stopping use is necessary if your pain or nasal congestion gets worse or lasts longer than the maximum recommended duration (typically seven days). If symptoms continue or if new ones appear, official guidance is to discontinue the medicine.

Q: Does Ya Ke affect blood sugar levels?

Official regulatory documents require caution for use in patients who have pre-existing high blood sugar (hyperglycemia) or diabetes mellitus. This caution implies a potential impact on blood sugar levels.

Q: Can Ya Ke cause skin sensitivity to the sun?

Official labeling documents the risk of severe skin adverse events, such as Stevens-Johnson Syndrome (SJS). The label advises discontinuing use at the first sign of a skin rash or other hypersensitivity reaction.

Q: Is Ya Ke safe to use before an upcoming surgery?

Official warnings strictly prohibit the use of this medicine immediately before or after a specific type of heart surgery (Coronary Artery Bypass Graft, or CABG). For all other types of surgical procedures, regulatory guidance advises consultation with a health professional prior to use.

Q: Why is Ya Ke only available by prescription?

According to product information, this combination medicine is generally available over-the-counter (OTC) for the purpose of temporary relief of cold and flu symptoms.

Q: If I have a mild allergic reaction to Ya Ke, what are the first signs?

Official regulatory documents describe the initial signs of a severe allergic reaction, which can include symptoms like hives, swelling of the face, trouble breathing, or wheezing. The label advises immediate discontinuation of use if an allergic reaction occurs.

Q: How long does the decongestant effect of Pseudoephedrine last?

Pharmacodynamic information indicates that the decongestant effect from the Pseudoephedrine component is typically reported to last for a duration of 4 to 12 hours, depending on the specific formulation.

How should Ya Ke be stored and disposed of?

Official Storage and Disposal Requirements

Storage and disposal instructions for Ya Ke (Ibuprofen and Pseudoephedrine) are strictly defined by regulatory labeling to maintain product stability and ensure public safety.

Storage Condition Requirement
Temperature Store at Controlled Room Temperature (20^circC to 25^circC).
Protection Keep tightly closed in the original container, away from moisture, light, and excessive heat.
Prohibited Do not freeze or refrigerate the tablets.
Child Safety Store strictly out of the sight and reach of children.

Disposal of unused or expired Ya Ke must follow official guidance. Tablets should be discarded through an authorized drug take-back program or according to local pharmaceutical waste requirements. It is officially mandated that the medicine must not be flushed down the toilet or poured down a drain.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Ya Ke found in:

A-Z Index: