Valeriana

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Valeriana

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Method of action: Antispasmodic, Hypnotic, Sedative

Treatment option: Migraine

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Valeriana

What is Valerian? A Concise Overview

Property Description
Active components Valerenic acids (Sesquiterpenoids)
Type Traditional Herbal Remedy (Phytomedicine)
Pharmacological class Sedative, Anxiolytic
Common use Sleep and Nervous Tension Support
Distinguishing Feature Strong, distinctive earthy scent

Valerian: Defining a Traditional Herbal Remedy

Valeriana, widely known as Valerian root, is a traditional herbal remedy (phytomedicine) derived from the dried roots and rhizome of the perennial flowering plant, Valeriana officinalis. Native to Europe and parts of Asia, the plant is historically recognized for its calming properties. Its sustained use has led to the inclusion of Valerian in several major pharmacopeias.

Valerian is generally classified as an over-the-counter (OTC) botanical supplement. It is most commonly prepared as concentrated extracts or tinctures for oral use, but is also available in capsules or dried for infusions. A distinctive physical characteristic of Valerian is its strong, earthy odor, which comes from the active compounds in its dried root.


Active Composition and Pharmacological Class

Valerian is classified pharmacologically as a natural agent with sedative and anxiolytic (anxiety-reducing) effects. Its activity is supported by pharmacological studies which point to a complex composition, including the key active constituents known as the valerenic acids (sesquiterpenoids).

These compounds are believed to modulate nerve impulses in the central nervous system, consistent with its use as a natural sleep aid. Valerian is recognized as a traditional herbal medicinal product for relieving mild symptoms of mental stress and for aiding in sleep. This classification establishes its long-standing use for promoting calmness and supporting rest.


Primary Therapeutic Purpose: Calmness and Sleep Support

The general therapeutic purpose of Valerian is to provide gentle support to the central nervous system, helping to foster a state of calmness and improve the overall quality of sleep. It is primarily utilized by those experiencing temporary nervous restlessness or mild difficulty initiating sleep. Valerian’s role is purely supportive and it is not intended as a treatment for serious medical conditions.

Regulatory References

  1. Valerianae radix (Valerian root) - EMA Overview

What side effects are possible with Valeriana?

Possible Side Effects and Safety Information: Valeriana

The safety profile of Valeriana, as documented in official regulatory sources, focuses on gastrointestinal effects and constraints related to its sedative properties. The frequency of most adverse reactions is often categorized as Not known (cannot be reliably estimated from available data) in official Summary of Product Characteristics (SmPC) documents.

Documented Adverse Reactions

The most commonly reported adverse reactions are related to the Gastrointestinal System, including symptoms such as nausea and abdominal cramps or general upset stomach. Other effects noted in the literature, often mild and transient, include fatigue or tiredness. Severe symptoms are typically observed only in cases of acute overdose.

Population-Specific Safety Constraints

Official regulatory bodies explicitly recommend against the use of Valeriana root preparations in several specific groups due to a lack of sufficient safety data to establish its safety profile. These groups include children and adolescents (under 18), pregnant women, and women who are breastfeeding.

High-Level Safety Restrictions

Because of its established sedative nature, Valeriana may impair the ability to drive or operate complex machinery; this is a mandatory safety consideration in the official labeling. Furthermore, regulatory documentation advises that the possibility of additive effects when Valeriana is used concurrently with alcohol or other sedative medications cannot be ruled out.

Dose- and Duration-Related Concerns

The most serious safety concerns are linked to improper use. Delirium is reported as a potential severe withdrawal symptom, but only following the abrupt cessation of very high doses taken chronically over extended periods. Acute overdose symptoms, such as hand tremor and light-headedness, are documented to disappear spontaneously, typically within 24 hours.

Overdose and Emergency Response

Overdose and When to Seek Help for Valeriana

The following information details the officially documented overdose profile for Valeriana, based strictly on government regulatory sources.


Domain Official Regulatory Statement
Documented Overdose Presentation Acute overdose symptoms are classified as benign and transient.
Physiological Systems Affected Symptoms include fatigue, lightheadedness, hand tremor, abdominal cramp, chest tightness, and mydriasis.
Dose-Related Factor Symptoms have been reported following the intake of approximately 20 grams of Valerian root material.
Population-Specific Risk Overdose of liquid preparations carries a risk of resulting in alcohol intoxication due to the ethanol content.
Emergency Response If symptoms arise, treatment should be supportive.
Urgent Medical Help Required Immediate medical attention is required for severe symptoms, such as passing out or trouble breathing.

