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Sertralin Teva

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of Sertralin Teva

This section defines Sertralin Teva, covering its identity, core classification, and general therapeutic goals, while strictly excluding information about specific uses, dosing, or safety instructions.

Property Description
Active ingredient Sertraline hydrochloride
Form Film-coated tablet (Oral form)
Pharmacological class Selective Serotonin Reuptake Inhibitor (SSRI)
General purpose To stabilize mood and emotional balance
Origin Synthetic compound

What Type of Medicine is Sertralin Teva and What is its Core Purpose?

Sertralin Teva is a prescription-only medicine (POM) containing the active substance Sertraline, and it is classified as a Psychotropic agent. The drug belongs to the therapeutic class of antidepressants and the pharmacological class of Selective Serotonin Reuptake Inhibitors (SSRIs). This classification is clinically recognized.

The SSRI designation confirms the drug's focused action on the central nervous system to influence emotional processing. Its core therapeutic purpose is to help stabilize persistent mood disturbances and support the restoration of emotional equilibrium, often used in scenarios where a patient requires support for managing generalized anxiety or prolonged emotional stress.


Composition and Pharmaceutical Form: Understanding Sertraline Hydrochloride

The essential medicinal entity within this product is the synthetic compound Sertraline hydrochloride. Sertralin Teva is a specific brand manufactured and distributed by Teva Pharmaceuticals, and it is a single-ingredient product, focusing the therapeutic action solely on Sertraline.

It is prepared for oral administration and is supplied as film-coated tablets. The film coating is a distinctive pharmaceutical feature designed to facilitate easy swallowing and ensure the stability of the active component during its transit to the digestive system.


The Antidepressant Action: How Sertraline Modulates Mood

The function of Sertraline is defined by its highly specific action on the brain's communication system. Sertraline primarily works to achieve the potentiation of serotonergic neurotransmission.

This mechanism is accomplished because Sertraline selectively inhibits the reuptake of the neurotransmitter serotonin at the presynaptic neuronal membrane. By blocking the rapid reabsorption of serotonin, the drug gradually increases the effective concentration of this key neurotransmitter in the spaces between neurons, reinforcing its fundamental role as a psychotropic agent.

Regulatory References

  1. NIH StatPearls: Sertraline
  2. serotonin
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What side effects are possible with Sertralin Teva?

Possible Side Effects and Safety Information

The safety profile of Sertralin Teva is based on documented adverse reactions and specific safety statements published in governmental regulatory documents.

Frequency-Classified Adverse Reactions

Adverse reactions are classified by their documented frequency. These include:

  • Very Common (1 in 10 patients or more): Nausea, dry mouth, insomnia, diarrhea, and ejaculation failure (in males).
  • Common (1 in 100 to less than 1 in 10 patients): Headache, dizziness, fatigue, somnolence, tremor, decreased appetite, increased sweating, and decreased libido.

Side effects are also grouped by the body system affected, known as System-Organ Classes (SOCs), which include Gastrointestinal Disorders, Nervous System Disorders, and Psychiatric Disorders.


Serious Adverse Reactions and Safety Constraints

Regulatory documents highlight several severe, though rare, adverse reactions and specific safety constraints:

  • Serious Adverse Reactions: These include Serotonin Syndrome (potentially life-threatening), seizures or convulsions, Hyponatraemia (low sodium levels), and abnormal bleeding or bruising.
  • Suicidal Thoughts and Behavior: Risk is heightened, particularly in children, adolescents, and young adults (under 25), especially during the initial stages of treatment or following dose changes.

Population-Specific Considerations

Certain patient populations require specific consideration, as noted in the official prescribing information:

  • Hepatic Impairment (Liver Problems): A lower or less frequent dose is recommended due to the body’s reduced ability to clear the medicine.
  • Elderly Patients: May be at an increased risk of developing Hyponatraemia.

Abrupt discontinuation of the medicine can lead to withdrawal symptoms (e.g., dizziness, sensory disturbances), requiring gradual dosage reduction as a safety measure. The medicine is also contraindicated with irreversible Monoamine Oxidase Inhibitors (MAOIs).

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Overdose and Emergency Response

Overdose and When to Seek Help: Official Regulatory Information

This section outlines the documented overdose manifestations and required emergency actions for Sertralin Teva (sertraline), based strictly on government-approved prescribing information.


