Solu-Ket

Quick links to important sections

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Solu-Ket

Solu-Ket is a pharmaceutical preparation classified as a Nonsteroidal Anti-inflammatory Drug (NSAID), containing Ketoprofen as its single active ingredient.

Property Description
Active ingredient Ketoprofen
Form Solution for injection, capsules, tablets, gel
Pharmacological class Nonsteroidal Anti-inflammatory Drug (NSAID)
General purpose Relief of pain, inflammation, and fever
Origin Synthetic (Propionic acid derivative)

Solu-Ket: Classification and Identity

Solu-Ket is a pharmaceutical preparation whose sole active ingredient is Ketoprofen. This medication is broadly classified as a Nonsteroidal Anti-inflammatory Drug (NSAID), a powerful synthetic agent belonging to the propionic acid class of compounds. This classification makes it a nonsteroidal anti-inflammatory agent (NSAIA) whose function is clinically recognized for modulating the body's inflammatory response.

The core identity of Solu-Ket is rooted in its active substance, Ketoprofen, which is distinguished from many over-the-counter NSAIDs by its generally prescription-only (Rx) status and the availability of forms designed for rapid systemic effect, such as its solution for injection preparation. As an NSAID, its established purpose is to reduce inflammation and relieve pain, confirmed by its inclusion in the Anatomical Therapeutic Chemical (ATC) classification system.

Composition, Form, and General Purpose

The active component, Ketoprofen, is typically utilized as a racemic mixture in pharmaceutical formulations. Solu-Ket is associated with various dosage forms, which dictates the route of administration, including solutions for injection (parenteral), oral forms like capsules or tablets, and topical applications like gels. The availability of an injectable form is a key differentiator, often reserved for scenarios requiring prompt and effective systemic action.

This versatile formulation serves the general therapeutic purpose of addressing symptoms driven by inflammatory processes. Solu-Ket’s core function is to produce three concurrent actions: analgesic (pain relief), anti-inflammatory (reduction of swelling and stiffness), and antipyretic (fever reduction). This foundational understanding confirms its role as a symptomatic relief agent targeting the biological source of discomfort, making it suitable for situations involving acute inflammatory pain.

Regulatory References

  1. Ketoprofen: Clinical properties (NIH/NLM)

What side effects are possible with Solu-Ket?

Possible Side Effects and Safety Information

The safety profile of Solu-Ket (Ketoprofen) is defined by established patterns documented for Nonsteroidal Anti-inflammatory Drugs (NSAIDs), with adverse reactions officially grouped by system and frequency in regulatory labeling.

Reactions categorized as Common often affect the Gastrointestinal system, including dyspepsia, nausea, and abdominal pain. Effects classified as Uncommon may involve the Nervous system, such as headache, dizziness, and fatigue. Less frequent, Rare reactions include hypersensitivity events and visual disturbances, while the frequency of certain serious reactions, such as Acute Kidney Injury, may be classified as Not Known.

Serious adverse risks are primarily focused on two areas. Serious Gastrointestinal (GI) Events, including ulceration, bleeding, and perforation, are critical considerations that can occur without prior warning symptoms. Additionally, the medicine is associated with a risk of Serious Cardiovascular Thrombotic Events, such as myocardial infarction and stroke, which may occur early in treatment and the risk can increase with the duration of use.

Safety constraints documented in regulatory labeling include explicit contraindications in patients with active peptic ulcer/hemorrhage, severe heart failure, severe renal failure, or severe hepatic failure. Older adults are noted as a population with an increased risk for serious and potentially fatal GI events. The medication is also strictly contraindicated during the third trimester of pregnancy.

Overdose and Emergency Response

Overdose and When to Seek Help

Official regulatory information describes that an overdose of Solu-Ket (ketamine), typically resulting from an excessive dosage or administration that is too rapid, can lead to several serious clinical manifestations affecting the central nervous, respiratory, and cardiovascular systems.

Documented Overdose Manifestations

The following severe symptoms have been associated with an overdose, based on regulatory labeling:

  • Respiratory Compromise: This includes potentially life-threatening conditions such as respiratory depression and respiratory arrest.
  • Cardiovascular Effects: Severe overdose can result in profound hypotension (low blood pressure) due to cardiovascular depression.
  • Neurological Events: Manifestations include convulsions and laryngospasm.

Emergency Actions and When to Seek Help

Immediate emergency medical attention is required if any signs of a severe overdose occur, particularly for respiratory arrest, profound hypotension, or convulsions.

Regulatory documents emphasize that the treatment of an overdose is primarily supportive.

