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Xefo 8 Mg

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Name of the medicinal product
Qualitative and quantitative composition
Therapeutic indications
Dosage (Posology) and method of administration
Contraindications
Special warnings and precautions for use
Interaction with other medicinal products and other forms of interaction
Undesirable effects

Components:

Lornoxicam

Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 26.06.2023

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Name of the medicinal product
Xefo 8 Mg
Qualitative and quantitative composition

Xefo 8 Mg (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and antipyretic properties. Xefo 8 Mg differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug. Xefo 8 Mg is approved for use in Japan.

Therapeutic indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Xefo 8 Mg is used to treat acute mild to moderate pain, and to treat pain and inflammation of the joints caused by certain types of rheumatic diseases.

Dosage (Posology) and method of administration

Oral

Pain relief

Adult: 8-16 mg daily. Max: 24 mg daily.

Oral

Osteoarthritis; Rheumatoid arthritis

Adult: 12 mg daily in 2-3 divided doses, up to 16 mg daily if needed.

Parenteral

Pain relief

Adult: 8 mg once or twice daily by IM/IV inj. Max: 24 mg daily.

Contraindications

It is contra-indicated in the following groups of patients those allergic to Xefo 8 Mg, or any of its excipients

Special warnings and precautions for use
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Xefo 8 Mg is used in short-term treatment of pain after dental surgery, pain associated with acute sciatica and pain and inflammation in osteoarthritis and rheumatoid arthritis.

Interaction with other medicinal products and other forms of interaction

Increased Xefo 8 Mg blood conc when given concomitantly with cimetidine. Enhanced effects of anticoagulants, sulfonylureas, methotrexate, ciclosporin, digoxin. Decreased effects of diuretics, ACE inhibitors.

Potentially Fatal: Increased risk of lithium toxicity.

Undesirable effects

General : Headache, dizziness, somnolence, changes in appetite, increased sweating, loss of weight, oedema, allergic reactions, debility, weight increase.

Central nervous system (CNS): Depression, insomnia.

Eyes : Conjunctivitis, vision disorders.

Gastro-intestinal: Abdominal pain, diarrhoea, dyspepsia, nausea, vomiting, flatulence, dysphagia, constipation, gastritis, dry mouth, stomatitis, gastro-esophageal reflux, peptic ulceration with or without bleeding, esophagitis, haemorrhoidal or rectal bleeding.

Haematological : Anemia, ecchymosis, prolonged bleeding time, thrombocytopenia

Liver: Increased transaminases.

Musculo-skeletal: Cramps in leg, myalgia.

Neurological : Migraine, paraesthesia, taste perversion, tinnitus and tremor.

Respiratory : Dyspnoea, symptoms of irritation in upper respiratory tract.

Skin: Allergic skin reactions such as dermatitis, flushing and pruritis, loss of hair.

Urogenital : Micturition disorders.

Vascular : Palpitations, tachycardia, changes in blood pressure.

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