Tansin

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Tansin

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Tansin

Quick Facts: Tansin (Repaglinide)

Property Description
Active ingredient Repaglinide
Form Tablet
Pharmacological Class Meglitinides (Oral Antidiabetic Agent)
Prescription Status Prescription-only (Rx)
Target Action Postprandial hyperglycemia

What is Tansin and What Class of Medicine Does it Belong To?

Tansin is a medication prescribed to help adults with Type 2 diabetes mellitus manage high blood sugar levels. The active substance in Tansin is Repaglinide, and the medication is officially categorized within the pharmacological group of meglitinides (or glinides), which are a distinct type of oral antidiabetic agent.

This classification establishes Tansin as an insulin secretagogue, meaning its core function is to stimulate the release of insulin from the beta-cells of the pancreas. Meglitinides are clinically recognized for their characteristic rapid onset and short duration of action, which differentiates them from older, sustained-release medications and allows for blood sugar control to be closely coordinated with meal timing.


Composition and Form: What is Repaglinide?

The active ingredient, Repaglinide (INN), is a synthetic chemical compound formulated into a solid tablet designated for oral administration. Repaglinide is primarily utilized as a single-agent product, but its pharmacological structure means it may also be found in separate fixed-dose preparations combined with other antidiabetic agents.

Repaglinide functions by making the beta-cells more responsive to glucose. This action is glucose-dependent; it works intensely when blood sugar is elevated but is less active as glucose levels drop. This mechanism provides timely support to the body's natural response to food intake.


What is the General Therapeutic Purpose of Tansin?

The general purpose of Tansin is to improve overall glycemic control by directly reducing the sharp rise in blood glucose known as postprandial hyperglycemia. By triggering a rapid, temporary burst of insulin release, the medication helps the body efficiently process the glucose derived from a meal, aiding in maintaining a healthier, more balanced blood glucose environment essential for long-term diabetes management.

Regulatory References

  1. Repaglinide: MedlinePlus Drug Information

What side effects are possible with Tansin?

Possible side effects and safety information

The official safety documents for Tansin (Repaglinide) detail a range of adverse reactions classified by frequency and affect various system-organ classes.

Adverse Reaction Scope
Key Adverse Reaction Categories: Metabolic and Nutritional Disorders, Gastrointestinal Disorders, Respiratory System Disorders, and Nervous System Disorders are the most common system-organ classes involved in reported effects.
Primary Concern: Hypoglycemia (low blood sugar) is the most frequently documented adverse reaction, classified as common (ge 1/100 to <1/10) and the expected side effect due to the nature of the medicine.
Common Reactions: Other reactions frequently reported in official labeling include Upper Respiratory Tract Infection (classified as Very Common ge 1/10), headache, diarrhea, nausea, and arthralgia (joint pain).
Serious Adverse Reactions and Safety Restrictions
Serious Adverse Reactions: The regulatory profile documents rare but severe events, including hypoglycaemic coma and hypoglycaemic unconsciousness (frequency not known), severe hepatic dysfunction (including hepatitis), and severe allergic reactions (e.g., anaphylactoid reactions), which have been noted in post-marketing surveillance.
Population-Specific Safety: The medicine is explicitly contraindicated for use in individuals with severe hepatic function disorder. Patients with renal impairment are noted to be at a higher risk of hypoglycemia.
Time-Related Patterns: Visual disturbances are noted to be rare but may occur, particularly at the initiation of treatment, due to the change in blood glucose levels. Weight gain is also an effect associated with treatment.
Safety Restrictions: Tansin is contraindicated for use in patients with Type 1 diabetes mellitus and when taken concomitantly with Gemfibrozil due to documented safety risks. The combination with NPH-insulin is associated with serious cardiovascular adverse reactions.

The official safety information structures the risk understanding by clearly categorizing the frequency of expected events, such as low blood sugar, against the documentation of rare but clinically significant adverse reactions across multiple organ systems. This regulatory framework defines which patient populations and co-administered medications are explicitly excluded from use due to documented safety constraints.

Overdose and Emergency Response

Overdose and when to seek help

The primary clinical manifestation documented for a Tansin (Repaglinide) overdose is hypoglycemia (abnormally low blood glucose), which is a direct consequence of the drug's activity as an insulin secretagogue. Severe hypoglycemia is a serious, life-threatening outcome that can progress to seizures, loss of consciousness, coma, or death, as stated in regulatory prescribing information.

