Эскапел

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Эскапел

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Эскапел

Quick Facts

Property Description
Active Ingredient Levonorgestrel
Form Oral Tablet
Pharmacological Class Progestogen-Only Emergency Contraceptive
Common Use Postcoital contraception
Origin Synthetic Steroid Hormone

Pharmacological Identity: What Type of Medicine is Эскапел?

Эскапел (Escapelle) is a specialized pharmaceutical preparation designated as an emergency contraceptive, which is a time-critical intervention intended to prevent pregnancy following unprotected intercourse or confirmed contraceptive failure. The product's active core is Levonorgestrel, which belongs to the high-level pharmacological classification of progestins. This classification confirms the medicine acts using a hormonal substance related to natural progestins. The preparation is recognized for its role in acute hormonal intervention. Эскапел is positioned specifically for women of reproductive age requiring immediate intervention. The drug contains a potent synthetic progestogen and is classified as a single-ingredient product, or monotherapy, presented as an oral tablet suitable for ingestion.

Composition and General Purpose of Levonorgestrel

The primary purpose of the Эскапел preparation is to provide postcoital contraception, serving as a backup method against the risk of unintended pregnancy. The active substance, Levonorgestrel, is a synthetic steroid hormone integrated with pharmaceutical excipients to create the final oral tablet structure. The drug's mechanism is fundamentally preventative; this intervention is effective primarily by preventing or delaying ovulation. This mechanism ensures that the drug functions by interrupting the reproductive process before conception. By targeting this crucial event in the female reproductive cycle, the medicine offers a focused, acute hormonal action intended solely for intervention, such as when a primary barrier method fails or is not used. Levonorgestrel maintains an established role in global public health.

Regulatory References

  1. Levonorgestrel in WHO Essential Medicines

What side effects are possible with Эскапел?

Possible side effects and safety information

The safety profile for Levonorgestrel (Эскапел) is formally characterized by adverse reactions categorized by frequency, which are generally acute and self-limiting. Based on official regulatory classifications, these effects primarily involve the nervous, gastrointestinal, and reproductive systems.


Adverse Reaction Frequency and System Groupings

The most frequent effects are classified as Very Common (ge 1/10) and include headache, nausea, lower abdominal pain, fatigue, and non-menstrual bleeding or spotting. Effects classified as Common (ge 1/100 to < 1/10) include dizziness, vomiting, diarrhea, breast tenderness, pelvic pain, and menstrual disturbances such as delayed or painful menstruation (dysmenorrhea).


Time-Related and Serious Safety Notes

A specific, expected time-related pattern involves the subsequent menstrual period, which is typically expected as predicted but may be delayed by up to seven days. Post-marketing surveillance has documented rare, serious adverse events with an unknown frequency, including thromboembolic events and generalized hypersensitivity reactions (such as rash or facial swelling).


Population and Scope Restrictions

Official labeling contains specific constraints on use. The medicine is not recommended for individuals with severe hepatic dysfunction. Effectiveness may also be reduced in cases of severe malabsorption syndromes. Furthermore, if the intervention fails, the likelihood of an ectopic pregnancy is increased, which is a consideration for women with a history of salpingitis or ectopic pregnancy. Critically, Levonorgestrel is exclusively for emergency use and does not provide protection against sexually transmitted diseases (STDs).

Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory profile for Levonorgestrel defines overdose scenarios based on documented clinical presentations and required emergency actions, emphasizing that serious undesirable effects have generally not been reported following the acute ingestion of large doses.


Documented Manifestations

Symptoms formally documented in connection with acute, high-dose exposure typically involve common gastrointestinal issues. These non-severe effects comprise nausea and vomiting. Regulatory information also notes that withdrawal bleeding may occur a few days following the acute ingestion of the medicine. No specific population-based considerations (e.g., for hepatic or renal impairment) are explicitly documented in the overdose sections of the prescribing information.


Emergency Actions and Medical Guidance

Immediate medical help is required if severe, life-threatening manifestations occur. Emergency Services must be contacted immediately if a person experiences clinical signs such as collapse, a seizure, trouble breathing, or unconsciousness (inability to be awakened). For all instances of confirmed or suspected overdose, individuals must also contact a certified Poison Control center for official guidance.


