Uritab

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Uritab

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Uritab

Property Description
Active Ingredients Alfuzosin Hydrochloride and Allopurinol
Form Fixed-dose combination tablet (Oral)
Pharmacological Class Alpha-Blocker and Xanthine Oxidase Inhibitor
Common Use Managing smooth muscle tension and hyperuricemia
Origin Synthetic

What is the Identity of Uritab?

Uritab is a synthetic, prescription-only medication specifically designed as a fixed-dose combination product for oral administration. This unique structure means a single tablet contains two different active pharmaceutical ingredients, a design that is clinically recognized for delivering complementary therapeutic actions simultaneously. The preparation is frequently presented as an Extended-release tablet, a distinguishing feature ensuring the controlled, sustained delivery of the Alfuzosin component throughout the day. This fixed-combination approach positions Uritab for adult male patients who require concurrent intervention for urological and metabolic factors.

Which Pharmacological Classes Define Uritab’s Action?

The identity of Uritab is defined by the distinct pharmacological classes of its two components: Alfuzosin Hydrochloride and Allopurinol. Alfuzosin is classified as a selective Alpha-1 Adrenergic Receptor Antagonist, often referred to simply as an Alpha-Blocker. Allopurinol, conversely, is classified as a Xanthine Oxidase Inhibitor. These classifications confirm the drug’s dual identity as both an agent for functional relief and a modulator of purine catabolism.

What is Uritab’s General Purpose?

The general purpose of Uritab is to exert a dual therapeutic effect by combining distinct physiological actions. The Alfuzosin component is designed to achieve smooth muscle relaxation in the lower urinary tract, while the Allopurinol component works to restrict the cellular production of uric acid. The integrated mechanism supports the easing of urinary flow alongside the management of circulating uric acid levels. Pairing an alpha-blocker with a urate-lowering agent provides concurrent benefit for symptoms associated with both functional obstruction and high uric acid levels.

Regulatory References

  1. NIH StatPearls: Allopurinol

What side effects are possible with Uritab?

Possible Side Effects and Safety Information

The safety profile for Uritab is based on the established regulatory documentation for its two components, Alfuzosin and Allopurinol. Adverse reactions are classified by frequency and grouped into specific physiological systems.

Frequency-Classified Adverse Reactions

Classification Examples of Officially Listed Effects
Common Dizziness, headache, nausea, fatigue, and skin rash (associated with Allopurinol).
Uncommon Postural hypotension, syncope (fainting), and rhinitis.
Rare/Very Rare Severe cutaneous adverse reactions (SCARs), including Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), priapism, and angina pectoris in patients with pre-existing coronary artery disease.

Safety Constraints and Population Notes

The official labeling documents specific safety constraints and time-related patterns:

  • Serious Adverse Reactions: The regulatory profile highlights rare, serious events such as priapism linked to the alpha-blocker component and severe hypersensitivity to the Allopurinol component.
  • Population Restriction: The Alfuzosin component is contraindicated for use in individuals with moderate to severe hepatic impairment.
  • Time-Related Patterns: Postural hypotension and syncope may occur within a few hours of administration, particularly following the initial dose. Also, an increase in acute gout attacks may be observed during the initial phase of Allopurinol administration.

This information structures the official understanding of the medicine’s risk characteristics without providing any instructional or clinical advice.

Overdose and Emergency Response

Overdose and When to Seek Help

An overdose of Uritab must be treated as a medical emergency. The officially documented manifestations of overexposure relate to the effects of its two active components. Immediate medical attention is required for any suspected overdose.

Documented Manifestations and Severe Outcomes

Overexposure to the Alfuzosin component primarily creates a risk of severe Systemic Hypotension (low blood pressure), which may be accompanied by Reflex Tachycardia (increased heart rate) and could potentially lead to Cardiovascular Collapse. The Allopurinol component carries a documented risk of Profound Renal Impairment and Hepatic Dysfunction following massive or chronic overexposure. Gastrointestinal disturbances such as nausea, vomiting, and diarrhea may also occur. Urgent medical help must be sought if the individual has collapsed, experienced a seizure, or cannot be awakened.

