Xido

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Xido

Quick Facts

Property Description
Active ingredient Gliclazide
Form Tablet (Oral route), including Modified-Release (MR)
Pharmacological class Sulfonylurea / Oral Antidiabetic Medicine
General use Management of Type 2 Diabetes Mellitus in adults
Origin Synthetic

Xido: Classification, Composition, and Origin

Xido is a synthetic oral antidiabetic medicine containing the active substance Gliclazide, which is classified within the Sulfonylurea class of drugs. It functions as a single-ingredient product designed for metabolic management in adults. Gliclazide belongs to the second generation of sulfonylureas, which is characterized by its pharmacological profile compared to earlier agents in its class.

The medicine's composition is centered on Gliclazide, a chemically derived compound. This compound belongs to the pharmacological class of insulin secretagogues, meaning its core function is to prompt the body to release stored insulin from functional pancreatic beta-cells. The profile of Gliclazide is defined by its insulin-releasing action.


What is the Main Purpose of Gliclazide (Xido)?

The core purpose of Xido is to achieve and maintain control of elevated blood sugar levels (hyperglycemia) in individuals diagnosed with Type 2 Diabetes Mellitus. It assists the body by promoting the regulation of glucose metabolism, addressing the foundational deficiency in this condition.

Xido works by modulating the function of specialized ion channels on the pancreatic cells, a mechanism that triggers the release of insulin. Its primary action is the enhancement of glucose-mediated insulin secretion. This drug facilitates the body's natural insulin release when blood sugar is high. Its general benefit lies in offering targeted support for endogenous insulin release, serving as a component in the long-term metabolic strategy for managing the disease.


What Forms of Xido are Available?

Xido is administered via the oral route and is supplied as a tablet, which may be a standard or modified formulation. A common therapeutic presentation is the modified-release (MR) tablet, a design that allows for the steady delivery of the active ingredient Gliclazide over an extended period.

The modified-release formulation is typically taken once daily for a sustained effect. The MR tablet is designed for consistent blood sugar control throughout the day. The specific design of the MR tablet aids in providing a more stable therapeutic concentration, contributing to day-to-day blood sugar level control with a simplified dosing schedule compared to formulations requiring multiple daily doses.

What side effects are possible with Xido?

Possible Side Effects and Safety Information

The safety profile of Gliclazide (Xido) is officially documented based on regulatory classification, adverse reaction frequency, and organ system groupings. As the medicine belongs to the sulfonylurea class, its most frequent and characteristic adverse reaction, classified under Metabolism and Nutrition Disorders, is Hypoglycaemia (low blood sugar). This effect is considered the primary expected safety concern.

Less frequent adverse reactions are grouped into official System-Organ Classes. These include Gastrointestinal Disturbances (such as nausea, vomiting, and abdominal pain) and Skin and Subcutaneous Tissue Disorders (including rashes and itching). Changes in blood counts, such as anaemia or thrombocytopenia, are typically classified as Rare events in regulatory documents.

Official labels describe certain reactions as potentially Serious Adverse Reactions, including Severe and Prolonged Hypoglycaemia and rare but serious instances of Hepatitis leading to jaundice, or severe Bullous Skin Reactions (e.g., Stevens-Johnson syndrome).

Population-Specific Constraints are defined in official prescribing information. The medicine is strictly contraindicated in patients with severe renal or hepatic insufficiency, as well as during pregnancy and lactation. Furthermore, the regulatory safety profile notes that transient visual disturbances may occur, particularly at the beginning of treatment, due to initial changes in blood glucose levels. The drug is also contraindicated for use in individuals with Type 1 diabetes or diabetic keto-acidosis.

Overdose and Emergency Response

A Xido overdose is officially documented as presenting with severe and prolonged hypoglycemia, which is the most frequent and significant manifestation. This critical metabolic disturbance can lead to a progressive sequence of clinical signs. Initial manifestations may include intense hunger, headache, fatigue, confusion, and agitation. However, the condition can rapidly escalate to severe neuroglycopenic effects such as speech disorders, convulsions, and ultimately hypoglycaemic coma. Official regulatory labeling states that the primary serious outcomes are the potential for permanent brain damage or death if the low blood glucose is not addressed promptly and sustainedly.

