Xplode TAB

Cyanocobalamin (Xplode TAB) (commonly known as Vitamin B12) is the most chemically complex of all the vitamins. Cyanocobalamin (Xplode TAB)'s structure is based on a corrin ring, which, although similar to the porphyrin ring found in heme, chlorophyll, and cytochrome, has two of the pyrrole rings directly bonded. The central metal ion is Co (cobalt). Cyanocobalamin (Xplode TAB) cannot be made by plants or by animals, as the only type of organisms that have the enzymes required for the synthesis of Cyanocobalamin (Xplode TAB) are bacteria and archaea. Higher plants do not concentrate Cyanocobalamin (Xplode TAB) from the soil and so are a poor source of the substance as compared with animal tissues. Cyanocobalamin (Xplode TAB) is naturally found in foods including meat (especially liver and shellfish), eggs, and milk products. [HMDB]

Ginseng extract (Xplode TAB) is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng extract (Xplode TAB) is also known to contain phytoestrogens.

Resveratrol (Xplode TAB) (3,5,4'-trihydroxy-trans-stilbene), a naturally occurring antioxidant, is used as a dietary supplement for the prevention of heart and circulatory system disorders, cancer and other degenerative disorders including Alzheimer’s disease. Resveratrol (Xplode TAB) is widely present in blueberries, red grape skin and other berries. Resveratrol (Xplode TAB) can reduce the ill-effects of smoking, alcohol and high-fat diet. Resveratrol (Xplode TAB) is widely available as a dietary supplement formulation and as transdermal patches. However, the safety and efficacy is not studied and approved by the USFDA.

A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, Vitamin C (Xplode TAB), functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C (Xplode TAB) is considered an antioxidant.

Zinc (Xplode TAB) Capsule: Each capsule contains Zinc (Xplode TAB) sulphate monohydrate 54.93 mg, thiamine nitrate 10 mg, riboflavin 10 mg, pyridoxine hydrochloride 3 mg, vitamin B12 (coated) equivalent to Zinc (Xplode TAB) 15 mcg, ascorbic acid 150 mg, folic acid 1 mg, nicotinamide 50 mg and calcium pantothenate 12.5 mg.

Zinc (Xplode TAB) Syrup: Each 5 mL contains Zinc (Xplode TAB) gluconate 34.9 mg, thiamine mononitrate 2.5 mg, riboflavin 2.5 mg, pyridoxine hydrochloride 1 mg, Zinc (Xplode TAB) 3 mcg, ascorbic acid 50 mg, d-panthenol 12.5 mg and niacinamide 25 mg in a flavoured liquid glucose sorbitol syrup base.

Cyanocobalamin (Xplode TAB) Nasal Spray is indicated for the maintenance of normal hematologic status in pernicious anemia patients who are in remission following intramuscular vitamin B12 therapy and who have no nervous system involvement.

Cyanocobalamin (Xplode TAB) Nasal Spray is also indicated as a supplement for other vitamin B12 deficiencies, including:

I. Dietary deficiency of vitamin B12 occurring in strict vegetarians (Isolated vitamin B12 deficiency is very rare).

II. Malabsorption of vitamin B12 resulting from structural or functional damage to the stomach, where intrinsic factor is secreted, or to the ileum, where intrinsic factor facilitates vitamin B12 absorption. These conditions include HIV infection, AIDS, Crohn's disease, tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). Folate deficiency in these patients is usually more severe than vitamin B12 deficiency.

III. Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, HIV infection, AIDS, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). Total gastrectomy always produces vitamin B12 deficiency. Structural lesions leading to vitamin B12 deficiency include regional ileitis, ileal resections, malignancies, etc.

IV. Competition for vitamin B12 by intestinal parasites or bacteria. The fish tapeworm (Diphyllobothrium latum) absorbs huge quantities of vitamin B12 and infested patients often have associated gastric atrophy. The blind loop syndrome may produce deficiency of vitamin B12 or folate.

V. Inadequate utilization of vitamin B12. This may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia.

It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption, use of a gluten-free diet in non-tropical sprue, or administration of antibiotics in tropical sprue. Such measures remove the need for long-term administration of vitamin B12.

