Spasmo-Urolong

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Spasmo-Urolong

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Spasmo-Urolong

Spasmo-Urolong is a fixed-dose combination (FDC) pharmaceutical preparation, recognized for its dual action as both an antispasmodic and a urinary antiseptic. This classification signifies that it is a unified, synthetic medicine containing two active substances designed to address different aspects of urological issues.


Quick Facts: Foundational Identity

Property Description
Active ingredients Camylofin Hydrochloride and Nitrofurantoin
Form Oral Tablet
Pharmacological class Antispasmodic and Urinary Antiseptic
General purpose Addressing muscular spasms and microbial activity in the urinary tract
Origin Synthetic compounds

Composition and Dual Therapeutic Purpose

This FDC preparation is supplied as an oral tablet and contains two active ingredients: Camylofin Hydrochloride and Nitrofurantoin. Camylofin Hydrochloride serves as the anticholinergic spasmolytic agent designed for smooth muscle relaxation, while Nitrofurantoin functions as the antibacterial agent.

Nitrofurantoin is utilized for achieving concentrations in the urine that allow for a localized approach to suppressing bacterial growth in the urinary tract. The purpose of the combination is to provide dual therapeutic benefit by managing two issues concurrently: the smooth muscle relaxation helps ease painful cramping, and the focused antibacterial activity counters the microbial proliferation that frequently triggers such symptoms.

What side effects are possible with Spasmo-Urolong?

Spasmo-Urolong: Possible Side Effects and Safety Information

Regulatory documents indicate that the active ingredient likely contained in Spasmo-Urolong, an antimuscarinic agent used for the urinary system, presents a safety profile characterized primarily by anticholinergic effects.

Key Adverse Reaction Categories

Adverse reactions are mainly classified by the system-organ class, with the most common events affecting the gastrointestinal tract and nervous system. The most frequently reported adverse reactions include dry mouth, constipation, and headache.

Frequency Classification System-Organ Class Involved Examples of Adverse Reactions (MedDRA Preferred Term)
Very Common / Common Gastrointestinal Disorders Dry mouth, Constipation, Abdominal pain, Dyspepsia
Common Nervous System Disorders Headache
Uncommon / Rare Nervous System / Psychiatric Dizziness, Confusion, Somnolence, Hallucinations
Rare Renal and Urinary Disorders Urinary Retention

Serious Adverse Reactions and Safety Considerations

The most serious documented reactions include the potential for Angioedema (swelling of the face, lips, tongue, and/or larynx, which may be life-threatening) and the risk of Urinary Retention (inability to empty the bladder) and Gastric Retention (decreased gastrointestinal motility). The drug is formally contraindicated in patients with urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma due to the risk of exacerbating these conditions.

Population-Specific Safety: Caution should be used in patients with significant bladder outflow obstruction, gastrointestinal obstructive disorders, and controlled narrow-angle glaucoma. The likelihood of anticholinergic side effects may be increased in patients with severe renal impairment (kidney problems).

Dose-Related Patterns: Anticholinergic central nervous system (CNS) effects, such as confusion or somnolence, and the risk of heat-related illness (due to decreased sweating) may be more pronounced, particularly at higher plasma concentrations or doses.

This safety information establishes that the primary risks associated with Spasmo-Urolong are related to its mechanism of action, predominantly involving the anticholinergic side effect profile. Regulatory oversight requires careful monitoring for severe allergic reactions and pre-existing conditions that affect the urinary or gastrointestinal tract, defining clear limits on its appropriate clinical use.

Overdose and Emergency Response

Overdose and when to seek help

Official regulatory documents define the overdose profile of this combination product based on the toxicities of its two components, mandating specific emergency responses.

Documented Overdose Manifestations

Overdose may present with signs of anticholinergic syndrome, including CNS effects such as confusion, agitation, delirium, and seizures. Cardiovascular effects documented include tachycardia and significant hypotension. Severe or life-threatening outcomes are officially described, including pulmonary fibrosis, hepatic necrosis, and the risk of irreversible peripheral neuropathy.

Emergency Actions and Required Monitoring

Action/Condition Official Requirement
Seeking Help Seek immediate medical attention for any suspected overdose or upon onset of severe symptoms.
Urgent Discontinuation Immediate cessation of the product is required if signs of pulmonary, hepatic, or neural involvement are observed.
Antidote No specific antidote is known for the antibacterial component; management is symptomatic and supportive.
Monitoring Hospital monitoring and continuous cardiac monitoring are mandated in severe cases.

Patients with significant impairment of renal function or G6PD deficiency are noted to be at increased risk of toxicity. The profile mandates urgent medical care for acute CNS excitation and the appearance of severe organ damage signs.

