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Офтан Катахром

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Офтан Катахром

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Treatment option: Cataract

Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of Офтан Катахром

Property Description
Active Ingredients Adenosine, Cytochrome C, Nicotinamide
Form Sterile Eye Drops (Ophthalmic Solution)
Pharmacological Class Tissue Metabolism Regulator; Anti-cataract Agent
General Purpose Supports ocular energy production and antioxidant defense
Origin Type Combination of Endogenous and Derived Compounds

What Type of Medicine is Офтан Катахром?

Офтан Катахром is a specialized, multi-component ophthalmic preparation supplied as sterile eye drops for topical ophthalmic use. It is categorized within the therapeutic class of Tissue Metabolism Regulators and is frequently recognized as an Anti-cataract Agent. Unlike simple lubricants, this combination drug is designed to influence the complex biochemical processes within the ocular structures. The preparation is manufactured by Santen, a company specializing in ophthalmic pharmaceuticals.

Composition and Origin: The Multicomponent Formula

The product's identity is defined by its core formula containing three key active substances: the nucleoside Adenosine, the hemoprotein Cytochrome C, and the vitamin B3 derivative Nicotinamide. This unique combination is the foundation of the drug's mechanism, aiming to supplement molecules required for vital biological functions of the lens. Adenosine serves as a source for Adenosine Triphosphate (ATP) generation, which is critical for cellular energy supply. This ensures the inclusion of a key compound that supports the energy necessary for healthy cell function in the eye.

General Purpose of the Metabolic Ophthalmic Preparation

The overall therapeutic goal of the preparation is to help preserve the functional integrity and biochemical balance of the ocular lens. By supplying Adenosine and supporting the function of Cytochrome C, the preparation helps address the energy demands and oxidative requirements of the eye's tissues. Cytochrome C functions as a mitochondrial antioxidant. This combined metabolic support and protection is utilized for addressing cumulative biochemical stress in the eye, aiming to bolster the lens's natural capacity to maintain clarity over time.

Regulatory References

  1. NIH Cytochrome C Review
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What side effects are possible with Офтан Катахром?

Possible Side Effects and Safety Information

This section describes the officially documented adverse effects and safety characteristics of Офтан Катахром, as detailed in governmental regulatory sources.

Frequency-Classified Adverse Reactions

Adverse effects are categorized by how often they are reported in clinical use, based on official regulatory classifications:

Classification Type of Reaction (Examples)
Common Transient brief burning or stinging sensation in the eye.
Rare/Infrequent Allergic conjunctivitis, contact dermatitis, and other local hypersensitivity reactions (e.g., rash, swelling of the face).
Extremely Rare/Very Rare Transient systemic effects, including nausea, arterial hypotension (low blood pressure), dizziness, and dyspnea (shortness of breath). These are attributed to component absorption.
Not Known Systemic effects such as flushing, pulsation in the temples, and fainting (syncope), attributed to the known vasodilatory action of Nicotinamide (or its metabolites).

Serious Adverse Reactions

No events are explicitly classified as Serious Adverse Reactions (SARs) in the available regulatory documents. The documented systemic effects are consistently noted as being extremely rare and transient.

Population-Specific Safety Considerations

  • Pediatric Population: The medicine is contraindicated for use in children and adolescents under 18 years of age due to the lack of sufficient data on efficacy and safety in this age group.
  • Pregnancy and Lactation: Use is not recommended due to insufficient experience and clinical data, unless a physician determines the expected therapeutic benefit for the mother outweighs the potential risk to the fetus or child.

Key Safety Restrictions and Limitations

  • Hypersensitivity: The preparation is contraindicated in individuals with known hypersensitivity or allergy to any component of the formulation.
  • Soft Contact Lenses: The preservative, Benzalkonium Chloride, can be absorbed by soft contact lenses. Lenses must be removed before instillation and can be reinserted 15 minutes after application.
  • Visual Acuity: Patients experiencing temporary blurred vision or irritation immediately after application should avoid driving or operating complex machinery until normal vision is restored.