Documented Overdose Manifestations

Symptoms of Sertraline overdose are primarily described as serotonin-mediated effects. Commonly reported signs include somnolence, dizziness, tremor, nausea, vomiting, diarrhea, and tachycardia (fast heart rate).

Severe Outcomes and Required Actions

While isolated sertraline overdose is often not fatal, deaths have been reported, particularly when the drug is taken in combination with other drugs and/or alcohol. Documented severe outcomes include the risk of Serotonin Syndrome, seizures, coma, and QTc prolongation (an abnormal heart rhythm) which necessitates cardiac monitoring.

Urgent Medical Action is Mandatory:

  • Seek immediate medical attention or call a Poison Control center for any suspected overdose.
  • Call emergency services immediately if the person has collapsed, had a seizure, has trouble breathing, or cannot be awakened.

There is no specific antidote for Sertraline. Management is symptomatic and supportive, including establishing an airway and considering the use of activated charcoal. Induction of emesis (vomiting) is not recommended.

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Therapeutic Uses of Sertralin Teva

Sertralin Teva (sertraline) is considered relevant for managing and may be part of symptomatic management across several domains of mood, anxiety, and stress-related disorders. It is applied in clinical settings marked by heightened patient distress and where symptoms create noticeable interference with daily stability.

As part of its therapeutic application, Sertraline is commonly used to address conditions characterized by periods of heightened symptoms, including Major Depressive Disorder (MDD), Obsessive-Compulsive Disorder (OCD), Panic Disorder (PD), Social Anxiety Disorder (SAD), Post-Traumatic Stress Disorder (PTSD), and Premenstrual Dysphoric Disorder (PMDD).

In these therapeutic contexts, the medication helps address symptom clusters that may become intense or disruptive, such as pervasive sadness, hopelessness, intrusive thoughts, and recurrent, intense fear episodes. The overall purpose is to provide support that helps ease the symptom burden across these areas. This use generally assists with easing the symptom load, contributing to improved day-to-day comfort.


Quick Fact: Supportive Management for Intrusive Thoughts Sertraline is applied in scenarios requiring additional management of discomfort associated with unwanted, repetitive thoughts and the ritualized behaviors that create noticeable functional strain.

Regulatory References

  1. Sertraline
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Eligibility and Restrictions for Use

Official Eligibility Profile

The eligibility for using Sertralin Teva is strictly defined by regulatory documents, which establish certain absolute prohibitions and specific restrictions based on age, physiological status, and underlying health conditions.

Eligibility Status Constraint / Population
Absolute Contraindicated Use Must not be used concurrently with Monoamine Oxidase Inhibitors (MAOIs), including linezolid, or with the medicine pimozide [FDA Label, EMA SmPC].
Absolute Contraindicated Use Individuals with known hypersensitivity to sertraline or any excipients [EMA SmPC].
Not Established / Not Recommended Safety and effectiveness are not established for children under 6 years of age [FDA Label].
Conditional Use Only Approved for pediatric patients (6–17 years) only for Obsessive-Compulsive Disorder (OCD) [Health Canada PM].
Conditional / Restricted Use Use is not recommended in cases of severe hepatic impairment due to reduced clearance [TGA SmPC]. Use in mild to moderate hepatic impairment requires careful monitoring [FDA Label].
Conditional Use Only Use requires caution with a history of mania or hypomania, unstable epilepsy, or bleeding disorders [FDA Label, EMA SmPC].
Not Recommended Status Use is generally not recommended during pregnancy or breastfeeding unless the clinical necessity outweighs potential risks [EMA SmPC].
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What should I know about interactions with other medicines?

Sertralin Teva's official interaction profile details several required co-administration restrictions and prohibitions. The medicine is formally contraindicated with Monoamine Oxidase Inhibitors (MAOIs), including the antibiotics Linezolid and intravenous Methylene Blue. This combination is prohibited due to the risk of Serotonin Syndrome. A mandatory 14-day separation period must be observed when switching between Sertralin Teva and an MAOI. Co-administration with Pimozide is also contraindicated, as Sertralin Teva increases Pimozide plasma concentrations, raising the risk of cardiac effects.

