Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 2020-04-05
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Sterilised Water for injections bufus is indicated to be used as a vehicle for dilution and reconstitution of suitable medicinal products for parenteral administration.
The dosage administered will be dictated by the nature of the additive used. The administration rate will be dependent upon the dose regimen of the prescribed drug.
Following suitable admixture of prescribed additives, the dosage is usually dependent upon the age, weight and clinical condition of the patient as well as laboratory determinations.
The solution should only be used if it is clear without visible particles.
Method of administration
For parenteral use.
The directions for use will be dependent upon the appropriate medicinal product to which this solvent is added, which will dictate the appropriate volumes as well as administration route.
Sterilised Water for injections bufus should not be administered alone because it may cause haemolysis. The contraindications related to the added medicinal product should be considered.
Water for injections bufus is hypotonic and it should not be administered alone, because it may cause haemolysis.
May cause haemolysis if administered alone.
The nature of the additive will determine the likelihood of any other undesirable effects.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the MHRA Yellow Card Scheme: Tel: Freephone 0808 100 3352. Website: www.mhra.gov.uk/yellowcard
No effects are anticipated if used as instructed.
Haemolysis may occur following infusion of large volumes of hypotonic solutions using sterile Water for injections bufus as diluent.
The signs and symptoms of overdose will also be related to the nature of the medicinal product being added. In the event of accidental overdose, the treatment should be discontinued and the patient should be observed for the appropriate signs and symptoms related to the medicinal product administered.
Pharmacotherapeutic Group: Solvents and diluting agents, including irrigating solutions, ATC code: V07AB.
Sterilised Water for injections bufus being only the vehicle for the administration of the added medicinal product, the pharmacodynamics will depend on the nature of the drug added.
Sterilised Water for injections bufus being only the vehicle for the administration of the added medicinal product, the pharmacokinetics will depend on the nature of the drug added.
Sterilised Water for injections bufus being only the vehicle for the administration of the added medicinal product, the preclinical safety data will depend on the nature of the drug added.
Sterilised Water for injections bufus must not be mixed with other medicinal products unless their compatibility has been established.
For single use.
Any unused product or waste material should be disposed of in accordance with local requirements.
Keep out of sight and reach of children.