Official Emergency Procedures

As stated in regulatory documents, No Specific Antidote is Known for the active ingredients in Uritab. Management is strictly symptomatic and supportive. This includes initiating Cardiovascular Support, placing the patient in a Supine Position, and administering Intravenous Fluids to manage hypotension. Severe toxicity may require Hemodialysis to manage the Allopurinol component. Continuous Blood Pressure Monitoring and monitoring of Renal and Liver Function are required during hospital observation. Patients with pre-existing renal impairment carry a specific documented risk for increased toxicity.

Therapeutic Uses of Uritab

What Uritab Treats: Main Uses and Benefits

The medication Uritab is used in situations involving certain distressing symptoms linked to organ-specific functional stress. The primary application for Uritab is relevant for managing the signs and symptoms of benign prostatic hyperplasia (BPH). This therapeutic area aligns with the established indications for its Alfuzosin component. This application is relevant for easing symptoms that interfere with daily functioning, such as urinary frequency, weak stream, and urgency.

Supportive Relief During Acute Symptomatic Episodes

This domain is commonly used across conditions presenting with acute episodes and may assist with symptom clusters that may become intense or disruptive. It is relevant when supportive symptom management is appropriate and symptoms are associated with acute or episodic changes. This support may help maintain a sense of stability when symptoms are more noticeable, assisting with functional stability during difficult episodes.

Managing Intensity and Burden of Manifestations

Uritab is applied across domains where additional symptomatic support is needed, particularly when symptoms create noticeable physiological strain and interfere with daily comfort. It assists with maintaining functional stability and provides support that helps ease the overall symptom burden, contributing to improved day-to-day comfort during periods of heightened symptoms.


Quick Fact: Supports Management of Symptoms that Interfere with Daily Functioning

Eligibility and Restrictions for Use

Uritab (alfuzosin) is intended for use in adult men and has specific exclusions and limitations documented in official regulatory labeling to ensure patient safety.

Contraindications (Must Not Use)

Official documents strictly prohibit Uritab use for patients who meet the following criteria:

  • Hepatic Impairment: Patients with moderate or severe liver impairment (Child-Pugh B and C). The drug is not cleared effectively in these conditions.
  • Hypersensitivity: Individuals with a known allergy or hypersensitivity (e.g., angioedema) to alfuzosin or any component of the formulation.
  • Concomitant Medications: Those taking other alpha-adrenergic antagonists (alpha-blockers) or potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir).

Eligibility and Special Populations

Population Category Regulatory Status
Women Not indicated or not recommended for use.
Pediatric Patients Not indicated; safety and efficacy are not established in this age group.
Severe Renal Impairment Use with caution (creatinine clearance <30 mL/min).
Pregnancy/Lactation Not indicated for use in women; therefore, not for use during pregnancy or breastfeeding.

Use in elderly men is generally approved, though older individuals may require caution due to potential age-related organ sensitivity.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory information outlines several substance-related restrictions and cautions for Uritab, driven by the metabolic pathways of its two components (Alfuzosin and Allopurinol).

Classification Interacting Substances Regulatory-Defined Restriction
Contraindicated Combinations Potent CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir) Co-administration is prohibited due to significantly increased Alfuzosin exposure.
Other Alpha-1 Adrenergic Antagonists Combination is prohibited due to the risk of severe additive hypotension.
Mandatory Dose Adjustment Thiopurines (Azathioprine, Mercaptopurine) Allopurinol significantly inhibits metabolism, requiring the thiopurine dose to be reduced (typically to 25%).

Pharmacodynamic and Exposure Cautions

The Alfuzosin component carries a risk of additive pharmacodynamic effects with other agents that lower blood pressure. Caution is officially advised for co-administration with other antihypertensive medications or Nitrates, due to the potential for hypotension. Similarly, co-administration with PDE5 Inhibitors (e.g., Sildenafil) can potentially cause symptomatic hypotension. The drug must be taken with food to avoid a documented 50% reduction in Alfuzosin absorption.

Population-Specific Notes

The Alfuzosin component is formally contraindicated in patients with moderate or severe hepatic impairment, as reduced clearance leads to increased blood levels and exposure.

