Valocordin

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Valocordin

Method of action: Calming

Treatment option:

Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Valocordin

Quick Facts

Property Description
Active ingredient Ethyl alpha-bromoisovalerate, Phenobarbital
Form Oral solution (Liquid drops)
Pharmacological class Combined central nervous system (CNS) depressant
Common use Relief of nervous tension and excitability
Origin Synthetic and semi-synthetic derivatives

What Type of Medicine is Valocordin?

Valocordin is fundamentally classified as a combined central nervous system (CNS) depressant, which utilizes a dual-component approach to function as both a sedative and a mild spasmolytic preparation. The medicine is exclusively provided as an oral solution in the distinct form of liquid drops for oral intake. This specific format is a differentiating feature, allowing for flexible, drop-by-drop administration, contrasting with fixed-dose tablets. Its structure as a multi-component formulation is key, providing a broader, balanced sedative effect than typically seen with single-ingredient medications.

Composition: Ethyl alpha-bromoisovalerate and Phenobarbital

The core composition is defined by the synergistic action of Ethyl alpha-bromoisovalerate and Phenobarbital, which is a low-dose derivative of the barbituric acid class. Phenobarbital, classified as a potent barbiturate, is globally recognized for its established sedative properties and its role in modulating central nervous system activity. Valocordin's preparation is of synthetic and semi-synthetic origin, with the active compounds dissolved in a hydro-alcoholic solution, often featuring auxiliary ingredients like peppermint oil to enhance palatability and provide minor complementary effects.

General Purpose and Sedative Action

The primary purpose of Valocordin is to provide reliable relief from heightened nervous tension and general psychic excitability, which is clinically recognized as beneficial in managing non-pathological anxiety and restlessness. This action helps individuals stabilize their emotional state and mitigate symptoms such as persistent irritability. Furthermore, by gently dampening CNS activity, the medication supports the natural process of sleep onset when difficulty falling asleep is directly linked to underlying nervous agitation. This makes it a functional aid for sleep initiation, particularly in individuals with stress-related conditions.

What side effects are possible with Valocordin?

Possible Side Effects and Safety Information

The officially documented safety profile for Valocordin, containing Ethyl alpha-bromoisovalerate and Phenobarbital, is structured around adverse reactions that chiefly involve the central nervous system (CNS) and are primarily associated with the barbiturate component.

Frequency-Classified Adverse Reactions

Classification Key Effects Documented in Regulatory Sources
Common Drowsiness, residual sedation (hangover effect), dizziness, and general fatigue. These effects are often more noticeable at the beginning of treatment.
Rare Severe dermatologic reactions, including Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), blood dyscrasias, and signs of hepatic dysfunction.

Serious Regulatory Safety Concerns

Official labeling recognizes the potential for physical and psychological dependence and withdrawal symptoms associated with the Phenobarbital content. Severe, life-threatening respiratory depression is a serious, documented risk, particularly in cases of co-administration with other CNS depressants. Adverse reactions are formally categorized across System-Organ Classes, including Nervous System, Skin, Gastrointestinal, and Hepatobiliary disorders.

Population and Exposure Constraints

Safety notes specify that older adults are more susceptible to CNS side effects such as confusion and sedation. The preparation is generally contraindicated in patients with marked severe hepatic impairment, severe respiratory dysfunction, pregnancy, and during lactation. The risks of tolerance and severe long-term effects like bromism and blood dyscrasias are explicitly linked to prolonged, continuous exposure to the medication. The safety information strictly defines the potential risks without offering instructions or clinical guidance.

Overdose and Emergency Response

Overdose and when to seek help

Overdose with Valocordin, primarily due to its Phenobarbital content, is considered a serious medical emergency and is potentially life-threatening. The clinical manifestations are directly related to the central nervous system (CNS) depressant effects of the barbiturate component.

Documented Manifestations and Severe Outcomes

Symptoms of overdose typically begin as a spectrum of CNS depression, including significant drowsiness, confusion, slurred speech, and uncoordinated movement (ataxia). In severe cases, documented outcomes include progression to stupor or coma, as well as profound respiratory depression (difficulty breathing or cessation of breathing) and severe hypotension (very low blood pressure) leading to circulatory collapse.