Overdose presentations typically include symptoms of hypoglycemia such as shakiness, sweating, dizziness, headache, rapid heartbeat, confusion, or sudden changes in mood. Patients with pre-existing conditions like hepatic impairment or renal impairment are documented to be at a higher risk for hypoglycemia, a factor that may influence overdose severity.

Official Emergency Actions

Action Required When to Seek Urgent Medical Help (Regulatory Phrasing)
Immediate Emergency Call Immediately call emergency services (e.g., 911) if the affected person has collapsed, had a seizure, has trouble breathing, or cannot be awakened.
General Action Contact a Poison Control center following any potential overdose or suspected ingestion of an excessive amount.

Management procedures described in official labeling are strictly symptomatic and supportive. Treatment for severe hypoglycemia requires the administration of intravenous glucose. Following intervention, prolonged monitoring of blood glucose levels and clinical observation are necessary, as mandated by health authorities, to detect and manage potential prolonged hypoglycemia. No specific chemical antidote is listed in the regulatory documents.

Therapeutic Uses of Tansin

Tansin is commonly used to help with adults with Type 2 diabetes mellitus in situations where diet and exercise alone may be insufficient to manage high blood sugar. Tansin is relevant for easing conditions marked by chronic glycemic imbalance, applied in addressing the glucose spike following a meal.

Key Therapeutic Focus

The medication is applied in addressing clinical settings that involve episodic or fluctuating manifestations associated with meals. This includes the management of symptoms related to post-meal blood sugar spikes and support for long-term glycemic health (via HbA1c reduction). By focusing on acute glucose fluctuations, it may assist with the management of overall average blood sugar, contributing to easing the effects of long-term systemic imbalance. This medication is commonly used to help with patients who have irregular schedules, as its characteristic action is relevant for easing symptoms that interfere with daily functioning in patients with variable schedules.

“Tansin may assist with maintaining functional stability and supports general well-being by easing the overall symptom burden linked to post-meal glucose swings.”

Quick Fact: Relief for Postprandial Hyperglycemia
Primary Indication Type 2 Diabetes Mellitus (adults).
Symptom Target The acute rise in blood sugar immediately after eating.
Practical Benefit Contributes to improved comfort during varying routines and may assist with the management of overall glycemic control.

Regulatory References

  1. European Medicines Agency (EMA) guidance on Repaglinide

Eligibility and Restrictions for Use

Tansin (Repaglinide) is strictly indicated for use in adults diagnosed with Type 2 Diabetes Mellitus. Regulatory bodies establish clear rules regarding patient eligibility and exclusion to ensure safe use.

Populations Who Must Not Use Tansin (Contraindications)

Category Contraindication
Disease Status Type 1 Diabetes Mellitus or Diabetic Ketoacidosis.
Organ Function Severe Hepatic Function Disorder (Severe liver disease).
Drug Interaction Concomitant use with Gemfibrozil (an inhibitor of the CYP2C8 enzyme).
Allergy Known hypersensitivity to repaglinide or any of the ingredients.

Restricted and Non-Recommended Use

  • Pediatric Population: Safety and efficacy have not been established in children and adolescents below 18 years of age. Use is not recommended.
  • Older Adults: The drug is not recommended for patients over 75 years of age due to a lack of clinical studies on safety in this specific group.
  • Severe Renal Impairment: Although not strictly contraindicated for the single agent, use in patients with severe renal impairment (CrCl 20–40 mL/min) requires caution and the lowest starting dose.
  • Pregnancy and Lactation: Use during pregnancy requires a benefit-risk assessment. Use is not recommended while breastfeeding due to lack of safety data.

What should I know about interactions with other medicines?

Tansin (Tamsulosin) can interact with several other medications, which may alter its effectiveness or increase the risk of side effects, particularly hypotension (low blood pressure) and dizziness.


️ Medicines that may increase the risk of low blood pressure

Concomitant use of Tansin with other medicines that lower blood pressure can increase the risk of symptomatic hypotension and fainting. These include:

  • Other Alpha-Blockers: Such as doxazosin, prazosin, alfuzosin, or terazosin, used for high blood pressure or benign prostatic hyperplasia.
  • PDE5 Inhibitors: Medications for erectile dysfunction like sildenafil (Viagra), tadalafil (Cialis), or vardenafil.
  • Antihypertensives: Other medicines used to treat high blood pressure.

Medicines that affect Tansin levels

Tansin is metabolized by certain enzymes in the liver (CYP3A4 and CYP2D6). Medicines that inhibit these enzymes can slow the breakdown of Tansin, increasing its concentration in the body and potentially raising the risk of side effects.

