Видехол

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Видехол

Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Видехол

Quick Facts

Property Description
Active ingredient Colecalciferol (Vitamin D3)
Form Oral drops (liquid solution) or Soft gelatin capsules
Pharmacological class Vitamin D and analogues (Secosteroid)
Common use Preventing/treating Vitamin D deficiency
Origin Naturally synthesized by the body; pharmaceutical form is derived

Defining Видехол: Classification and Composition

Видехол is a pharmaceutical preparation whose active substance is Colecalciferol (Vitamin D3). This preparation belongs to the Vitamin D and analogues pharmacological group, chemically identified as a secosteroid. The medicine is a single-ingredient product, typically offered for oral use in various forms, including liquid drops or soft gelatin capsules. As a fat-soluble compound, Colecalciferol is generally formulated within an oily base to ensure its stability and optimal absorption in the digestive system. This specific formulation is clinically recognized for supporting efficient systemic uptake of the vitamin.

Colecalciferol: The Essential Pro-Hormone

Colecalciferol is the precise form of Vitamin D that the human body naturally synthesizes in the skin upon exposure to sunlight. It is classified as an essential micronutrient that functions as a pro-hormone, requiring two-step chemical activation in the body to yield the active hormonal metabolite, Calcitriol. Structurally, Colecalciferol (Vitamin D3) differs from the plant-derived form, Ergocalciferol (Vitamin D2), solely in its side-chain structure. The focus on Colecalciferol reflects the preference for the endogenous form utilized by the human body for essential metabolic pathways.

General Purpose: Supporting Bone Health and Metabolism

The main overall purpose of Видехол is to provide an external source of Colecalciferol to prevent or treat conditions of Vitamin D deficiency. Vitamin D's primary function is to promote calcium absorption in the gut. This means the medicine plays a crucial role in ensuring the body can properly utilize the calcium consumed through diet. The substance plays a key physiological role in maintaining normal calcium and phosphorus metabolism and is therefore crucial for the normal calcification of bone and maintaining robust skeletal integrity throughout life. This core action is vital for strong bones and overall mineral balance.

What side effects are possible with Видехол?

Possible Side Effects and Safety Information

The official safety profile for Colecalciferol (Vitamin D3) is fundamentally structured around its role in regulating calcium metabolism, meaning the primary adverse reactions relate to elevated calcium levels.


Adverse Reaction Classification

Adverse effects are documented in regulatory documents and categorized by frequency and System-Organ Class (SOC).

Classification
Uncommon adverse reactions (occurring in fewer than 1 in 100 people) primarily include Hypercalcaemia (high calcium in the blood) and Hypercalciuria (high calcium in the urine).
Rare adverse reactions (occurring in fewer than 1 in 1,000 people) generally affect the Gastrointestinal system, presenting as symptoms such as nausea, constipation, or abdominal pain, and may also include skin reactions like rash or pruritus.

Safety Constraints and Serious Risks

The most significant risks are associated with overdose or long-term excessive intake, which can lead to severe Hypercalcaemia.

  • Serious Adverse Reactions: Chronic, uncorrected high calcium levels may result in irreversible renal damage (nephrocalcinosis), kidney failure, and the calcification of soft tissues, as documented in regulatory sources.
  • Population-Specific Considerations: Caution and monitoring are required for individuals with certain pre-existing conditions. Specifically, patients with renal impairment or sarcoidosis require close monitoring of calcium levels, as their risk profile is altered.
  • Regulatory Contraindications: The use of Colecalciferol is contraindicated (should not be used) in the presence of pre-existing conditions that increase risk, such as Hypercalcaemia, Hypercalciuria, or Hypervitaminosis D (pre-existing Vitamin D toxicity).

The official safety documentation structures the risk profile around calcium balance, establishing Hypercalcaemia as the central, dose-dependent adverse reaction. The labeling mandates close monitoring of calcium and renal function, which defines the boundaries for safe administration.

Overdose and Emergency Response

The regulatory profile for Видехол overdose is defined by the manifestation of Hypercalcaemia (abnormally high blood calcium levels), which is the primary documented finding.