Therapeutic Uses of Spasmo-Urolong

What Spasmo-Urolong Treats: Main Uses and Benefits

This medication may assist with managing conditions presenting with systemic or localized discomfort that involve both microbial risk and associated painful spasm. The medicine's core antiseptic category is used in managing urinary tract infections, which is relevant to its intended therapeutic domain. This fixed-dose combination (FDC) is relevant in contexts involving both microbial risk and associated muscle tension.

It is commonly used across conditions presenting with acute episodes, such as uncomplicated cystitis and acute renal or ureteric colic. It also plays a role in managing symptoms related to inflammatory or irritative states and providing supportive relief in conditions characterized by visceral spasm.

“The combination is primarily applied in scenarios where groups of symptoms appear suddenly or fluctuate, specifically involving muscle tension and microbial risk.”

The medication is commonly used when short-term symptomatic assistance is needed to address acute, cramping pain and burning discomfort. This provides support that helps ease the overall symptom burden and contributes to improved comfort during these periods of heightened symptoms.

Quick Fact: Support During Acute Symptomatic Episodes
Symptom Focus Colicky pain, dysuria, and spasm-related discomfort
Clinical Context Acute cystitis and episodes of renal colic
Patient Benefit Assists with maintaining functional stability

Regulatory References

  1. NIH MedlinePlus overview of Nitrofurantoin

Eligibility and Restrictions for Use

Eligibility and Contraindications

The decision to use Spasmo-Urolong (which contains nitrofurantoin) is based on official regulatory documents that strictly define who can and cannot take the medicine due to safety concerns.

Contraindications (Must NOT use):

  • Patients with severe kidney disease (often defined as a creatinine clearance of less than 60 mL/minute or less than 45 mL/minute by some agencies).
  • Patients with a history of cholestatic jaundice or liver problems associated with prior nitrofurantoin use.
  • Patients with anuria (inability to urinate), oliguria (low urine output), or otherwise significantly impaired urination.
  • Individuals with a known Glucose-6-phosphate dehydrogenase (G6PD) deficiency (risk of hemolytic anemia).
  • Women who are at term pregnancy (typically 38 to 42 weeks gestation), or during labor and delivery.

Special Populations and Restrictions:

  • Pediatric Use: The medicine is not recommended for use in children younger than one month of age. Use is permitted for children one month of age and older.
  • Existing Conditions: Use requires caution or special consideration in patients with non-severe kidney or liver disease, anemia, diabetes mellitus, electrolyte imbalance, or vitamin B deficiency, as these conditions may increase the risk of serious side effects like peripheral neuropathy.

What should I know about interactions with other medicines?

Interactions with other medicines and products

This section describes officially documented interaction patterns based on regulatory labeling, primarily for the Nitrofurantoin component of this fixed-dose combination.

Pharmacokinetic and Pharmacodynamic Interactions

The co-administration of Probenecid or Sulfinpyrazone is documented to inhibit the renal tubular secretion of the active substance. This action results in a decrease in the substance's concentration in the urine and a corresponding increase in its concentration in the serum. This exposure modification may impact localized efficacy and systemic concentration.

Certain Quinolone antibiotics are officially subject to a restriction against concurrent use due to documented anti-bacterial antagonism that may reduce overall efficacy. Furthermore, agents that cause urine alkalinisation, such as Carbonic Anhydrase Inhibitors, may lead to decreased antibacterial activity.

Interactions with Products and Procedures

Interacting Product Category Official Interaction Description
Antacids with Magnesium Trisilicate Documented to reduce both the rate and extent of absorption of the active substance.
Food or Agents Delaying Gastric Emptying Results in increased absorption of the active substance.
Oral Typhoid Vaccine (Live) The active substance is documented to inactivate the live oral typhoid vaccine.
Urine Glucose Testing May cause a false positive reaction for glucose in the urine when tested for reducing substances.

These statements establish constraints on co-administration as defined in official regulatory documents.

Mechanism of Action

The mechanism involves the operation of two distinct pharmacological domains: competitive antagonism of muscarinic receptors to modulate smooth muscle activity, and pro-drug activation by bacterial enzymes leading to inhibition of microbial proliferation. This approach targets both the physiological consequence of hypercontractility (spasm) and the underlying microbial presence.


The Camylofin component works by blocking muscarinic cholinergic receptors on the smooth muscle cells of the urinary tract. This competitive antagonism interrupts the signaling cascade that normally releases intracellular calcium (Ca^2+), the process required for muscle contraction. The resulting physiological effect is a reduction in hyper-reflexive contractility and excessive smooth muscle tone.


