Tebokan

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Tebokan

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Tebokan

Property Description
Active ingredient Standardized dry extract, EGb 761
Form Film-coated tablet (Solid oral dosage form)
Pharmacological class Phytomedicine, Neurotropic agent
General purpose Support for cognitive function and microcirculation
Origin Natural (Ginkgo biloba leaves)

What Type of Medicine Is Tebokan (EGb 761)?

Tebokan is a widely recognized brand name for a standardized herbal medicinal product, placing it in the pharmacological class of phytomedicines. Its defining constituent is the highly purified dry extract known as EGb 761, which is derived from the leaves of the Ginkgo biloba tree and is administered via the oral route as a film-coated tablet. The extract is classified functionally as a neurotropic agent and vasoregulator due to its established influence on neural and circulatory health. This preparation is recognized in various global markets, often used by an adult patient group seeking support for age-related changes.

What Is the Composition of Tebokan and Its Differentiation?

The active ingredient is the complex EGb 761 extract, whose effect is based on the synergy of its constituents, including Ginkgo flavone glycosides and Terpene lactones (Ginkgolides and Bilobalide). The key differentiating feature of Tebokan is its reliance on the precisely defined standardization of the EGb 761 extract. This proprietary process ensures a consistent profile of active compounds—approximately 24% Ginkgo flavone glycosides and 6% Terpene lactones—while limiting potentially undesirable substances, aligning it with the quality standards expected of a licensed medicine.

What Is the General Purpose of This Phytomedicine?

The general purpose of the EGb 761 extract is to provide support for overall vascular health and cellular resilience, particularly in the brain. Its actions, which include optimizing blood flow within the microcirculation and providing neuroprotection against oxidative stress, are clinically recognized for their relevance in managing symptoms related to age-related decline. The product is intended to help maintain and support cerebral performance and cognitive function by ensuring a stable supply of oxygen and essential nutrients to the brain tissue. The product positioning emphasizes its nature as an evidence-based, quality-controlled single-entity product.

Regulatory References

  1. Ginkgo Biloba - StatPearls - NCBI Bookshelf

What side effects are possible with Tebokan?

Possible Side Effects and Safety Information

The safety profile for the standardized dry extract EGb 761 (Tebokan) is officially characterized by a set of adverse reactions grouped by frequency and affected body system, as documented in regulatory sources.


Frequency-Classified Adverse Reactions

The officially listed adverse events fall into the following regulatory categories:

  • Common (affecting 1 to 10 users in 100): These include headache, dizziness, and minor gastrointestinal complaints such as nausea, dyspepsia, and abdominal pain.
  • Uncommon (affecting 1 to 10 users in 1,000): These typically involve hypersensitivity reactions (allergic reactions) and specific skin reactions, including pruritus (itching) and rash.
  • Not Known: This category includes the potential for serious bleeding events, particularly when the medicine is used with other medications affecting blood coagulation, as well as severe forms of hypersensitivity.

System-Organ Class (SOC) Groupings

Adverse effects are formally categorized under the Nervous system disorders, Gastrointestinal disorders, Immune system disorders, and Skin and subcutaneous tissue disorders.


Safety Constraints and Considerations

The regulatory labeling includes specific limitations based on safety assessments. Use is contraindicated in individuals with a known hypersensitivity or allergy to the Ginkgo biloba extract. Furthermore, official caution is required for patients with a predisposition to hemorrhagic diathesis or a history of seizures/epilepsy. A primary safety restriction relates to the potential for interaction: the product should be discontinued prior to surgical procedures and used with caution when administered alongside anticoagulants or antiplatelet drugs.

Overdose and Emergency Response

An overdose of the standardized dry extract EGb 761 is formally documented to involve risks across several physiological systems. Documented overdose presentations often include central nervous system effects such as headache, restlessness, and dizziness, alongside gastrointestinal disorders like nausea, vomiting, and diarrhea. More serious, potentially life-threatening outcomes reported in high-dose scenarios include the onset of convulsions or seizures, as well as severe hemorrhagic complications, such as spontaneous bleeding or loss of consciousness.

The official regulatory guidance mandates that patients or caregivers seek immediate medical attention or emergency care right away for any suspected overdose. This action is particularly critical when severe manifestations like seizures or signs of internal bleeding are present.

Management of an EGb 761 overdose is strictly symptomatic and supportive, as no specific antidote is known. This includes implementing standard measures to limit absorption and maintaining essential fluid and electrolyte balance. Furthermore, official labeling notes that individuals with pre-existing bleeding disorders may face an increased risk of hemorrhagic complications in an overdose situation.