Mechanism of Action

Modulating Lower Urinary Tract Muscle Tone

This domain relates to the Alfuzosin component, which acts as a selective competitive antagonist at Alpha-1 Adrenergic Receptors (alpha1-ARs) in the smooth muscle of the lower urinary tract. By blocking the binding of the neurotransmitter Norepinephrine, this mechanism suppresses the neurological signals that cause muscle fibers to contract, thereby resulting in the reduction of sustained contractile force in the smooth muscle tissues, a factor that influences outflow resistance. This action is restricted to modulating the dynamic component of muscle tone which affects outflow resistance.


Inhibiting Uric Acid Production

This domain covers the action of the Allopurinol component, which functions by inhibiting the key metabolic enzyme, Xanthine Oxidase (XO), responsible for the final steps in purine catabolism. Through a dual action of initial competitive inhibition and subsequent non-competitive inhibition by its active metabolite (Oxypurinol), this mechanism directly blocks the biochemical synthesis of uric acid. The physiological consequence is a sustained reduction in the systemic concentration of circulating urate within the body.


Complementary Physiological Modulation

The overall mechanism of action involves the complementary activity of two distinct processes: one modulates smooth muscle contractile signaling and the other modulates purine metabolic synthesis. These two mechanisms function independently yet concurrently to alter two separate physiological systems.

Dosage and Administration Information

How to use Uritab

Uritab is a fixed-dose combination product approved for oral administration, utilizing an extended-release formulation to ensure sustained delivery of the active components.


Administration Schedule and Route

The medication is administered once daily and must be taken in a fed state, specifically immediately after the same meal each day. This timing is a required condition for the proper absorption of the Alfuzosin component. The tablet must be swallowed whole and must not be crushed, chewed, or split to prevent disruption of the extended-release system.


Dosing Regimen and Titration

The standard regimen for the Alfuzosin component is 10 mg once daily. For the Allopurinol component, the therapy often starts at a low dose, such as 100 mg daily, requiring a subsequent gradual dose titration over several weeks to reach a maximum of 800 mg daily, depending on the therapeutic goal. Furthermore, high fluid intake, yielding a daily urinary output of at least two liters, is recommended to support the function of the Allopurinol component.


Population-Specific Constraints

The use of this medication is contraindicated in patients with moderate or severe hepatic impairment (Child-Pugh B and C). For patients with severe renal impairment, caution is advised, and significant dose reduction is mandatory for the Allopurinol component, with official starting doses as low as 100 mg daily or less based on creatinine clearance. The medication is not indicated for use in the pediatric population.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Uritab


Evidence for Managing Symptoms of Benign Prostatic Hyperplasia (BPH)

Research exploring how symptoms change over time for BPH is extensive and is primarily based on the Alfuzosin component of Uritab. Studies have been conducted using well-structured designs, including Randomized Controlled Trials (RCTs) where one group of adult men received the treatment and another received an inactive substance (placebo). Studies examined changes measured during the study period.

Study Focus: Symptom Change and Functional Measures

Studies evaluated outcomes related to functional imbalance and daily functioning. The research examined changes in the International Prostate Symptom Score (IPSS), a standard questionnaire where patients report perceived discomfort and the impact of urinary symptoms. Additionally, studies monitored objective measures such as peak urinary flow rate (Qmax) and the volume of urine remaining in the bladder after voiding (post-void residual volume, PVR). These outcomes reflect daily functioning or activity level. Findings from studies examined patterns in the measured outcomes across different adult male populations.


Evidence for Managing Elevated Uric Acid Levels (Hyperuricemia)

Study Focus: Biomarker Shifts and Clinical Events

The primary outcome studied was the change in the serum uric acid (sUA) biomarker level—a measurable outcome used in research exploring short-term symptom changes. Research also examined outcomes describing episodic or acute changes, specifically gouty arthritis flares. Studies monitored physiological strain or stress in patients with chronic hyperuricemia, with some long-term research exploring potential associations with cardiovascular outcomes.

Studies reported measurements of shifts in the sUA biomarker level across various adult populations within short timeframes. In long-term studies, research described patterns of incidence of gout flares in the population being followed. Findings varied in the context of cardiovascular outcomes, requiring further study to clarify any association.


Long-Term Research and Follow-up Outcomes

While initial studies for the Alfuzosin component were short-term, data from longer-term observational settings evaluating daily-life functioning have been used to monitor symptom patterns related to LUTS. The evidence contributes to understanding symptom patterns, but the data are still emerging regarding long-term maintenance.

For the Allopurinol component, long-term research is ongoing, with data available from studies extending for several years that monitored the sustained reduction of serum uric acid and tracked outcomes related to episodic or acute changes, such as gout flare frequency. Research highlights what has been observed so far and what is still uncertain about the durability of the outcomes.


What Remains Uncertain About the Combination Evidence

A primary research limitation is that comparative evidence is lacking for the specific fixed-dose combination product. While each active ingredient has been evaluated independently in extensive, high-quality RCTs, there is limited information on the outcomes of combining the two agents specifically for patients who require simultaneous management of BPH and chronic hyperuricemia. The full long-term outcomes of the combination are not fully established. Results apply only to the populations studied, and evidence quality varies across the breadth of the literature.

Key Studies & References

  1. NIH StatPearls: Allopurinol (Used to establish pharmacological class and action)
  2. MedlinePlus Drug Information: Alfuzosin (Used to establish pharmacological class)

Frequently Asked Questions (FAQ)

Common questions about Uritab (FAQ)


Q: What is the main condition Uritab is prescribed to treat?

According to official product information, this medication is indicated for the management of symptoms associated with an enlarged prostate (Benign Prostatic Hyperplasia or BPH) and supports the lowering of high uric acid levels linked to conditions like gout.


Q: How quickly does Uritab start to work after taking it?

Official product information indicates that the Alfuzosin component reaches its highest blood concentration several hours after dosing. While some effects may be observed early on, it is expected that full therapeutic effects will emerge over time.


Q: How long do the side effects of Uritab usually last?

Safety data indicates that immediate effects like dizziness are most common soon after the first dose. For the Allopurinol component, initial flare-ups of gout symptoms have been observed but may decrease in frequency over several months as treatment continues.


Q: Does Uritab cause weight gain or weight loss?

Regulatory post-marketing reports for the Allopurinol component have listed unusual changes in weight, including both gain and loss, as a possible side effect. This is not reported as a common event, and regulatory guidance recommends professional consultation if significant changes occur.


Q: Can Uritab be taken with a multivitamin or common supplements?

Official product information primarily focuses on prescription drug interactions, meaning comprehensive information on all supplements is not available. Regulatory standards recommend informing a healthcare professional about all herbal remedies, vitamins, or supplements used, as some may affect medication processing.


Q: Is it safe to drink alcohol while using Uritab?

Official warnings state that consuming alcohol while using this medication is associated with an increased risk of side effects. This combination may enhance the risk of dizziness, lightheadedness, and fainting due to the drug’s potential to lower blood pressure.


Q: Do I need to avoid any specific foods or drinks while on Uritab?

Yes, official prescribing information advises that the medication must be taken with food to ensure proper absorption. Furthermore, regulatory documents state that grapefruit and grapefruit juice must be avoided, as they can significantly increase the levels of the Alfuzosin component in the blood and raise the risk of adverse effects.


Q: Can people with high blood pressure take Uritab?

Because this medication can cause a drop in blood pressure, caution is officially advised for patients taking other antihypertensive medications. The regulatory profile recommends close monitoring of blood pressure when therapy is initiated or adjusted.


Q: Is Uritab a generic medication?

The medication is a fixed-dose combination of two active ingredients: Alfuzosin and Allopurinol. According to regulatory listings, both of these components are available in generic forms, which are chemically equivalent to the original brand-name drugs.


Q: Does Uritab treat the cause of the condition or just the symptoms?

The mechanism of action involves a dual approach. The Alfuzosin component works to relax smooth muscles, primarily helping to relieve functional urinary symptoms. The Allopurinol component works by blocking a specific metabolic enzyme, thereby addressing a primary metabolic cause related to uric acid production.


Q: What are the signs of an allergic reaction to Uritab?

The official safety profile highlights the risk of severe allergic reactions, or hypersensitivity. Reported signs for the components can include a skin rash, hives, or itching. More serious reactions involve blistering, peeling of the skin, swelling of the face or throat, and difficulty breathing.


Q: Can Uritab affect sleep or cause insomnia?

Official reports for the components of this medication have listed both drowsiness and sleeplessness (insomnia) as possible adverse reactions. These are reported in post-marketing experience or clinical trials.


Q: Is Uritab a controlled substance?

The official classification of the drug components, Alfuzosin and Allopurinol, confirms that this fixed-dose combination medication is not designated as a controlled substance by the major regulatory bodies.


Q: What happens if a dose of Uritab is missed?

Regulatory patient information contains rules for handling a missed dose. The general instruction is to take the dose as soon as it is remembered. However, if it is almost time for the next scheduled dose, the rule states to skip the missed dose entirely and simply take the next one at the regular time, without doubling up.


Q: Does Uritab change the color of urine or other body fluids?

Official documentation for the Allopurinol component notes that dark urine is a potential side effect. Dark urine can be a finding associated with serious issues, and regulatory guidance recommends professional consultation if it occurs.


Q: Why is Uritab only available with a prescription?

This medication is categorized as prescription-only because it requires professional guidance to manage the potential for serious side effects like low blood pressure and severe skin reactions. Furthermore, the Allopurinol component often requires medical monitoring of kidney and liver function.


Q: How long is the typical course of treatment with Uritab?

For the chronic conditions this medication is intended to treat, such as BPH and gout, treatment is often necessary long-term or for the life of the patient. Regulatory guidance indicates that the exact duration of therapy is not fixed and must be determined by individual medical oversight.


Q: What are the potential effects of taking Uritab with grapefruit juice?

The official label advises against taking this medication with grapefruit or grapefruit juice. Grapefruit is an inhibitor of the enzyme that processes the Alfuzosin component. This interaction can lead to significantly higher drug levels and raise the risk of adverse effects, including severe low blood pressure.


Q: Is Uritab a form of chemotherapy or similar intense treatment?

Although the Allopurinol component is sometimes used to manage high uric acid levels in patients undergoing certain cancer treatments, the drug itself is not classified as chemotherapy. Its core mechanism is focused on blocking a specific metabolic enzyme, not on directly killing rapidly dividing cells.


Q: What are the documented risks of stopping Uritab suddenly?

Official patient information warns that abruptly discontinuing the Allopurinol component carries a high risk of worsening gout symptoms. Regulatory requirements state that treatment should only be discontinued under the guidance of a healthcare provider.


Q: Can Uritab be taken with cold and flu medicine?

Caution is advised because some over-the-counter cold and flu medications, especially those containing decongestants, can interact with the Alfuzosin component. This interaction may potentially increase the risk of side effects, and regulatory standards recommend consultation before combining them.


Q: Does Uritab have any known sexual side effects?

Yes, official safety documents for the Alfuzosin component list sexual side effects, including ejaculatory dysfunction. A rare, but severe, documented side effect is priapism (a painful and prolonged erection), which is highlighted as a serious medical event.


Q: Are there any specific laboratory tests needed while taking Uritab?

Yes, regulatory authorities advise that patients often require regular blood tests while taking the Allopurinol component. These tests are necessary to monitor levels of uric acid and to check for potential effects on kidney or liver function.


Q: Why does Uritab have a black box warning?

Official prescribing information confirms that Uritab does not carry a Black Box Warning. This question likely stems from confusion with other similar urate-lowering drugs, such as Febuxostat, which does carry a warning for an increased risk of cardiovascular death.


Q: Does Uritab interfere with driving or operating machinery?

Official warnings state that this medication may cause dizziness, fainting, or lightheadedness. Due to this risk, the regulatory labeling advises that activities requiring full mental alertness, such as driving or operating machinery, should be avoided until the patient is certain the medication does not cause these effects.

How should Uritab be stored and disposed of?

How to Store and Dispose of Uritab?

The official storage and disposal requirements for Uritab are established to maintain the product's stability and ensure environmental safety.


Mandatory Storage Conditions

Regulatory documents stipulate that Uritab tablets must be stored at a controlled room temperature, generally not exceeding 25 C (77 F). The product must be protected from both light and excess moisture, requiring that the container be kept tightly closed when not in use. It is explicitly stated that the medicine should not be frozen or stored in environments like the bathroom, which are prone to high humidity and heat.


Official Disposal and Safety

For safety, the official label requires that Uritab be stored out of the sight and reach of children.

When discarding unused or expired tablets, regulatory guidelines prohibit flushing the medicine down a toilet or pouring it into a drain. Disposal must follow local or national regulations for pharmaceutical waste, often utilizing a medicine take-back program to prevent release into the environment.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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