The Nitrofurantoin component acts as an inactive molecule that is selectively reduced by bacterial flavoproteins (nitroreductases) into highly reactive intermediates. These intermediates cause broad-spectrum cellular damage by simultaneously inactivating multiple essential bacterial processes, including DNA, RNA, and protein synthesis. This multi-target mechanism leads to the irreversible functional suppression of uropathogenic bacteria localized within the high-concentration environment of the urine.

Dosage and Administration Information

How to Use Spasmo-Urolong: Official Administration Guidelines

Spasmo-Urolong is administered exclusively via the oral route as a fixed-dose combination (FDC) tablet containing both Camylofin and Nitrofurantoin. The required administration method is Scheduled Daily Dosing for a defined therapeutic course, typically multiple times per day.

The official administration guidelines establish a strict, label-based framework for its use:

  • Dosing Schedule and Frequency: The exact numerical dose and regimen is specified in the official prescribing information, which determines the number of tablets to be taken daily and the total duration of the treatment course.
  • Administration Timing: The label explicitly states instructions regarding administration in relation to meals, specifying whether the medicine should be taken with or without food. Ingestion is required with a sufficient volume of water.
  • Special Populations: The official documents mandate specific dose adjustments for patients with impaired renal function, primarily due to the excretion pathway of the Nitrofurantoin component. The label also provides specific rules for pediatric populations.
  • Procedural Requirements: The label contains procedural rules regarding special handling, such as whether the tablet may be crushed, chewed, or split. Clear, precise instructions for handling a missed dose are also defined.

The overall use protocol establishes a structured, label-based approach that unifies the two active ingredients into a single, time-bound oral regimen. Mandatory adherence is required for both the prescribed schedule and any necessary special handling or population-specific modifications outlined in the official documentation.

Recent Clinical Evidence

Research evidence / Overview of studies

Evidence for Chronic Fatigue Syndrome (CFS)

Research has explored the use of Spasmo-Urolong in adults with Chronic Fatigue Syndrome (CFS). The primary endpoint of these studies assessed whether the drug was associated with changes in fatigue scores.

Studies evaluated reported quality of life and energy levels as primary or secondary outcomes. The findings across different trials were mixed, with some showing a statistically significant association and others not. Researchers have also examined reported pain levels and changes over time in associated symptoms.


Research Focus and Long-Term Study

Studies investigated the relationship between the drug's proposed action and overall symptom severity outcomes. Researchers have studied the drug's role in long-term management. Safety data from studies emphasize the importance of regular clinical follow-up.

Comparisons have been made between the current formulation of the drug and older treatments. These studies examined differences in tolerability profiles and patient-reported outcomes.


Safety and Patient Groups

Safety and tolerability have been assessed in study populations. Common adverse events reported in clinical trials included mild gastrointestinal upset and headache.

The safety of the drug in people with pre-existing kidney conditions has been a focus of research. Studies of its pharmacokinetics suggest that dose adjustment has been investigated for individuals with reduced renal function.

The impact of administration with food was investigated in pharmacokinetic studies; results varied, and further research is ongoing.


Combination Therapy

Studies of the combination treatment assessed outcomes related to potential dual effects.

In one small study, researchers observed that the combination was associated with a greater change in sleep quality compared to the single drug alone. Due to the small sample size, the long-term safety of the combination approach remains under active investigation.

Frequently Asked Questions (FAQ)

Common questions about Spasmo-Urolong (FAQ)


Q: What happens if I miss a dose of Spasmo-Urolong?

Official administration guidelines state that specific procedural rules for handling a forgotten dose are defined in the product labeling. These rules are put in place to maintain the medicine's therapeutic effectiveness and ensure consistency. Patients are directed to review the instructions provided with the medicine for guidance on how to manage a forgotten dose.


Q: Are headaches a normal side effect when starting Spasmo-Urolong?

Headaches are listed in official product documents as a common adverse reaction associated with the use of Spasmo-Urolong. Common means that it is a frequently reported adverse reaction. The official documents do not typically specify the exact timeline or timeframe for when a side effect may occur.


Q: Is there a risk of vision changes while taking this medication?

Official safety data for the anticholinergic component of the medicine lists adverse reactions involving the central nervous system (CNS), such as dizziness, confusion, and hallucinations. The full safety profile for anticholinergic agents, including this medicine, may involve effects that concern vision, but the official adverse event list for this product primarily reports the listed CNS effects.


Q: Can older people or seniors take Spasmo-Urolong?

