Selektine

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Selektine

Quick Facts

Property Description
Active Ingredient Meloxicam
Pharmacological Class Nonsteroidal Anti-Inflammatory Drug (NSAID)
Form Tablet, Capsule, Oral Suspension, Injectable Solution
General Purpose Analgesic, Anti-inflammatory, and Antipyretic relief
Origin Synthetic Compound (Oxicam Derivative)

What Type of Medicine is Selektine (Meloxicam)?

Selektine is a medicinal product whose active component is Meloxicam, which is fundamentally classified as a Nonsteroidal Anti-Inflammatory Drug (NSAID). Meloxicam is a synthetic compound chemically defined as an oxicam derivative, distinguishing it structurally within the broader NSAID families. The drug is designed to provide systemic relief by counteracting the biological processes that cause inflammation, pain, and fever. Meloxicam is recognized for its preferential selectivity toward inhibiting the Cyclooxygenase-2 (COX-2) enzyme at lower doses, a property which differentiates its therapeutic profile from many older, non-selective NSAIDs.

Composition, Origin, and Delivery Forms

The active substance Meloxicam constitutes the sole medicinal component of Selektine, making it a single-ingredient product designed for systemic action. The drug is available in multiple systemic dosage forms, commonly including oral preparations like tablets or capsules, an oral suspension, and an injectable solution. These variations ensure the drug can be delivered effectively, providing rapid action via injection or sustained relief through oral formats. The medication is categorized as a prescription-only medicine (Rx).

The General Purpose and Therapeutic Action of Selektine

The core therapeutic purpose of Selektine is to provide comprehensive relief through its combined analgesic (pain-relieving), anti-inflammatory (swelling-reducing), and antipyretic (fever-reducing) effects. By modulating prostaglandin biosynthesis, which mediates the inflammatory response, the medicine helps to ease chronic discomfort and reduce associated swelling, a benefit recognized for its effectiveness in managing conditions involving long-term inflammation. This systemic action supports improved functional status and general comfort by addressing the physical symptoms of the inflammatory process.

What side effects are possible with Selektine?

Possible Side Effects and Safety Information

The official safety profile for Selektine (Meloxicam) outlines potential adverse reactions categorized by frequency and the body's organ systems. The majority of reported events involve the gastrointestinal system and are frequently classified as Common, including dyspepsia, nausea, diarrhea, abdominal pain, and headache. Regulatory documents distinguish these common reactions from less frequent but more critical safety concerns.


Serious Adverse Reactions and Key Safety Constraints

The medicine is associated with a risk of Serious Adverse Reactions, which are subject to high-level regulatory warnings. These include potentially fatal Gastrointestinal Events (bleeding, ulceration, and perforation) and serious Cardiovascular Thrombotic Events such as myocardial infarction and stroke.

Safety data specifies that the risk for both serious gastrointestinal and cardiovascular events increases with the duration of use.


Special Population and Contraindications

Official labeling notes specific safety considerations for patient groups. Older adults are documented to have a higher frequency of adverse reactions, particularly serious gastrointestinal complications. Use of the medicine is generally restricted in patients with severe, uncontrolled heart failure or advanced renal disease.

Furthermore, Selektine is officially contraindicated for the relief of pain in the setting of Coronary Artery Bypass Graft (CABG) surgery and in individuals with a history of allergic-type reactions (e.g., asthma, hives) to aspirin or other Nonsteroidal Anti-Inflammatory Drugs.

Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory documentation mandates that individuals must seek medical attention immediately in the event of any suspected overdose with Selektine (Meloxicam).

Documented Clinical Manifestations

The overdose profile includes both generally reversible and severe manifestations. Common, documented presentations often include lethargy, drowsiness, nausea, vomiting, and epigastric pain. Gastrointestinal bleeding is also a potential occurrence following overdose.

Severe and Life-Threatening Outcomes

Severe poisoning may lead to critical systemic effects. The official labeling lists potential outcomes such as Acute Renal Failure, Hepatic Dysfunction, Respiratory Depression, Coma, and Convulsions. Life-threatening cardiovascular events, including Cardiovascular Collapse and Cardiac Arrest, are also cited in severe cases documented in the regulatory information.

Official Management and Procedures

Management of overdose is focused on symptomatic and supportive care. The regulatory documentation states that administration of activated charcoal within one to two hours post-ingestion, or repeated administration in severe cases, may be useful. The label also mentions cholestyramine as a measure to accelerate the removal of the drug. However, due to the high protein-binding nature of the medication, forced diuresis, hemodialysis, and similar clearance procedures are documented as likely ineffective.