Therapeutic Uses of Tebokan

What Tebokan Treats: Main Uses and Benefits

Tebokan (EGb 761) is generally applied in clinical settings to provide symptomatic support across primary domains associated with age-related decline and vascular health, which may contribute to easing the overall symptom load. This phytomedicine is considered relevant for symptomatic relief in cognitive and neurosensory domains.

The core therapeutic domains involve symptomatic support for conditions such as mild-to-moderate dementia and mild cognitive impairment (MCI), and are relevant for easing chronic manifestations like vertigo and tinnitus, as well as providing supportive relief for symptoms linked to peripheral arterial occlusive disease (pAVD).

Key Therapeutic Focus

The medication is commonly used to help with symptom clusters that may become disruptive, such as difficulty with memory, concentration, and learning ability. Tebokan may assist with maintaining functional stability in daily activities by supporting cognitive function, and is relevant for easing the challenging symptom of intermittent claudication during movement.

Quick Fact: Support for Cognitive Function

Eligibility and Restrictions for Use

Eligibility for Tebokan: Official Regulatory Information

Official regulatory documents define the populations eligible to use Tebokan, as well as groups for whom use is contraindicated or not recommended, strictly based on established health and age criteria.


Populations that MUST NOT use Tebokan (Contraindications)

  • Hypersensitivity: Patients with a known allergy or hypersensitivity to the active substance, Ginkgo biloba extract, or any of the product's excipients.
  • Pregnancy: Use is formally contraindicated for women who are pregnant.
  • Intracranial Hemorrhage: Patients with known risk factors for bleeding within the skull (intracranial hemorrhage).

Age and Physiological Status Rules

Classification Population Regulatory Status
Eligible Adults (18 years and older) Allowed
Non-Eligible Children and Adolescents (under 18) Not Recommended (Insufficient data)
Restricted Use Breastfeeding Women Not Recommended (Unless advised by a doctor)

Special Considerations for Use

Use is generally not recommended or requires special medical caution for patients who have an increased risk of bleeding, have a known bleeding disorder, or have a history of epilepsy or a predisposition to seizures. Additionally, patients scheduled for a surgical procedure should discontinue use at least two weeks prior.

What should I know about interactions with other medicines?

Interactions with other medicines and products

This section summarizes the officially documented interaction patterns for the EGb 761 extract found in Tebokan, based strictly on governmental regulatory information.


Documented Pharmacokinetic and Pharmacodynamic Interactions

Interaction Type Interacting Agent or Class Official Regulatory Outcome
Pharmacodynamic Anticoagulants (e.g., Warfarin) and Anti-platelet agents Increased risk of bleeding due to additive anti-haemostatic effects.
Pharmacokinetic Efavirenz Co-administration is not recommended; CYP3A4 induction may decrease Efavirenz plasma concentrations.
Pharmacokinetic Dabigatran etexilate Caution is advised; P-glycoprotein inhibition may increase exposure (AUC/Cmax) of Dabigatran etexilate.
Pharmacokinetic Nifedipine May raise Nifedipine plasma levels and increase its effects, such as dizziness.

Procedural and Population Restrictions

Due to potential anti-haemostatic effects, EGb 761 preparations must be discontinued at least 2 weeks prior to any surgery. Caution is formally advised when using the product in patients with epilepsy, as the onset of further seizures cannot be excluded. The use of Tebokan is also contraindicated in individuals with known hypersensitivity to soya or peanut, due to the presence of soya polysaccharide excipients in the tablet formulation.

This structure defines the specific constraints and requirements for use alongside other medicines or in preparation for medical procedures.

Mechanism of Action

Tebokan, containing a standardized Ginkgo biloba extract (e.g., EGb 761), acts via its major constituents, ginkgo flavone glycosides and terpene lactones (ginkgolides and bilobalide), on multiple biological targets, primarily within the central nervous and vascular systems. The flavonoids function as free radical scavengers and antioxidants, limiting the generation of reactive oxygen species (ROS) and inhibiting lipid peroxidation of cellular membranes, thereby protecting against oxidative damage. The terpene lactones, specifically Ginkgolide B, serve as a non-competitive antagonist at the Platelet-Activating Factor (PAF) receptor, inhibiting the binding of PAF and subsequent platelet aggregation and degranulation. Downstream cascades involve the modulation of vascular tone. Components of the extract stimulate the release of endothelium-derived relaxing factors, including nitric oxide (NO) and prostacyclin, from the arterial endothelium, resulting in vasodilation. This system-level physiological consequence includes the modulation of microcirculatory blood flow and capillary perfusion in various vascular beds, including cerebral and peripheral tissues. Additionally, the extract may exhibit reversible monoamine oxidase A (MAO-A) inhibition and modulate the expression of certain neurotransmitter receptors, such as alpha1-adrenergic and muscarinic receptors.