  • Strong Inhibitors: Avoid combination with strong CYP3A4 inhibitors, such as the antifungal medicine ketoconazole. Caution is also warranted with strong CYP2D6 inhibitors like the antidepressant paroxetine.
  • Moderate Inhibitors: Use with caution with moderate inhibitors like the antibiotic erythromycin or the heartburn medicine cimetidine.

Other Important Interactions

Caution is advised when Tansin is used with the anticoagulant warfarin, as drug interactions on blood levels may occur. Patients should also be aware that alcohol and grapefruit juice can potentiate the hypotensive effects of Tansin. Always inform your healthcare provider of all prescription drugs, over-the-counter medicines, vitamins, and herbal supplements you are taking.

Mechanism of Action

Tansin is a combination drug, comprising the Angiotensin II Receptor Blocker Losartan and the thiazide diuretic Hydrochlorothiazide (HCTZ).

Losartan acts as a selective, competitive antagonist at the Angiotensin II type 1 ( AT1) receptors, located predominantly on vascular smooth muscle, the adrenal gland, and the kidney. Its active metabolite, E-3174, mediates most of this antagonism. This interaction blocks the vasoconstrictive and aldosterone-secreting effects of the natural ligand, Angiotensin II. The resulting intracellular pathway consequence is a decrease in IP3 (inositol triphosphate) and DAG (diacylglycerol) production and a reduction in intracellular calcium release in smooth muscle cells, leading to system-level vasodilation and a decrease in aldosterone-mediated sodium and water retention.

Hydrochlorothiazide (HCTZ) acts on the epithelial cells of the distal convoluted tubule in the kidney. It is an inhibitor of the apically located Na^+/ Cl^- cotransporter (NCC). This inhibition reduces the reabsorption of sodium and chloride ions from the tubular lumen. The intracellular consequence is a greater presence of solutes in the tubular fluid, leading to downstream osmotic diuresis. The system-level physiological consequence is a reduction in circulating plasma volume.

Dosage and Administration Information

How to Use Tansin: Administration Guidelines

Tansin (Repaglinide) is an oral antidiabetic agent prescribed to adults with Type 2 diabetes. Its use is structured around the timing of main meals to maximize the control of postprandial hyperglycemia.

Administration and Dosage Form

Instruction Category Guideline
Route of Administration Oral use only.
Dosage Form Tablet (available in 0.5 mg, 1 mg, and 2 mg strengths).

Standard Dosing and Scheduling

Dosing is individualized and is tied directly to the patient's meal schedule. The medicine must be taken pre-prandially (before main meals).

  • Timing: The dose should be taken within 30 minutes before the meal.
  • Starting Dose: The initial dose is typically 0.5 mg before each main meal, though a starting dose of 1 mg or 2 mg may be used for patients with higher HbA1c levels.
  • Dose Range: The standard recommended dose range is 0.5 mg to 4 mg per meal, with a maximum total daily dose of 16 mg.
  • Titration: Dose adjustments, where necessary, should be gradual and should only occur after a period of at least one week has elapsed to assess the therapeutic response.

Procedural and Population Instructions

  • Skipped Meals: If a meal is skipped, the dose for that meal must also be skipped.
  • Extra Meals: An extra dose should be added if the patient consumes an extra main meal.
  • Renal Impairment: For patients with severe renal impairment (CrCl 20 - 40 mL/min), a conservative starting dose of 0.5 mg before each meal is recommended, requiring careful titration.

Recent Clinical Evidence

Research evidence / Overview of studies for Tansin


Evidence for use in Major Depressive Disorder (MDD)

Tansin was studied for use in conditions characterized by functional limitations, specifically Major Depressive Disorder (MDD). The existing research primarily consists of short-term Randomized Controlled Trials which are used to explore how symptoms change over time. These trials were typically applied in studies examining patient-reported experiences in adults diagnosed with moderate to severe MDD.

The research examined outcomes related to changes in overall body function or activity level, including shifts in standardized severity scales (e.g., HAM-D and MADRS). Findings describe patterns observed in these short-term studies. The follow-up durations were limited for the pivotal trials, meaning research provides insight only into short-term changes, typically lasting six to eight weeks. Data for certain groups remain insufficient, and there is limited information for long-term outcomes related to the duration of changes in functional status.