Therapeutic Uses of Selektine

What Selektine Treats: Main Uses and Benefits

Selektine (Meloxicam) is considered relevant in the symptomatic management of inflammatory and chronic joint conditions. The medication is used to address the symptomatic burden of conditions such as Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, and Juvenile Rheumatoid Arthritis in pediatric patients aged 2 years and older.

The medicine is applied in settings where symptoms are related to physical discomfort and inflammatory states, helping to ease persistent pain, joint swelling, and stiffness. It is also relevant when supportive symptom management is appropriate for adult patients, such as when addressing discomfort in certain acute post-procedure settings. This approach contributes to easing the overall symptom load and supports general well-being.

Quick Fact: Management of Joint Pain and Inflammation

“The supportive relief provided may assist patients with maintaining functional stability and supports them in coping more steadily during symptomatic episodes.”

Regulatory References

  1. NIH DailyMed overview

Eligibility and Restrictions for Use

Official Population Eligibility for Selektine

Eligibility to use Selektine (Meloxicam) is strictly defined by regulatory authorities and focuses on age, organ function, and pre-existing medical conditions. The medicine is approved for use in adults for standard indications and in pediatric patients ge 2 years of age for Juvenile Rheumatoid Arthritis. Use is not established in children under two years.


Absolute Contraindications

Selektine is contraindicated and must not be used by the following groups:

  • Patients with a known hypersensitivity to Meloxicam or any history of allergic-type reactions to aspirin or other NSAIDs.
  • Patients in the setting of coronary artery bypass graft (CABG) surgery.
  • Women in the third trimester of pregnancy (after 30 weeks gestation).
  • Patients with severe, non-dialyzed renal failure or severe liver impairment.
  • Individuals with active gastrointestinal ulceration or hemorrhage.

Restricted and Conditional Use

Use is restricted or requires special medical consideration for older adults, patients with volume depletion (which must be corrected prior to use), and those with certain cardiovascular conditions like severe heart failure. Women between 20 and 30 weeks gestation are advised to limit use.

What should I know about interactions with other medicines?

Interactions with Other Medicines and Products

Official regulatory information for this medication establishes clear constraints on coadministration with several classes of other medicines and products. These constraints are primarily designed to prevent severe reactions, particularly Serotonin Syndrome and Hypertensive Crisis, which result from the drug's mechanism of action as a monoamine oxidase inhibitor.

Contraindicated Combinations

Coadministration is strictly prohibited with the following medicine categories due to the high risk of severe adverse events:

  • Other Monoamine Oxidase (MAO) Inhibitors: Combining this medication with other MAO inhibitors is contraindicated.
  • Serotonergic Agents: This includes most antidepressants (SSRIs, SNRIs, tricyclics), as well as certain opioid analgesics (e.g., Meperidine, Tramadol, Methadone), and migraine treatments (Triptans).
  • Specific Cough/Cold Agents: Products containing Dextromethorphan are contraindicated.

Required Washout Periods

Regulatory labeling requires a mandatory washout period when stopping this medication before starting a contraindicated serotonergic agent, or vice-versa. This gap in treatment is necessary to allow the drug or the interacting agent to clear the body sufficiently to mitigate the risk of a dangerous interaction.

Other Product Constraints

Specific formulations of this product may require the avoidance of large volumes of tyramine-containing foods and beverages, such as aged cheeses, cured meats, and certain beers. This dietary restriction is typically dose-dependent and may not apply to the lowest approved doses, but patients must adhere to the limits specified in the official prescribing information for their specific form and dose.

Mechanism of Action

Core Action: Preferential Inhibition of COX-2

This mechanism is based on the drug's ability to selectively inhibit the Cyclooxygenase-2 (COX-2) enzyme, which is responsible for synthesizing key inflammatory mediators. By binding to and functionally restricting this enzyme, the drug directly limits the overall production of prostaglandins that mediate pain and inflammation throughout the body.

Modulation of Nociceptive and Thermal Pathways

The subsequent reduction in prostaglandin synthesis affects multiple biological systems. Peripherally, it decreases the chemical sensitization of nociceptors (pain receptors), thereby reducing the transmission of nociceptive signals to the central nervous system. Centrally, this same mechanism is applied in the hypothalamus, where reduced prostaglandin synthesis functionally resets the elevated hypothalamic thermal set-point.