  • Required Medical Care: Maintaining a patent airway and ensuring adequate respiration is critical. This often requires assisted ventilation to support breathing until the effects of the drug subside. All necessary supportive measures must be taken by medical professionals in an emergency setting.

Overdose severity is closely linked to the amount of drug and the rate at which it is administered, demanding immediate professional intervention to manage these life-threatening physiological effects.

Therapeutic Uses of Solu-Ket

What Solu-Ket Treats: Main Uses and Benefits

Solu-Ket is commonly used in situations involving certain distressing symptoms, focusing on conditions characterized by pain, inflammation, and fever. The medication is applied in addressing conditions presenting with systemic or localized discomfort, including symptomatic relief in rheumatoid arthritis, osteoarthritis, and other inflammatory processes like acute gouty arthritis, tendinitis, and primary dysmenorrhea (menstrual pain).

The medication is often used during phases when symptoms become more noticeable, such as in post-traumatic scenarios involving sprains and strains, or following acute clinical procedures. It assists with maintaining functional stability by addressing pronounced symptoms and is relevant for managing symptoms that interfere with daily comfort, such as persistent joint stiffness and tenderness. The medication may assist with managing difficult episodes and can contribute to improved comfort during periods of heightened symptoms.


Quick Fact: Relief for Symptoms Related to Heightened Physiological Activity The medication is relevant for easing pain, and contributes to managing swelling and fever when symptoms are linked to inflammatory or irritative states.


Regulatory References

  1. Ketoprofen: MedlinePlus Drug Information

Eligibility and Restrictions for Use

The eligibility for using Solu-Ket (Ketoprofen) is strictly defined by regulatory authorities based on a patient's age, medical history, and physiological status.


Populations for Whom Use is Contraindicated (Absolute Prohibition)

Solu-Ket must not be used by individuals who are absolutely prohibited according to official regulatory labels:

  • Patients with a known hypersensitivity or allergy to Ketoprofen, aspirin, or other NSAIDs, including those with a history of aspirin-sensitive asthma.
  • Patients with active peptic ulcer disease or active gastrointestinal bleeding/ulceration.
  • Patients in the setting of Coronary Artery Bypass Graft (CABG) surgery for perioperative pain.
  • Pregnant women in the Third Trimester (from 30 weeks gestation onward) due to risk of fetal harm.

Populations Requiring Conditional Use

Population/Condition Official Regulatory Status
Pediatric Patients (typically under 18) Safety and efficacy are not established for prescription use in most children and adolescents.
Renal or Hepatic Impairment Requires close monitoring. Severe impairment is contraindicated; non-severe impairment may require a limitation on the maximum daily dose to avoid toxicity.
Older Adults (ge 65 years) Use is permitted but requires caution and monitoring due to increased risk of serious adverse GI and renal events.
Cardiovascular Risk Factors Must use with caution (e.g., patients with history of heart failure or hypertension) due to the risk of serious cardiovascular events.
Breastfeeding/Lactation Use is not recommended as the risk to the infant is unknown.

What should I know about interactions with other medicines?

The official regulatory profile for Solu-Ket (Ketoprofen) establishes specific restrictions and monitoring requirements when co-administered with other products. Formal contraindications include use with other Nonsteroidal Anti-inflammatory Drugs (NSAIDs) or high-dose aspirin due to the heightened risk of serious gastrointestinal ulceration and bleeding. The medication is also strictly contraindicated for treating pain following Coronary Artery Bypass Graft (CABG) surgery.

Exposure and Clearance Modifications

Several documented interactions alter systemic exposure. Co-administration with Probenecid significantly reduces Ketoprofen's plasma clearance, resulting in increased concentrations. Conversely, concurrent use with aspirin has been shown to increase Ketoprofen plasma clearance and decrease its protein binding. Ketoprofen can also alter the elimination of drugs like Lithium and Methotrexate, leading to elevated serum levels and potential toxicity of the co-administered agent.

Pharmacodynamic and Substance Interactions

Pharmacodynamic interactions result in additive risks, such as the increased potential for bleeding when combined with anticoagulants, antiplatelet agents, Selective Serotonin Reuptake Inhibitors (SSRIs), or corticosteroids. Furthermore, Ketoprofen may diminish the antihypertensive or natriuretic effects of Diuretics, Angiotensin Converting Enzyme (ACE) Inhibitors, and Angiotensin II Receptor Blockers (ARBs), carrying a documented risk of renal impairment in susceptible individuals. The regulatory profile notes that while food does not alter total absorption, it slows the rate, delaying the time to peak concentration. Alcohol is officially noted as an independent factor that exacerbates the gastrointestinal bleeding risk.