Sertralin Teva acts as a mild-to-moderate inhibitor of the CYP2D6 enzyme. This pharmacokinetic interaction can increase the circulating levels of co-administered medicines that are primarily metabolized by this enzyme. Conversely, co-administration with Cimetidine results in a formal decrease in Sertralin Teva's clearance.

Pharmacodynamic interactions include an increased risk of Serotonin Syndrome when taken alongside other serotonergic agents, such as Triptans, Tramadol, Lithium, or the herbal product St. John's Wort. There is also a formally documented increased risk of bleeding when Sertralin Teva is used concomitantly with antiplatelet agents like NSAIDs or anticoagulants such as Warfarin. Caution is noted for patients with hepatic impairment, as the medicine's clearance is reduced in this population, altering the overall exposure profile. The prescribing information advises against the co-administration of alcohol.

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Mechanism of Action

How Sertralin Teva Works

The core action of Sertralin Teva (Sertraline) is strictly focused on modulating defined neural pathways within the central nervous system, which regulates emotional signaling. The mechanism of action is composed of two primary, time-dependent domains.


Selective Blockade of Serotonin Reuptake

Sertraline is a selective inhibitor of the Serotonin Transporter (SERT) protein, the primary molecular target. It physically blocks the channel responsible for recycling Serotonin (5-HT) back into the nerve cell. This action prolongs the presence and activity of 5-HT in the synaptic space, initiating the modulation of specific serotonergic pathways.


Adaptive Receptor Modulation and Neuroplasticity

Sustained elevation of Serotonin triggers a gradual biological response that is necessary for the adaptive mechanistic cascade to complete. This involves the desensitization of negative feedback receptors (autoreceptors) and an influence on regulatory proteins like Brain-Derived Neurotrophic Factor (BDNF). This mechanism-driven cascade modifies the early molecular steps, resulting in an adjustment of signaling patterns within neural circuitry.

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Dosage and Administration Information

How Sertralin Teva is Used: Administration Guidelines

Sertralin Teva is used according to specific administration patterns.

Administration Overview

Property Instruction
Route of Administration The medicine is strictly for oral administration.
Frequency Sertraline is taken once daily.
Timing Relative to Food Tablets may be taken with or without food.
Maximum Adult Dose The highest dose approved for most adult conditions is 200 mg per day.

Dosing and Schedule Protocol

The initiation of treatment follows a titration schedule. For Major Depressive Disorder and Obsessive-Compulsive Disorder, the usual starting dose is 50 mg once daily. For Panic Disorder, Post-Traumatic Stress Disorder, and Social Anxiety Disorder, the starting dose is lower at 25 mg once daily and is increased to 50 mg after one week. Dose adjustments, typically in 25 mg or 50 mg increments, are generally implemented at intervals of no less than one week.

Administration for Specific Populations and Forms

For patients with mild hepatic impairment, the starting and maximum dosage is typically half the standard dose. Sertraline clearance may be reduced in older adults, meaning the drug may take up to two or three weeks to reach steady-state concentration. If the oral concentrate form is used, it must be diluted immediately before consumption with specific liquids, such as water or orange juice.

Discontinuation of sertraline requires a gradual dosage reduction (tapering), as abrupt cessation is not recommended.

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Recent Clinical Evidence

Research Evidence: Overview of Studies for Sertralin Teva

The information below summarizes the available research base for Sertralin Teva (sertraline). It describes the types of studies conducted, what symptoms were measured, and what remains uncertain, without providing any medical advice or claims about the drug’s performance in any individual.


Evidence for Use in Major Depressive Disorder (MDD) and Prevention

Research examining MDD has historically centered on Randomized Controlled Trials (RCTs). These studies was evaluated in research exploring how symptoms change over time over the typical acute treatment period of around 6 to 12 weeks. Researchers tracked outcomes related to systemic or functional imbalance, specifically looking at how patients met criteria for remission or a specific response threshold. Studies monitored outcomes related to overall depression severity.

Studies have also explored the use of sertraline in a continuation or maintenance phase for individuals who have already completed the acute phase. This research monitored outcomes over longer follow-up durations—sometimes many months—to look at the measurement of symptom stability and to examine the recurrence of symptoms.


