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Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 18.03.2022
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Vismodegib is used for treating locally advanced or metastatic basal cell carcinoma in patients whose carcinoma has recurred after surgery, and in patients who are not candidates for surgery or radiation. (locally advanced Basal cell carcinoma; metastatic Basal cell carcinoma;)
Vismodegib (Vismodegib) is a cancer medicine that interferes with the growth of certain cancer cells in the body.
Vismodegib is used to treat basal cell carcinoma that has spread to other parts of the body.
Vismodegib may also be used for purposes not listed in this medication guide.
The recommended dose of Vismodegib is 150 mg taken orally once daily until disease progression or until unacceptable toxicity.
Vismodegib may be taken with or without food. Swallow capsules whole. Do not open or crush capsules.
If a dose of Vismodegib is missed, do not make up that dose; resume dosing with the next scheduled dose.
How supplied
Dosage Forms And Strengths
Vismodegib (Vismodegib) capsules, 150 mg. The capsule has a pink opaque body and a grey opaque cap, with “150 mg” printed on the capsule body and “VISMO” printed on the capsule cap in black ink.
Storage And Handling
Each Vismodegib (Vismodegib) capsule has a pink opaque body and a grey opaque cap with “150 mg” printed on the capsule body and “VISMO” printed on the capsule cap in black ink. Vismodegib capsules are available in bottles of 28 capsules (NDC 50242-140-01).
Store at room temperature 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F).
Manufactured by: Patheon, Inc. Mississauga, Canada. Distributed by: Genentech USA, Inc. A Member of the Roche Group 1 DNA Way South San Francisco, CA 94080-4990. Revised: May 2015
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What is the most important information I should know about Vismodegib?
Do not take this medication if you are pregnant. Vismodegib can cause severe birth defects or death of a baby if the mother or the father is taking this medication at the time of conception or during pregnancy. You must use an effective form of birth control to prevent pregnancy while you are taking Vismodegib, whether you are a man or a woman. Vismodegib use by either parent may cause birth defects.
If you are pregnant and your sexual partner is taking Vismodegib, do not have sex without using a latex condom and spermicide. Continue using condoms and spermicide for at least 2 months after your partner stops taking Vismodegib.
For Women: Use effective birth control while taking Vismodegib and for at least 7 months after your treatment ends. Call your doctor at once if you quit using birth control, if your period is late, or if you think you might be pregnant.
For Men:Always use a latex condom and spermicide when having sex, even if you have had a vasectomy. Continue using condoms and spermicide for at least 2 months after you stop taking Vismodegib.
Call your doctor at once if a pregnancy occurs while either sexual partner is taking Vismodegib.
Use Vismodegib as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Vismodegib comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Vismodegib refilled.
- Take Vismodegib by mouth with or without food.
- Swallow Vismodegib whole. Do not open, break, crush, or chew before swallowing.
- If you miss a dose of Vismodegib, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Vismodegib.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled Indications
Basal cell carcinoma, metastatic or locally advanced: Treatment of metastatic basal cell carcinoma, or locally-advanced basal cell carcinoma that has recurred following surgery or in adult patients who are not candidates for surgery and not candidates for radiation therapy
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What other drugs will affect Vismodegib?
Clinically relevant pharmacokinetic interactions are not expected between Vismodegib and a substrate, inducer or inhibitor of cytochrome 450 enzymes or an inhibitor of P-glycoprotein (P-gp) or between Vismodegib and gastric pH elevating agents.
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What are the possible side effects of Vismodegib?
Applies to Vismodegib: oral capsule
In addition to its needed effects, some unwanted effects may be caused by Vismodegib (the active ingredient contained in Vismodegib). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Vismodegib:
Less common:
- Bloody or cloudy urine
- coma
- confusion
- convulsions
- decreased urine output
- dizziness
- dry mouth
- fast or irregular heartbeat
- headache
- increased thirst
- muscle pain or cramps
- nausea or vomiting
- pain in the lower back or side
- shortness of breath
- swelling of the face, ankles, or hands
- thirst
- unusual tiredness or weakness
Minor Side Effects
Some of the side effects that can occur with Vismodegib may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
More common:
- Absent, missed, or irregular menstrual periods
- change in taste
- decreased appetite
- diarrhea
- difficulty having a bowel movement (stool)
- difficulty with moving
- hair loss or thinning of the hair
- loss of taste
- muscle spasm or stiffness
- pain in the joints
- stopping of menstrual bleeding
- weight loss
Vismodegib inhibits the hedgehog signalling pathway and is indicated for treatment of adult basal cell carcinoma. FDA approved on Jan 30, 2012.