Requirements of vitamin B12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with intranasal or oral supplementation.

Cyanocobalamin (Xplode TAB) Nasal Spray is not suitable for vitamin B12 absorption test (Schilling Test).

CNS depressant, tranquilizer.

Sedative, relaxant.

Treatment for Insomnia, anxiety, poor appetite.

Agitation.

Increase vitality in conditions of weakness, prolonged stress, poor immunity, or chronic disease.

Hypotensive.

Improves gastro-intestinal motility.

Immune system stimulant.

Increase synthesis of cholesterol in liver.

Helps to regulate blood sugar and lipid levels.

Regulates adrenal gland function.

Promotes neurological functions; supports CV health; helps prevent tumor.

For systemic use of Vitamin C (Xplode TAB): prevention and treatment of hypo- and avitaminosis of Vitamin C (Xplode TAB); providing increased need for Vitamin C (Xplode TAB) during growth, pregnancy, lactation, with heavy loads, fatigue and during recovery after prolonged severe illness; in winter with an increased risk of infectious diseases.

For intravaginal use: chronic or recurrent vaginitis (bacterial vaginosis, nonspecific vaginitis) caused by the anaerobic flora (due to changes in pH of the vagina) in order to normalize disturbed vaginal microflora.

Patients with deficiency of B-complex vitamins, Zinc (Xplode TAB) and Zinc (Xplode TAB) or where supplementation of these vitamins and Zinc (Xplode TAB) can be beneficial. Such patients and conditions include: Patients who are on prolonged antibiotic therapy; those who are suffering from infection, injuries, burns, fever, illness; patients with diarrhoea and GI disorders; patients who have undergone surgical operations; patients on diet restrictions eg, in diabetes, anorexia and alcoholism and in elderly persons; pregnant and lactating women due to increased nutritional needs.

Cyanocobalamin (Xplode TAB) nasal spray contains Cyanocobalamin (Xplode TAB), a man-made form of vitamin B12. Vitamin B12 is important for growth, cell reproduction, blood formation, and protein and tissue synthesis.

Cyanocobalamin (Xplode TAB) nasal spray is used to treat vitamin B12 deficiency in people with pernicious anemia and other conditions.

Cyanocobalamin (Xplode TAB) nasal spray is usually given after treatment with an injection form of this medicine.

Cyanocobalamin (Xplode TAB) may also be used for purposes not listed in this medication guide.

The use of Ginseng extract (Xplode TAB) in cultural and traditional settings may differ from concepts accepted by current Western medicine. When considering the use of herbal supplements, consultation with a primary health care professional is advisable. Additionally, consultation with a practitioner trained in the uses of herbal/health supplements may be beneficial, and coordination of treatment among all health care providers involved may be advantageous.

A number of Ginseng extract (Xplode TAB) species used in herbal products grow around the world. Some of these plants include American Ginseng extract (Xplode TAB), Korean Ginseng extract (Xplode TAB), Sanchi Ginseng extract (Xplode TAB), Chikusetsu Ginseng extract (Xplode TAB), Himalayan Ginseng extract (Xplode TAB), zhuzishen, and dwarf Ginseng extract (Xplode TAB). Ginseng extract (Xplode TAB) is also known as Siberian Ginseng extract (Xplode TAB), devil's shrub, eleuthero, touch-me-not, and wild pepper.

Ginseng extract (Xplode TAB) has been used to improve the body's resistance to stress and to increase vitality.

Ginseng extract (Xplode TAB) has not been evaluated by the FDA for safety, effectiveness, or purity. All potential risks and/or advantages of Ginseng extract (Xplode TAB) wort may not be known. Additionally, there are no regulated manufacturing standards in place for these compounds. There have been instances where herbal/health supplements have been sold which were contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Ginseng extract (Xplode TAB) may also have uses other than those listed in this product guide.