Evidence for Use in Obsessive-Compulsive Disorder (OCD) and Anxiety Disorders

The evidence for OCD was evaluated in controlled trials that specifically monitored outcomes related to symptoms where patients experience intrusive thoughts and ritualized behaviors. These studies focused on both adults and separate trials examining children and adolescents. The data monitored patterns related to symptom return after treatment was discontinued in the study environment.

Sertraline was studied for other conditions like Panic Disorder (PD), Social Anxiety Disorder (SAD), and Post-Traumatic Stress Disorder (PTSD). Research primarily used short-term RCTs that monitored outcomes describing episodic or acute changes, such as the reported frequency of panic attacks or changes in social avoidance behavior.


Long-Term Studies and Limitations

Studies for several indications, including MDD and OCD, explored the measurement of outcomes over extended follow-up durations (e.g., 6 months to one year). This research examined the potential for a return of symptoms in people who had already been observed to respond in earlier treatment phases. While these studies contribute to the broader evidence landscape, there is limited information for long-term outcomes beyond the duration of these controlled trials, meaning the full picture of symptom stability over many years is not fully established.

A key limitation is that subgroup findings are uncertain for some conditions, such as PTSD in military veterans, meaning the results apply only to the populations studied. Research for this drug provides context but not individual predictions.

Key Studies & References

  1. StatPearls: Sertraline (General Overview, Indications, and Clinical Context)
  2. MedlinePlus Drug Information: Sertraline (Patient-focused clinical applications and side effects overview)
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Frequently Asked Questions (FAQ)

Common questions about Sertralin Teva (FAQ)

Q: How quickly should I expect to feel the effects of Sertralin Teva?

According to official product information, patients may notice the initial antidepressant effects within about a week of starting the medication. However, the maximum beneficial effect is typically reached after a longer period, often between two to four weeks of consistent treatment. Consistent use is typically required for the full therapeutic effect to emerge.

Q: Does Sertralin Teva cause weight gain or weight loss?

Changes in weight have been reported in connection with the use of Sertralin Teva. Weight loss has been observed, especially in children, and is sometimes associated with a decreased appetite. Conversely, weight gain may occur with longer-term use of the medication, though these changes are often modest.

Q: What non-prescription medicines or supplements should be avoided while taking Sertralin Teva?

Official regulatory warnings advise caution regarding non-prescription products that can impact the central nervous system or increase the risk of bleeding. This includes the herbal supplement St. John's Wort, which can raise the risk of a reaction called Serotonin Syndrome. There is also an increased risk of bleeding when Sertralin Teva is used alongside antiplatelet agents, such as over-the-counter NSAIDs (like ibuprofen).

Q: Is it normal to feel worse during the first week of taking Sertralin Teva?

During the first few weeks of treatment, official documents note that psychomotor restlessness, which is a feeling of agitation and being unable to sit still, may occur. Regulatory warnings indicate that close monitoring is important during the initial treatment period, as a temporary worsening of some symptoms is a possibility.

Q: How long does Sertralin Teva typically stay in your system after stopping treatment?

The mean elimination half-life of sertraline, the active ingredient, is approximately 26 hours. This means it takes about one day for half of the drug to be eliminated from the body. However, its active breakdown product has a much longer half-life, meaning it takes several days for the medicine to be fully cleared from the system.

Q: Can you drive or operate machinery while taking Sertralin Teva?

Official regulatory information advises exercising caution when engaging in activities that require complex motor and mental skills, such as driving or operating heavy equipment. Official labeling advises caution with these activities until the individual effect of the medicine is known, as side effects like dizziness or somnolence may occur.

Q: Can Sertralin Teva interact with alcohol, and what are the risks?

The official prescribing information advises against the co-administration of alcohol while using Sertralin Teva. The use of both together may increase the risk of central nervous system (CNS) depression, which can interfere with mental or motor skills.

Q: Is Sertralin Teva commonly prescribed for Obsessive-Compulsive Disorder (OCD)?

Sertralin Teva is an officially approved treatment for Obsessive-Compulsive Disorder (OCD). OCD is one of the primary conditions for which this medication is indicated in regulatory documents.

Q: Is it normal to feel increased anxiety or restlessness when first starting Sertralin Teva?

