Components:
Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 26.06.2023

Attention! Information on this page is intended only for medical professionals! Information is collected in open sources and may contain significant errors! Be careful and double-check all the information on this page!
Top 20 medicines with the same components:
Each 5-mg MR tablet also contains the following excipients: Lactose 36.9 mg. Tablet Core: Anhydrous colloidal silica, croscarmellose sodium, lactose monohydrate, magnesium stearate, povidone K 29/32 and red ferric oxide E 172. Tablet Shell: Anhydrous colloidal silica, calcium hydrogen phosphate dihydrate, glyceryl behenate, magnesium stearate, povidone K 29/32 and yellow ferric oxide E 172.
Trolic modified-release tablet is consist of a Trolic-containing core and an inert coating. Delayed release of Trolic is dependent on an intact coating.
Trolic (Trolic) Tablets are indicated in the following conditions:
- Endocrine Disorders
Primary or secondary adrenocortical insufficiency
(hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance)
Congenital adrenal hyperplasia
Hypercalcernia associated with cancer
Nonsuppurative thyroiditis
- Rheumatic Disorders
As adjunctive therapy for short-term administration
(to tide the patient over an acute episode or exacerbation) in:
Psoriatic arthritis
Rheumatoid arthritis, including juvenile rheumatoid arthritis
(selected cases may require low-dose maintenance therapy)
Ankylosing spondylitis
Acute and subacute bursitis
Acute nonspecific tenosynovitis
Acute gouty arthritis
Post-traumatic osteoarthritis
Synovitis of osteoarthritis
Epicondylitis
- Collagen Diseases
During an exacerbation or as maintenance therapy in selected cases of:
Systemic lupus erythematosus
Systemic-dermatomyositis (polymyositis)
Acute rheumatic carditis
- Dermatologic Diseases
Pemphigus
Bullous dermatitis herpetiformis
Severe erythema multiforme
(Stevens-Johnson syndrome)
Exfoliative dermatitis
Mycosis fungoides
Severe psoriasis
Severe seborrheic dermatitis
- Allergic States
Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment:
Seasonal or perennial allergic rhinitis
Bronchial asthma
Contact dermatitis
Atopic dermatitis
Serum sickness
Drug hypersensitivity reactions
Ophthalmic Diseases
Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as:
Allergic cornea marginal ulcers
Herpes zoster ophthalmicus
Anterior segment inflammation
Diffuse posterior uveitis and choroiditis
Sympathetic ophthalmia
Allergic conjunctivitis
Keratitis
Chorioretinitis
Optic neuritis
Iritis and iridocyclitis
- Respiratory Diseases
Symptomatic sarcoidosis
Loeffler's syndrome not manageable by other means
Berylliosis
Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy
Aspiration pneumonitis
- Hematologic Disorders
Idiopathic thrombocytopenic purpura in adults
Secondary thrombocytopenia in adults
Acquired (autoimmune) hemolytic anemia
Erythroblastopenia (RBC anemia)
Congenital (erythroid) hypoplastic anemia
- Neoplastic Diseases For palliative management of:
Leukemias and lymphomas in adults
Acute leukemia of childhood
- Edematous States
To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus
- Gastrointestinal Diseases
To tide the patient over a critical period of the disease in:
Ulcerative colitis
Regional enteritis
- Nervous System
Acute exacerbations of multiple sclerosis
- Miscellaneous
Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy
Trichinosis with neurologic or myocardial involvement
Trolic is a steroid. Trolic prevents the release of substances in the body that cause inflammation. Trolic also suppresses the immune system.
Trolic is used as an anti-inflammatory or an immunosuppressant medication. Trolic treats many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders.
Trolic may also be used for purposes not listed in this medication guide.
Recommended Dosing
Dosage of Trolic should be individualized according to the severity of the disease and the response of the patient. For pediatric patients, the recommended dosage should be governed by the same considerations rather than strict adherence to the ratio indicated by age or body weight.
The maximal activity of the adrenal cortex is between 2 am and 8 am and is minimal between 4 pm and midnight. Exogenous corticosteroids suppress adrenocorticoid activity the least when given at the time of maximal activity. Trolic is a delayed-release formulation of Trolic which releases the active substance beginning approximately 4 hours after intake. The timing of Trolic administration should take into account the delayed-release pharmacokinetics and the disease or condition being treated.
The initial dosage of Trolic may vary from 5 to 60 mg per day depending on the specific disease entity being treated. Patients currently on immediate release Trolic, prednisolone, or methylprednisolone should be switched to Trolic at an equivalent dose based on relative potency (2.4).