Ascorbic acid (Vitamin C (Xplode TAB)) occurs naturally in foods such as citrus fruit, tomatoes, potatoes, and leafy vegetables. Vitamin C (Xplode TAB) is important for bones and connective tissues, muscles, and blood vessels. Vitamin C (Xplode TAB) also helps the body absorb iron, which is needed for red blood cell production.

Ascorbic acid is used to treat and prevent Vitamin C (Xplode TAB) deficiency.

Ascorbic acid may also be used for purposes not listed in this medication guide.

Zinc (Xplode TAB) is a naturally occurring mineral. Zinc (Xplode TAB) is important for growth and for the development and health of body tissues.

Zinc (Xplode TAB) sulfate is used to treat and to prevent Zinc (Xplode TAB) deficiency.

Zinc (Xplode TAB) sulfate may also be used for purposes not listed in this medication guide.

The recommended initial dose of Cyanocobalamin (Xplode TAB) (Cyanocobalamin (Xplode TAB)) Nasal Spray is one spray (500 mcg) administered in ONE nostril once weekly. Cyanocobalamin (Xplode TAB) (Cyanocobalamin (Xplode TAB)) Nasal Spray should be administered at least one hour before or one hour after ingestion of hot foods or liquids. Periodic monitoring of serum B levels should be obtained to establish adequacy of therapy.

Priming (Activation) of Pump

Before the first dose and administration, the pump must be primed. Remove the clear plastic cover and the plastic safety clip from the pump. To prime the pump, place nozzle between the first and second finger with the thumb on the bottom of the bottle. Pump the unit firmly and quickly until the first appearance of spray. Then prime the pump an additional 2 times. Now the nasal spray is ready for use. The unit must be re-primed before each dose. Prime the pump once immediately before each administration of doses 2 through 8.

How supplied

Cyanocobalamin (Xplode TAB) (Cyanocobalamin (Xplode TAB)) Nasal Spray is available as a spray in 3 mL glass bottles containing 2.3 mL of solution. It is available in a dosage strength of 500 mcg per actuation (0.1 mL/actuation). A screw-on actuator is provided. This actuator, following priming, will deliver 0.1 mL of the spray. Cyanocobalamin (Xplode TAB) (Cyanocobalamin (Xplode TAB)) Nasal Spray is provided in a carton containing a nasal spray actuator with dust cover, a bottle of nasal spray solution, and a package insert. One bottle will deliver 8 doses (NDC 67871-773-35).

Pharmacist Assembly Instructions For Cyanocobalamin (Xplode TAB) (Cyanocobalamin (Xplode TAB)) Nasal Spray

The pharmacist should assemble the Cyanocobalamin (Xplode TAB) (Cyanocobalamin (Xplode TAB)) Nasal Spray unit prior to dispensing to the patient, according to the following instructions:

1. Open the carton and remove the spray actuator and spray solution bottle.
2. Assemble Cyanocobalamin (Xplode TAB) (Cyanocobalamin (Xplode TAB)) Nasal Spray by first unscrewing the white cap from the spray solution bottle and screwing the actuator unit tightly onto the bottle. Make sure the clear dust cover is on the pump unit.
3. Return the Cyanocobalamin (Xplode TAB) (Cyanocobalamin (Xplode TAB)) Nasal Spray bottle to the carton for dispensing to the patient.

Mfd. for QOL Medical, LLC

Kirland, WA 98033, USA

1.866.469.3773

www.Cyanocobalamin (Xplode TAB) (Cyanocobalamin (Xplode TAB)).com

3078 Rev. 02/06

FDA rev date: 9/15/2006

2 caps daily.

Adult & childn ≥12 yr 1 cap daily.

This medication administered orally, IM, IV, intravaginally.

For the prevention of deficiency conditions Vitamin C (Xplode TAB) dose is 25-75 mg / day, for the treatment - 250 mg / day or more in divided doses.

For intravaginal used ascorbic acid drugs in appropriate dosage forms.