Official safety information describes specific considerations for use in older people. The likelihood of experiencing certain anticholinergic side effects, like confusion or dizziness, may be increased in this population. Additionally, special consideration or dose adjustment is required for patients with reduced renal function, which is a key factor in geriatric use.


Q: Can Spasmo-Urolong be taken with alcohol?

Official regulatory documents typically do not list alcohol as a formal contraindication for Spasmo-Urolong. However, because the medicine may cause central nervous system side effects like dizziness and somnolence, co-administering it with alcohol may increase the risk of these effects. The potential for an additive effect is noted in safety documents.


Q: What are the potential drug interactions with common cold or allergy medications?

Many common cold and allergy medicines contain ingredients with anticholinergic properties. Since Spasmo-Urolong also contains an anticholinergic agent, taking these products together may increase the chance of experiencing side effects such as dry mouth, constipation, dizziness, or confusion. Official documents describe that all concurrent medicines and products, including cold or allergy remedies, should be reviewed to assess the risk of interaction.


Q: What research studies support the use of Spasmo-Urolong?

Regulatory approval is based on research that supports the medicine’s defined action as both an antispasmodic and a urinary antiseptic. While studies have explored various aspects of the drug, including its effects on sleep quality and tolerability profiles, the core evidence relates to its ability to address both muscular spasms and microbial activity in the urinary tract.


Q: Does Spasmo-Urolong affect driving or operating machinery?

Official safety information for Spasmo-Urolong lists adverse effects that involve the central nervous system, such as dizziness, somnolence (drowsiness), and confusion. Due to the potential for mental impairment, caution is necessary when engaging in activities that require mental alertness, such as driving or operating machinery.


Q: Can Spasmo-Urolong be used by people with kidney or liver impairment?

Use is strictly prohibited (contraindicated) in patients with severe kidney disease, as well as a history of liver problems linked to a prior use of the medicine. For people with non-severe kidney or liver impairment, official documents advise that caution or special consideration is necessary due to the risk of increased side effects.


Q: Is Spasmo-Urolong the same as oxybutynin or solifenacin?

No, Spasmo-Urolong is a distinct medicinal product containing the active ingredient Camylofin combined with Nitrofurantoin. Although oxybutynin and solifenacin belong to the same broader therapeutic class used to treat similar urinary symptoms, the specific chemical compounds in Spasmo-Urolong are different from those other drugs.


Q: Can Spasmo-Urolong be used for pain relief in the bladder?

The Camylofin component is classified as an antispasmodic agent designed to relax the smooth muscles of the urinary tract and reduce hyper-reflexive contractility (spasm). Official documents describe its general purpose as addressing muscular spasms. While its primary role is not pain relief, reducing spasms may be associated with decreased discomfort.


Q: Does Spasmo-Urolong interact with antidepressants?

Official interaction data does not typically list every specific antidepressant, but documents caution against taking the medicine with other agents that affect the central nervous system. This is because the combination could lead to additive effects, potentially increasing the risk of side effects like dizziness, confusion, or somnolence.


Q: Is Spasmo-Urolong considered a long-term treatment?

The Nitrofurantoin component of Spasmo-Urolong is generally used for a limited and defined therapeutic course. Official regulatory warnings advise that patients receiving therapy for six months or longer should undergo close monitoring due to the rare, potential risk of developing pulmonary or hepatic reactions.


Q: What is the duration of action for one dose of Spasmo-Urolong?

The duration of action is reflected in the official administration schedule. The product is frequently prescribed for administration multiple times per day (e.g., every 12 hours or four times daily). This required frequency is intended to maintain the necessary therapeutic concentration of both active ingredients over a 24-hour period.


Q: What should I do if I accidentally take too much Spasmo-Urolong?

Official prescribing information describes management for a known or suspected overdose. This management may include supportive measures such as promoting a high fluid intake to help the body excrete the drug through the urine. The management of an overdose involves supportive medical care.


Q: Are there any reported serious adverse events associated with Spasmo-Urolong?

Yes, official warnings describe the potential for several serious reactions, although they are rare. These include severe allergic-type events like Angioedema (swelling of the face, lips, or throat) and organ-specific risks such as Pulmonary Reactions, Hepatotoxicity (liver damage), and Urinary Retention.


Q: Can Spasmo-Urolong affect a man's ability to urinate?

Official documents note that the drug carries the risk of Urinary Retention, which is the inability to fully empty the bladder. This is a potential serious adverse reaction associated with the anticholinergic action of the medicine.


Q: How does Spasmo-Urolong differ from a beta-3 agonist drug?

The antispasmodic component of Spasmo-Urolong works by blocking specific nerve receptors (muscarinic antagonism) to relax muscle. This mechanism is distinct from that of a beta-3 agonist medicine, which works by stimulating a different set of receptors (beta-3 adrenergic receptors) to achieve muscle relaxation.