Immediate medical attention or hospitalization are required for any severe or prolonged hypoglycemic episode, even if symptoms temporarily improve with oral sugar intake. Individuals should contact emergency services immediately in such scenarios. Management is strictly symptomatic and supportive. Due to the high risk of recurrent hypoglycemia, official guidance mandates prolonged hospital monitoring, often for 12 to 24 hours or more, to ensure stable glucose levels. The core intervention described is the administration of glucose (e.g., intravenous dextrose), as no specific chemical antidote is known. The risk of severe and prolonged reactions is noted to be higher in certain populations, including elderly subjects and those with impaired hepatic or renal function.

Therapeutic Uses of Xido

What Xido treats: main uses and benefits

Xido (Dapagliflozin and Metformin Extended-Release) is commonly used as an adjunct to diet and exercise in situations where patients experience systemic imbalance related to type 2 diabetes mellitus. The medication plays a role in managing symptoms related to systemic imbalance by supporting the management of blood glucose levels. This is relevant for easing the symptoms that become more disruptive during flare-ups associated with the condition.

The medication is applied in addressing clinical situations including: supporting patients experiencing systemic imbalance in type 2 diabetes, easing symptomatic burden related to the risk of hospitalization for heart failure in adults with T2DM and cardiovascular risk factors, and assisting with functional stability in adults with heart failure with reduced ejection fraction. The overall therapeutic approach also may assist with managing certain cardiovascular risks, particularly in contexts involving heightened systemic burden.

This supports the patient during difficult episodes by easing distress and assists with maintaining functional stability, particularly in situations where symptoms become temporarily overwhelming. It contributes to improved comfort during periods of heightened symptoms associated with temporary physiological imbalance.


Quick Fact: Supports Management of symptoms related to systemic imbalance


Eligibility and Restrictions for Use

The eligibility for Xido (Gliclazide) is defined by official regulatory documentation, which outlines the specific patient groups permitted to use the medicine and those who are strictly prohibited.

Eligibility Scope

Xido use is restricted to adults diagnosed with Type 2 Diabetes Mellitus whose blood sugar is not controlled by diet and exercise alone. It is not recommended for children and adolescents under 18 years of age, as safety and effectiveness have not been established in this population. Use in older adults is generally permitted.

Patients with mild to moderate renal insufficiency may use the medicine with careful monitoring. However, Xido is absolutely contraindicated and must not be used in the following populations:

  • Known hypersensitivity to Gliclazide, other sulfonylureas, or sulfonamides.
  • Type 1 diabetes, diabetic pre-coma, coma, or keto-acidosis.
  • Severe hepatic or severe renal insufficiency.
  • Women who are pregnant or breastfeeding.
  • Patients receiving concomitant treatment with miconazole.

Additional caution is required for patients who are malnourished or have conditions like G6PD deficiency.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The interaction profile of Xido, which contains Gliclazide, is officially documented to include interactions that either potentiate or counteract its glucose-lowering action, alongside effects on drug exposure. The most significant restriction is the formal contraindication of co-administration with Miconazole (systemic or oromucosal gel) due to the documented risk of severe hypoglycemia.


Interaction Classifications

Interaction Type Interacting Agents (Examples) Official Outcome Description
Potentiation Other antidiabetic agents, Beta-blockers, ACE Inhibitors, NSAIDs Documented to increase the glucose-lowering effect, raising the risk of hypoglycemia.
Counteraction Glucocorticoids, Danazol, Chlorpromazine (high-dose) Documented to reduce the therapeutic efficacy, potentially leading to elevated blood glucose levels.

Exposure and Special Constraints

Official regulatory information specifies that certain substances alter the drug's presence in the body. CYP2C9 inhibitors like Fluconazole are noted to increase plasma concentrations of Gliclazide, while CYP2C9 inducers such as St. John's Wort are documented to cause a reduction in exposure. Phenylbutazone (systemic) is officially noted to increase the drug's effect by displacing it from plasma protein binding. The official label notes that alcohol increases the hypoglycemic reaction risk. Caution is documented for patients with severe renal or hepatic insufficiency due to the increased risk of severe hypoglycemic reactions from potential drug accumulation.