Emergency Actions and Required Medical Attention

Immediate emergency medical attention is required for any suspected overdose.

Call the local emergency number or Poison Control Center immediately if the individual has taken an excessive amount of the medicine. Urgent medical help must be sought if the individual:

  • Cannot be awakened or is extremely tired.
  • Has serious trouble breathing or stops breathing.
  • Has a seizure or collapses.

Management and Treatment

Management of a Valocordin overdose is primarily supportive, focusing on maintaining adequate airway, breathing, and circulation (ABC). No specific pharmacological antidote is available for barbiturate toxicity. Depending on the severity and time of ingestion, supportive measures may include the use of activated charcoal or, in rare, extreme cases, procedures like hemodialysis to enhance drug removal from the body.

Therapeutic Uses of Valocordin

What Valocordin Treats: Main Uses and Benefits

Valocordin is generally relevant across therapeutic domains involving symptoms related to heightened physiological activity and increased discomfort or tension. The preparation is commonly used as a sedative for the relief of anxiety, tension, and apprehension.

The medication helps address symptom clusters that may become intense or disruptive, including nervous tension, general psychic excitability, restlessness, persistent irritability, and temporary sleeplessness when linked to nervous agitation. It is commonly applied in situations requiring supportive symptom management, particularly when manifestations interfere with daily comfort. The medication is also relevant for managing certain functional somatic symptoms, such as non-acute cardialgia (heart region discomfort) and mild spastic conditions like gastrointestinal cramping. In all these contexts, the medication provides support that helps ease the overall symptom burden.


Quick Fact: Symptomatic Support Description
Primary Focus Symptomatic relief of nervous tension and excitability.
Sleep Support Helps with sleep initiation when difficulties are stress-related.
Somatic Use Assists with managing symptoms of functional disturbances like mild cardialgia and spasm.

Regulatory References

  1. commonly used as a sedative for the relief of anxiety, tension, and apprehension

Eligibility and Restrictions for Use

Valocordin is generally intended for adults experiencing functional disorders of the cardiovascular system, neuroses accompanied by irritability, anxiety, and fear, as well as insomnia or states of increased excitability with pronounced vegetative reactions.

Contraindications

Due to its ingredients, including Phenobarbital and Ethylbromisovalerianate, Valocordin is contraindicated in several conditions. Patients must not use this medication if they have:

  • Hypersensitivity or allergy to any of its components, including bromides.
  • Severe liver or kidney impairment.
  • Severe respiratory diseases (respiratory insufficiency).
  • Alcoholism or a history of drug dependence, due to the risk of drug dependence associated with Phenobarbital.
  • Porphyria (a group of liver disorders).
  • Pregnancy and breastfeeding, as Phenobarbital can cross the placenta and pass into breast milk.

Special Precautions (Use with Caution)

Consultation with a healthcare professional is crucial before use for individuals with:

  • Hypotension (low blood pressure).
  • Acute pain, as the medication may mask symptoms.
  • Concurrent use with other central nervous system depressants, due to the enhanced sedative effects.

Note: Long-term use can lead to the accumulation of bromide in the body, potentially causing chronic intoxication.

What should I know about interactions with other medicines?

Valocordin Interactions with other medicines and products

Official regulatory documents emphasize that the primary and most significant interaction profile for this product is based on its potential to cause additive central nervous system (CNS) depression.


Interacting Product Categories and Restrictions

This medication contains components that act as CNS depressants, necessitating specific constraints on co-administration with other substances that produce similar effects. Concomitant use with alcoholic beverages must be explicitly avoided. Additionally, the co-administration of Valocordin with other sedatives or tranquilizers is restricted due to the combined potential to increase drowsiness and impair mental and physical performance.

Interaction Domain Practical Regulatory Implication
Central Nervous System Depressants (e.g., sedatives, tranquilizers) Potential for additive effects; requires consultation with a healthcare professional.
Alcoholic Beverages (Ethanol) Must be avoided entirely due to the pronounced increase in CNS depressant effects.

Official Interaction Structure

The regulatory structure defining the interaction profile focuses on preventing excessive sedation. The mechanistic basis of the interactions is the additive effect of the respective substances on the central nervous system. This framework establishes the necessary constraint on concurrent use, mandating that products and substances within these categories must not be used at the same time to mitigate the clinically significant risk of an exaggerated depressant outcome.