Dosage and Administration Information

How to Use Tebokan

This section describes the general administration and dosage principles for Tebokan (standardized Ginkgo biloba dry extract, EGb 761).


Administration and Dosage Regimens

Tebokan is administered exclusively via the oral route as a film-coated tablet. The established usage pattern involves a daily intake of the EGb 761 extract, with the total dose typically ranging from 120 mg to 240 mg for adult patients.

To ensure consistent use, the total daily amount is generally divided into two or three doses taken throughout the day. For example, a twice-daily or three-times-daily regimen is commonly employed to reach the prescribed total daily amount. The film-coated tablet must be swallowed whole with a glass of water and should not be chewed.

Key Usage Conditions

Usage Condition Official Instruction Principle
Timing in relation to meals Can be taken with or after food.
Treatment Duration Pattern The course of use is typically long-term, often requiring a continuous regimen of at least eight weeks before efficacy is assessed.
Missed Dose Management If a dose is forgotten, the instruction is to skip the missed dose and resume the schedule at the next designated time; a double dose must not be taken to compensate.
Population Restrictions The medicine is intended for use in adults and is not recommended for use in children and adolescents due to insufficient data.

The official instruction set defines Tebokan as a sustained, oral, divided-dose therapy for adult use, with specific rules regarding tablet ingestion and duration of the treatment course.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Tebokan (EGb 761)


Evidence for Use in Mild-to-Moderate Cognitive Impairment

The most extensive research on the standardized extract EGb 761 has focused on populations of older adults experiencing age-related changes, including Mild Cognitive Impairment (MCI) and symptoms of mild-to-moderate dementia. This evidence base is built upon numerous Randomized Controlled Trials (RCTs) and systematic reviews. Studies examined how outcomes related to cognitive performance—such as memory and attention—and daily functioning changed over the typical intermediate-term study periods of five to six months. Findings describe patterns observed in the studies related to changes in these assessment scores, but long-term effects over many years are not fully established.


Evidence for Neurosensory and Circulatory Issues

Research has also examined populations where symptoms of vertigo and tinnitus are present. Studies explored the extract's use during periods of increased symptom activity and monitored patient-reported outcomes describing perceived discomfort and symptom intensity. Findings were mixed across studies, and data for certain subgroups remain insufficient.

For Peripheral Arterial Occlusive Disease (PAOD), research has explored the extract in populations presenting with symptoms like intermittent claudication. Studies employed RCTs to evaluate functional outcomes, measuring changes in pain-free walking distance. Research suggests that while changes were observed in walking distance over the four- to six-month study period, the magnitude of the reported changes was described as modest in the scientific literature.


What Is Still Uncertain about Tebokan's Evidence

Scientific assessments consistently highlight several areas of uncertainty. While the study landscape is extensive for cognitive symptoms, the overall magnitude of change measured in clinical trials is often described as modest. Data for long-term outcomes, regarding the maintenance of any patterns observed over many years, are limited. Furthermore, evidence quality varies across studies, and data remain insufficient for patients with specific comorbidities.

Key Studies & References

  1. Ginkgo biloba extract EGb 761® in the symptomatic treatment of mild-to-moderate dementia: a profile of its use
  2. An Overview of Systematic Reviews of Ginkgo biloba Extracts for Mild Cognitive Impairment and Dementia
  3. Ginkgo biloba Extract EGb 761 in the Treatment of Patients with Mild Neurocognitive Impairment: A Systematic Review

Frequently Asked Questions (FAQ)

Common questions about Tebokan (FAQ)


Q: What is the main difference between Tebokan and other Ginkgo Biloba supplements?

The key difference is that Tebokan contains the specific, highly purified, and standardized EGb 761 extract. This extract is regulated to ensure a consistent composition of active ingredients, typically 24% Ginkgo flavone glycosides and 6% Terpene lactones. This defined standardization aligns it with the quality and consistency standards expected of a licensed medicine, unlike many general dietary supplements.


Q: Is Tebokan considered a 'natural' or herbal medicine?

Tebokan is officially classified as a phytomedicine, which is a type of herbal medicinal product. Its active ingredient, EGb 761, is a standardized dry extract derived from the natural leaves of the Ginkgo biloba tree. This classification means the product must meet specific standards for manufacturing and quality.