Zinc (Xplode TAB) 1 mg/mL (Zinc (Xplode TAB) Chloride Injection, USP) contains 1 mg Zinc (Xplode TAB)/mL and is administered intravenously only after dilution. The additive should be diluted prior to administration in a volume of fluid not less than 100 mL. For the metabolically stable adult receiving TPN, the suggested intravenous dosage is 2.5 to 4 mg Zinc (Xplode TAB)/day (2.5 to 4 mL/day). An additional 2 mg Zinc (Xplode TAB)/day (2 mL/day) is suggested for acute catabolic states. For the stable adult with fluid loss from the small bowel, an additional 12.2 mg Zinc (Xplode TAB)/liter of small bowel fluid lost (12.2 mL/liter of small bowel fluid lost), or an additional 17.1 mg Zinc (Xplode TAB)/kg of stool or ileostomy output (17.1 mL/kg of stool or ileostomy output) is recommended. Frequent monitoring of Zinc (Xplode TAB) blood levels is suggested for patients receiving more than the usual maintenance dosage level of Zinc (Xplode TAB).

For full term infants and children up to 5 years of age, 100 mcg Zinc (Xplode TAB)/kg/day

(0.1 mL/kg/day) is recommended. For premature infants (birth weight less than 1500 g) up to 3 kg in body weight, 300 mcg Zinc (Xplode TAB)/kg/day (0.3 mL/kg/day) is suggested.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.

How supplied

Zinc (Xplode TAB) 1 mg/mL (Zinc (Xplode TAB) Chloride Injection, USP) is supplied in 10 mL Plastic Vials (List No. 4090).

Store at 20 to 25°C (68 to 77°F).

HOSPIRA, INC., LAKE FOREST, IL 60045 USA. Revised: October, 2004

See also:
What is the most important information I should know about Cyanocobalamin (Xplode TAB)?

You should not use this medication if you are allergic to cobalt, or if you have Leber's disease. Cyanocobalamin (Xplode TAB) can lead to optic nerve damage (and possibly blindness) in people with Leber's disease.

To treat pernicious anemia, you will have to use this medication on a regular basis for the rest of your life. Not using the medication can lead to irreversible nerve damage in your spinal cord.

Pernicious anemia is also treated with folic acid to help maintain red blood cells. However, folic acid will not treat Vitamin B12 deficiency and will not prevent possible damage to the spinal cord. Use all of your medications as directed.

Avoid eating or drinking hot foods or liquids within 1 hour before or after using the nasal form of this medication.

Tell your doctor if you develop nasal congestion, a cold, or allergies. The nasal spray may not work as well if you are congested.

Your dose needs may change if you become pregnant, if you breast-feed, or if you eat a vegetarian diet. Tell your doctor about any changes in your diet or medical condition.

See also:
What is the most important information I should know about Ginseng extract (Xplode TAB)?

Should not be used by persons with hypoglycaemia, insulin dependent diabetes, high blood pressure or heart disorders, unless approved by their physician.

AV-block II and III degree, sinoatrial block, SSS, bradycardia (HR < 40 bpm), hypotension (in case of myocardial infarction, systolic blood pressure less than 100 mm Hg), cardiogenic shock, congestive heart failure IIB-III stages, acute heart failure, Prinzmetal's angina, lactation, concomitant use of MAO inhibitors, hypersensitivity to atenolol.

See also:
What is the most important information I should know about Zinc (Xplode TAB)?

Hypersensitivity to any of the ingredients of Zinc (Xplode TAB).