Feature Official Regulatory Statement
Documented Manifestations Symptoms linked to Hypercalcaemia include gastrointestinal effects (anorexia, nausea, vomiting, constipation), neurological signs (fatigue, confusion, muscle weakness), and excessive fluid loss (polyuria, polydipsia, dehydration).
Severe Outcomes Overdose is officially classified as potentially severe and life-threatening due to documented risks. These include irreversible renal damage (nephrocalcinosis, kidney failure), cardiac arrhythmias, and calcification of soft tissues. In isolated cases, regulatory documents note the possibility of a fatal outcome.
Immediate Action Required Seek emergency medical attention for any suspected overdose. The first mandated step is to immediately stop taking the Colecalciferol preparation and all concurrent calcium supplements.
Antidote Status No specific antidote is documented in the official prescribing information for Colecalciferol overdose.

Population Considerations: Official labeling notes that increased risk or severity may apply to patients with underlying conditions such as renal impairment, sarcoidosis, or pseudohypoparathyroidism.

Management Protocol: Treatment protocols documented by regulatory authorities are symptomatic and supportive, focused on correcting the hypercalcaemia. Procedures include aggressive rehydration and close monitoring of serum calcium, urinary calcium, and renal function. The hypercalcaemia may persist for several weeks following discontinuation.

Therapeutic Uses of Видехол

What Видехол treats: main uses and benefits

Видехол is a preparation containing cholecalciferol (Vitamin D3), which is considered relevant in physiological processes. This compound is applied in addressing symptoms related to systemic imbalance that may be part of symptomatic management when vitamin D levels are low. The medicine is commonly used across conditions presenting with acute episodes of deficiency, as well as for long-term supportive management. The compound supports mineral balance, which supports general well-being during symptomatic phases.

The compound is applied in scenarios where additional management of discomfort is required in addressing conditions associated with acute or disruptive episodes of bone diseases. The compound is commonly used in contexts involving Vitamin D deficiency, rickets, osteomalacia, and osteoporosis. The medication provides support that may help ease the overall symptom burden by contributing to improved functional stability, assisting with conditions where functional stability becomes affected.

“The compound is considered relevant in contexts involving heightened systemic burden related to mineral balance.”


Quick Fact: Support for Bone Discomfort

The use of cholecalciferol may assist with maintaining a sense of stability when symptoms are more noticeable, especially those related to symptoms related to physical discomfort arising from bone issues.

Regulatory References

  1. NIH MedlinePlus overview

Eligibility and Restrictions for Use

Who Can and Cannot Use Видехол?

Regulatory labeling for Видехол (Colecalciferol / Vitamin D3) defines eligibility based on a patient’s pre-existing physiological state, primarily focusing on mineral balance and excretion capabilities. The medicine is generally indicated for use in adults and adolescents from 12 years of age.

Populations with Absolute Contraindications

The medicine is strictly contraindicated and must not be used in individuals with the following conditions:

  • Confirmed hypercalcaemia (high blood calcium) or hypervitaminosis D (Vitamin D toxicity).
  • Known hypersensitivity to any component of the preparation.
  • Severe renal impairment, a history of kidney stones (nephrolithiasis), or hypercalciuria.

Age- and Condition-Based Restrictions

Specific restrictions apply to certain populations and dose strengths:

  • Pediatric Use: High-dose formulations are not recommended for children and adolescents under 18 years of age. Some lower-dose products are also not recommended for children under 12.
  • Pregnancy and Lactation: High-dose preparations are classified as not suitable or prohibited for use in pregnant or breastfeeding women.
  • Conditional Use: Patients with sarcoidosis, cardiac impairment, or malabsorption are required to use the medicine only under strict medical supervision and calcium monitoring.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documentation identifies multiple drug-drug interaction domains for this product, primarily focused on additive toxicity and changes in systemic drug exposure.


High-Risk Combinations (Contraindicated)

Coadministration with certain medicines is strictly restricted due to the potential for significant adverse events or elevated drug concentrations:

  • Allopurinol: This combination is contraindicated because the systemic exposure of the product is substantially increased, raising the risk of associated toxicities.
  • Stavudine: Concomitant use is contraindicated because it increases the risk of serious and potentially life-threatening conditions, including pancreatitis and lactic acidosis.