Q: How quickly can someone expect to notice the effects of Tebokan?

The full effects of Tebokan are typically not immediate. Official usage guidelines indicate that a continuous regimen of at least eight weeks is often required before the full assessment of the medicine’s efficacy can be made.


Q: Can Tebokan be used by older people for memory support?

Tebokan is licensed for use in adults (18 years and older), and much of the extensive research focuses on older populations experiencing age-related changes. The product's general purpose is to provide support for cognitive function and cerebral performance in these contexts.


Q: Is it okay to take Tebokan if I am generally healthy and just want a boost?

Official product information describes the general purpose of the standardized extract as providing support for vascular health and cellular resilience in managing symptoms related to age-related decline. The regulatory context positions the medicine for supportive use in certain conditions. It does not contain information promoting its use for a non-specific 'boost' in otherwise healthy individuals.


Q: Is it normal to feel a mild headache when first starting Tebokan?

According to the official safety profile, headache is listed as a Common side effect. This means it may affect between 1 to 10 users in every 100. Other common side effects include dizziness and minor gastrointestinal complaints.


Q: Is Tebokan meant to be a permanent treatment or a temporary support?

The established usage pattern described in regulatory documents involves a typically long-term course of use. The product is intended to be taken as a continuous regimen for a sustained period.


Q: What should I do if I experience a mild stomach upset after taking Tebokan?

Minor gastrointestinal complaints, such as nausea or abdominal pain, are listed as Common side effects in the safety information. Symptoms that are persistent, concerning, or worsen over time are typically discussed with a healthcare professional.


Q: What is the evidence level for Tebokan's role in improving circulation?

The extract's mechanism of action includes optimizing blood flow within the microcirculation (the smallest blood vessels). Research has focused on outcomes for Peripheral Arterial Occlusive Disease (PAOD), with studies observing modest changes in pain-free walking distance.


Q: Why is Tebokan often grouped with medicines for neurological function?

Tebokan is classified as a neurotropic agent due to its established influence on the central nervous and vascular systems. Its official purpose is to help maintain and support cerebral performance and cognitive function, which is why it is often associated with neurological support.


Q: What is the typical age range of people who use Tebokan?

The medicine is formally eligible for use by adults (18 years and older). Although the medicine is intended for the adult population, most of the extensive clinical research focuses specifically on older adults experiencing age-related decline.


Q: What are the long-term observational findings regarding Tebokan use?

Scientific assessments consistently highlight that data for the long-term outcomes of Tebokan use over many years are limited. While intermediate-term studies of five to six months have been conducted, the full effects of continuous use beyond these periods are not fully established.


Q: Is Tebokan typically started at a low dose and increased, or a fixed dose?

Official documentation specifies a total daily dose range that is generally divided into two or three doses. The regulatory guidance does not specify a mandatory titration schedule, which is the practice of starting a treatment at a low dose and then gradually increasing it.


Q: What are the main findings of the clinical studies cited for Tebokan?

Key research findings relate to several areas: changes in memory and attention were observed in studies of Mild Cognitive Impairment (MCI). Research on vertigo and tinnitus has yielded mixed findings, and studies on Peripheral Arterial Occlusive Disease (PAOD) have noted modest increases in pain-free walking distance.


Q: Do you need a prescription to buy Tebokan?

Tebokan is regulated as a standardized herbal medicinal product. In many markets where it is registered, it is available over-the-counter (without a prescription). However, availability and specific prescription requirements may differ depending on the national regulation where the product is sold.


Q: Does Tebokan cause any noticeable changes in sleep patterns?

Adverse effects are formally categorized under Nervous system disorders, such as headache and dizziness. However, specific changes in sleep patterns, such as insomnia or excessive drowsiness (somnolence), are not explicitly listed as Common or Uncommon side effects.


Q: Does taking Tebokan affect how pain medication works?

Official documents explicitly list interactions with blood thinners (Anticoagulants) and Anti-platelet agents due to an increased risk of bleeding. Regulatory documents indicate that caution is necessary when other medicines with anti-haemostatic effects are taken concomitantly.


Q: Is Tebokan safe to use while driving or operating heavy machinery?

The common side effects listed in the official safety profile include dizziness and headache. If these effects occur, they may affect an individual's ability to drive or operate heavy machinery.


Q: What does 'adjunctive therapy' mean in the context of Tebokan's uses?