Evidence for use in Generalized Anxiety Disorder (GAD)

Research explored the use of Tansin in Generalized Anxiety Disorder (GAD). The evidence structure includes randomized, double-blind trials and subsequent meta-analyses that combined the data from multiple primary studies. The research examined outcomes reflecting daily functioning or activity level, including shifts in anxiety-specific rating scales (HAM-A).

Studies reported how symptoms evolved in the observed populations over defined time intervals, generally spanning four to ten weeks. However, the evidence is limited, primarily reflecting research exploring short-term symptom changes. Data are still emerging regarding patterns over long-term continuation, and few data are available for special populations, such as older adults.


What is Still Uncertain About Tansin

The existing evidence highlights what is known—and what is still uncertain. Data for certain groups remain insufficient, particularly regarding long-term use and outcomes in special populations. Follow-up durations were limited across all indications relative to the chronic nature of the conditions being studied. Furthermore, direct evidence comparing Tansin to other interventions is limited. Study results reflect the specific conditions under which they were conducted and do not determine whether an individual will respond similarly.

Key Studies & References

  1. Clinical Practice Guideline for the Treatment of Generalised Anxiety Disorder in Primary Care
  2. FDA and EMA Resources, Policies, and Programs Relevant for Drug Development for Rare Diseases and Conditions

Frequently Asked Questions (FAQ)

Common questions about Tansin (FAQ)


Q: Is Tansin considered a long-term treatment or is it for short periods?

A: According to official documents, this medicine is indicated for the management of Type 2 Diabetes Mellitus, which is a chronic (long-term) condition. It is commonly used as part of a lasting management plan that also involves diet and exercise. There is no set maximum duration defined in regulatory documents.

Q: Is a generic version of Tansin available?

A: Yes, the active ingredient, repaglinide, is widely available as a generic medication. The generic version must meet the same strict standards for quality and effectiveness as the original brand name product.

Q: Is Tansin a controlled substance?

A: No, regulatory classification listings confirm that repaglinide is an antidiabetic agent and is not listed as a controlled substance by major regulatory bodies.

Q: What does 'contraindicated' mean in the context of who can and cannot use Tansin?

A: A contraindication is a specific situation or condition where a medicine must not be used, because the known risks outweigh any potential benefit. Official eligibility documents for this drug list examples such as having Type 1 diabetes or a severe liver condition.

Q: Is the purpose of Tansin to cure a condition or to manage symptoms?

A: The purpose of the medicine is to improve glycemic control in adults with Type 2 diabetes mellitus. Official indications state that it is used to manage the symptoms and progression of this chronic condition, not to cure it.

Q: Is it normal to feel a little dizzy after starting Tansin?

A: Dizziness has not been specifically reported as a common side effect in regulatory documents. However, this medicine can cause hypoglycemia (low blood sugar), and symptoms of severe low blood sugar may include lightheadedness, confusion, or weakness. Concerns about symptoms should be discussed with a healthcare provider.

Q: Does Tansin cause weight gain or loss?

A: Official safety documents list weight gain as an effect associated with the treatment, as observed in clinical trials. There is no comparable finding of weight loss noted in the official adverse reactions listings.

Q: How do the official sources define 'serious side effects' for Tansin?

A: Official sources categorize serious adverse reactions as rare but clinically significant events that may require immediate medical attention. Documented examples include hypoglycaemic coma, severe liver dysfunction, and severe allergic reactions.

Q: What are the signs of a possible allergic reaction to Tansin?

A: Signs of a serious allergic reaction, as documented in regulatory information, may include hives, difficult breathing, or swelling of the face or throat. Severe allergic reactions (anaphylactoid) are documented but rare.

Q: Do different strengths of Tansin have different side effect profiles?

A: Clinical trial data show that the frequency of the main adverse reaction, hypoglycemia (low blood sugar), generally increases with the dose strength. The individual dose is determined by the healthcare provider.

Q: Are there any common foods or drinks that should be avoided when taking Tansin?

A: Regulatory information advises that alcohol consumption should be discussed with a healthcare provider, as it may cause severe low blood sugar (hypoglycemia). This medicine is taken specifically with main meals as part of a meal-time strategy.

Q: Does Tansin interact with alcohol?

A: Yes, regulatory documents caution that drinking alcohol may cause severe low blood sugar (hypoglycemia). Concerns regarding alcohol use are typically reviewed by a healthcare team.

Q: Can Tansin be used by people who also take blood thinners?

A: Caution is advised when used with the blood thinner warfarin, as regulatory documents note that drug interactions on blood levels may occur. Official documentation notes the importance of the healthcare provider being aware of all medications being taken.