Use Cyanocobalamin (Xplode TAB) (b12) spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Cyanocobalamin (Xplode TAB) (b12) spray. Talk to your pharmacist if you have questions about this information.
• Cyanocobalamin (Xplode TAB) (b12) spray is used in the nose.
• Follow the directions provided by your doctor or other health care provider. If you are unsure how to use Cyanocobalamin (Xplode TAB) (b12) spray, contact your doctor or other health care provider.
• Do not use Cyanocobalamin (Xplode TAB) (b12) spray within 1 hour before or after eating or drinking hot foods or liquids.
• Prime the pump before the first use. Place the nozzle between the first and second finger with the thumb on the bottom. Point the nozzle away from yourself and others. Pump the unit firmly and quickly until the medicine sprays out, then spray two more times.
• Re-prime the pump before each dose. Point the nozzle away from yourself and others, then spray once.
• Use Cyanocobalamin (Xplode TAB) (b12) spray in only 1 nostril each week.
• To use Cyanocobalamin (Xplode TAB) (b12) spray, sit down and tilt your head back slightly. Place the tip of the spray container into the nose. Using a finger from your other hand, press against the opposite nostril to close it off. Breath gently through the open nostril and spray a dose of medicine from the container. After using the medicine, rinse the tip of the spray unit in hot water and dry with a clean tissue to prevent contamination.
• Cyanocobalamin (Xplode TAB) (b12) spray is usually used 1 time per week. Do not use it more often than 1 time per week without checking with your doctor.
• This bottle contains 8 doses. Do not continue to use this bottle after 8 doses have been used. It may not give the correct amount of medicine.
• Continue to use Cyanocobalamin (Xplode TAB) (b12) spray even if you feel well. Do not miss any doses.
• If you miss a dose of Cyanocobalamin (Xplode TAB) (b12) spray, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Cyanocobalamin (Xplode TAB) (b12) spray.

Use Ginseng extract (Xplode TAB) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Ginseng extract (Xplode TAB) with a meal.
• There are different types of Ginseng extract (Xplode TAB), which vary widely in quality. Read product labeling carefully.
• Ginseng extract (Xplode TAB) may cause trouble sleeping. Do not take it in the early evening or at bedtime.
• If you miss taking a dose of Ginseng extract (Xplode TAB) for 1 or more days, there is no cause for concern. If your doctor recommended that you take it, try to remember to take your dose every day.

Ask your health care provider any questions you may have about how to use Ginseng extract (Xplode TAB).

How to use Cyanocobalamin (Xplode TAB) nasal

Ascorbic acid (Vitamin C (Xplode TAB)) is used to prevent or treat low levels of Vitamin C (Xplode TAB) in people who do not get enough of the vitamin from their diets. Most people who eat a normal diet do not need extra ascorbic acid. Low levels of Vitamin C (Xplode TAB) can result in a condition called scurvy. Scurvy may cause symptoms such as rash, muscle weakness, joint pain, tiredness, or tooth loss.

Vitamin C (Xplode TAB) plays an important role in the body. It is needed to maintain the health of skin, cartilage, teeth, bone, and blood vessels. It is also used to protect your body's cells from damage. It is known as an antioxidant.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This vitamin may also be used with other vitamins for a certain eye condition (macular degeneration).

How to use Vitamin C (Xplode TAB)

Take this vitamin by mouth with or without food, usually 1 to 2 times daily. Follow all directions on the product package, or take as directed by your doctor.

If you are taking the extended-release capsules, swallow them whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. Take this product with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise.

If you are taking the wafers or chewable tablets, chew them thoroughly and then swallow. If you are taking the lozenges, place the lozenge in your mouth and allow it to slowly dissolve.

If you are taking the powder, mix it thoroughly in the proper amount of liquid and stir well. Drink all of the liquid right away. Do not prepare a supply for future use. If you are using the liquid form of this vitamin, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

Dosage is based on your medical condition and response to treatment.

Use this vitamin regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

If you think you may have a serious medical problem, seek immediate medical attention.

See also:
What other drugs will affect Cyanocobalamin (Xplode TAB)?

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.

Some products that may interact with this drug include: drugs that affect the bone marrow (such as chloramphenicol), vitamins/supplements that contain intrinsic factor.

Certain medications can decrease the absorption of vitamin B12, including: colchicine, metformin, extended-release potassium products, antibiotics (such as gentamicin, neomycin, tobramycin), anti-seizure medications (such as phenobarbital, phenytoin, primidone), medications to treat heartburn (such as H2 blockers including cimetidine/famotidine, proton pump inhibitors such as omeprazole/lansoprazole).

Vitamin B12 is an ingredient found in many combination vitamin and nutritional products. Tell your doctor or pharmacist if you are taking other products that contain Cyanocobalamin (Xplode TAB), vitamin B12, or hydroxocobalamin.