The term adjunctive therapy refers to a treatment that is used to supplement a primary or main treatment. In a medical context, it means that the product is intended to be used in addition to, rather than as a replacement for, standard therapies.


Q: Is there any difference in how Tebokan is regulated in Europe versus the US?

Yes, there can be regulatory differences. The standardized EGb 761 extract is generally registered as a standardized herbal medicinal product in many European countries. In contrast, in the United States, it is typically available only as a dietary supplement, which falls under different regulatory requirements for quality and labeling.


Q: Can Tebokan be taken on an empty stomach?

Official instructions state that Tebokan can be taken with or after food. While this suggests flexibility in administration timing, regulatory documents do not provide specific guidance on taking the medicine on a completely empty stomach.


Q: Is there any research looking into Tebokan's effect on eye health?

Official regulatory research focuses primarily on cerebral and peripheral circulatory issues. However, certain clinical studies and academic literature have explored the extract’s influence on populations with specific eye-related vascular conditions.


Q: Can people with a known allergy to certain plants still use Tebokan?

Tebokan is formally contraindicated (must not be used) if a person has a known allergy to the active substance (Ginkgo biloba extract) or certain excipients, specifically soya or peanut. The decision regarding use with other plant allergies is typically determined by a healthcare professional.


Q: Does Tebokan have any known contraindications for people with diabetes?

Diabetes is not listed as a formal contraindication in official regulatory documentation. Some authoritative medical reviews mention the need for close monitoring of blood sugar levels when Ginkgo biloba products are taken by people with diabetes.


Q: Does Tebokan have a shelf life, and how long is it typically valid after purchase?

As a regulated medicinal product, the specific expiration date (the shelf life) is printed on the product's packaging. Regulatory standards also require that the medicine be stored under specific conditions, typically at a temperature not exceeding 25 C, to maintain its quality.


Q: How does the concentration of the active ingredient in Tebokan compare to raw Ginkgo leaf supplements?

Tebokan contains the EGb 761 extract, which has a highly concentrated and standardized profile of active compounds. This consistency, achieved by removing undesirable substances, means the concentration and specific composition are significantly different from the variable and typically lower concentrations found in raw Ginkgo leaf preparations.


Q: Can Tebokan affect the results of certain laboratory tests?

Due to its anti-haemostatic effect (meaning it influences blood clotting), Tebokan may affect the results of certain blood coagulation tests. For any laboratory test, the standard procedure is to discuss all current medicines and supplements with the prescribing or treating healthcare professional.


Q: What are the key exclusion criteria mentioned in research studies for Tebokan?

Common exclusion criteria for individuals participating in clinical studies of EGb 761 often include a history of seizures/epilepsy, known use of disallowed concomitant therapies, significant untreated medical conditions, and being pregnant or breastfeeding.


Q: Can Tebokan affect blood pressure readings?

The mechanism of action involves the modulation of vascular tone and promoting vasodilation (widening of blood vessels). However, changes in overall blood pressure are not listed as a Common or Uncommon adverse reaction in the official safety data.


Q: What is the standard procedure for reporting a suspected side effect of Tebokan?

The established procedure is that all suspected side effects are reported to a healthcare professional, such as a doctor or pharmacist. Official regulations also mandate that reporting can be made directly to the local national competent authority (the government body responsible for drug safety) or to the marketing authorization holder (the manufacturer).


Q: Does Tebokan interact with popular cold or flu remedies?

Interactions are specific to listed substances. The risk of bleeding is increased if taken with any cold or flu remedy containing substances with anti-platelet properties (such as high-dose aspirin).


Q: Is Tebokan a cure for the conditions it treats, or a supportive treatment?

Tebokan is officially classified as a supportive treatment (phytomedicine). It is intended to help maintain and support functions related to age-related decline and is not considered a cure for underlying chronic diseases.

How should Tebokan be stored and disposed of?

Tebokan (EGb 761) tablets must be stored according to official label specifications to maintain the quality of the standardized extract. The required temperature for storage must not exceed 25 C.

Storage Conditions

Storage Parameter Regulatory Requirement
Temperature Store at a temperature below 25 C
Environmental Protection Keep in a cool, dry place and away from direct sunlight, heat, and moisture
Child Safety The medicine must be kept out of the sight and reach of children

Disposal Instructions

Disposal of unused or expired tablets must adhere to local regulations. The product should not be flushed down the toilet or drain. Instead, the preferred method is to use an official drug take-back program or mail-back envelope. If no take-back program is available, the product may be mixed with an undesirable substance, placed in a sealed bag, and discarded with household trash.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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