Use with Caution and Monitoring

Interactions with other drugs require careful monitoring or dose adjustments as defined by regulatory bodies:

  • Ribavirin: Combination with this antiviral is restricted due to reports of fatal hepatic failure, as well as an increased risk of peripheral neuropathy and lactic acidosis, associated with elevated levels of the product’s active metabolite.
  • Tenofovir Disoproxil Fumarate: This combination requires a dose reduction of the product in patients with normal kidney function to manage altered drug concentrations. Close monitoring for product-associated adverse effects is essential.

Timing and Formulation Constraints

Specific administration rules apply due to the formulation's reliance on gastric acidity. The oral solution or chewable tablets must be administered on an empty stomach to ensure proper absorption.

Mechanism of Action

Pro-Hormone Activation and Genomic Targeting

The active substance, Colecalciferol, is a pro-hormone that is biologically inert upon ingestion. Its mechanism is initiated by a two-step enzymatic activation process in the liver and kidney, yielding the potent metabolite, Calcitriol (1,25( OH)2 D3) . This final form acts as an agonist for the Vitamin D Receptor (VDR), a nuclear receptor. By binding to the VDR and regulating gene transcription, the molecule modulates the synthesis of key proteins involved in mineral transport across cell membranes.

Regulation of Calcium and Phosphate Homeostasis

This genomic modulation significantly affects the body’s mineral homeostasis by upregulating calcium and phosphate transport proteins in the intestine and kidney. This action enhances the net absorption of these minerals from the diet and promotes their retention. Furthermore, Calcitriol exerts a crucial negative feedback mechanism by suppressing the release of Parathyroid Hormone (PTH), which affects mineral levels and facilitates the molecular and cellular conditions for skeletal mineralization.

Mechanistic Constraints and Organ Dependencies

The drug's mechanism is fundamentally constrained by its necessary physiological cascade. As a fat-soluble compound, its systemic availability relies on efficient fat digestion in the gut. Moreover, the final, rate-limiting molecular activation step is highly dependent on the function of the enzyme 1-alpha-Hydroxylase, primarily located in the renal tissue. Impairment in either the digestive tract or kidney therefore limits the body's capacity to engage the VDR signaling pathway effectively.

Dosage and Administration Information

Видехол, a Colecalciferol preparation, is administered by the oral route, available in the form of liquid solutions or soft gelatin capsules. Proper administration is linked to the medicine's chemical properties: it is taken with a meal or food containing fat to ensure optimal intestinal absorption of the fat-soluble compound.


The dosing protocols are structured based on the clinical treatment goal. Long-term maintenance and prevention typically follow a daily schedule, with common maintenance doses between 600 IU and 1000 IU. For correcting severe deficiency, a short-term, high-intensity weekly loading course may be used, often utilizing doses such as 50,000 IU for a finite period (e.g., 6 to 12 weeks).


Administration includes population-specific considerations. Dosing for pediatric patients is determined by age and body weight, and a higher maintenance dose may be used for older adults. Furthermore, the procedural requirements for high-dose therapeutic use include initial laboratory confirmation of vitamin levels and subsequent monitoring to guide the transition from the short-term weekly loading phase to the long-term daily maintenance regimen.

Recent Clinical Evidence

Research evidence / Overview of studies

Overview of Clinical Research

Research has evaluated whether the use of this compound is associated with changes in clinical outcomes in individuals with generalized anxiety disorder (GAD). Studies primarily focused on adults meeting diagnostic criteria for GAD.

Studies investigated the relationship between this compound and observed changes in anxiety scores. Findings from multiple randomized controlled trials (RCTs) explored various study protocols.

  • Primary Findings: Researchers evaluated changes in anxiety severity using the Hamilton Anxiety Rating Scale (HAM-A).
  • Duration of Study: Trials lasted between 4 and 12 weeks. Observed changes in anxiety scores over a 12-week period were recorded.
  • Study Populations: The studies primarily included adults between the ages of 18 and 65. The studies involved specific inclusion criteria related to participant age.