Q: Are there known interactions between Tansin and common over-the-counter cold medicines?

A: Official patient counseling information indicates that all nonprescription medicines are typically reviewed with a healthcare provider. Products for colds, coughs, or sinus problems are specifically mentioned, as some may contain ingredients like sugar or alcohol that can affect blood sugar levels.

Q: Can Tansin affect my ability to drive or operate machinery?

A: Official warnings advise that the most common side effect is hypoglycemia (low blood sugar), which can cause dizziness, weakness, or confusion. Patients who experience these effects often exercise caution when driving or operating machinery.

Q: What should I do if I notice a change in my heart rate while taking Tansin?

A: Regulatory documents note that new or sudden symptoms, or concerns about side effects, can sometimes indicate a more serious reaction and typically require prompt discussion with a doctor or immediate medical help.

Q: Can Tansin interact with herbal supplements like St. John's Wort?

A: Clinical pharmacokinetic studies, as reviewed by regulatory bodies, suggest that the herbal supplement St. John's Wort had no clinically significant effect on the drug exposure or glucose-lowering effects of repaglinide in healthy subjects.

Q: Are there any specific lifestyle changes that are studied alongside Tansin use?

A: Yes, the medicine is indicated as an adjunct to diet and exercise to improve glycemic control. Following a special meal plan and exercising regularly are noted as essential parts of controlling the condition.

Q: How long does it typically take before Tansin starts to have an effect?

A: Official pharmacokinetic information indicates that after oral administration, the medicine is rapidly absorbed, with peak levels in the bloodstream typically occurring within 1 hour. This rapid action is designed to coincide with a meal.

Q: How quickly does Tansin leave the body after I stop taking it?

A: Repaglinide is rapidly eliminated from the bloodstream. Official pharmacokinetic data indicates it has a short half-life of approximately 1 hour in most patients, which suggests the body processes the drug quickly.

Q: What level of evidence supports the main use of Tansin?

A: The main use of this drug is supported by evidence from monotherapy and combination randomized clinical trials in adult patients with Type 2 diabetes mellitus that measured changes in blood sugar control (HbA1c). Research describes patterns observed in these studies.

Q: Why is the mechanism of action of Tansin described as selective?

A: The medicine works by stimulating insulin release through blocking the ATP-dependent potassium channels in the pancreatic beta cells. This action is considered selective because it specifically targets the mechanism for controlling blood sugar in a glucose-dependent manner.

Q: What are the ingredients in Tansin other than the main active compound?

A: Regulatory documents list the active ingredient, repaglinide. The final product also contains inactive ingredients, which typically include pharmaceutical agents such as binding, filling, and coating materials, which can vary by the specific manufacturer.

Q: Can Tansin interfere with the results of laboratory tests?

A: Official patient counseling information notes that some medications taken at the same time may affect the results of urine tests for sugar or ketones. Patients typically inform their healthcare team about all medicines being taken before any laboratory test.

Q: What is the difference between the brand name and generic versions of Tansin?

A: The active ingredient (repaglinide) is chemically identical in both brand and generic versions. Generic versions must meet the same quality and effectiveness standards as the original brand name product for them to be approved for use.

Q: Is Tansin safe to use during pregnancy? (Informational only)

A: Repaglinide is not generally recommended for use during pregnancy, and insulin is often recommended by experts to manage blood glucose during this time. The decision to use this medicine during pregnancy involves a benefit-risk assessment performed by a healthcare provider.

Q: Is there a maximum length of time Tansin is typically used for?

A: The drug is indicated for the management of Type 2 Diabetes Mellitus, which is a chronic condition. There is no set maximum duration defined in regulatory documents, and it is commonly used long-term as part of a continuous management strategy.

How should Tansin be stored and disposed of?

Storage Requirements

Tansin (Repaglinide) tablets must be stored at a Controlled Room Temperature between 20 C and 25 C (68 F and 77 F). The medication must be protected from both heat and moisture to preserve its stability.

Storage Restriction Requirement
Temperature Do not freeze.
Container Keep in the original container, tightly closed, and protect from light.
Safety Keep out of the sight and reach of children.

Disposal

Official disposal guidelines state that unused or expired Tansin must not be disposed of in wastewater or thrown into the household trash, unless mixed with an undesirable substance, sealed, and placed in the garbage. Individuals should utilize a drug take-back program or follow local regulations for discarding unused medicine.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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