Treatment Approach

The established management for Levonorgestrel overdose is symptomatic and supportive treatment. This procedural approach is defined because regulatory documents explicitly confirm that no specific antidote is known for this preparation.

Therapeutic Uses of Эскапел

What Эскапел Treats: Main Uses and Benefits

Эскапел is specifically indicated for emergency contraception, and is commonly used as a time-critical intervention following an event where a woman is at risk of an unplanned pregnancy. The primary function is to assist in reducing the risk of pregnancy following unprotected sexual intercourse or a known or suspected contraceptive failure. This therapeutic application is relevant in clinical contexts that involve acute or disruptive symptom patterns of risk, and is used to provide support during an acute risk state for women of reproductive age.

The drug is commonly used across conditions presenting with acute, non-routine episodes of exposure to pregnancy risk. Key therapeutic indications include postcoital contraception following contraceptive method failure, a lapse in routine hormonal contraception, or an instance of unprotected sexual intercourse. The application is relevant in clinical settings that involve a temporary, unstable physiological state, supports the patient during difficult episodes by easing the associated physiological burden, and is used to provide supportive relief when symptoms interfere with routine activities.

Quick Fact: Relief for Acute Risk
Primary Use Domain Emergency Contraception
Risk State Addressed Acute exposure to unintended pregnancy risk
Patient Benefit Assists in reducing the risk and easing the associated burden
Use Context Contraceptive failure or unprotected intercourse

Eligibility and Restrictions for Use

The eligibility for Эскапел (Levonorgestrel) is strictly defined by regulatory guidelines for its role as an emergency contraceptive. The medicine is intended only for females of reproductive age who have begun their menstrual cycles (post-menarcheal). Its use is strictly defined for a single instance of emergency contraception and is not indicated for, nor is it effective as, a regular method of birth control.

Use of Эскапел is contraindicated if a known or suspected pregnancy exists, as the medicine is not effective for terminating an existing pregnancy. It is also prohibited for individuals with a known hypersensitivity or allergy to levonorgestrel or any other component in the tablet. The product is not intended for use in pre-menarcheal or post-menopausal women.

Women taking certain medications, specifically hepatic enzyme-inducing drugs (e.g., certain anti-epileptic or anti-tuberculosis medicines), must note that regulatory information suggests the effectiveness of Levonorgestrel may be reduced. While small amounts of the active ingredient pass into breast milk, official labeling generally indicates that no documented harmful effects on the infant's health have been found.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official regulatory profile for Levonorgestrel (the active ingredient in Эскапел) is dominated by pharmacokinetic interactions, specifically those involving liver enzyme metabolism. Co-administration of Levonorgestrel with certain medicinal products and supplements can enhance the drug's metabolism, which results in a reduction of its plasma concentration.

Substance Category
Enzyme-Inducing Medicines
Reciprocally Affected Medicines

Enzyme-Inducing Medicines and herbal products induce the CYP3A4 enzyme system, accelerating the clearance of Levonorgestrel. This reduced systemic exposure is officially documented with specific anticonvulsants, anti-infectives (such as Rifampicin), HIV treatments (such as Efavirenz), and the herbal product St. John's wort (Hypericum perforatum). This interaction is clinically relevant for women who have used enzyme-inducing agents within the last four weeks.

Reciprocally Affected Medicines include Cyclosporin. Levonorgestrel may inhibit the metabolism of Cyclosporin, which could increase the immunosuppressant's plasma levels. No medicinal products are listed as strictly contraindicated combinations in the regulatory labels due to interaction risk. No timing-based separation rules are documented.

Mechanism of Action

The biological effect of Levonorgestrel is mediated through a multi-faceted pharmacodynamic mechanism that primarily acts to inhibit key physiological events in the reproductive cycle.


Central Inhibition of the Ovulatory Cascade

This domain addresses the drug's primary action as a synthetic progestogen agonist on the Progesterone Receptor ( PR). Activation of the PR centrally suppresses the Hypothalamic-Pituitary-Ovarian ( HPO) Axis . This action specifically prevents the necessary surge of Luteinizing Hormone ( LH), which is the molecular signal required for the follicle to rupture. The resulting anovulation (failure to release an egg) is the primary physiological consequence of the central inhibition.