Connection to the Overall Safety Profile: The official safety profile is characterized by the high frequency of mild, local eye effects, balanced by the extremely rare and transient nature of the documented systemic reactions. The primary safety limitations are focused on pediatric use and managing the risk associated with soft contact lenses.

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Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory profile for this multi-component ophthalmic solution primarily addresses the risk associated with accidental systemic exposure.

Property Official Regulatory Statement
Documented Overdose Manifestations No specific ocular symptoms or systemic clinical manifestations are detailed in regulatory documents. Systemic toxicity from accidental oral ingestion is documented as unlikely due to the low concentration of active ingredients.
Physiological Systems Affected No specific physiological systems are listed as being adversely affected by overdose, consistent with the low systemic toxicity assessment.
Emergency-Response Statements No explicit, mandated immediate actions (e.g., call emergency services, specific first-aid steps) are defined by regulators for overdose.
Antidote Information No specific pharmacological antidote is mentioned in the official prescribing information.

Official Overdose Statements:

  • Acute systemic toxicity resulting from the accidental oral ingestion of the eye drops is formally documented as unlikely by regulatory bodies.
  • This low-risk assessment is attributed to the minimal content of active ingredients present in the topical formulation.
  • Official prescribing information does not detail a symptomatic profile or specific conditions that trigger an urgent need to seek medical attention for an overdose event.

The regulatory documentation thus defines the overdose profile by its low acute systemic risk. Because of this low toxicity assessment, regulators have not mandated a detailed list of manifestations, specific interventions, or defined explicit conditions under which immediate medical help must be sought.

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Therapeutic Uses of Офтан Катахром

What Офтан Катахром Treats: Main Uses and Benefits

Офтан Катахром is used for the supportive therapeutic management of cataract of various genesis. Primary indications include Age-related Cataract, Complicated Cataracts, and Post-traumatic Cataracts. The medicine is applied across domains where supportive symptom management is appropriate, often targeting patients in the initial stages of development for long-term chronic therapy.

The preparation assists with managing the visual symptoms associated with early lens clouding, specifically impaired clarity and light-related disturbances such as glare. The preparation can contribute to easing the burden on visual function, which supports day-to-day comfort and stability when symptoms are more noticeable. As part of this supportive role, it helps maintain a sense of stability when symptoms are more noticeable and supports the management of further opacification.


Quick Fact: Supportive Management for Symptoms of Visual Clarity

Regulatory References

  1. Russian Government Patent Filing on Cataract Treatment
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Eligibility and Restrictions for Use

Who Can and Cannot Use Офтан Катахром?

The population eligibility for Офтан Катахром is defined by strict regulatory criteria, establishing both absolute contraindications and conditions for restricted use. This information is derived exclusively from official government-approved instructions for medical use.

Absolute Contraindications

The medicine must not be used by individuals who meet the following two absolute exclusion criteria:

  • Hypersensitivity: Patients with known or suspected allergy to any component of the ophthalmic solution, including the active ingredients (Adenosine, Cytochrome C, Nicotinamide) or any excipients.
  • Age Restriction: Patients who are under 18 years of age. Use in the pediatric and adolescent population is formally contraindicated due to the absence of documented efficacy and safety data for this age group.

Conditional and Restricted Use

For certain adult populations, use is conditional due to a lack of clinical experience:

  • Pregnancy and Lactation: Use during pregnancy or breastfeeding is restricted and possible only under a physician’s prescription. This conditional status requires a formal assessment that the expected therapeutic benefit for the mother outweighs the potential risk to the fetus or infant.

Other Population Rules

Use is permitted for the general adult population (age 18 and over). Official documentation does not list specific eligibility restrictions based on impaired renal (kidney) or hepatic (liver) function.

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What should I know about interactions with other medicines?

Interactions with other medicines and products

The official interaction profile for Офтан Катахром (eye drops) is primarily defined by the general regulatory requirements for administering multiple topical medications, rather than specific systemic drug-drug interactions.