Official Overdose Statements

Acute overdose from ingesting approximately 20 grams of Valerian root is documented in regulatory sources to cause a specific cluster of benign symptoms that typically resolve spontaneously within 24 hours. These reported manifestations include central nervous system effects such as fatigue and lightheadedness, as well as hand tremor, abdominal cramp, chest tightness, and mydriasis (pupil dilation). The mandated management for these symptomatic effects is strictly supportive treatment, as no specific antidote is officially documented in regulatory labeling.

A distinct, severe risk is noted in the regulatory profile concerning chronic, long-term misuse: The ingestion of very high doses over several years has been associated with the potential for withdrawal symptoms, including delirium. Additionally, overdose involving liquid Valerian preparations may carry a specific risk of alcohol intoxication due to the presence of ethanol in the formulation. Immediate medical attention must be sought if any severe manifestations, such as passing out or trouble breathing, are observed.

Therapeutic Uses of Valeriana

Valeriana (Valerian root) is commonly used across therapeutic domains involving heightened emotional tension and is relevant when additional symptomatic support is needed to promote rest. Valeriana is considered relevant within traditional therapeutic areas, where it is applied in addressing conditions marked by temporary physiological stress, supporting patients during difficult episodes. Valeriana is often used for conditions presenting with episodic or fluctuating manifestations, aligning with traditional therapeutic contexts.


Supportive Symptom Management

This traditional remedy is applied across two key domains: functional sleep disturbances and for addressing symptoms related to mild nervous tension and restlessness. Valeriana is commonly used to help with difficulty initiating sleep and diminished sleep quality, as well as to address symptom clusters that interfere with daily comfort, such as inner agitation and worry. This supportive approach contributes to maintaining functional stability when symptoms are more noticeable.

“The primary use of Valeriana is to provide gentle support to ease the transition into rest and support the handling of feelings of temporary inner unease.”


Quick Fact: Support for Mild Nervous Tension The herb is primarily applied in contexts where tension is linked to temporary situational factors, providing support that helps ease the overall symptom burden, assisting patients to cope more steadily.

Regulatory References

  1. Health Canada NHPID Monograph on Valerian

Eligibility and Restrictions for Use

Who Can and Cannot Use Valeriana?

Valeriana (Valerian root) is a widely used herbal supplement, but its use is not appropriate for everyone. While generally considered safe for healthy adults seeking aid for sleep or mild anxiety, specific populations should exercise caution or avoid it entirely.


Populations Recommended to Avoid Valeriana

Certain groups should avoid Valeriana due to potential risks, lack of safety data, or interactions with the central nervous system (CNS).

Population Reason for Caution/Avoidance
Pregnant and Breastfeeding Individuals Lack of sufficient safety data to rule out harm to the fetus or infant. Avoid use.
Children under 3 years old Lack of safety data; potential unknown effects on the developing CNS.
Individuals Taking CNS Depressants Valeriana can potentiate the sedative effects of alcohol, benzodiazepines, barbiturates, and other sedating medications.
Individuals Undergoing Surgery Valeriana may interact with anesthesia and should be discontinued at least two weeks before a scheduled procedure.

Use with Caution

Older adults may be more susceptible to the sedative effects and should start with lower doses. Individuals with liver disease should also use Valeriana with caution, although documented cases of liver toxicity are rare and typically associated with products containing multiple ingredients.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The interaction profile of Valeriana is defined by officially documented effects and restrictions, primarily involving pharmacodynamic consequences and specific substance interactions.

Pharmacodynamic and Substance Interactions

Interaction Entity Official Regulatory Restriction and Outcome
Hypnotics and other Sedatives Co-medication is not recommended due to the potential for additive effects on the central nervous system, as this pharmacodynamic interaction cannot be excluded.
Alcohol (Ethanol) Excessive concomitant consumption must be avoided. The effect of Valeriana may be potentiated by alcohol.

Metabolic and Population Constraints

Regulatory documentation formally addresses the potential for pharmacokinetic interactions, confirming an absence of clinically relevant effects with several major metabolic pathways.

  • Cytochrome P450 Enzymes (CYP): No clinically relevant interactions have been observed with medicinal products metabolized by the CYP2D6, CYP3A4/5, CYP1A2, or CYP2E1 pathways.