Mechanism of Action

Enhanced Inhibition via mathrmGABAmathrmA Receptor Potentiation

The primary mechanism involves the Phenobarbital and Ethyl alpha-bromoisovalerate components acting as Positive Allosteric Modulators on the inhibitory mathrmGABAmathrmA receptor complex. This action significantly enhances the effects of the brain’s main inhibitory neurotransmitter, GABA, by increasing the flow of chloride ions into neurons. The resulting neuronal hyperpolarization elevates the nerve cell's threshold for firing, leading to a pervasive reduction of central nervous system (CNS) excitability, which results in a generalized state of central depression.


Combined Modulation of Central and Peripheral Systems

The comprehensive effect is achieved through a multi-target mechanism: Phenobarbital not only enhances inhibition but also non-selectively attenuates excitatory pathways like those involving glutamate, further increasing the threshold for action potential firing in nerve cells. Complementing this central action, the alpha-bromoisovalerate component exerts a secondary, mild peripheral influence on visceral smooth muscle tone. This peripheral action contributes to the overall effect profile by modulating smooth muscle tension.

Dosage and Administration Information

Official Administration Guidelines

Valocordin is formulated as an oral solution and is administered exclusively via the oral route. The parameters for its use are defined by established protocols for the active sedative component, Phenobarbital. The medication is typically intended for a short-term course; effectiveness for hypnotic use may diminish after approximately two weeks of continuous administration.

Parameter Official Instruction
Route of Administration Oral
Standard Adult Dose The standard daily oral dose for sedation is 30 to 120 mg, administered in two or three divided doses.
Timing in relation to food To promote faster absorption, the solution is generally recommended for ingestion on an empty stomach.
Preparation Requirement The prescribed quantity must be delivered by accurate counting of the liquid drops or precise volume measurement of the solution.

Population-Specific Use Rules

Administration of the solution is subject to specific adjustments based on patient physiology. A reduced dosage is required for patients categorized as older adults or those who are generally debilitated, due to potentially increased sensitivity to the active component. Dose reductions are also necessary for individuals with documented impaired renal function or hepatic disease. Usage standards indicate that patients must not increase the prescribed dosage without consulting a healthcare professional.


Procedural Structure

The standardized use protocol involves determining the necessary total daily dose and then dividing this amount into smaller portions for a multi-dose schedule. This oral dosage is then measured precisely and ingested. Adherence to this structured, dose-adjusted regimen, often spanning a short-term course, is essential for appropriate use.

Recent Clinical Evidence

Research Evidence / Overview of Studies


Phase I and II Trials: Understanding the Compound

Research explores the compound's potential activity to assess the potential for effects on nerve signaling.

Initial studies have explored whether the compound may affect pain perception and has an onset of action. These early trials were primarily focused on characterizing the compound's behavior in the body in a limited number of healthy volunteers.


Phase III and Long-Term Outcomes

Phase III trials involved a larger and more diverse population. Further research has evaluated whether the compound is associated with ongoing changes in symptom reporting and has examined the outcomes of long-term use.

Studies have characterized outcomes of this formulation in most adults, and research is ongoing to characterize outcomes in individuals with severe kidney disease. Phenobarbital, one of the components, has a half-life measured in days and is known to induce liver enzymes (CYP450), which may affect the metabolism of other medications.


Combination Therapy

Studies have evaluated whether the combination of compounds differs from either treatment alone, with research focusing on outcomes in managing chronic conditions. These studies aimed to assess whether using both compounds together resulted in different or similar reported outcomes compared to using each compound individually.


Safety and Tolerability Profiles

Safety studies have reported common side effects.

Side effects that led to study withdrawal were reported and characterized. Research continues to monitor the safety profile to fully understand how the compound is tolerated across different populations. Regulatory bodies have noted that supportive clinical documentation for Valocordin's components, which include phenobarbital and ethyl bromisovalerianate, have in the past been regarded as insufficient to meet modern scientific standards for well-established use.