Timing and Administration Constraints

The most relevant restriction concerns co-administration with other eye drops. To ensure optimal exposure and prevent the physical washout of the medication, the concurrent use of Офтан Катахром with any other topical ophthalmic solution requires a mandatory separation period. This administration-timing constraint is necessary to avoid a reduction in the concentration and therapeutic benefit of either medicine. This rule is a procedural requirement defined by regulatory documents for sequential eye drop administration, and is not a pharmacokinetic interaction.

Absence of Documented Systemic Interactions

Due to its topical route of administration and minimal expected systemic absorption of the active components (Adenosine, Cytochrome C, and Nicotinamide), official regulatory labeling does not contain specific data on systemic pharmacokinetic interactions. Consequently, no explicit contraindicated combinations with other medicines are documented in official sources. Furthermore, the label does not specify any clinically relevant interactions with food, alcohol, or herbal products. This profile confirms that the medicine's interaction focus is strictly limited to the correct technique for administering multiple eye drops.

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Mechanism of Action

The mechanism of action for Oftan Catachrom is multi-faceted, utilizing its components to modulate multiple biological systems implicated in lens homeostasis.

Oxidative Stress Modulation: Cytochrome C

This domain focuses on the regulation of free-radical activity within the lens. The component Cytochrome C acts within the redox signaling pathway to scavenge reactive oxygen species (ROS) and modulate pro-apoptotic signaling cascades. This action contributes to interrupting the signaling associated with cellular and protein degradation, influencing the maintenance of the lens's physiological equilibrium.

Metabolic and Energy Support: Adenosine

Adenosine modulates cellular energy metabolism by acting as a precursor for essential high-energy molecules and influencing local microcirculation within the ocular tissue. By modulating the energy balance of the lens cells, this component influences the processes of nutrient exchange and metabolic byproduct clearance, thereby modulating the effects of metabolic dysregulation on lens homeostasis.

Coenzyme Activation: Nicotinamide

Nicotinamide serves as a precursor for coenzymes (NAD^+ and NADP^+) crucial for countless enzymatic and repair reactions throughout the lens. This mechanism supports the availability of these cofactors, which modulates the activity of multiple cellular maintenance pathways. This component engages cascades related to cell survival and repair, influencing the processes underlying changes in lens structure.

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Dosage and Administration Information

How to Use Офтан Катахром: Official Dosing and Administration

This section outlines the official, label-based instructions for using Офтан Катахром (Adenosine, Cytochrome C, Nicotinamide Ophthalmic Solution).

Administration Details

Property Instruction
Route Local (Topical) ophthalmic application only (eye drops).
Standard Adult Dose 1-2 drops per administration in the affected eye(s).
Frequency 3 times per day.
Treatment Course Generally prescribed for long-term, chronic use.

Essential Procedural Instructions

The correct administration technique is vital for ensuring proper use and preventing contamination of the sterile solution.

  1. Instillation Site: The drops are to be applied locally into the conjunctival sac of the eye.
  2. Contamination Precaution: Patients are instructed to not touch the dropper tip to the eye, eyelashes, or any other surface.
  3. Concurrent Drops: If the patient is using other topical ophthalmic preparations, a minimum time interval of 5 to 15 minutes must be observed between the application of each product.
  4. Contact Lenses: Soft contact lenses must be removed prior to instillation due to the preservative (benzalkonium chloride). Lenses may be reinserted approximately 15 minutes after the drops have been applied.
  5. Post-Opening Use: Once the bottle is opened, the solution must be discarded after 4 weeks (or 1 month), regardless of the amount of solution remaining.

Population-Specific Use

Official prescribing information notes specific rules for certain patient groups. The use of Офтан Катахром is not recommended for children under 18 years due to a lack of sufficient data on efficacy and safety in this population. For pregnant or lactating individuals, use is permitted only under medical supervision when the expected benefit is determined to outweigh potential risks.

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Recent Clinical Evidence

Research Evidence / Overview of Studies for Офтан Катахром

Evidence Base for Cataract Management

The research base for Офтан Катахром consists primarily of clinical trials and observational studies conducted to support national regulatory review. These studies focused on the lens clouding characteristic of cataract. Researchers examined what types of changes were measured in adult populations over defined time intervals.