Mechanistic Scope and Limitations

The drug's action is confined to modulating processes linked to the prostaglandin cascade; it does not address underlying tissue damage or pathways independent of COX-derived mediators. This preferential selectivity for COX-2 is kinetic and may diminish at higher concentrations where inhibition of the constitutive COX-1 enzyme increases.

Dosage and Administration Information

Selektine (Meloxicam) is administered systemically, primarily through the oral route as a tablet, capsule, or suspension, and is also approved as an intravenous (IV) injectable solution for use in appropriate clinical settings. The standard administration approach is guided by the commitment to employing the lowest effective dose for the shortest possible duration necessary, as therapy must be periodically re-evaluated.

For most adult patients, the oral therapy begins with a dose of 7.5 mg taken once daily. This dosage may be adjusted upward to a maximum daily limit of 15 mg. The medicine is explicitly designed for once-daily dosing across all approved routes. Oral forms should be consumed with water or liquid and may be taken irrespective of meal times. If using the oral suspension, the bottle should be gently shaken before the dose is measured.

Important adjustments apply for specific patient populations. For instance, in older adults undergoing long-term treatment and in patients with severe renal impairment who are on hemodialysis, the recommended maximum daily dose is restricted to 7.5 mg. For pediatric use, dosing is determined based on weight, not to exceed the 7.5 mg maximum. Should a dose be missed, the schedule should simply be resumed at the next regularly scheduled time; taking a double dose to compensate is not permitted.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Selektine


Evidence for Use in Osteoarthritis

This section summarizes the key Randomized Controlled Trials (RCTs) and large-scale, controlled observational studies that examined Selektine in adults with Osteoarthritis. It describes the types of functional and pain-related assessments used by researchers to measure reported change in these trials.

Selektine was studied in research exploring the study of symptoms in adults living with Osteoarthritis, a condition marked by functional limitations. Research examined how patients reported their experience when taking the medicine, focusing on short-to-intermediate time intervals. In these studies, Selektine was evaluated against an inactive placebo and established comparative medicines.

Studies monitored patient-reported outcomes, focusing on standardized metrics like the WOMAC Index, which is used to measure changes in pain, joint stiffness, and daily functioning. Research describes patterns observed in patients' reports of their symptom intensity over the study period. The research focus was on short-term symptomatic changes, and not on long-term modification of the underlying joint condition.


Evidence for Use in Rheumatoid Arthritis and Ankylosing Spondylitis

This block covers the research for Rheumatoid Arthritis (RA) and Ankylosing Spondylitis (AS). It details the specific clinical assessment criteria selected by investigators as study endpoints.

For adult Rheumatoid Arthritis, Research examined Selektine in RCTs that included patients during periods of increased symptom activity. These studies explored outcomes related to physical discomfort. Research focused on the composite measure known as the ACR 20 assessment criteria, which involves monitoring joint counts. Similarly, in Ankylosing Spondylitis (AS), research examined changes in outcomes related to spinal stiffness and overall disease activity. Studies monitored pain reduction using specialized indices like BASDAI.

For both RA and AS, results apply only to the populations studied, and studies primarily focus on short-term symptomatic change. Research does not address the long-term structural changes associated with these conditions, and long-term effects on disease progression are not fully established by the existing symptomatic trials.


Evidence in Pediatric Patients (Juvenile Idiopathic Arthritis)

Selektine was studied in children aged 2 to 16 years with specific forms of JIA, a special population where evidence is often limited. Studies were typically active-controlled trials, meaning the medicine was evaluated against another medicine already used for this condition. Research monitored changes in the disease using the ACR Pediatric 30 assessment criteria, which tracks how symptoms evolved in the observed populations.

Findings describe patterns that were observed in the patient-reported assessments when assessed against the active comparator over the initial short-term assessment period. Data are still emerging, and information is insufficient for patients younger than 2 years of age or those with the systemic-onset form of the condition.

Key Studies & References

  1. Meloxicam Tablets, USP for oral use: Full Prescribing Information
  2. Gastrointestinal safety profile of meloxicam: a meta-analysis and systematic review of randomized controlled trials

Frequently Asked Questions (FAQ)

Common questions about Selektine (FAQ)

Q: Can Selektine be used for any other condition besides the one it is approved for?

A: Official regulatory documents define the approved uses for Selektine as treating the signs and symptoms of Osteoarthritis, Rheumatoid Arthritis, and Juvenile Idiopathic Arthritis. The use of this medicine for any other condition is not covered in the official prescribing information.