Key Studies & References

  1. Corvalol (Valocordin) - Wikipedia (for general composition and regulatory context)
  2. PHENOBARBITAL tablet Label - DailyMed (NIH/FDA) (for component safety, half-life, and enzyme induction)
  3. Phenobarbital for Severe Acute Alcohol Withdrawal Syndrome | ClinicalTrials.gov (NCT03586089) (for phenobarbital's use in acute settings and research design)

Frequently Asked Questions (FAQ)

Common questions about Valocordin (FAQ)

Q: How long does the therapeutic effect of Valocordin generally last?

Pharmacological data for the active ingredient, Phenobarbital, indicates a variable duration of action. The effect of a single dose can last from approximately four hours up to two days, depending on individual metabolism.

Q: Is Valocordin intended for occasional use or can it be taken regularly?

According to official product information, Valocordin is generally intended for a short-term course of administration. Prolonged, continuous exposure carries explicit risks, including the development of tolerance and potential long-term adverse effects like bromism.

Q: Is Valocordin suitable for use by people over the age of 65?

Official guidance notes that due to increased sensitivity, use in older adults is subject to the requirement of a reduced dosage compared to standard adult use. This population may also experience increased susceptibility to central nervous system side effects, such as confusion and sedation.

Q: What is the safety profile of Valocordin for people with kidney conditions?

The medication is contraindicated (should not be used) in patients with severe kidney impairment. For individuals with documented impaired renal function that is not severe, the official rules specify that dose adjustments are necessary to mitigate risks.

Q: What are the major types of medications that may interact with Valocordin?

Regulatory information primarily focuses on the potential for additive CNS depression when Valocordin is used alongside other sedatives or tranquilizers. Furthermore, the Phenobarbital component is known to induce liver enzymes (CYP450), which may affect the way many other types of medications are metabolized in the body.

Q: Is the active ingredient in Valocordin known to cause tolerance over time?

Yes, official labeling explicitly recognizes the risk of tolerance associated with this medication. This risk is specifically linked to prolonged, continuous exposure to the product.

Q: Are there any reported long-term safety concerns with Valocordin?

Official regulatory notes explicitly link prolonged, continuous exposure to several potential risks. These risks include the development of tolerance, long-term effects like bromism (chronic bromide intoxication), and potential blood dyscrasias (disorders of the blood).

Q: What is the maximum duration of continuous use advised by manufacturers?

Official guidance specifies that for hypnotic (sleep-inducing) use, the effectiveness may diminish after approximately two weeks of continuous administration. This information informs the typical short-term duration of the course.

Q: Does Valocordin have any known interactions with herbal supplements like St. John's Wort?

Official warnings associated with the Phenobarbital component note a theoretical risk of reduced effectiveness when it is co-administered with St. John's Wort. This is due to the herb's potential to induce liver enzymes that are responsible for metabolizing the drug.

Q: Does Valocordin affect the ability to operate heavy machinery?

The documented CNS effects, such as drowsiness, dizziness, and cognitive impairment, are known to impact a person's abilities. Official warnings state that these effects, combined with the alcohol content in the solution, may affect a person's capacity to safely drive or use heavy machines.

Q: Is Valocordin a controlled substance or prescription-only medication?

Regulatory sources confirm that the active component, Phenobarbital, is a prescription drug that is regulated by authorities. Due to its nature, it is subject to strict regulatory handling requirements to prevent misuse and diversion.

Q: Why is Valocordin often confused with Corvalol in some regions?

Regulatory and legal documents from countries like the US often associate Valocordin and Corvalol together. This is primarily because both preparations are sold in certain regions and both contain significant amounts of the regulated prescription drug Phenobarbital.

Q: How quickly does Valocordin typically begin to have an effect?

Pharmacological data for the active component, Phenobarbital, indicates that peak concentrations in the bloodstream are typically reached several hours after the product is taken orally. The pharmacological data indicates that the full effect is not immediate, as peak concentrations are reached several hours after administration.

Q: Are there any specific food or beverage items that interact with Valocordin?

Official administration conditions state that the solution is generally recommended for ingestion on an empty stomach to ensure faster absorption. No other specific food interactions are noted in the core regulatory texts.

Q: Can Valocordin interact with over-the-counter pain relievers?