Studies explored the medicine’s use in research exploring short-term symptom changes as well as longer-term patterns. The research provides insight into how a combination of metabolic support and antioxidant components was studied in the eye. Findings describe patterns observed in the studies related to physiological strain or stress, and research provided context on how patients reported their experience during the trial periods.


Investigating Effects in Initial-Stage and Various Cataract Types

Офтан Катахром was studied for its use in patients diagnosed with cataract of various origins, including age-related, complicated, and post-traumatic types. Studies focused mainly on individuals in the initial stages of the condition. Researchers monitored specific outcomes related to functional imbalance and activity level.

Research examined measured outcomes such as visual acuity and the evolution of lens opacification (clouding) over time. Studies report how symptoms evolved in the observed populations, and findings indicate patterns related to the monitored endpoints. These trials documented effects on biochemical measures that contribute to understanding metabolic and oxidative symptom patterns. The evidence contributes to the broader evidence landscape for conditions marked by functional limitations.


Long-Term Studies and Follow-Up Observation Periods

As this medicine is used in research exploring long-term chronic management, studies were designed to observe responses over defined time intervals that lasted many months. The follow-up durations were designed to document any sustained patterns in the progression of lens opacification.

Studies monitored how symptoms evolved in the observed populations during the extended treatment period. However, the durability and long-term outcomes related to progression delay are not fully established in accessible, independent literature. The existing studies provide limited insight into the long-term changes over several years.


Overall Consistency and Research Gaps

The overall evidence level is low due to specific limitations in the available research base. Evidence quality varies across studies, and comparative evidence is lacking, particularly from large-scale, independently published randomized controlled trials (RCTs).

The main research gaps relate to the need for publicly accessible, high-quality studies that allow for independent meta-analysis. The follow-up durations were limited in the context of chronic disease management, and the sample sizes used in many reported trials were modest. This means research provides context but not individual predictions, and the findings describe group patterns, not personal outcomes.

Key Studies & References

  1. Patent RU2662364C2: Combined agent for conservative treatment of cataract and method of its application
  2. Cytochrome c: One of the Most Important Metalloproteins to Drive Cellular Life (Review supporting antioxidant role)
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Frequently Asked Questions (FAQ)

Common questions about Офтан Катахром (FAQ)

Q: Is Офтан Катахром the same as regular artificial tears or eye drops?

A: Official documentation describes this preparation as a multi-component ophthalmic solution. It is categorized within the therapeutic class of a Tissue Metabolism Regulator and an Anti-cataract Agent. This official classification distinguishes its purpose from simple lubricating or moisturizing products, commonly known as artificial tears.


Q: What is the role of cytochrome C in the eye drops?

A: According to the official product information, Cytochrome C is included to support the processes that regulate cell damage in the eye. Its role is described as helping to scavenge reactive oxygen species (ROS), thereby helping to support the eye's natural defenses against oxidative stress.


Q: Is it true that Офтан Катахром contains substances that nourish the eye?

A: Official documents state that the preparation contains components, such as Adenosine and Nicotinamide, that support the eye's essential biological processes. These substances are described as helping to support cellular energy metabolism and influencing nutrient exchange within the ocular tissue.


Q: Does alcohol consumption affect the use of this eye drop?

A: Regulatory documents defining the medicine’s official interaction profile do not specify or document any clinically relevant interactions with alcohol.


Q: Can Офтан Катахром interact with blood thinners or diabetes medication?

A: Due to its topical (local) administration route, official regulatory labeling states that the medicine has minimal expected systemic absorption into the bloodstream. Consequently, official sources do not contain specific data on systemic pharmacokinetic interactions with other types of medication, such as blood thinners or diabetes drugs.


Q: Are the reported side effects reversible when use is stopped?

A: Official safety information notes that documented systemic effects, such as low blood pressure or dizziness, are considered transient, meaning they are temporary. Local effects, such as stinging, are generally mild and brief.


