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Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 26.06.2023
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Supirocin-B Plus (pseudomonic acid A, or Bactroban or Centany) is an antibiotic originally isolated from Pseudomonas fluorescens. It is used topically, and is primarily effective against Gram-positive bacteria. Supirocin-B Plus is bacteriostatic at low concentrations and bactericidal at high concentrations. Supirocin-B Plus has a unique mechanism of action, which is selective binding to bacterial isoleucyl-tRNA synthetase, which halts the incorporation of isoleucine into bacterial proteins. Because this mechanism of action is not shared with any other antibiotic, Supirocin-B Plus has few problems of antibiotic cross-resistance.
Supirocin-B Plus ointment is indicated for the topical treatment of impetigo due to susceptible isolates of Staphylococcus aureus (S. aureus) and Streptococcus pyogenes (S. pyogenes).
Supirocin-B Plus topical cream is used to treat secondarily infected traumatic skin lesions due to specific bacteria. Supirocin-B Plus topical ointment is used to treat impetigo. Supirocin-B Plus works by killing bacteria or preventing their growth.
Supirocin-B Plus is available only with your doctor's prescription.
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What is the most important information I should know about Supirocin-B Plus?
Supirocin-B Plus ointment is contraindicated in patients with known hypersensitivity to Supirocin-B Plus or any of the excipients of Supirocin-B Plus ointment.
Use Supirocin-B Plus ointment as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Apply one-half of the medicine from the single-use tube directly into one nostril and the other half into the other nostril.
- Throw away the tube after using. Do not reuse.
- Press the sides of the nose together and gently massage for about 1 minute after application to spread the ointment throughout the inside of the nostrils.
- Supirocin-B Plus ointment should not be used along with other nasal products/medicines.
- To clear up your infection completely, use Supirocin-B Plus ointment for the full course of treatment. Keep using it even if you feel better in a few days.
- Wash your hands immediately after using Supirocin-B Plus ointment.
- If you miss a dose of Supirocin-B Plus ointment, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Supirocin-B Plus ointment.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Supirocin-B Plus treats or prevents infections on skin in small cuts, wounds or on scraped skin caused by bacteria.
Chloramphenicol may interfere w/ the antibacterial action of Supirocin-B Plus in RNA synthesis.
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What are the possible side effects of Supirocin-B Plus?
The following adverse reactions are discussed in more detail in other sections of the labeling:
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.
The following local adverse reactions were reported by at least 1% of subjects in connection with the use of Supirocin-B Plus ointment in clinical trials: burning, stinging, or pain in 1.5% of subjects; itching in 1% of subjects. Rash, nausea, erythema, dry skin, tenderness, swelling, contact dermatitis, and increased exudate were reported in less than 1% of subjects.
Postmarketing Experience
In addition to adverse reactions reported from clinical trials, the following reactions have been identified during postmarketing use of Supirocin-B Plus ointment. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. These reactions have been chosen for inclusion due to a combination of their seriousness, frequency of reporting, or potential causal relationship to Supirocin-B Plus ointment.
Immune System Disorders
Systemic allergic reactions, including anaphylaxis, urticaria, angioedema, and generalized rash.