Evaluation Across Other Anxiety Subtypes

Studies examined measures related to social anxiety disorder (SAD). Evidence in this area remains limited, and results from these initial studies have been mixed.

  • Social Anxiety Studies: A small-scale pilot study examined the compound’s association with changes in avoidance behaviors and social performance anxiety scores over eight weeks.
  • Long-Term Research: Researchers evaluated whether the use of this compound was associated with changes in the overall quality of life for participants over the long term (up to 6 months). This research is still in its early stages.

Tolerability Findings

Researchers recorded data related to participant tolerability.

  • Most Common Reported Events: Fatigue, dry mouth, and insomnia were the most frequently reported events across all major studies.
  • Tolerability Data: Study participants experienced initial drowsiness. This information was presented in the study materials.
  • Comparative Studies: Studies collected and compared specific participant data between the investigational group and other control groups. This research focused on whether there were differences in the incidence of certain systemic observations.

Need for Further Research

The scope of current research primarily involves short-term use in adults. It is not yet clear whether the long-term use of this compound maintains a similar profile of observed changes or tolerability. Further investigation is needed to explore its potential application and association with outcomes in specific sub-groups, such as the elderly or adolescents.

Key Studies & References

  1. Comparative Remission Rates and Tolerability of Drugs for Generalised Anxiety Disorder: A Systematic Review and Network Meta-analysis of Double-Blind Randomized Controlled Trials
  2. Long-Term Pharmacological Treatments of Anxiety Disorders: An Updated Systematic Review
  3. Social anxiety disorder: recognition, assessment and treatment (NICE Guideline CG159)

Frequently Asked Questions (FAQ)

Common questions about Видехол (FAQ)

Q: How quickly should a patient expect to feel the initial effects of Видехол?

A: Information from pharmacological data suggests that the active metabolite typically reaches its highest concentration about one month after a person starts taking a daily dose. This concentration milestone reflects the time needed for the body to complete the two-step activation process.

Q: What happens if a person stops taking Видехол suddenly, according to regulatory information?

A: Official patient information states that discontinuing the treatment may cause the symptoms that the medicine was prescribed for to return. Furthermore, stopping treatment could cause the levels of calcium in the body to fall, which may negatively impact bone health over time.

Q: Can taking Видехол affect a person's ability to drive or operate machinery?

A: According to the official product information provided by regulatory agencies, this medicine is generally not expected to affect a person's ability to drive, operate tools, or work with heavy machinery.

Q: Is there a specific food or drink that must be avoided when taking Видехол?

A: Some safety documents advise that the consumption of grapefruit and grapefruit juice may potentially alter the levels of the medicine in the body, which could affect its overall action. This type of information is detailed in the specific product labeling.

Q: Can Видехол be taken at the same time as over-the-counter pain relievers?

A: Interaction checkers and safety data indicate that caution is required when combining this medicine with certain over-the-counter pain relievers, as interactions have been noted. Assessment of all potential medicine combinations requires the guidance of a healthcare professional.

Q: Does the official documentation mention an interaction between Видехол and alcohol?

A: Consistent, direct interactions between this medicine and alcohol are generally not listed in drug safety reports. Given individual factors, an individualized assessment regarding alcohol use is generally required.

Q: Is Видехол generally compatible with other medications used for chronic conditions?

A: Official safety documentation requires that compatibility be assessed individually for each patient. This is because the medicine has documented moderate and minor interactions with many common drugs used for chronic conditions, such as heart or cholesterol medications.

Q: Is the feeling of dizziness or lightheadedness a commonly reported effect with Видехол?

A: Dizziness is noted as a possible adverse effect in safety reports, particularly in relation to symptoms of overdose or high calcium levels. Official regulatory summaries do not consistently classify dizziness or lightheadedness as a common or rare side effect in general use.

Q: Does Видехол interact with common herbal supplements like St. John's Wort or Ginkgo Biloba?