Cyanocobalamin (Xplode TAB) may interfere with certain laboratory tests (including intrinsic factor, blood tests for other types of anemia), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Certain drugs may interfere with laboratory tests for vitamin B12 levels, possibly causing false results. Tell laboratory personnel and all your doctors if you take any of the following: antibiotics (such as amoxicillin, erythromycin), methotrexate, pyrimethamine.

This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.

See also:
What other drugs will affect Ginseng extract (Xplode TAB)?

Patients on anticoagulants e.g coumadin should avoid Ginseng extract (Xplode TAB) because Ginseng extract (Xplode TAB) is known to increase or decrease blood coagulation. Ginseng extract (Xplode TAB) has potential to cause hypoglycaemia, because some components of Ginseng extract (Xplode TAB) can elevate plasma insulin levels. Therefore, diabetics who take Ginseng extract (Xplode TAB) must have their blood sugars monitored closely.

See also:
What other drugs will affect Resveratrol (Xplode TAB)?

May increase risk of bleeding w/ anticoagulants & antiplatelets.

In an application with barbiturates, primidone increases the excretion of ascorbic acid in the urine.

With the simultaneous use of oral contraceptives reduces the concentration of ascorbic acid in blood plasma.

In an application of Vitamin C (Xplode TAB) with iron preparations ascorbic acid, due to its regenerative properties, transforms ferric iron in the bivalent, which improves its absorption.

Ascorbic acid in high doses can decrease urine pH that while the application reduces the tubular reabsorption of amphetamine and tricyclic antidepressants.

With the simultaneous use of aspirin reduces the absorption of ascorbic acid by about a third.

Vitamin C (Xplode TAB) in an application with warfarin may decrease effects of warfarin.

With the simultaneous application of ascorbic acid increases the excretion of iron in patients receiving deferoxamine. In the application of ascorbic acid at a dose of 500 mg / day possibly left ventricular dysfunction.

In an application with tetracycline is increased excretion of ascorbic acid in the urine.

There is a described case of reducing the concentration of fluphenazine in plasma in patients treated with ascorbic acid 500 mg 2 times / day.

May increase the concentration of ethinyl estradiol in the blood plasma in its simultaneous application in the oral contraceptives.

See also:
What other drugs will affect Zinc (Xplode TAB)?

Pyridoxine reduces the effects of levodopa (but this does not occur if a dopa decarboxylase is also given); decreases serum concentrations of phenobarbitone. Concurrent administration of drugs eg, isoniazid, penicillamine and oral contraceptives increase the requirement for pyridoxine.

Absorption of Zinc (Xplode TAB) from the GIT may be reduced by neomycin, aminosalicylic acid, histamine H₂-receptor antagonists and colchicine. Serum concentrations may be decreased by concurrent administration of oral contraceptives. Many of these interactions are unlikely to be of clinical significance but should be taken into account when performing assays for blood concentrations.

Parenteral chloramphenicol may attenuate the effect of vitamin B12 in anaemia.

Folate deficiency states may be produced by a number of drugs including antiepileptics, oral contraceptives, antituberculous drugs, alcohol and folic acid antagonists eg, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides; folic acid may decrease serum-phenytoin concentrations.

There may be an increased risk of myopathy or rhabdomyolysis when nicotinic acid is used concurrently with statins. Nicotinamide may increase the requirements for insulin or oral hypoglycaemics.

Ascorbic acid may increase the absorption of iron-deficiency states.

Ascorbic acid is often given in addition to desferrioxamine to patients with iron overload (thalassemia) to achieve better iron excretion. However, early on in treatment when there is excess tissue iron, there is some evidence that ascorbic acid may worsen the iron toxicity, particularly to the heart. Thus, ascorbic acid should not be given for the first month after starting desferrioxamine treatment.

The absorption of Zinc (Xplode TAB) may be reduced by iron supplements, penicillamine, phosphorus-containing preparations and tetracyclines. Zinc (Xplode TAB) supplements reduce the absorption of copper, ciprofloxacin, iron, norfloxacin, penicillamine and tetracyclines.