Official safety guidance highlights the need for a consultation with a healthcare professional before combining the product with any other medicines or supplements, due to the potential for unforeseen interactions with the active ingredients in Valocordin.

Q: Does Valocordin have a known effect on blood pressure?

The side effect profile for the component Phenobarbital includes the possibility of Hypotension (low blood pressure). The official text also notes a precaution for individuals with pre-existing low blood pressure.

Q: Can Valocordin affect a person's coordination or balance?

Yes, the regulatory documents list side effects associated with central nervous system depressants like Phenobarbital. These effects commonly include ataxia (lack of voluntary coordination) and impaired coordination.

Q: Can Valocordin be taken alongside common vitamin or mineral supplements?

General safety advice highlights the need for a consultation with a healthcare provider before taking any vitamin pills or supplements alongside this medication. This is a crucial step because supplements can sometimes interact with drug components.

Q: What is the general level of evidence or research for Valocordin's main uses?

Regulatory bodies have issued statements noting that the supportive clinical documentation for the product's components has in the past been regarded as insufficient to meet modern scientific standards for the classification of well-established use.

Q: Can Valocordin cause unusual or vivid dreams?

While the safety profile does not specifically list 'vivid dreams,' side effects for the component Phenobarbital include general psychiatric disturbances. These include insomnia and hallucinations, which are part of the listed psychiatric disturbances.

Q: Is Valocordin known to interact with caffeine products?

Regulatory warnings for similar central nervous system (CNS) drugs advise that stimulants like caffeine can alter how the body absorbs or reacts to medication. This suggests a potential interaction, although a specific warning is not named in the core text.

Q: Does Valocordin contain a substance that requires special caution for import/export?

Yes, the product contains Phenobarbital, which is designated as a controlled substance by various international regulatory bodies. Its handling, export, and import are consequently subject to strict regulatory requirements and special caution in many jurisdictions.

Q: Can Valocordin affect the results of any common medical tests?

Research has noted that the Phenobarbital component is known to induce liver enzymes (CYP450). This enzyme induction may affect the metabolism and plasma levels of other substances and medications, potentially influencing the results of certain medical tests.

Q: What is the chemical classification of the main active components in Valocordin?

Valocordin is classified as a combined central nervous system (CNS) depressant. Its primary active component, Phenobarbital, belongs to the widely recognized barbituric acid class of drugs.

Q: Are there official warnings about the effects of Valocordin in children and adolescents?

Official warnings associated with the Phenobarbital component specifically note that psychiatric symptoms are seen particularly in children. These adverse reactions include abnormal behavior, aggression, and paradoxical excitement.

Q: What are the official recommendations if a dose is missed?

General regulatory guidance for this class of medication provides a protocol that usually involves taking the missed dose promptly, provided it is not close to the time of the next scheduled dose, and advises against doubling up.

Q: Is Valocordin used outside of Europe, and are the formulations the same?

Regulatory and legal documents confirm that the product is primarily sold in Eastern European countries. It is specifically noted that the product is not approved by the FDA for distribution in the United States.

Q: Can Valocordin cause issues with memory or concentration?

The official side effect profile lists both cognitive impairment and memory impairment, which are known to affect mental performance. These effects are associated with the Phenobarbital component.

Q: What is the risk of overdose symptoms associated with Valocordin components?

Overdose symptoms associated with the barbiturate class are severe and involve central nervous system depression. These symptoms typically include profound sedation, life-threatening respiratory depression, and potential progression to coma and death.

How should Valocordin be stored and disposed of?

Valocordin is an oral solution containing Phenobarbital, a component subject to strict regulatory handling requirements. Storage must maintain the product's stability and prevent misuse.

Storage Requirements

The medicine is typically required to be stored at controlled room temperature, generally below mathbf25 C or mathbf30 C, and must be protected from light and freezing. The bottle must be kept tightly closed and stored in the original packaging to preserve its content integrity. All medicines, especially those with sedative properties, must be kept strictly out of the sight and reach of children.

Disposal Instructions

Due to the presence of Phenobarbital (a controlled substance), disposal must adhere to specific government regulations. The preferred method for discarding unused or expired Valocordin is through authorized drug take-back programs. The product should not be poured into wastewater systems (sinks or toilets) or placed directly into household trash.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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