Mechanism of Action

Solu-Ket acts by directly modulating key signaling pathways within the central and peripheral nervous systems. Its effects emerge from action across several distinct mechanistic domains, leading to changes in physiological signaling.

Primary NMDA Receptor Blockade and Excitatory Dampening

Solu-Ket's primary action involves acting as a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor, a key regulator of excitatory neurotransmission driven by glutamate. This mechanistic domain involves the rapid blockage of ion flow through the receptor, which acts to dampen overactive or dysregulated signaling in the CNS, contributing to changes in the activity of neural circuits involved in sensation and arousal.

Downstream Modulation of Synaptic Plasticity Cascades

Beyond immediate receptor antagonism, Solu-Ket initiates powerful downstream signaling sequences that engage neurotrophic factors, such as BDNF, and intracellular pathways, including mTOR. This mechanistic domain is relevant in cascades where key signaling events are modified to influence synaptic structure and function, influencing feedback regulation within targeted neural pathways over time.

Secondary System Engagement for Broad Mechanistic Influence

The drug also engages a range of secondary biological targets, including opioid receptors and monoaminergic transporter systems. This multi-target engagement is associated with modulating pathways linked to heightened physiological responses, influencing multiple signal transduction sequences.

Dosage and Administration Information

Solu-Ket (ketamine hydrochloride) is an injectable general anesthetic that must be administered only by, or under the close supervision of, a physician experienced in anesthesia and in the maintenance of a patent airway and ventilation.

Administration Routes and Forms

Ketamine injection can be administered via the intravenous (IV) or intramuscular (IM) routes. In specific settings, such as pain management, ketamine may also be administered as a continuous subcutaneous infusion or, less commonly, as an oral solution, although these may be considered off-label uses depending on the country's regulatory approvals.

Route of Administration Typical Onset of Action Duration of Surgical Anesthesia
Intravenous (IV) Within 30 seconds 5 to 10 minutes
Intramuscular (IM) 3 to 4 minutes 12 to 25 minutes

For IV administration, it is recommended to inject the initial dose slowly, typically over a period of 60 seconds. Rapid IV injection may cause respiratory depression and an enhanced pressor response. The higher concentration (100 mg/mL) must be diluted with an equal volume of sterile water for injection, normal saline, or 5% dextrose in water before IV use. Resuscitation equipment must be readily available during administration.

Dosage and Monitoring

Dosage is highly individualized and depends on the patient's requirements, age, and route of administration. For induction of general anesthesia, an average IV dose is typically 2 mg/kg, and an IM dose is approximately 10 mg/kg. To maintain anesthesia, increments of one-half to the full induction dose can be repeated as needed. Continuous monitoring of vital signs, including blood pressure and respiratory function, is mandatory throughout the procedure. Due to potential hypersalivation, an antisialagogue may be administered prior to induction.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Solu-Ket

Evidence for Use in Chronic Inflammatory Conditions

Research exploring how symptoms change over time in chronic conditions, such as rheumatoid arthritis and osteoarthritis, has been a focus of studies examining the active ingredient Ketoprofen. These research efforts primarily involved meta-analyses that consolidate findings from many randomized controlled trials (RCTs), as well as comparative studies against placebo or other related medicines. Studies monitored outcomes reflecting physical discomfort, including assessments of pain assessment scores and measures reflecting changes in daily functioning or activity level, such as joint stiffness. What remains uncertain is the long-term evidence regarding use over many years, as there is limited information for long-term outcomes on symptomatic control.

Evidence for Use in Acute, Short-term Pain

Studies was studied for its use in research scenarios involving acute or disruptive episodes, such as postoperative pain and primary dysmenorrhea (menstrual pain). The research base includes systematic reviews and single-dose randomized controlled trials. These trials assessed short-term or episodic symptom patterns in adult populations. Research highlights changes measured during the study period by focusing on outcomes describing episodic or acute changes, such as the time until changes in pain assessment were reported and the overall intensity of discomfort. Consequently, data for certain groups remain insufficient when exploring sustained, multi-day pain control; the majority of the available evidence relates only to the outcomes observed after a single dose.

Evidence for Use in Localized and Highly Specific Conditions

The active ingredient was studied for localized conditions, like sprains and strains, particularly using topical applications. These trials explored outcomes related to physical discomfort and the functional status assessment over a short-term follow-up duration. Highly specific, complex conditions like acute vaso-occlusive crises (severe pain episodes in Sickle Cell Disease) was studied for its use in Phase 3 randomized trials in hospitalized adults. Evidence is limited to small clinical trials studying this specific population, and comparative evidence is often lacking regarding which administration route is optimal for functional assessment.