In situations of less severity, lower doses will generally suffice while in selected patients higher initial doses may be required. The initial dosage should be maintained or adjusted until a satisfactory response is noted. If after a reasonable period there is a lack of satisfactory clinical response, Trolic should be discontinued and the patient transferred to other appropriate therapy. It should be emphasized that dosage requirements are variable and must be individualized on the basis of the disease under treatment and the response of the patient.
After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reached. It should be kept in mind that constant monitoring is needed in regard to drug dosage. Included in the situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease process, the patient's individual drug responsiveness, and the effect of patient exposure to stressful situations not directly related to the disease entity under treatment. In this latter situation it may be necessary to increase the dosage of Trolic for a period of time consistent with the patient's condition. If a period of spontaneous remission occurs in a chronic condition, treatment should be discontinued. If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly.
Recommended Monitoring
Blood pressure, body weight, routine laboratory studies (including 2-hour postprandial blood glucose and serum potassium), and chest X-ray should be obtained at regular intervals during prolonged therapy with Trolic. Upper GI X-rays are desirable in patients with known or suspected peptic ulcer disease.
Method of Administration
Trolic is for oral administration.
Trolic should be taken daily with food.
Trolic tablets should not be broken, divided, or chewed because the delayed release of Trolic is dependent on an intact coating.
Corticosteroid Comparison Chart
For the purpose of comparison, one 5 mg Trolic tablet is the equivalent milligram dosage of the following various corticosteroids:
Betamethasone, 0.75 mg | Paramethasone, 2 mg |
Cortisone, 25 mg | Prednisolone, 5 mg |
Dexamethasone, 0.75 mg | Trolic, 5 mg |
Hydrocortisone, 20 mg | Triamcinolone, 4 mg |
Methylprednisolone, 4 mg |
These dose relationships apply only to oral or intravenous administration of these compounds. When these substances or their derivatives are injected intramuscularly or into joint spaces, their relative properties may be greatly altered.
How supplied
Dosage Forms And Strengths
Delayed-release Tablets
- Trolic 1 mg Trolic: Pale yellowish-white, round, unscored delayed-release tablet embossed with “NP 1” on one side.
- Trolic 2 mg Trolic: Yellowish-white, round, unscored delayed-release tablet embossed with “NP 2” on one side.
- Trolic 5 mg Trolic: Light yellow, round, unscored delayed-release tablet embossed with “NP 5” on one side.
Storage And Handling
Trolic delayed-release tablets (1 mg Trolic) are pale yellowish-white, round, unscored tablets embossed with “NP 1” on one side and supplied as:
NDC Number | Size |
75987-020-01 | Bottle of 30 tablets |
75987-020-02 | Bottle of 100 tablets |
Trolic delayed-release tablets (2 mg Trolic) are yellowish-white, round, unscored tablets embossed with “NP 2” on one side and supplied as:
NDC Number | Size |
75987-021-01 | Bottle of 30 tablets |
75987-021-02 | Bottle of 100 tablets |
Trolic delayed-release tablets (5 mg Trolic) are light yellow, round, unscored tablets embossed with “NP 5” on one side and supplied as:
NDC Number | Size |
75987-022-01 | Bottle of 30 tablets |
75987-022-02 | Bottle of 100 tablets |
Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F)..
Protect Trolic tablets from light and moisture.
Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.
Distributed by: Horizon Pharma USA, Inc. 520 Lake Cook Road, Suite 520 Deerfield, IL 60015. Revised: June 2013
See also:
What is the most important information I should know about Trolic?
Hypersensitivity to Trolic or any component of the formulation; administration of live or live attenuated vaccines with immunosuppressive doses of Trolic; systemic fungal infections
Canadian labeling: Additional contraindications (not in US labeling): Herpes simplex of the eye, measles, or chickenpox (except when being used for short-term or emergency therapy); peptic ulcer; nonspecific ulcerative colitis; diverticulitis; viral or bacterial infection not controlled by anti-infectives
Documentation of allergenic cross-reactivity for corticosteroids is limited. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty.
Use Trolic delayed-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Trolic delayed-release tablets by mouth with food.
- Swallow Trolic delayed-release tablets whole. Do not break, crush, chew, or divide before swallowing.
- Do not suddenly stop taking Trolic delayed-release tablets without checking with your doctor. You may have an increased risk of side effects. If you need to stop Trolic delayed-release tablets, your doctor may gradually lower your dose.
- If you miss a dose of Trolic delayed-release tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Trolic delayed-release tablets.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Trolic is used to treat conditions such as arthritis, blood disorders, breathing problems, severe allergies, skin diseases, cancer, eye problems, and immune system disorders. Trolic belongs to a class of drugs known as corticosteroids. It decreases your immune system's response to various diseases to reduce symptoms such as swelling and allergic-type reactions.
