Solicam

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Solicam

Property Description
Active ingredient Piroxicam
Form Gel
Pharmacological class Nonsteroidal Anti-Inflammatory Drug (NSAID)
Common use Localized symptomatic relief of pain and inflammation
Origin Synthetic (Oxicam derivative)

Solicam is a proprietary pharmaceutical preparation primarily classified as a Nonsteroidal Anti-Inflammatory Drug (NSAID), specifically formulated for external, localized use. Its single active ingredient is Piroxicam, a synthetic compound that belongs to the oxicam chemical subclass of anti-inflammatory agents. This designation identifies Solicam as a modern medicine designed to intervene directly in the body's inflammatory processes.

Solicam's Composition and Physical Form

The drug is delivered in a gel dosage form, a semi-solid preparation intended for cutaneous (topical) administration. The core active ingredient, Piroxicam, is suspended within an inert hydrogel base that facilitates its release and absorption through the skin layers into the underlying affected tissues. This specific formulation is designed to target inflammation in a concentrated area, a key differentiating factor from oral therapies. Topical NSAIDs, including Piroxicam, are a recognized treatment option for localized pain.

General Purpose and Mechanism of Piroxicam

The general purpose of the Piroxicam contained in Solicam is to provide localized symptomatic relief of pain and swelling stemming from inflammatory processes, such as those associated with a typical muscle strain or joint tenderness. The core mechanism involves Piroxicam acting as a potent cyclooxygenase inhibitor, which in turn blocks the production of the prostaglandins—the key chemical messengers that initiate and sustain inflammation. By suppressing these inflammatory mediators at the site of application, the medication reduces the associated pain sensations and physical swelling. This topical approach ensures that the anti-inflammatory and analgesic effects are concentrated where they are most needed.

What side effects are possible with Solicam?

Possible Side Effects and Safety Information

The safety profile for Solicam (Piroxicam gel) is primarily defined by local application site reactions, as documented in official regulatory sources. Systemic adverse reactions, while less frequent due to low absorption, are also noted as potential outcomes.


Adverse Reaction Classifications

Category Examples (Regulatory Terminology)
Common Local effects such as dermatitis, pruritus (itching), erythema (redness), and rash at the application site.
Systemic Risk Potential for gastrointestinal effects (e.g., nausea, dyspepsia) and rare renal events (e.g., interstitial nephritis), noted as NSAID class effects.
Very Rare Severe Cutaneous Adverse Reactions (SCARs), including Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN).

Key Safety Constraints

The official labeling outlines specific restrictions and safety considerations:

  • Hypersensitivity: The medicine is contraindicated in individuals with a history of asthma, urticaria, or other allergic-type reactions following the use of Piroxicam, aspirin, or other Nonsteroidal Anti-Inflammatory Drugs (NSAIDs).
  • Pregnancy Restriction: Use is specifically contraindicated during the third trimester of pregnancy due to recognized NSAID class risks to fetal cardiopulmonary and renal systems.
  • Time-Related Risk: The highest risk for the development of severe cutaneous adverse reactions (SCARs) is documented as occurring within the first month of treatment.
  • Other Constraints: A safety note is included regarding a fire hazard, stating that fabric (clothing or bedding) in contact with the product may burn more easily.

Overdose and Emergency Response

Overdose and when to seek help

Overdose of Solicam (Piroxicam) is primarily linked to the potential for systemic toxicity following excessive topical use or accidental oral ingestion of the gel formulation. Regulatory documentation defines the manifestations across several body systems. Documented signs include gastrointestinal disturbances like nausea, vomiting, severe heartburn, and signs of gastrointestinal bleeding. Central Nervous System effects may involve headache and confusion, progressing to severe outcomes such as convulsions and coma. Life-threatening outcomes documented in official labeling include acute renal failure, acute liver failure, and major GI perforation, which can result in shock.

Emergency Actions

Regulators mandate that individuals must seek immediate medical attention for any suspected overdose or when severe systemic symptoms are observed. Emergency medical care is required for complications such as signs of GI bleeding, seizures, or respiratory distress. The official management strategy is strictly defined as symptomatic and supportive treatment because no specific antidote is known. Hospital monitoring is often required to stabilize vital signs and assess organ function. Regulatory notes also highlight a risk of fetal toxicity if systemic exposure occurs during the third trimester of pregnancy.

Therapeutic Uses of Solicam

What Solicam Treats: Main Uses and Benefits

Solicam (Piroxicam gel) is applied across domains where additional symptomatic support is needed for painful, inflammatory conditions of the muscles and joints. It is relevant in contexts marked by increased discomfort or tension, assisting patients when symptoms create noticeable physiological strain.


Acute Symptom Management in Soft-Tissue Injuries

This domain covers the medication's role in addressing the discomfort and swelling associated with acute, sudden-onset musculoskeletal trauma. It is commonly used in conditions like muscle strains, ligament sprains, and contusions. Solicam helps address symptom clusters that appear suddenly, offering supportive therapeutic benefit to ease the overall symptom burden.

Relief for Localized Joint and Tendon Inflammation

Solicam is relevant in conditions characterized by chronic, yet localized, pain and swelling, such as tendonitis, bursitis, and the episodic flare-ups of osteoarthritis in peripheral joints. It is applied in addressing symptoms that fluctuate, which contributes to improved comfort during periods of heightened symptoms.


Addressing Physical Discomfort in Symptomatic Episodes

The gel is applied in addressing symptoms related to physical discomfort and inflammatory or irritative states when they become more noticeable. Used during phases when symptoms intensify and supportive relief is needed, Solicam may assist with maintaining functional stability and helps patients cope more steadily by easing distress.

Quick Fact: Supportive relief for symptoms related to physical discomfort and inflammatory states (Swelling, Pain, Tenderness).

Regulatory References

  1. Summary of Product Characteristics from the HPRA

Eligibility and Restrictions for Use

Eligibility and Contraindications for Solicam

Regulatory documents strictly define the populations eligible to use Solicam (Piroxicam gel) and those who are prohibited. Use is established for adults and generally acceptable for older adults, though the latter requires particular care.

Absolute Contraindications

The medicine is strictly prohibited in the following populations:

  • Individuals with known hypersensitivity to Piroxicam or any excipients.
  • Patients with cross-sensitivity reactions (e.g., asthma, urticaria) to Aspirin or other NSAIDs.
  • Pregnant women during the third trimester of pregnancy.
  • Application to areas with open skin lesions, dermatoses, or infection.

Restricted and Conditional Use

Use is not established or not recommended for children under 12 years of age. For women who are breastfeeding, attempting to conceive, or in the first five months of pregnancy, use is generally not recommended. Patients with a history of peptic ulceration, intestinal inflammatory disease, renal dysfunction, or hepatic disease must use the medicine with particular care due to the potential for systemic absorption.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Solicam (Piroxicam) has a documented interaction profile primarily based on the drug's properties as an NSAID and its systemic absorption, which is formally described in regulatory documents.

Documented Pharmacodynamic and Pharmacokinetic Interactions

Interacting Substance/Class Official Interaction Pattern (Regulatory Basis)
Other NSAIDs (including COX-2 selective) Co-administration is formally restricted or contraindicated due to the enhanced risk of serious gastrointestinal events.
Oral Anticoagulants (e.g., Warfarin) Piroxicam may enhance the effects of these medicines, leading to an officially documented increased risk of bleeding.
ACE Inhibitors / ARBs / Diuretics May diminish the antihypertensive or natriuretic effect of these medicines through pharmacodynamic antagonism.
Lithium, Methotrexate, Digoxin Piroxicam increases the serum concentration of these substances by documented mechanisms involving reduced renal excretion or altered clearance.
Antiplatelet Agents / SSRIs / SNRIs Combination results in an increased risk of serious gastrointestinal bleeding (additive antiplatelet effect).
Alcohol (Excessive Amounts) Associated with a formally documented increased risk of serious gastrointestinal complications.

The regulatory profile specifies that Piroxicam is metabolized by CYP2C9. Individuals who are classified as poor metabolizers exhibit higher systemic Piroxicam exposure due to reduced clearance, a consideration noted in official labeling. Additionally, a specific timing rule may apply for co-administration with Pemetrexed, requiring interruption for several days surrounding its use to mitigate toxicity risk.

Mechanism of Action

Targeting the Cyclooxygenase Enzyme

The mechanism involves the non-selective inhibition of the Cyclooxygenase (COX) enzymes, specifically the COX-1 and COX-2 isoforms, within the peripheral tissue. This molecular targeting is the initial step that prevents the enzymes from converting arachidonic acid into prostanoids.


Suppressing the Inflammatory Cascade

The enzymatic inhibition directly interferes with the Arachidonic Acid Cascade, resulting in a reduced local production of Prostaglandins ( PGE2). This suppression of humoral mediators modulates the chemical signals that influence localized tissue responses, specifically vascular permeability and nociceptor sensitization.


Modulating Peripheral Nociception

The resulting decrease in PGE2 concentration modulates the chemical sensitization of peripheral afferent fibers (nociceptors). This mechanism alters the threshold for neural stimulation, resulting in the modulation of afferent signaling from the peripheral tissue.

Dosage and Administration Information

How Solicam is Used

The usage of Solicam is defined by its formulation as a topical gel for external, localized administration. The product is a 0.5% w/w Piroxicam gel intended for cutaneous use only, delivering the active ingredient directly to the site of application.

Administration Protocol

Administration Component Instruction
Route and Form Topical (external) application as a ready-to-use gel.
Standard Single Dose 1 gram of gel, typically approximated as a strip measuring 3 cm or 1 1/4 inches.
Dosing Frequency Applied to the affected area two to four times daily.
Duration Principle Intended for short-term use; treatment duration is reviewed by a professional at regular intervals.

Procedural Instructions and Constraints

The protocol requires that the measured dose be gently massaged into the skin until the gel is no longer visible. A key procedural step involves washing the hands well immediately after each application, unless the hands are the area being treated. As an administration constraint, the gel must be kept strictly away from the eyes and mucous membranes. Furthermore, the application site should not be covered with occlusive dressings or airtight bandages.

Usage in Specific Populations

Solicam is intended for adult use. For older adults, the lowest dose compatible with symptom management is used. The use of this topical formulation in children and adolescents is generally not recommended or is limited by age, as experience in these populations has not been established.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Solicam

This section focuses on the official research evidence for Piroxicam gel, describing the types of studies, populations, and outcomes tracked. This overview is purely descriptive and offers no medical advice.


Evidence for Acute Soft-Tissue Injuries

Research for acute issues, such as muscle strains and ligament sprains, consists primarily of short-term Randomized Controlled Trials (RCTs) typically spanning one to two weeks in adults with recent trauma. Studies monitored patient-reported outcomes describing perceived discomfort and changes in restriction of joint movement. Studies report patterns observed in the measurements of symptomatic change in pain scores in groups using the gel compared to those using a placebo. However, follow-up durations were limited, and there is limited information on how the use of the gel during the acute phase relates to long-term functional outcomes or recurrence of the injury.


Evidence for Localized Joint and Tendon Inflammation

For chronic, localized conditions like osteoarthritis (of the knee or hand) and tendinitis, the evidence relies on intermediate-term RCTs that applied in research contexts involving fluctuating or unstable symptoms. These studies in adults and older adults typically spanned two to four weeks. Findings described patterns in the measured outcomes compared to placebo, focusing on daily functioning or activity level and pain severity. The available evidence is generally consistent across various topical NSAID formulations that examined these symptoms.


Study Limitations and Gaps

The available clinical research focuses mainly on short-term relief, with limited information for long-term outcomes regarding continued use. Data for certain groups remain insufficient, including children or adolescents and individuals with complex comorbidities; the research results apply primarily to the populations studied. Evidence quality varies across studies, and comparative evidence is lacking for many direct, head-to-head comparisons against other topical or oral pain relievers, meaning that certainty remains low in these areas.

Key Studies & References

  1. Summary of Product Characteristics (Piroxicam 0.5% Gel) - Regulatory Document supporting approved indications and limitations (HPRA)

Frequently Asked Questions (FAQ)

Common questions about Solicam (FAQ)

Q: Is Solicam an antibiotic or a painkiller?

A: The active ingredient in Solicam, Piroxicam, is formally classified as a Nonsteroidal Anti-Inflammatory Drug (NSAID). Its intended use is to provide relief from pain and inflammation by blocking the chemical messengers involved in the inflammatory process, and it is not used to treat bacterial infections like an antibiotic.

Q: Does Solicam cause hair loss?

A: Hair loss or thinning of the hair is mentioned in the safety data compiled from regulatory reports, where it is categorized as a less common potential adverse effect. Official product information contains a complete list of reported side effects, categorized by frequency.

Q: Is there a generic version of Solicam available?

A: Yes, the single active compound in Solicam is Piroxicam. Piroxicam is the generic name for this compound, and other products containing Piroxicam gel may be available.

Q: Is Solicam considered a high-risk medication?

A: Official documents outline several warnings and precautions associated with NSAIDs, the class of drugs Solicam belongs to. These warnings describe the potential for serious systemic side effects, such as gastrointestinal issues or severe skin reactions, with the highest risk for severe skin reactions documented within the first month of treatment.

Q: Does Solicam have a potential for dependency?

A: No, the active ingredient, Piroxicam, is classified as a Nonsteroidal Anti-Inflammatory Drug (NSAID). This type of medicine is not generally associated with potential for drug dependence.

Q: Are there any documented long-term effects of Solicam use?

A: Official clinical research for the topical gel formulation focuses on short-term use and has limited information regarding long-term functional outcomes from continuous use. However, the NSAID class of medicines is associated with known systemic risks when used long-term.

Q: Is Solicam safe to use while breastfeeding?

A: Low concentrations of Piroxicam have been documented in breast milk. Available data indicates that Piroxicam is not expected to cause adverse effects in older breastfed infants. However, due to limited experience in the newborn period, official resources suggest that for nursing a newborn or preterm infant, professional guidance regarding alternatives is generally considered due to limited available data.

Q: Is Solicam a type of biological medicine?

A: No, Solicam is not considered a biological medicine. It is a synthetic pharmaceutical preparation classified as a Nonsteroidal Anti-Inflammatory Drug (NSAID).

Q: Is there a specific time of day that is best to take Solicam?

A: Official administration protocol directs that the gel should be applied two to four times daily to the affected area. The regulatory documentation does not specify an optimal time of day for application.

Q: Do people typically gain weight when taking Solicam?

A: NSAIDs, the class of drugs Solicam belongs to, have been associated with potential side effects such as edema (swelling) and unusual weight gain. These potential adverse effects are officially noted as part of the safety information for this class of medicine.

Q: What is the main ingredient in Solicam?

A: The single active ingredient in the product is Piroxicam. This is a synthetic compound that gives the gel its anti-inflammatory properties.

Q: Are headaches a common side effect reported with Solicam?

A: Headaches are listed as a common adverse reaction in the safety data derived from regulatory reports for the active ingredient, Piroxicam, particularly when it is systemically absorbed.

Q: What happens if I miss a dose of Solicam?

A: Official guidance for a missed dose indicates it may be applied as soon as it is remembered, unless it is almost time for the next scheduled application. If it is almost time for the next dose, the usual protocol is to skip the missed dose and resume the regular schedule. Doses are not to be doubled.

Q: Is the medication designed to cure the condition or just manage symptoms?

A: Solicam is officially indicated for the localized symptomatic relief of pain and inflammation. It works by blocking the chemical messengers that cause symptoms, but it is not intended to cure the underlying condition itself.

Q: Are there any specific warnings for people with diabetes taking Solicam?

A: Regulatory documents note that patients with pre-existing conditions like diabetes are advised to use the medication with particular caution. This is because NSAID use can be associated with an increased risk of issues such as high blood pressure, the management of which is usually considered in this context.

Q: What is the recommended storage temperature for Solicam?

A: Solicam gel must be stored in its closed container at a temperature below 25 C (77 F). The product should not be refrigerated or frozen and must be protected from excessive heat, moisture, and light.

Q: Does age affect the way Solicam works?

A: Official guidance specifies that for older adults, the lowest dose compatible with symptom management is recommended. This indicates that age is a factor in how the medicine is generally utilized according to official protocol.

Q: What is the significance of the research evidence for Solicam?

A: The research evidence determines the approved indications and the safety profile of Solicam. It formally confirms its appropriate use for localized soft-tissue injuries and inflammatory conditions and documents the observed symptomatic changes compared to placebo.

Q: Can I drive or operate machinery after taking Solicam?

A: Solicam is a topical gel with low systemic absorption. However, official labeling states that driving or operating machinery should be avoided if individuals experience systemic side effects such as dizziness or somnolence (drowsiness).

Q: How does Solicam affect the immune system?

A: Solicam's active ingredient, Piroxicam, works by inhibiting cyclooxygenase (COX) enzymes. This action is described as suppressing the inflammatory cascade by reducing local production of prostaglandins, which are key chemical mediators in the body's inflammatory response.

Q: Is there a cumulative effect with long-term use of Solicam?

A: Pharmacokinetic studies for the topical gel formulation document that the active ingredient's plasma levels rise slowly over the course of treatment. This finding suggests a potential for systemic accumulation of the active ingredient with repeated, long-term application.

Q: Do studies support the long-term use of Solicam?

A: The clinical research evidence provided in official documents primarily focuses on short-term relief in trials typically spanning one to four weeks. Information regarding outcomes for long-term continuous use is limited in the available studies.

Q: Are there any foods or drinks I should avoid while on Solicam?

A: Official labeling specifically notes that excessive amounts of alcohol are associated with an increased risk of serious gastrointestinal complications when used with Piroxicam. No specific warnings related to non-alcoholic foods or drinks are commonly documented for the topical formulation.

Q: Can Solicam be taken by someone who has kidney issues?

A: The use of Piroxicam is officially noted for patients with pre-existing renal dysfunction (kidney issues). Due to the potential for systemic NSAID effects on the kidneys, the medication is typically used with particular care in this population.

Q: Can Solicam interact with over-the-counter allergy medications?

A: The regulatory profile describes the need for particular care regarding co-administration with other NSAIDs, which might be present in some over-the-counter combination products. Caution is also advised with any drugs that may affect the kidneys or blood pressure.

Q: How long can a person safely stay on Solicam treatment?

A: Solicam is officially intended for short-term use. Regulatory documentation specifies that the duration of treatment should be formally reviewed by a professional at regular intervals.

Q: Does taking Solicam require frequent blood tests?

A: The labeling for the active ingredient (Piroxicam) as an NSAID advises that individuals using the medication long-term or who have certain pre-existing conditions (e.g., kidney or liver impairment) may need to undergo frequent medical tests to monitor their condition.

Q: Can Solicam make my skin more sensitive to the sun?

A: Official safety information for Piroxicam notes an increased risk of photosensitivity (increased sensitivity of the skin to sunlight) as a potential adverse effect. Official guidance often recommends minimizing sun exposure when using the gel due to this risk.

Q: What is the average duration of the effect of one dose of Solicam?

A: Regulatory studies for the gel formulation show that the active ingredient is continuously and gradually released from the skin to the underlying tissue. The systemic half-life of Piroxicam is approximately 50 hours.

Q: Why are people with liver problems advised to be cautious with Solicam?

A: Individuals with hepatic disease (liver problems) must use the medicine with particular care. This caution relates to the drug's metabolism by the CYP2C9 enzyme and the potential for systemic exposure and liver damage, as noted in regulatory warnings for NSAIDs.

Q: Is it necessary to take Solicam with food?

A: Solicam is a topical gel applied externally to the skin. The official procedural instructions detail the manner of application (massaging the gel in and washing hands) and do not mention any requirement to take the medicine with food.

Q: Does Solicam affect blood pressure?

A: Yes, regulatory documents warn that Piroxicam may cause or worsen hypertension (high blood pressure). It may also diminish the therapeutic effects of medicines that are prescribed for controlling blood pressure.

How should Solicam be stored and disposed of?

Storage and Disposal of Solicam (Piroxicam Gel)


Official Storage Requirements

Solicam gel must be stored at a temperature below 25 C (77 F). To maintain the product's quality, it is essential to not refrigerate or freeze the gel. The medication should be kept in the original container with the cap tightly closed to protect it from excessive moisture and light.

Stability and Child Safety

Once the tube is opened, the in-use shelf-life is 6 months; any unused gel remaining after this period must be discarded. As a critical safety measure, Solicam must be stored out of the sight and reach of children.

Disposal Instructions

To prevent environmental contamination, do not dispose of unused or expired Solicam gel via wastewater (drains) or ordinary household trash. The product should be returned to a pharmacy or an official drug take-back program for proper pharmaceutical waste management.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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