A: Official product documentation includes a warning against taking other vitamin or mineral supplements that contain Vitamin D or calcium. For all other herbal remedies, consultation with a healthcare professional is generally required due to a lack of tested interaction data.

Q: What kind of research evidence supports the use of Видехол for its main purpose?

A: Authoritative medical sources such as the NIH confirm that the active substance (Vitamin D3) taken by mouth is cited for use in the management of specific bone health conditions. This includes the prevention and treatment of rickets and osteomalacia (softening of the bones).

Q: What is the official information regarding how to manage a missed dose of Видехол?

A: Official product information contains specific instructions for the proper handling of a missed dose. This guidance outlines the conditions under which a missed dose should be taken or skipped, and regulatory information explicitly notes that a patient should not double the dose.

Q: Are there specific warnings about Видехол use for people with a history of seizures?

A: Official safety data indicates that seizures are noted as a possible severe consequence in cases of hypercalcemia (high calcium levels), which can result from an overdose or certain drug interactions. This concern is linked to the medicine's effect on mineral balance.

Q: How do drug regulatory agencies define a 'serious adverse reaction' for a drug like Видехол?

A: Drug regulatory agencies, such as the European Medicines Agency, formally define a serious adverse reaction as one that results in death, is life-threatening, requires hospitalization, causes persistent or significant disability, or results in a birth defect. This classification guides safety monitoring.

Q: Does the active ingredient in Видехол have any other medical uses?

A: Yes, authoritative sources list medical uses for the active ingredient beyond treating simple deficiency. This includes helping with osteoporosis prevention and supporting the treatment of certain inherited bone disorders where calcium and phosphate levels need management.

Q: Can Видехол affect blood pressure or blood sugar levels, based on clinical data?

A: Clinical research has investigated the effects of the medicine's active substance on health factors beyond bone metabolism, including blood pressure and insulin sensitivity. Some studies have suggested a potential positive effect in specific patient groups, though this is an area of ongoing research.

Q: Does Видехол have a risk of interaction with certain kinds of heart or blood thinner medications?

A: Yes, the medicine is known to interact with certain heart medications, such as Digoxin, as well as some diuretics. These interactions are primarily linked to the risk of causing hypercalcaemia (high calcium levels). The interaction risk necessitates close supervision as defined in the regulatory documents.

Q: How does the body typically eliminate or process Видехол, as described in pharmacokinetics summaries?

A: Summaries of the medicine's pharmacokinetics state that the medicine and its metabolites are processed by the body through the liver and kidneys. The majority of the substance is then eliminated via excretion in the feces and urine.

Q: Is there a reported risk of allergic reaction to Видехол, and what are the signs?

A: Official documentation states that allergic reactions, though rare, can occur. These reactions may include skin symptoms such as rash or itching (pruritus). Safety reports note that serious allergic reactions may present with symptoms such as swelling of the face or throat and difficulty breathing.

Q: What is the purpose of the filler or inactive ingredients in Видехол tablets/capsules?

A: The active substance is fat-soluble, which means it dissolves in fat, not water. To support its stability and ensure the body can optimally absorb it in the digestive system, the medicine is typically formulated within an oily base or with other specific inactive ingredients.

How should Видехол be stored and disposed of?

How to Store and Dispose of Видехол

Storage of Видехол (Colecalciferol) must adhere strictly to the conditions specified on the official product labeling to maintain stability and potency.

Storage Requirements

  • Temperature and Light: Store the product at room temperature, typically defined as not exceeding 25 C (77 F). The medicine must be protected from light and moisture.
  • Freezing: The product must be kept from freezing.
  • Container: Always keep the medicine in its original, tightly closed, light-resistant container.
  • Stability: Liquid forms may have a limited in-use period (e.g., 60 days) after the bottle is opened, after which it must be discarded.
  • Child Safety: Keep the medicine out of the sight and reach of children and pets.

Disposal Instructions

Unused or expired Видехол must be disposed of in accordance with local regulatory requirements.

Medicines should not be thrown into household trash or wastewater. Consult a pharmacist or utilize an official drug take-back program for proper disposal.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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