  • Population-Specific Note: Caution regarding the alcohol content often present in liquid Valeriana formulations is required for patients with pre-existing conditions such as liver disease or epilepsy.


This official interaction structure is based on regulatory statements, focusing on defined risks and constraints rather than general safety or clinical interpretation.

Mechanism of Action

Potentiation of GABA A Receptor Inhibition

The primary mechanism centers on valerenic acid acting as a positive allosteric modulator on the GABA A receptor, the central control point for inhibitory neurotransmission in the brain. This molecular action enhances the effect of the brain's natural calming signal, increasing chloride ion ( Cl^-) influx into neurons and causing hyperpolarization. The resulting widespread suppression of neuronal excitability reduces the physiological state of arousal and vigilance.


Multi-Target Receptor Signaling

The overall CNS effect is shaped by the synergistic engagement of multiple active constituents that modulate targets beyond the GABA system. These secondary components interact with receptors such as the 5-HT 5A (serotonin) and A1 (adenosine) receptors, which are crucial for regulating the sleep-wake architecture. This multi-target mechanism contributes to reduced physiological vigilance and adjusts the neural circuitry required for transition to a quiescent state.


Mechanistic Constraints

The Valeriana mechanism provides a subtle reduction in CNS excitability, constrained by the lower receptor binding affinity of its active components. This constraint means the action is primarily one of subtle pathway adjustment and modulation of the body's native inhibitory processes, rather than intense suppression of central nervous system function.

Dosage and Administration Information

How to Use Valeriana

The usage of Valeriana is aligned with established guidelines for its role as a traditional herbal remedy, defining the routes, dosages, and duration of administration. Valeriana is primarily taken via the oral route as tablets, capsules, or liquid preparations, though some traditional preparations are intended for use as a bath additive.

Dosing and Frequency

Established dosing is purpose-specific. For the relief of symptoms related to mild nervous tension, preparations are typically administered in a divided regimen, taken up to three times daily. For sleep support, the standard pattern is a single dose taken approximately half an hour to one hour before bedtime. Single doses of certain dry extracts often fall in the range of 400–600 mg, while comminuted root preparations for herbal infusions use 0.3–3 grams of the substance. Consumption is generally restricted to a maximum of four single doses over 24 hours.

Administration Context and Duration

Valeriana is intended for a continued course of use, as it is not suitable for acute interventional treatment. To achieve the optimal supportive effect, a duration of two to four weeks is recommended. Administration is generally established for adults and adolescents over 12 years of age, with its use in younger children not recommended. Specific preparation steps apply to non-tablet forms; for example, herbal tea requires adding boiling water to the comminuted root to create an infusion.

Recent Clinical Evidence

Research Evidence Overview

The majority of research has examined Valeriana’s application in conditions characterized by fluctuating or episodic manifestations, such as mild difficulty falling asleep and subjective sleep quality complaints. Studies primarily involve short-term Randomized Controlled Trials (RCTs) in adult populations, monitoring both Subjective Sleep Quality (what patients report) and Objective Sleep Parameters.

Studies report how symptoms evolved in the observed populations, with many trials describing patterns where participants reported perceived discomfort or changes in self-reported sleep latency. However, when research examined Objective Sleep Parameters using tools like Polysomnography, the findings were mixed and inconsistent across systematic reviews. This variability highlights a key limitation, as the results apply only to the populations studied, and the follow-up durations were limited, typically restricted to a few weeks.

Valeriana was evaluated in research exploring short-term symptom changes associated with mild nervous tension and general restlessness. This research relies on a smaller base of modest-sized Randomized Controlled Trials and observational drug monitoring trials. The research highlights changes measured during the study period on subjective rating scales, though the specific findings for Valeriana monotherapy remain uncertain due to its frequent use in combination products.

Research Gaps and Uncertainty

Overall, there is limited information for long-term outcomes beyond the typical four-to-eight-week trial periods, and the long-term effects are not fully established. Furthermore, data for certain groups remain insufficient, with limited controlled trial evidence available for children and adolescents. Research provides context but not individual predictions for these special populations, and the high degree of methodological heterogeneity across studies contributes to the noted inconsistency of the evidence.

Key Studies & References

  1. European Union herbal monograph on Valeriana officinalis L., radix
  2. NATURAL HEALTH PRODUCT VALERIAN – VALERIANA OFFICINALIS Monograph (Health Canada)

Frequently Asked Questions (FAQ)

Common questions about Valeriana (FAQ)

Q: What is the main historical use of Valeriana?

