Xenetic

For adults and children undergoing:

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phlebography

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chest CT-scan

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intra-arterial digital subtraction angiography intravenous urography

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brain or whole-body CT scan

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intravenous digital subtraction angiography

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arteriography

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angiocardiography

300-mgI/mL IV urography Fast inj: 1.2 mL/kg (50-100 mL); slow inj: 1.6 mL/kg (100 mL). CT scan Brain: 1.4 mL/kg (20-100 mL); whole body: 1.9 mL/kg (20-150 mL). IV digital subtraction angiography 1.7 mL/kg (40-270 mL). Arteriography Brain:1.8 mL/kg (42-210 mL); lower limbs: 2.8 mL/kg (85-300 mL). Angiocardiography 1.1 mL/kg (70-125 mL). 350-mgI/mL IV urography 1 mL/kg (50-100 mL). CT scan Brain: 1 mL/kg (40-100 mL); whole body: 1.8 mL/kg (90-180 mL). IV digital subtraction angiography 2.1 mL/kg (95-250 mL). Arteriography Peripheral: 2.2 mL/kg (105-205 mL); lower limbs: 1.8 mL/kg (80-190 mL); abdominal 3.6 mL/kg (155-330 mL). Angiocardiography Adult 1.9 mL/kg (65-270 mL). Childn 4.6 mL/kg (10-130 mL).

is contraindicated in patients hypersensitive to the product.

A history of sensitivity to iodine contraindicates the use of this contrast

In the absence of specific studies, Xenetic is not indicated for myelography

Diuretics: In the event of dehydration induced by diuretics, there is an increased risk of acute kidney failure, in particular when high doses of iodinated contrast media are administered.

The subject should be rehydrated before the iodinated contrast medium is administered.

Metformin: Lactic acidosis was induced by functional kidney failure related to radiological investigation of a subject with diabetes mellitus.

Metformin treatment must be withdrawn 48 hours before the examination and only reinstituted 2 days after the examination

Beta-adrenergic blocking agents: Concurrent intravascular administration with beta-adrenergic

blocking agents may increase the risk of moderate to severe anaphylactoid reaction; also hypotensive effects may be exacerbated; discontinuation of the beta-adrenergic blocking agent

may be advisable before administration of contrast media in patients with other risk factors.

Benign reactions may occur: feeling of hotness, very rarely nausea, vomiting and redness of

the skin. These reactions are transient and devoid of clinical consequences.

More serious manifestations are possible. Reactions may occur as an isolated disorder or

combination of disorders: cutaneous, respiratory, neurosensory, gastrointestinal and

cardiovascular disorders. The latter may consist of cardiovascular collapse of variable severity. Exceptionally, shock and/or circulatory arrest may occur.