Q: How quickly should I expect to see the effects of Selektine?

A: Studies indicate that some patients may begin to experience pain relief within the first week of using the medicine. Research indicates that the peak effects observed in studies were generally reported after a period of use, such as two weeks, following initiation of the medicine.


Q: Does Selektine cause weight gain or weight loss?

A: Weight gain is listed in the regulatory documents as a potential side effect associated with Selektine. This can be related to fluid retention, also known as edema, which is sometimes reported with this class of medicine. Weight loss is not typically listed as a reported adverse event.


Q: Are there any long-term side effects associated with using Selektine for a long time?

A: Official warnings emphasize that the risk for serious cardiovascular events (like heart attack or stroke) and gastrointestinal events (like bleeding and ulceration) increases with the duration of use. Official warnings note that, consistent with regulatory guidelines, this medicine should be employed using the lowest effective dose for the shortest possible duration. Potential long-term effects on kidney and liver function are also noted.


Q: Does Selektine affect my ability to drive or operate machinery?

A: Side effects such as dizziness, drowsiness, and disturbances in vision have been reported in official documents for Selektine. If a person experiences any of these effects, their ability to drive or safely operate complex machinery may be impaired.


Q: Is there a generic version of Selektine available?

A: Yes, Selektine is a brand name for the active ingredient Meloxicam. Regulatory agencies have approved and listed various generic versions of this medication.


Q: Does Selektine interact with commonly used over-the-counter pain relievers?

A: Official information advises against combining Selektine with other Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) because this significantly raises the risk of serious gastrointestinal problems. If considering the coadministration of Selektine with other pain relievers, such as those containing acetaminophen, discussion with a medical professional is appropriate to review potential risks.


Q: Can I take vitamins or herbal supplements while using Selektine?

A: Official documentation notes that certain herbal products, such as Ginkgo, may increase the risk of bleeding when taken with Selektine. Supplements that contain potassium can also raise blood potassium levels. Regulatory constraints suggest that any supplements, vitamins, or herbal products should be reviewed with a medical professional before being taken concurrently with this medicine.


Q: Does Selektine cause sleep problems or fatigue?

A: Yes, regulatory documents list both insomnia (sleep problems) and fatigue as reported adverse reactions associated with the use of Selektine.


Q: Can Selektine affect mood or cause emotional changes?

A: Changes in mood, anxiety, and other emotional changes are noted in official sources as rare or uncommon side effects associated with Selektine.


Q: Is it normal to feel a minor symptom when first starting Selektine?

A: Regulatory documents list several common side effects that can occur, especially in the initial weeks of use, such as mild stomach upset (dyspepsia) or diarrhea. While these common effects are typically minor, new or worsening symptoms are generally reported to a medical professional for evaluation.


Q: Does Selektine have a potential for misuse or dependence?

A: No. Selektine is not classified by regulatory agencies as a controlled substance, and official documentation does not indicate a potential for dependence or misuse.


Q: Are there any specific laboratory tests required before or during the use of Selektine?

A: Official warnings mention that close monitoring of blood pressure is important during the use of this medicine. For patients using the medicine long-term or those with existing health issues, regulatory information may also recommend monitoring blood cell counts and kidney and liver function.


Q: What kind of medical history prevents someone from using Selektine?

A: Selektine is absolutely contraindicated for people with a history of an allergic-type reaction to aspirin or other NSAIDs. It must also not be used if a person has recently had coronary artery bypass graft (CABG) surgery or has a history of active bleeding or ulceration in the stomach or intestines.


Q: What should I do if I think Selektine is not working for me?

A: Official guidance states that dosages may be adjusted after the initial response to treatment is observed. If the expected therapeutic effects are not being experienced, medical consultation is required to determine the appropriateness of adjustment or alternative treatment approaches.


Q: Is there a maximum time someone can use Selektine?

A: Official documents do not set a formal maximum duration for chronic use. However, regulatory warnings strongly emphasize that Selektine should be used for the shortest duration possible to minimize the potential risk of serious side effects.


Q: Does Selektine affect fertility?

A: Yes. Based on its mechanism of action, Selektine may delay or prevent ovulation (the release of an egg) in women, which is a reversible effect upon stopping the medicine. Official prescribing information advises that this possibility should be considered for women who are having difficulty conceiving.


Q: Why does Selektine sometimes cause side effects?