Valeriana is officially described as a traditional herbal remedy, or phytomedicine. Historically, it is traditionally used to support sleep and address symptoms associated with mild nervous tension.

Q: Why do some people use Valeriana for anxiety or nervousness?

Regulatory bodies classify Valeriana as an agent with anxiolytic (anxiety-reducing) and sedative effects. Because of this pharmacological classification, it is described in official sources as an agent used to relieve mild symptoms of mental stress and nervous restlessness.

Q: Is Valeriana considered a natural or herbal product by regulators?

Yes, official bodies widely classify Valeriana as a traditional herbal medicinal product, also known as a phytomedicine. In countries like the United States, it is typically regulated as an over-the-counter botanical supplement.

Q: Are there official warnings about liver toxicity related to Valeriana?

Official information advises caution for individuals who have pre-existing liver problems. While some rare reports of liver issues exist in scientific literature, they are often linked to products containing multiple ingredients, and specific warnings for Valeriana monotherapy are uncommon in regulatory summaries.

Q: Can Valeriana cause an opposite reaction, such as agitation or excitability?

While not listed as a common or frequent side effect in primary regulatory summaries, some official compendiums and non-regulatory literature have noted experiences of paradoxical reactions, such as excitability or restlessness, in certain individuals.

Q: What are the signs of withdrawal if Valeriana is stopped suddenly after regular use?

Regulatory documentation reports delirium as a potential severe symptom after the abrupt cessation of very high doses taken over extended periods. General withdrawal symptoms after discontinuing normal, recommended doses are less frequently documented in official safety summaries.

Q: How close to a scheduled surgery should Valeriana use be stopped?

Due to the potential for interaction with anesthesia, regulatory authorities advise that the use of Valeriana preparations should be discontinued at least two weeks before a scheduled surgical procedure. This is a standard safety consideration in official labeling.

Q: Is it safe to take Valeriana with other herbal supplements for sleep, like hops or passionflower?

Official regulatory advice recommends against co-medication with other hypnotics or sedatives. This is because the possibility of additive sedative effects on the central nervous system cannot be excluded.

Q: What kind of warnings exist about combining Valeriana with other sedating drugs?

Official warnings exist regarding the combined use of Valeriana with other central nervous system depressants, including alcohol. Co-medication is not recommended because additive sedative effects may occur, which could impair the ability to drive or operate complex machinery.

Q: Is there enough strong scientific evidence to support all the claimed uses of Valeriana?

Official evaluations of the research evidence note that findings across systematic reviews are often mixed and inconsistent, especially when measuring objective effects. Limitations exist in long-term data, suggesting that the evidence supporting all traditional uses is not fully established.

Q: Are the findings about Valeriana's effectiveness for sleep inconsistent across studies?

Yes, regulatory overviews of clinical research specifically state that the findings regarding Valeriana’s effectiveness for sleep support have been mixed and inconsistent across systematic reviews, particularly when objective sleep measurements are used.

Q: Do experts recommend Valeriana for long-term chronic insomnia?

Regulatory documents define Valeriana as a traditional short-term remedy for use over a few weeks. Official research reviews indicate that there is limited information regarding long-term outcomes, and efficacy is usually observed after consistent short-term use, not for chronic conditions.

Q: Does Valeriana have a strong or noticeable scent?

Yes, Valeriana root is characterized by a strong, distinctive earthy scent. This is a well-known physical characteristic of the dried root noted in official monographs.

Q: Can Valeriana cause unusual or vivid dreams?

While official Summary of Product Characteristics (SmPC) documents do not commonly list this, some post-market reports and scientific literature have noted experiences of vivid dreams or nightmares in individuals taking Valeriana.

Q: Does Valeriana interact with any pain relievers or over-the-counter medicines?

Official warnings are focused on avoiding substances with a central nervous system (CNS) depressant or sedative effect. Regulatory documents also specify a lack of clinically relevant interactions with certain major liver enzyme pathways, meaning interactions with common non-sedating pain relievers are generally not noted.

Q: Are there any food products or beverages that should be avoided when taking Valeriana?

The only significant restriction noted in official regulatory documentation is the avoidance of excessive concomitant consumption of alcohol. This is because alcohol may potentiate the sedative effect of Valeriana.

Q: How long does Valeriana stay in the body or system?