Mechanism of Action

Modulation of Primary Inhibitory Signaling (GABAergic System)

Xido's mechanism involves its function as a positive allosteric modulator on the GABA-A receptor complex. The drug enhances the natural inhibitory effect of the neurotransmitter GABA by increasing the influx of chloride ions into the neuron. This molecular action results in a generalized dampening of neuronal excitability within the Central Nervous System, leading to a reduction of neuronal firing frequency.

Control of Excitatory Neurotransmitter Release

Additionally, Xido exhibits a secondary mechanism through the inhibition of presynaptic voltage-gated calcium channels (P/Q and N types). By limiting the required calcium influx at the nerve terminal, Xido modifies the threshold for presynaptic neurotransmitter release, thereby reducing the overall volume of forward-signaling pathways. This modification of early molecular steps produces changes in somatic reflex arcs and generalized CNS electrophysiology.

Dosage and Administration Information

How to Use Xido

The administration of Xido (Gliclazide) is by the oral route, with the medicine available as an Immediate-Release (IR) tablet and a Modified-Release (MR) tablet. The protocol for use ensures proper dosing and integration into the daily routine.

Dosing and Frequency

The dosing schedule is tailored to the specific tablet formulation. The Modified-Release formulation is administered once daily and the starting dose is typically 30 mg. This can be adjusted in successive steps to a maximum of 120 mg daily. The Immediate-Release formulation has a higher maximum daily dose of 320 mg, which is taken in divided doses if the total exceeds 160 mg per day.

Administration Protocol

The dosage is consumed at breakfast time or with the first main meal of the day. Use of the medicine involves maintaining a regular food intake that includes breakfast.

For the Modified-Release tablet, the tablets are swallowed whole and are not to be crushed, chewed, or divided. If a dose is forgotten, the next day's dose is not increased to compensate, and the regular schedule is maintained.

Population-Specific Use

For older adults (65 years and older), the regimen typically starts with the minimum daily dose of 30 mg for the MR form, while following the same subsequent dosing regimen as younger adults. The use of Gliclazide in the paediatric population (children and adolescents) is not recommended because the safety and efficacy have not been established.

Recent Clinical Evidence

Research Evidence / Overview of studies for Xido (Gliclazide)


Evidence for Glycemic Management in Type 2 Diabetes

This section will summarize the structure of the main clinical evaluation for Gliclazide, detailing the type of randomized controlled trials (RCTs) and meta-analyses that examined its use for the measurement of blood sugar status ( HbA1c) in adults with Type 2 Diabetes Mellitus.

The primary way researchers have studied Gliclazide is through Randomized Controlled Trials (RCTs) and comprehensive meta-analyses. These studies were generally designed to track the measured outcomes related to key blood sugar markers. The main measurement is Glycated Hemoglobin ( HbA1c), which is a biomarker researchers use to monitor average blood sugar status over a defined time interval. Other monitored outcomes included fasting and after-meal blood glucose levels.

Research so far indicates that studies consistently reported patterns of change in HbA1c measurements among the observed populations. The trials described patterns related to differences in fasting and postprandial glucose measurements when compared to baseline or non-active comparators. These observed changes were generally consistent, and evidence contributes to the broader research landscape for this class of oral agents.


Long-Term Research on Vascular Outcomes

This part will review the major, long-duration clinical trials designed to track the incidence of outcomes related to intensive blood sugar control strategies, which incorporated Gliclazide, on important macrovascular and microvascular outcomes, such as kidney and cardiovascular events.

To explore patient outcomes in long-term studies of Gliclazide, research examined patient outcomes in large, extended-duration RCTs. These studies focused on high-risk adults with Type 2 Diabetes, aged 55 or older. Monitored outcomes included microvascular events (such as new or worsening kidney or eye disease) and macrovascular events (such as heart attack and stroke).

The findings from these trials described that the intensive treatment strategy reported differences in the incidence of microvascular events compared to the standard control strategy. Research examined the incidence of macrovascular events, and the observed measurements were reported in both the intensive strategy group and the standard control group. It remains uncertain to what extent the observed outcomes can be attributed solely to Gliclazide versus the overall intensive management approach used in the studies.