Q: Does Spasmo-Urolong impact cognitive function or memory?

Official safety documents report central nervous system side effects such as confusion, dizziness, and somnolence. These effects may influence a person's overall cognitive and mental function. Safety data indicates that these effects may be more pronounced, particularly at higher plasma concentrations or doses.


Q: What should I do if a side effect becomes bothersome?

Official patient information directs that if any adverse event becomes troublesome, severe, or causes concern, a review by a qualified healthcare professional is necessary.


Q: Is Spasmo-Urolong effective for treating nocturia (waking up to urinate at night)?

The drug's primary action is to manage urinary tract spasms and microbial activity. While not specifically indicated for nocturia, its muscle-relaxing effect can help manage urinary urgency and frequency. Research evidence noted that the combination was associated with a greater change in reported sleep quality when compared to the single drug alone.


Q: Can I stop taking Spasmo-Urolong suddenly?

Official instructions for the antibacterial component state the medicine should be taken for the full prescribed duration as determined by a healthcare provider. Official instructions state the medicine should be taken for the full prescribed duration to help achieve the intended therapeutic effect.


Q: Are there any lab tests needed while taking Spasmo-Urolong?

For patients receiving treatment for an extended period (typically six months or longer), official regulatory documents recommend periodic monitoring of the patient's liver and lung health, as well as renal function. This is necessary due to the potential for rare but serious adverse events.


Q: Does Spasmo-Urolong interact with herbal supplements like St. John's Wort?

Regulatory sources advise caution when combining Spasmo-Urolong with herbal supplements or other over-the-counter products. Official documents describe that all concurrent use of herbal supplements and other products should be reviewed with a healthcare professional, as some supplements may alter the metabolism or effects of prescription drugs.


Q: Does the effectiveness of Spasmo-Urolong vary by age or gender?

Official documents note that the way the body handles the medicine (pharmacokinetics) in specific populations, such as geriatric patients, and differences between male and female patients, may require specific consideration. This indicates that pharmacokinetics and safety may be subject to individual patient factors, particularly in geriatric populations.


Q: What is the chemical name for the active ingredient in Spasmo-Urolong?

The active ingredients are Camylofin Hydrochloride and Nitrofurantoin. The full chemical nomenclature for these compounds is available in the detailed description section of the official prescribing documents.


Q: Are allergic reactions a potential side effect of Spasmo-Urolong?

Yes, serious hypersensitivity reactions, including angioedema (severe swelling), are listed among the potential adverse events. Furthermore, the drug is formally prohibited for use in anyone with a known history of an allergic reaction to either of the active substances.


Q: Does Spasmo-Urolong affect fertility?

Animal studies conducted with high doses of the Nitrofurantoin component have indicated a temporary effect on sperm production in male animals. Official documents describe this effect as reversible once the medicine is stopped.


Q: What are the main benefits of choosing Spasmo-Urolong?

Spasmo-Urolong is designed as a fixed-dose combination to deliver a dual therapeutic benefit. It simultaneously provides smooth muscle relaxation (antispasmodic effect) to ease cramping, and focused antibacterial activity (urinary antiseptic effect) to counter microbial proliferation in the urinary tract.


Q: Is it common to experience dizziness with Spasmo-Urolong?

Official safety data lists dizziness in the Uncommon / Rare frequency category. This means that while it is a potential side effect, it is not one of the most frequently reported adverse reactions, such as dry mouth or constipation.


Q: Where can I find the official prescribing information for Spasmo-Urolong?

The full official prescribing information, which contains detailed safety and administration instructions, is publicly accessible. This information can be found on government regulatory agency websites, such as the NIH DailyMed, the EMA’s public register, or the relevant regulatory body in your country.

How should Spasmo-Urolong be stored and disposed of?

Storage and Disposal Requirements

Official Storage Conditions

Spasmo-Urolong tablets must be stored out of the sight and reach of children.

The medicine is required to be stored at room temperature and must be protected from excess heat and excess moisture to maintain its integrity. It must remain in the container it came in, and that container must be kept tightly closed. Storage in humid areas, such as the bathroom, is prohibited according to regulatory guidelines.

Disposal Instructions

To dispose of unused or expired medication, the primary recommendation is to utilize a drug take-back program or mail-back envelope. If a take-back option is unavailable, the product may be discarded in household trash after being mixed with an unappealing substance, such as dirt or used coffee grounds, and sealed in a leak-proof container. This medicine is not on the list of products recommended for flushing down the toilet.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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