A: Selektine works by inhibiting the synthesis of prostaglandins to reduce pain and inflammation. Side effects can occur because prostaglandins are also involved in protective functions across the body, such as stomach lining defense, blood clotting, and kidney function. Inhibiting these essential functions can lead to various adverse effects.


Q: How does Selektine affect the heart, liver, and kidneys?

A: Official warnings describe potential effects on several major organs. This includes the risk of thrombotic events (like heart attack or stroke) and hypertension (high blood pressure) related to the cardiovascular system. There is also a risk of elevated liver enzymes and the potential for kidney function deterioration.


Q: Is Selektine considered a 'new' or 'old' drug treatment?

A: Selektine, containing Meloxicam, was first approved by major regulatory authorities around the turn of the 21st century. This means it is considered an established treatment option in the medical community.


Q: How is Selektine related to other drugs in its class?

A: Selektine is part of the Nonsteroidal Anti-Inflammatory Drug (NSAID) class and is an oxicam derivative. It is known for its preferential selectivity for inhibiting the COX-2 enzyme at lower doses, which sets its therapeutic profile apart from non-selective NSAIDs.


Q: Do people typically have to discontinue Selektine because of side effects?

A: Clinical trial data indicate that discontinuations due to adverse events did occur in studies. This was reported more frequently in patients receiving higher doses compared to those who received the lower, commonly recommended daily dose.


Q: Does alcohol change the effect of Selektine?

A: Yes, using alcohol, particularly in large amounts, significantly increases the risk of serious gastrointestinal bleeding and ulceration associated with Selektine.


Q: Is Selektine associated with hair loss?

A: Hair loss, or alopecia, is listed in official regulatory documents as a rare adverse reaction that has been reported with the use of Selektine.


Q: Can Selektine be used at the same time as cold and flu medicine?

A: Since many over-the-counter cold and flu medicines contain other NSAIDs or ingredients that affect blood pressure, combining them with Selektine is generally advised against. A medical consultation is generally required to screen for potential interactions before combining this medicine with cold and flu products.


Q: Is it possible to be allergic to Selektine?

A: Yes, it is possible. Selektine is strictly contraindicated for anyone with a known hypersensitivity to the active ingredient Meloxicam, or a history of allergic-type reactions to aspirin or other NSAIDs.


Q: What if I start feeling worse after beginning Selektine?

A: Regulatory guidance notes that immediate medical attention is necessary if signs of serious adverse events occur, such as trouble breathing, chest pain, or bloody stools. Worsening of the underlying condition or new, bothersome symptoms are typically reported to a medical professional for evaluation.


Q: Does the time of day matter when using Selektine?

A: Official instructions specify that Selektine should be taken once daily. The documents indicate that the medicine may be taken regardless of meal times, but do not specify a superior time of day for administration.


Q: Why does the official document mention a risk of serious adverse events?

A: The most serious risks, such as the potential for cardiovascular and gastrointestinal events, are subject to mandatory regulatory warnings. This ensures that users and healthcare providers are fully informed of the most serious potential dangers, often through prominent communications like Boxed Warnings.


Q: Are there any dietary restrictions specifically mentioned in the Selektine prescribing information?

A: For certain formulations of this medicine (such as if it were classified as an MAO inhibitor), official labeling may require the avoidance of large volumes of tyramine-containing foods, such as aged cheeses or cured meats. This restriction is not universal to all formulations.


Q: Is Selektine a cure for the condition it treats?

A: No. Research evidence indicates that Selektine is a symptomatic treatment that helps to relieve pain, inflammation, and stiffness. Official documentation confirms that studies do not provide information on long-term structural modification or a cure for the underlying joint conditions it addresses.

How should Selektine be stored and disposed of?

Storage and Handling Requirements

Selektine (meloxicam) must be stored at Controlled Room Temperature, which is defined as 20 C to 25 C (68 F to 77 F). The medicine should be protected from excessive heat, light, and moisture.

Regulatory requirements mandate that the product is kept in its tightly closed, original container to maintain stability. For the safety of the household, Selektine must be stored out of the sight and reach of children.

Official Disposal Instructions

Unused or expired Selektine should be disposed of through an authorized drug take-back program. If a take-back program is unavailable, the FDA advises mixing the medicine with an undesirable substance, such as dirt or used coffee grounds, and placing the mixture in a sealed container before discarding it in the household trash. The medication must not be flushed down the toilet or poured down a drain.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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