How to use Trolic
Take this medication by mouth, with food or milk to prevent stomach upset, as directed by your doctor. Take the tablet form of this medication with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. If you are prescribed only one dose per day, take it in the morning before 9 A.M.
Take this medication exactly as directed by your doctor. Follow the dosing schedule carefully. The dosage and length of treatment are based on your medical condition and response to treatment. If you are taking this medication on a different schedule than a daily one (such as every other day), it may help to mark your calendar with a reminder.
Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Also, you may experience symptoms such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness. To prevent these symptoms while you are stopping treatment with this drug, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details. Report any new or worsening symptoms right away.
Tell your doctor if your condition persists or worsens.
See also:
What other drugs will affect Trolic?
Interactions with other Medicinal Products and other Forms of Interaction: Cardiac Glycosides: The effect of the glycosides can be enhanced by potassium deficiency.
Saluretics/Laxatives: Potassium excretion is enhanced.
Antidiabetic Agents: The blood sugar lowering effect is reduced.
Coumarin Derivatives: The efficacy of coumarin anticoagulants may be reduced or enhanced.
Non-Steroidal Antiphlogistic/Antirheumatic Agents, Salicylates and Indomethacin: The risk of gastrointestinal haemorrhages is increased.
Non-Depolarising Muscle Relaxants: Muscle relaxation may be prolonged.
Atropine and Other Anticholinergics: The concurrent use of Trolic may result in additional increases in intraocular pressure.
Praziquantel: Glucocorticoids may lower the praziquantel concentrations in the blood.
Chloroquine, Hydroxychloroquine, Mefloquine: There is an increased risk of occurrence of myopathies, cardiomyopathies.
Somatropin: The efficacy of somatropin may be reduced.
Oestrogens (eg,
Oral Contraceptives): May enhance the efficacy of glucocorticoids.
Liquorice: Inhibition of the metabolism of glucocorticoids is possible.
Rifampicin, Phenytoin, Barbiturates, Bupropion and Primidone: The efficacy of glucocorticoids is reduced.
Cyclosporine: The blood levels of cyclosporine are increased. There is an increased risk of seizures.
Amphotericine B: The risk of hypokalaemia may be increased.
Cyclophosphamide: The effects of cyclophosphamide may be enhanced.
ACE inhibitors: Increased risk of occurrence of blood count changes.
Aluminium and Magnesium Antacids: The absorption of glucocorticoids is reduced. However, due to the delayed release mechanism of Trolic, an interaction between Trolic and aluminium/magnesium antacids is unlikely.
Impact on Diagnostic Methods: Skin reactions caused by allergy testing may be suppressed. The TSH increase following the administration of protirelin may be reduced.
See also:
What are the possible side effects of Trolic?
Applies to Trolic: oral solution, oral syrup, oral tablet, oral tablet delayed release
As well as its needed effects, Trolic (the active ingredient contained in Trolic) may cause unwanted side effects that require medical attention.
Major Side Effects
If any of the following side effects occur while taking Trolic, check with your doctor immediately:
More common:
- Aggression
- agitation
- anxiety
- blurred vision
- decrease in the amount of urine
- dizziness
- fast, slow, pounding, or irregular heartbeat or pulse
- headache
- irritability
- mental depression
- mood changes
- nervousness
- noisy, rattling breathing
- numbness or tingling in the arms or legs
- pounding in the ears
- shortness of breath
- swelling of the fingers, hands, feet, or lower legs
- trouble thinking, speaking, or walking
- troubled breathing at rest
- weight gain
- Abdominal or stomach cramping or burning (severe)
- abdominal or stomach pain
- backache
- bloody, black, or tarry stools
- cough or hoarseness
- darkening of skin
- decrease in height
- decreased vision
- diarrhea
- dry mouth
- eye pain
- eye tearing
- facial hair growth in females
- fainting
- fever or chills
- flushed, dry skin
- fractures
- fruit-like breath odor
- full or round face, neck, or trunk
- heartburn or indigestion (severe and continuous)
- increased hunger
- increased thirst
- increased urination
- loss of appetite
- loss of sexual desire or ability
- lower back or side pain
- menstrual irregularities
- muscle pain or tenderness
- muscle wasting or weakness
- nausea
- pain in back, ribs, arms, or legs
- painful or difficult urination
- skin rash
- sleeplessness
- sweating
- trouble healing
- trouble sleeping
- unexplained weight loss
- unusual tiredness or weakness
- vision changes
- vomiting
- vomiting of material that looks like coffee grounds
Minor Side Effects
Some Trolic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:
More common:
- Increased appetite
- Abnormal fat deposits on the face, neck, and trunk
- acne
- dry scalp
- lightening of normal skin color
- red face
- reddish purple lines on the arms, face, legs, trunk, or groin
- swelling of the stomach area
- thinning of the scalp hair