Pharmacokinetic data suggests that the active compound, valerenic acid, is measurable in the blood for at least five hours after administration. Its estimated elimination half-life is approximately one to two hours in healthy adults.

Q: Is there a difference in strength or effect between Valeriana tea and a capsule extract?

Regulatory texts define different dosage ranges for comminuted root preparations (tea) versus dry extracts (capsules). Official monographs note that the extraction solvent and preparation method can lead to variations in the spectrum of active constituents, which may impact effect.

Q: Are there official restrictions on Valeriana use for people with specific pre-existing health conditions?

Official warnings recommend caution or avoidance for individuals with certain pre-existing conditions. These include people with liver disease (due to the potential alcohol content in some liquid forms) and those who are concurrently taking central nervous system (CNS) depressants.

Q: What types of research have been done on Valeriana for anxiety or depression?

Research cited in official monographs primarily includes studies on symptoms related to nervousness, mild mental stress, and general restlessness. Studies focusing on formal, diagnosed Generalized Anxiety Disorder or major depression are generally part of the broader scientific literature.

Q: Why are Valeriana products not approved by the FDA for medical treatment?

In the United States, Valeriana is regulated as a dietary supplement, not a prescription or over-the-counter drug. This means the Food and Drug Administration (FDA) has not formally reviewed it for safety and effectiveness as a medical treatment.

Q: Does the manufacturing process affect the potency of Valeriana products?

Yes, official documents note that the concentration and specific types of active components can vary depending on the method of extraction and the solvent used during manufacturing. These factors directly influence the final product’s composition and potential potency.

Q: Can Valeriana be used as a flavoring agent in foods or beverages?

Yes, in the United States, the Food and Drug Administration (FDA) lists Valeriana root extract as a substance permitted for direct addition to food for human consumption. It is used as a natural flavoring substance or adjuvant.

Q: Is there a recommended way to gradually stop taking Valeriana after long-term use?

Health authorities advise that if Valeriana has been used for an extended period, the dose should be gradually reduced over a period of one to two weeks before stopping completely. This is recommended to minimize the chance of adverse effects upon discontinuation.

Q: Does Valeriana have a legal age restriction for purchase?

Since Valeriana is typically sold as an over-the-counter supplement, the purchase itself is generally available to consumers. However, official safety documentation strongly recommends against its use in children and adolescents under 18 years of age due to a lack of safety data.

Q: Can Valeriana be taken with other vitamins or minerals?

Official regulatory documents do not list specific warnings or contraindications regarding common vitamins or minerals. Warnings are focused on avoiding substances that have a central nervous system (CNS) depressant or sedative effect.

Q: How long is Valeriana generally considered safe to use (short-term vs. long-term)?

Regulatory documents define its use as a traditional short-term remedy for use over a few weeks. The safety of Valeriana for long-term use, meaning use extending beyond the typical 4 to 8 weeks observed in clinical trials, is not fully established.

Q: Where is the Valeriana plant native to?

Official monographs from global health organizations confirm that the Valeriana officinalis plant, from which the herbal remedy is derived, is a perennial species native to Europe and parts of Asia.

Q: Can Valeriana cause dependence or addiction with long-term use?

Official documentation does not typically classify Valeriana as addictive. However, authorities advise a gradual reduction of the dose after long-term use, acknowledging the potential for dependence, which is why a gradual reduction in dose is advised after long-term use.

Q: Can Valeriana affect the way the liver breaks down other medications?

Official regulatory documentation, such as the Summary of Product Characteristics (SmPC), states that no clinically relevant interactions have been observed with medicinal products metabolized by major liver enzyme pathways (including CYP2D6, CYP3A4/5, CYP1A2, or CYP2E1).

How should Valeriana be stored and disposed of?

How to Store and Dispose of Valeriana?

The storage and disposal conditions for Valeriana are defined by regulatory documents to maintain product quality and safety.


Storage Requirements

Storage rules vary by product form. Many solid forms must be stored below 25°C and protected from light and moisture. All Valeriana products must be kept in the original package and used before the stated expiration date. A mandatory safety requirement is to store the medicine out of the sight and reach of children.


Disposal Instructions

Expired or unused Valeriana must be handled according to official pharmaceutical waste guidelines. Patients are typically required to return the unused product to a pharmacy for safe disposal. It is prohibited to dispose of the product via wastewater or household waste to prevent environmental contamination.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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