Regulatory documents mention that psychomotor restlessness, often described as a subjectively unpleasant feeling of anxiety and an inability to be still, is associated with the use of this drug. This reaction is most likely to occur within the first few weeks of starting treatment.

Q: What happens if you miss a dose of Sertralin Teva?

Official patient counseling outlines the general steps for handling a missed dose, which typically involves taking the dose when remembered unless it is near the next scheduled time. The guidance found in official documents is to not take two doses at once to make up for a missed one.

Q: Are there generics of Sertralin Teva available, and are they equally effective?

Sertralin Teva contains the active ingredient sertraline hydrochloride, which is widely available in generic form. Generic versions must meet the same quality and performance standards, including demonstrating bioequivalence, as the brand-name product.

Q: Does Sertralin Teva affect blood pressure or heart rate?

Adverse reactions reported in official documents can include changes to heart function, such as tachycardia (increased heart rate). Rarely, changes in blood pressure, specifically high or low blood pressure, may also occur.

Q: Why is it advised to take Sertralin Teva at the same time each day?

Sertralin Teva is a once-daily medication. Taking it consistently helps maintain steady drug concentration levels in the blood. This is important to ensure the medication works consistently and effectively over time.

Q: Do other medications for stomach acid or heartburn interact with Sertralin Teva?

Yes, interactions are possible. For example, official regulatory information notes that co-administration with cimetidine, a medication sometimes used for heartburn or stomach acid, can decrease the body's clearance of sertraline.

Q: Are there long-term health implications from taking Sertralin Teva for many years?

Clinical studies for most approved uses have explored outcomes for durations up to about one year. Official product information notes that research on symptom stability and health outcomes over many years is limited and not fully established.

Q: What is the difference between 'serotonin syndrome' and common side effects of Sertralin Teva?

Serotonin Syndrome is classified in regulatory documents as a potentially life-threatening serious adverse reaction, with distinct symptoms that include confusion, extreme agitation, and rapid vital sign changes. In contrast, common side effects, such as nausea or dry mouth, are generally expected, milder, and non-life-threatening.

Q: Can Sertralin Teva cause problems with appetite?

Yes, official safety data lists decreased appetite as a common side effect of Sertralin Teva. Changes in appetite are a matter to be discussed with a healthcare professional.

Q: Is there a link between Sertralin Teva and changes in vision?

Regulatory documents advise that Sertralin Teva can cause a mild widening of the pupils, known as mydriasis. In individuals susceptible to angle closure glaucoma, this widening could potentially trigger an acute episode of that condition.

Q: What should I tell my dentist or surgeon about taking Sertralin Teva?

It is important to inform a dentist or surgeon that you are taking Sertralin Teva because it increases the risk of abnormal bleeding or bruising. This is relevant if you are also taking antiplatelet agents or if certain anesthetics are used.

Q: What should be done if someone accidentally takes too much Sertralin Teva?

Official prescribing information contains an explicit warning to seek immediate help if an overdose is suspected. Official prescribing information advises immediate contact with a poison control center or emergency services.

Q: Can Sertralin Teva interact with herbal supplements like St. John's Wort?

Yes, regulatory documents specifically warn that co-administration with the herbal product St. John's Wort should be avoided. Combining these substances increases the risk of developing Serotonin Syndrome.

Q: Is Sertralin Teva effective for treating panic attacks?

Sertralin Teva is an approved treatment for Panic Disorder. Studies have been conducted that monitored outcomes related to the frequency of panic attacks in patients taking the medication.

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How should Sertralin Teva be stored and disposed of?

How to Store and Dispose of Sertralin Teva

Sertralin Teva tablets must be stored according to regulatory specifications to maintain stability and ensure safety.

Storage Requirements

The required storage condition is controlled room temperature, typically 20 C to 25 C (68 F to 77 F). The product must be kept out of the sight and reach of children and stored in its original container with the lid tightly closed.

  • Protection: The tablets must be protected from moisture and excessive heat; do not freeze the medication.

Disposal Instructions

Unused or expired Sertralin Teva should be disposed of via a local drug take-back program or mail-back envelope as the preferred methods. If these options are unavailable, the medication must be mixed with an undesirable substance (e.g., dirt or coffee grounds), sealed in a container, and discarded in the household trash. Do not flush the medication down the toilet or pour it down the sink.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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