See also:
What are the possible side effects of Cyanocobalamin (Xplode TAB)?

The incidence of adverse experiences described in the Table below are based on data from a short-term clinical trial in vitamin B12 deficient patients in hematologic remission receiving Cyanocobalamin (Xplode TAB) (Cyanocobalamin (Xplode TAB), USP) Gel for Intranasal Administration (N=24) and intramuscular vitamin B12 (N=25). In the pharmacokinetic study comparing Cyanocobalamin (Xplode TAB) Nasal Spray and Cyanocobalamin (Xplode TAB) Nasal Gel, the incidence of adverse events was similar.

The intensity of the reported adverse experiences following the administration of Cyanocobalamin (Xplode TAB) (Cyanocobalamin (Xplode TAB), USP) Gel for Intranasal Administration and intramuscular vitamin B12 were generally mild. One patient reported severe headache following intramuscular dosing. Similarly, a few adverse experiences of moderate intensity were reported following intramuscular dosing (two headaches and rhinitis; one dyspepsia, arthritis, and dizziness), and dosing with Cyanocobalamin (Xplode TAB) (Cyanocobalamin (Xplode TAB), USP) Gel for Intranasal Administration (one headache, infection, and paresthesia).

The majority of the reported adverse experiences following dosing with Cyanocobalamin (Xplode TAB) (Cyanocobalamin (Xplode TAB), USP) Gel for Intranasal Administration and intramuscular vitamin B12 were judged to be intercurrent events. For the other reported adverse experiences, the relationship to study drug was judged as "possible" or "remote". Of the adverse experiences judged to be of "possible" relationship to the study drug, anxiety, incoordination, and nervousness were reported following intramuscular vitamin B12 and headache, nausea, and rhinitis were reported following dosing with Cyanocobalamin (Xplode TAB) (Cyanocobalamin (Xplode TAB), USP) Gel for Intranasal Administration.

The following adverse reactions have been reported with parenteral vitamin B12:

Generalized: Anaphylactic shock and death.

Cardiovascular: Pulmonary edema and congestive heart failure early in treatment; peripheral vascular thrombosis.

Hematological: Polycythemia vera.

Gastrointestinal: Mild transient diarrhea.

Dermatological: Itching; transitory exanthema.

Miscellaneous: Feeling of swelling of the entire body.

See also:
What are the possible side effects of Ginseng extract (Xplode TAB)?

May cause nervousness, increased blood pressure, irritability in high doses. Ginseng extract (Xplode TAB) and /or adulterants have estrogenic activity and may cause vaginal bleeding and mastalgia [breast soreness] and patients with estrogen dependent malignancies may need to avoid Ginseng extract (Xplode TAB).

Adverse effects of Resveratrol (Xplode TAB) in humans have not been reported. Long-term side effects are not known. A small and brief clinical trial conducted in 2011 in obese patients given 150 mg per day of Resveratrol (Xplode TAB) noted no adverse reactions.

Applies to ascorbic acid: oral capsule, oral capsule extended release, oral capsule liquid filled, oral granule, oral liquid, oral lozenge/troche, oral powder, oral powder for solution, oral powder for suspension, oral solution, oral syrup, oral tablet, oral tablet chewable, oral tablet extended release, oral wafer

As well as its needed effects, ascorbic acid (the active ingredient contained in Vitamin C (Xplode TAB)) may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking ascorbic acid, check with your doctor or nurse as soon as possible:

Less common or rare: - with high doses

• Side or lower back pain

Minor Side Effects

Some ascorbic acid side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common or rare: - with high doses

• Diarrhea
• dizziness or faintness (with the injection only)
• flushing or redness of skin
• headache
• increase in urination (mild)
• nausea or vomiting
• stomach cramps

See also:
What are the possible side effects of Zinc (Xplode TAB)?

Applies to Zinc (Xplode TAB) sulfate: capsules, tablets

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur while taking Zinc (Xplode TAB) sulfate (the active ingredient contained in Zinc (Xplode TAB))

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe vomiting; unusual restlessness; very dry mouth, eyes, or skin.