Q: How does the medicine know where to work inside the eye?

A: The drug is specifically designed for local action. It is applied directly into the conjunctival sac of the eye, which is the site of instillation defined in the administration instructions. This local application allows the active components to be absorbed directly by the ocular tissues where their intended metabolic and antioxidant effects are studied.


Q: Is Офтан Катахром intended for use in both eyes, even if only one is affected?

A: The official standard administration guidance describes use in the affected eye(s). Official guidance describes use in the affected eye(s), reinforcing that application is guided by a healthcare professional.


Q: Are there different strengths of Офтан Катахром available?

A: Official regulatory documents only describe one standard formulation with defined concentrations of the three active components. The official administration guidance specifies a single standard dose (1–2 drops, 3 times per day).


Q: Does Офтан Катахром help prevent the condition from getting worse?

A: Official research documentation states that studies examined the medicine's use in research exploring long-term management and progression of the condition. However, the durability and long-term outcomes specifically related to progression delay are not fully established in accessible, independent literature.


Q: Are there any studies looking at the long-term safety of Офтан Катахром?

A: Official research documentation states that studies were designed to observe patient responses over defined time intervals that lasted many months. It is noted that the follow-up durations were limited in the context of very long-term chronic disease management.


Q: Is it possible to use too much of the eye drop?

A: Official regulatory guidance states the product is for topical ophthalmic use only. The official administration guidance provides a standard dose of 1–2 drops per application. Guidance for similar ophthalmic solutions suggests that the accidental ingestion of the medicine is unlikely to cause toxicity due to the low content of active ingredients.


Q: Can Офтан Катахром cause changes to my blood pressure?

A: Official safety documents list arterial hypotension (low blood pressure) as an extremely rare and transient systemic effect. This effect is attributed to the absorption of a component and is noted as temporary.


Q: What if I accidentally swallow a small amount of the liquid?

A: Regulatory guidance states the product is for topical ophthalmic use only and should not be swallowed. However, official information notes that accidental ingestion is unlikely to cause toxicity due to the low quantity of active ingredients in the product.


Q: Is this a vitamin supplement for the eyes?

A: The drug is officially classified as a Tissue Metabolism Regulator and Anti-cataract Agent. While one component, Nicotinamide, is a Vitamin B3 derivative, the product’s overall classification is that of a prescribed medicine, not a general dietary or health supplement.


Q: Can the drops be used to soothe general eye irritation or dryness?

A: The preparation's stated therapeutic goal and classification are to help preserve the functional integrity and biochemical balance of the ocular lens. It is categorized as an Anti-cataract Agent, and general soothing or lubrication is not listed as its primary purpose in official documentation.


Q: Is Офтан Катахром available without a prescription in some places?

A: Regulatory and official commercial descriptions often list this medicine as requiring a prescription in the jurisdictions where it is authorized for sale. This means professional authorization is typically required.


Q: Are there different forms of the drug (e.g., ointment vs. drops)?

A: The medicine is officially described and supplied only as Sterile Eye Drops (Ophthalmic Solution). Other forms, such as ointments, are not described in the official product information.

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How should Офтан Катахром be stored and disposed of?

Official Storage and Disposal Requirements

Requirement Regulatory Statement
Storage Temperature Store at a temperature not exceeding 30 C.
Prohibited Environment The solution must not be frozen.
Protection Protect the eye drops from light and keep the container tightly closed.
Post-Opening Stability The multi-dose container must be discarded 28 days after the date of first opening.
Child Safety The medicine must be kept out of the sight and reach of children.
Disposal Dispose of the unused product according to local regulations.

The regulatory labeling defines strict environmental controls for Oftan Catachrom to ensure product integrity. Storage is restricted to temperatures no higher than 30 C with an explicit prohibition against freezing. The stability of the product once the bottle is opened is limited, requiring the user to discard any remainder after 28 days. Finally, all unused or expired medication must be handled and disposed of strictly according to the specific regulations enforced by local authorities.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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