Saridon Triple Action

Relief of pain eg mild to severe headache, toothache, menstrual discomfort, post-op & rheumatic pain, pain & fever associated w/ colds & flu.

Adult 1-2 tab. Adolescent 12-16 yr 1 tab. May be taken up to 3 single doses w/in 24 hr. Do not take for >1 wk or at doses higher than recommended.

Hypersensitivity to pyrazolones or related compd, phenylbutazone-containing products, Paracetamol (Saridon Triple Action), acetylsalicylic acid or proven allergy to Caffeine (Saridon Triple Action); inherited G6PD deficiency (evidenced by hemolytic anemia), acute hepatic porphyria. Pregnancy & lactation. Childn <12 yr or infants.

Acetaminophen is metabolized (eliminated by conversion to other chemicals) by the liver. Therefore drugs that increase the action of liver enzymes that metabolize acetaminophen [for example, carbamazepine (Tegretol), isoniazid (INH, Nydrazid, Laniazid), rifampin (Rifamate, Rifadin, Rimactane)] reduce the levels of acetaminophen and may decrease the action of acetaminophen. Doses of acetaminophen greater than the recommended doses are toxic to the liver and may result in severe liver damage. The potential for acetaminophen to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.

Cholestyramine (Questran) reduces the effect of acetaminophen by decreasing its absorption into the body from the intestine. Therefore, acetaminophen should be administered 3 to 4 hours after cholestyramine or one hour before cholestyramine.

Acetaminophen doses greater than 2275 mg per day may increase the blood thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore, prolonged administration or large doses of acetaminophen should be avoided during warfarin therapy

Hypersensitivity reactions; nephrotoxicity. Nausea, drowsiness, coma and convulsions on large doses.