Frequently Asked Questions (FAQ)

Common questions about Solu-Ket (FAQ)

Q: How quickly should someone expect Solu-Ket to start working?

A: The time it takes for Solu-Ket to reach its highest levels in the bloodstream, known as peak plasma concentration, is typically around 1 to 2 hours following an oral dose. This timing can vary based on the specific type of formulation used (e.g., immediate-release or extended-release) and whether the medication is consumed with food, as described in official pharmacokinetic data.


Q: Is it safe to take Solu-Ket with common pain relievers?

A: Regulatory documents strongly advise against taking Solu-Ket alongside other nonsteroidal anti-inflammatory drugs (NSAIDs), as this significantly increases the risk of serious stomach and intestinal bleeding. While studies indicate no direct interaction with Acetaminophen (Paracetamol), concurrent pain medications are typically discussed with a healthcare professional.


Q: Can older adults use Solu-Ket safely?

A: Official documents state that use in older adults (generally 65 years and older) is allowed but requires specific caution and close monitoring. The caution is advised because this population has an increased risk for serious gastrointestinal problems, and regulatory documents note that careful consideration of dosage is required.


Q: What is the safety profile of Solu-Ket during pregnancy according to official sources?

A: Solu-Ket use is strictly contraindicated (meaning it must not be used) during the Third Trimester of pregnancy because of the documented risk of harm to the fetus. For the first and second trimesters, regulatory advice indicates the medicine should only be used if the potential benefit justifies the potential risks.


Q: Does Solu-Ket make people feel sleepy or tired?

A: Yes, the official safety profile of Solu-Ket lists dizziness and drowsiness as potential side effects. The feeling of fatigue or tiredness is also noted in regulatory documents, and awareness of these possibilities is part of the patient information.


Q: Why do official documents mention Solu-Ket can cause changes in vision?

A: Official regulatory documents list visual disturbances as a possible adverse reaction to Solu-Ket. It is important to know that this reaction is generally classified as a Rare event on the medication's safety profile.


Q: Can Solu-Ket be taken with high blood pressure medication?

A: Official documents warn that Solu-Ket may reduce the effects of certain high blood pressure medicines, such as ACE Inhibitors, Angiotensin II Receptor Blockers (ARBs), and Diuretics. Using these medicines together can potentially increase the risk of kidney problems, and close patient monitoring is generally advised.


Q: What types of drug interactions are generally of most concern with Solu-Ket?

A: Regulatory warnings highlight the importance of monitoring for additive risks when combining drugs. Of primary concern are interactions that increase the likelihood of gastrointestinal bleeding (e.g., with blood thinners or steroids) and combinations that pose a risk of kidney impairment (e.g., with certain blood pressure medications).


Q: Does Solu-Ket affect fertility?

A: Official information regarding NSAIDs indicates that use is not recommended in women attempting to conceive because this class of medicine may temporarily impair female fertility. This effect is generally considered reversible upon discontinuation of the medicine.


Q: What is the main mechanism of action of Solu-Ket, explained simply?

A: The medicine's primary action is described as the inhibition of prostaglandin synthesis by blocking the cyclooxygenase (COX) enzyme. Prostaglandins are natural chemicals in the body that promote and signal inflammation, pain, and fever, so blocking their production helps relieve these symptoms.


Q: Is Solu-Ket a controlled substance?

A: Solu-Ket, which contains the active ingredient Ketoprofen, is classified as a Nonsteroidal Anti-inflammatory Drug (NSAID). It is not listed as a controlled substance by the U.S. Drug Enforcement Administration (DEA) or similar international bodies.


Q: What happens if a dose of Solu-Ket is forgotten?

A: General patient instructions often advise taking the missed dose as soon as it is remembered. However, if it is almost time for the next scheduled dose, many official patient guides suggest skipping the missed dose entirely. Taking double doses to compensate for a missed one is generally advised against.


Q: How long does Solu-Ket stay in the body after the last use?

A: Official pharmacokinetic data indicates that the medicine is quickly processed and eliminated from the body. The time it takes for half of the medicine to be cleared, known as the elimination half-life, typically ranges from approximately 1 to 3 hours.


Q: Are there any specific foods to avoid when using Solu-Ket?