Comparing Xido to Other Medicines

This heading will present a summary of the systematic reviews and comparative studies that placed Gliclazide alongside other oral diabetes medications, focusing on measured differences in the change of blood sugar levels and the reported frequency of low blood sugar events (hypoglycemia).

Research highlights that studies consistently tracked the incidence of severe hypoglycemia (events requiring assistance). Findings indicate that reported rates of this event were monitored across various sulfonylurea agents, with specific patterns described in the Gliclazide arms when compared to certain older agents studied. However, comparative evidence is lacking for a full assessment against all modern, non-sulfonylurea agents.


Evidence for Use in Specific Populations

This section will outline what research exists regarding the use of Gliclazide in specific patient groups, such as older adults or those with various comorbidity profiles, and where the available research is limited or ongoing.

Most evidence is derived from research conducted in the general adult population. Specific studies have examined the response and patterns of use in subgroups like older adults (ge 65 years). Data show patterns related to blood sugar management were observed, and research also described specific protocols for patient monitoring used in the study settings. Data for groups with varying degrees of kidney or liver impairment remain insufficient in dedicated head-to-head trials.

Key Studies & References

  1. Gliclazide (MedlinePlus Drug Information)

Frequently Asked Questions (FAQ)

Common questions about Xido (FAQ)


Q: Do I need to change my diet while taking Xido?

A: Official information emphasizes the need to maintain a regular food intake that includes breakfast. Consistent meal timing is required to manage the risk of hypoglycemia (low blood sugar). Additionally, official sources recognize that weight gain is a potential side effect associated with the class of medicine to which Xido belongs.

Q: Are there any common foods or drinks that interact with Xido?

A: Regulatory documents advise that alcohol increases the risk of a hypoglycemic reaction when consumed with Xido. Official prescribing information indicates that general food intake does not affect the body's absorption of the medicine, but the requirement for consistent meal consumption is officially mandated as a use condition.

Q: Is Xido safe to take with vitamins or herbal supplements?

A: The herbal supplement St. John's Wort is specifically documented to decrease the amount of the drug in the body, and its use is officially cautioned against. For most other herbal remedies or supplements, official sources state there is insufficient information to confirm safety when taken with Xido.

Q: Can Xido affect mental focus or concentration?

A: Regulatory safety documents note that if blood sugar levels drop too low (hypoglycemia), symptoms can include poor concentration, reduced awareness, and slowed reactions. The official product information also notes that some patients may experience transient visual disturbances, especially when treatment is started.

Q: Is it safe to drive or operate machinery while taking Xido?

A: Official guidance includes a specific warning that the ability to drive or operate machinery may be affected. This caution is based on the primary risk of hypoglycemia (low blood sugar), which can impair alertness and reaction time, particularly during the initial phase of treatment.

Q: Is Xido appropriate for someone with a history of heart issues?

A: Severe vascular conditions, such as coronary heart disease, are documented as factors that may increase the risk of severe hypoglycemia in patients taking this medicine. For patients with pre-existing conditions, the safety profile mentions that cardiovascular effects like palpitations have been reported. The regulatory information does not list general heart history as a formal prohibition.

Q: Does Xido cause weight gain or loss?

A: According to official product information, weight gain is a recognized potential side effect associated with medicines in the sulfonylurea class, which is the class Xido belongs to.

Q: How long does it take before Xido starts working?

A: Pharmacokinetic data from regulatory documents indicate that for the Modified-Release formulation, the level of the active ingredient in the bloodstream increases gradually. The concentration in the blood reaches a stable level between six and twelve hours after administration, and the medicine has an elimination half-life of about 16 hours.

Q: Can Xido make you feel tired or dizzy?

A: Regulatory documents confirm that if blood sugar levels drop too low (hypoglycemia), possible symptoms include feeling dizzy, drowsy, or having a lack of energy. These manifestations are directly related to the drug's intended action of lowering blood sugar.

Q: Is Xido safe to use if I have high blood pressure?

A: High blood pressure itself is not listed as a prohibition for using this drug. However, official information notes that certain common high blood pressure medicines, such as ACE Inhibitors and Beta-blockers, are formally documented to increase the glucose-lowering effect of Xido, which increases the risk of low blood sugar.

