Components:
Medically reviewed by Oliinyk Elizabeth Ivanovna, PharmD. Last updated on 14.04.2022
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Top 20 medicines with the same components:
Intravenous
Congestive heart failure
Adult: Loading dose: 6-24 mcg/kg over 10 min followed by 0.05-0.2 mcg/kg/min continuous infusion, adjust according to response.
Renal impairment: Severe: Contraindicated.
Hepatic impairment: Severe: Contraindicated.
Peripheral/Central IV Individualised dosage. Initially 12-24 mcg/kg loading dose infused over 10 min followed by a continuous infusion of 0.1 mcg/kg/min. Assess response of patients after 30-60 min. Rate of infusion may be decreased to 0.05 mcg/kg/min or discontinued if the response is deemed excessive (hypotension, tachycardia). If the initial dose is tolerated & an increase haemodynamic effect is required, increase the rate of infusion to 0.2 mcg/kg/min. Duration of infusion: 24 hr.
Hypersensitivity to Simenda or to any of the excipients of Simenda. Marked mechanical obstructions affecting ventricular filling or outflow or both. Severe renal impairment (creatinine clearance <30 mL/min) and severe hepatic impairment. Severe hypotension and tachycardia. History of torsades de pointes.
No Important Interactions To Date
Simenda does not have clinically important pharmacokinetic interactions with captopril, beta-blockers, felodipine, digoxin, warfarin, isosorbide mononitrate, carvedilol, ethanol or itraconazole.
Headache, dizziness, hypotension, ventricular tachycardia, extrasystoles, AF, hypokalaemia, insomnia, GI disturbances and anaemia.
Potentially Fatal: Arrhythmias, tachycardia, AF w/ rapid ventricular response.
Simenda is a calcium sensitiser used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without a rise in intracellular calcium. Simenda exerts its effect by increasing calcium sensitivity of myocytes by binding to cardiac troponin C in a calcium-dependent manner. It also has a vasodilatory effect, by opening adenosine triphosphate (ATP)-sensitive potassium channels in vascular smooth muscle to cause smooth muscle relaxation.