A: Regulatory documents state that there are no specific foods listed that must be avoided when taking Solu-Ket. The medicine may be taken with food, milk, or antacids to help reduce the risk of stomach upset, although food may slow the rate at which the medicine is absorbed.


Q: Why is Solu-Ket sometimes given in a hospital setting?

A: Solu-Ket is available as an injectable solution, which is generally reserved for use in professional, supervised settings. The injectable form is typically utilized in scenarios that require a prompt and highly effective systemic action, often for episodes of acute pain.


Q: What is the difference between Solu-Ket and its generic form?

A: Solu-Ket is the brand name for the active ingredient, Ketoprofen. The generic form contains the same active drug, strength, and dosage form and must meet the same strict regulatory standards for quality, safety, and performance as the brand-name product.


Q: Is Solu-Ket known to interact with herbal supplements?

A: The official label may not list every possible interaction, but authoritative sources often advise caution with herbal supplements that are known to increase the risk of bleeding. Examples of such supplements include ginger, garlic, and willow bark.


Q: Do studies support the long-term use of Solu-Ket?

A: Official regulatory guidelines advise that NSAIDs like Solu-Ket should be used at the lowest effective dose for the shortest possible duration. This is because risks associated with long-term use, such as cardiovascular and gastrointestinal events, are documented to increase with the duration of use.


Q: How often do people typically need to take Solu-Ket?

A: The required frequency depends entirely on the specific health condition and the type of formulation prescribed. For example, immediate-release capsules are often described as being taken several times a day (e.g., every 6 to 8 hours), while an extended-release form may be taken only once daily.


Q: What should be done if an allergic reaction is suspected after using Solu-Ket?

A: If someone notices signs of a serious allergic reaction, such as difficulty breathing, swelling of the face, tongue, or throat, or a rash, the patient information emphasizes that seeking medical help immediately is necessary.


Q: Are there any lifestyle changes recommended when using Solu-Ket?

A: Regulatory guidance specifically includes the advice to avoid alcoholic beverages while using Solu-Ket. Alcohol can independently increase the risk of gastrointestinal adverse effects, compounding the risks associated with the medicine itself.


Q: Do official sources discuss Solu-Ket's effect on driving ability?

A: Official patient information advises caution with activities that require focused mental attention, such as driving or operating machinery. This is because side effects like dizziness, drowsiness, or visual changes are documented in the regulatory profile.


Q: How is the safety of Solu-Ket monitored by health authorities?

A: Health authorities, such as the FDA and EMA, continually monitor the safety of medications like Solu-Ket through pharmacovigilance programs. This ongoing process involves collecting and reviewing reports of side effects, which can lead to new warnings or changes in the official labeling if necessary.


Q: What evidence exists about Solu-Ket and mental alertness?

A: The official safety profile documents side effects that can impact mental alertness, including dizziness and drowsiness. Caution with tasks requiring concentration, such as driving, is often included in patient information.


Q: Can I stop taking Solu-Ket once I feel better?

A: For acute uses, such as short-term pain relief, the medicine is typically taken for a limited time. For chronic conditions, official guidelines advise that treatment should be reviewed regularly and used for the shortest possible duration.


Q: Does the efficacy of Solu-Ket change over time?

A: Official information indicates there is limited data on the outcomes and efficacy of Solu-Ket over very long periods (many years). For this reason, official guidelines emphasize the importance of regular review for all chronic use to assess continued suitability.


Q: Are there any specific blood tests required before starting Solu-Ket?

A: Official documents indicate that for patients who are at risk for kidney damage or those with existing liver impairment, close monitoring of kidney and liver health may be advised by a prescriber. This monitoring often involves conducting specific blood tests before and during treatment.


Q: Is Solu-Ket safe to use before surgery?

A: The use of NSAIDs like Solu-Ket before a surgical procedure may increase the risk of bleeding, and discussion with the surgeon is typically required to assess this possibility. Furthermore, the medication is strictly contraindicated for treating pain immediately following Coronary Artery Bypass Graft (CABG) surgery.

How should Solu-Ket be stored and disposed of?

How to Store and Dispose of Solu-Ket (Ketoprofen Injection)

Solu-Ket injection must be stored according to regulatory requirements to maintain its stability. The product should be stored at or below 25°C (77°F) and kept in its original outer carton for protection from light. It is strictly mandated not to freeze or refrigerate the medication. The container must be kept out of the sight and reach of children.

After the initial container puncture, the product must be used within 28 days. Any unused or expired product must be disposed of in accordance with local requirements. Medicines should not be disposed of via wastewater or household trash to protect the environment.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Solu-Ket found in:

A-Z Index: