Urezol

A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Urezol is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)

Urezol is indicated for the symptomatic relief of pain, burning, urgency, frequency, and other discomforts arising from irritation of the lower urinary tract mucosa caused by infection, trauma, surgery, endoscopic procedures, or the passage of sounds or catheters. The use of Urezol HCl for relief of symptoms should not delay definitive diagnosis and treatment of causative conditions. Because it provides only symptomatic relief, prompt appropriate treatment of the cause of pain must be instituted and Urezol HCl should be discontinued when symptoms are controlled.

The analgesic action may reduce or eliminate the need for systemic analgesics or narcotics. It is, however, compatible with antibacterial therapy and can help to relieve pain and discomfort during the interval before antibacterial therapy controls the infection. Treatment of a urinary tract infection with Urezol HCl should not exceed two days because there is a lack of evidence that the combined administration of Urezol HCl and an antibacterial provides greater benefit than administration of the antibacterial alone after two days.

Urezol is a pain reliever that affects the lower part of your urinary tract (bladder and urethra).

Urezol is used to treat pain, burning, increased urination, and increased urge to urinate. These symptoms are usually caused by infection, injury, surgery, catheter, or other conditions that irritate the lower urinary tract.

Urezol will treat the symptoms of a urinary tract infection, but this medication does not treat the actual infection. Take any antibiotic that your doctor prescribes to treat your infection.

Urezol may also be used for other purposes not listed in this medication guide.

Usual Adult Dose for Dysuria

190 to 200 mg orally 3 times a day after meals. Do not administer for more than 2 days when used with a urinary antibacterial.

Usual Pediatric Dose for Dysuria

>= 6 years to 18 years:

12 mg/kg/day orally divided into 3 doses for two days. Maximum dose: 600 mg/day.

Renal Dose Adjustments

CrCl >= 50 <80 mL/min: Administer every 8 to 16 hours.

CrCl <50 mL/min: not recommended

Liver Dose Adjustments

Data not available

Precautions

Urezol should not be administered to patients with CrCl <50 mL/min. Urezol should be used with caution in patients with renal impairment.

A yellowish tinge of the skin or sclera may indicate accumulation due to renal insufficiency and the need to discontinue Urezol.

Children younger than 12 years of age should not take Urezol unless directed by a physician.

Dialysis

Data not available

Other Comments

Treatment of a urinary tract infection with Urezol and an antibacterial should not exceed 2 days as there is no evidence that Urezol provides any greater benefit than the antibacterial alone after 2 days.

The urine may present reddish-orange after use of the drug.

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What is the most important information I should know about Urezol?

Do not take this medication if you are allergic to Urezol, or if you have kidney disease.

Urezol will treat the symptoms of a urinary tract infection, but this medication does not treat the actual infection. Take any antibiotic that your doctor prescribes to treat your infection.

To avoid stomach upset, take Urezol with food.

Urezol will most likely darken the color of your urine to an orange or red color. This is a normal effect and is not cause for alarm unless you have other symptoms such as pale or yellowed skin, fever, stomach pain, nausea, and vomiting. Darkened urine may also cause stains to your underwear, which may or may not be removed by laundering.

Urezol can also permanently stain soft contact lenses, and you should not wear them while taking this medicine.

Do not use Urezol for longer than 2 days unless your doctor has told you to.

Stop taking this medication and call your doctor at once if you have pale skin, fever, confusion, yellowing of your skin or eyes, increased thirst, swelling, or if you urinate less than usual or not at all.

Use Urezol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Urezol by mouth after meals.
• Taking Urezol at the same time(s) each day will help you remember to take it.
• If you miss a dose of Urezol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Urezol.

This medication is used to relieve symptoms caused by irritation of the urinary tract such as pain, burning, and the feeling of needing to urinate urgently or frequently. This drug does not treat the cause of the urinary irritation, but it can help relieve the symptoms while other treatments take effect. Urezol is a dye that works as a painkiller to soothe the lining of the urinary tract.

How to use Urezol

Take this medication by mouth, usually 3 times daily after meals or as directed by your doctor. If you are taking this medication along with antibiotics for symptoms related to a urinary tract infection, or are self-treating, do not take it for more than 2 days without talking to your doctor.

Dosage is based on your medical condition and response to therapy.

Inform your doctor if your condition persists or worsens.

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What other drugs will affect Urezol?

With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of paracetamol.

With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.

With the simultaneous use of anticholinergics may decrease absorption of paracetamol.

With the simultaneous use of oral contraceptives accelerated excretion of paracetamol from the body and may reduce its analgesic action.

With the simultaneous use with urological means reduced their effectiveness.

With the simultaneous use of activated charcoal reduced bioavailability of paracetamol.

When Urezol applied simultaneously with diazepam may decrease excretion of diazepam.

There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with paracetamol. A case of severe toxic liver injury.

Described cases of toxic effects of paracetamol, while the use of isoniazid.

When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of paracetamol, which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of paracetamol and phenobarbital.

In applying cholestyramine a period of less than 1 h after administration of paracetamol may decrease of its absorption.

At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.

With the simultaneous use of metoclopramide may increase absorption of paracetamol and its increased concentration in blood plasma.

When applied simultaneously with probenecid may decrease clearance of paracetamol, with rifampicin, sulfinpyrazone - may increase clearance of paracetamol due to increasing its metabolism in the liver.

At simultaneous application of Urezol with ethinylestradiol increases absorption of paracetamol from the gut.

Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).

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What are the possible side effects of Urezol?

Applies to Urezol: oral kit, oral tablet

In addition to its needed effects, some unwanted effects may be caused by Urezol (the active ingredient contained in Urezol). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking Urezol, check with your doctor or nurse as soon as possible:

Rare

• Blue or blue-purple color of skin
• fever and confusion
• shortness of breath, tightness in chest, wheezing, or troubled breathing
• skin rash
• sudden decrease in the amount of urine
• swelling of face, fingers, feet, and/or lower legs
• unusual tiredness or weakness
• weight gain
• yellow eyes or skin

Minor Side Effects

Some of the side effects that can occur with Urezol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common or rare:

• Dizziness
• headache
• indigestion
• itching of the skin
• stomach cramps or pain