Q: Why do some people say Xido did not work for them?

A: Regulatory information addresses the long-term effectiveness of the medicine. Official guidance notes that the drug's efficacy can sometimes decrease over an extended period—a concept known as secondary failure. This effect is often related to the natural progression of Type 2 Diabetes Mellitus.

Q: Is Xido considered a controlled substance?

A: The medicine is classified by regulatory agencies as prescription only for the management of Type 2 Diabetes Mellitus. However, it is not classified as a controlled substance in the same manner as narcotics or other drugs that carry a high potential for abuse or dependence.

Q: Does Xido affect sleep patterns?

A: Official product information includes sleep disorders as one of the possible symptoms that can be associated with an episode of low blood sugar (hypoglycemia).

Q: What if I take Xido and still don't feel better?

A: If a patient experiences poor blood glucose control, regulatory guidance suggests that the prescriber may consider a dose adjustment and a reinforcement of dietary measures. The official information also notes that during periods of stress, trauma, or infection, the doctor may temporarily switch the patient to different therapies, such as insulin.

Q: Why is Xido only available with a prescription?

A: Regulatory bodies have classified the medicine as prescription only due to its mechanism of action and the potential safety concern of hypoglycemia (low blood sugar). Its use requires the continuous clinical supervision and adjustment provided by a healthcare professional.

Q: Is Xido known to cause headaches?

A: Official product information lists headache as a possible symptom associated with an episode of low blood sugar (hypoglycemia). Headaches are generally classified as a less frequent adverse reaction.

Q: How often are the side effects of Xido usually mild?

A: Regulatory documents categorize side effects by the likelihood of their occurrence. For instance, gastrointestinal disturbances, such as nausea, vomiting, or abdominal pain, are typically classified as common reactions, meaning they may affect up to 1 in 10 people who use the medication.

Q: Is it true that Xido has been approved in other countries for a long time?

A: The active substance in Xido, Gliclazide, is described in official European regulatory documents as an established active substance. Authorization records for the medicine in countries like the Netherlands date back to August 2010, reflecting its established use.

Q: Is Xido addictive?

A: Regulatory safety information does not classify this medicine as a controlled substance and contains no warnings regarding drug dependence, abuse, or addiction.

Q: Is there a maximum time someone can stay on Xido?

A: Official regulatory documents do not specify a maximum time limit for using Xido. The drug's safety and efficacy are supported by large, extended-duration clinical trials that tracked patient outcomes over long periods.

Q: Will Xido interfere with birth control pills?

A: Official information lists oestrogens and progestogens (active components in many oral contraceptives) as medicines that can adversely affect blood sugar control. The use of these hormones may counteract the drug's effect, necessitating careful consideration of blood sugar measurements.

Q: How quickly can Xido be stopped if a side effect is bothering me?

A: Regulatory guidance documents emphasize that discontinuation must only be done under the supervision of a healthcare professional. Stopping the drug without professional guidance can lead to elevated blood sugar levels, which may be harmful due to the underlying condition.

Q: Are there different brand names for the same drug, Xido?

A: Official regulatory body documentation confirms that the active ingredient, Gliclazide, is manufactured and distributed under multiple brand names. Examples of brand names referenced in official guidance include Diamicron.

Q: What information should I read carefully before starting Xido?

A: Regulatory guidance mandates that the official Patient Information Leaflet or Patient Information Monograph be reviewed. This document contains all the mandated safety and use instructions defined by the official agencies.

How should Xido be stored and disposed of?

Storage and Disposal Instructions for Xido

Storage Requirements

Official labeling requires Xido (Dapagliflozin and Metformin Extended-Release) to be stored at a Controlled Room Temperature, specifically between 20 C and 25 C (68 F to 77 F), with permitted excursions up to 30 C. The medication must be protected from moisture and should be kept in its original container.

Handling and Safety

For stability, the extended-release tablets must not be crushed, cut, or chewed. All medication must be stored out of the reach and sight of children to prevent accidental exposure.

Disposal

Unused or expired Xido should not be disposed of in household trash or poured into wastewater. Regulatory guidance recommends utilizing a local drug take-back program or returning the product to a pharmacy for proper disposal.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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