Peripheral Modulation of Biological Barriers

Beyond central hormonal control, the mechanism involves local peripheral action to modulate the environment of the lower reproductive tract. Levonorgestrel modulates the physical properties of cervical mucus, causing it to thicken significantly and become less permeable. This increase in viscosity results in mechanical impedance, which reduces the motility and transit of sperm into the upper reproductive tract. Additionally, the drug induces rapid structural changes in the endometrium, potentially altering the endometrial structure and biochemical environment, which results in an altered environment for implantation.

Dosage and Administration Information

How to Use Эскапел — Administration Guidelines

Эскапел, containing 1.5 mg of Levonorgestrel, is formulated for a single, one-time use as an emergency contraceptive. The instructions for its administration are time-sensitive and procedural.

Administration Details

Feature Instruction
Route & Dosage Oral administration of a single 1.5 mg tablet.
Timing & Urgency Must be taken as soon as possible, and no later than 72 hours after unprotected intercourse.
Intake Condition Can be taken with or without food and at any time during the menstrual cycle, unless bleeding is overdue.

Procedural Instructions and Constraints

Replacement Dose:

If the tablet is lost due to vomiting within three hours of administration, a replacement dose (another 1.5 mg tablet) must be taken immediately to ensure proper absorption of the active ingredient.

Population-Specific Adjustment:

For patients concurrently taking medication known to induce hepatic enzymes (e.g., certain antiepileptics or rifampicin), a double dose of 3.0 mg may be indicated, or a non-hormonal emergency contraceptive should be considered.

Use Context:

This medicine is designated as an acute, backup method and is not intended for routine use as a regular contraceptive. After the single dose, it is recommended to use a local barrier method until the next menstrual period begins. Repeated administration within a single menstrual cycle is generally not advisable due to the potential for cycle disturbance.

Recent Clinical Evidence

Escapelle: Recent Clinical Evidence

Escapelle is a single-dose oral emergency contraceptive pill containing levonorgestrel 1.5 mg, a synthetic progestogen. Authoritative global health organizations recognize this formulation as a standard option for preventing pregnancy following unprotected intercourse or contraceptive failure.

Efficacy and Timing

Clinical trials have consistently shown that the effectiveness of the levonorgestrel regimen is highly time-dependent. Studies indicate that the sooner the pill is taken, the higher its potential to prevent an expected pregnancy. Specifically, meta-analyses based on earlier trials demonstrated a higher percentage of expected pregnancies prevented when the drug was taken within the first 24 hours, with effectiveness decreasing thereafter.

The regimen is formally indicated for use within 72 hours (3 days) of unprotected intercourse, though some evidence suggests limited efficacy may extend up to 96 hours (4 days). Its primary mechanism of action is believed to be the inhibition or delay of ovulation (the release of an egg), which is supported by clinical data showing high effectiveness when taken before the luteinizing hormone (LH) surge.

Tolerability and Pharmacokinetics

Levonorgestrel is generally considered well-tolerated. The most frequently reported adverse effects in clinical trials include changes to menstrual bleeding patterns (such as heavier bleeding), nausea, and headache. Pharmacokinetic studies have shown that the drug is rapidly absorbed after administration, which facilitates its intended use as a time-critical intervention.

Frequently Asked Questions (FAQ)

Common questions about Эскапел (FAQ)


Q: Is Эскапел the same as the morning-after pill?

A: Yes. Эскапел is the brand name for a product that contains levonorgestrel 1.5 mg, which is a formulation internationally recognized and commonly referred to by users as the emergency contraceptive pill or 'morning-after pill.' Official sources classify it as an oral emergency contraceptive.


Q: What is the difference between Эскапел and Postinor?

A: Regulatory registries indicate that both Эскапел and Postinor contain the same single active substance, levonorgestrel, which is used for emergency contraception. These are different brand names used to market the same active ingredient in various global regions.


Q: How long might side effects from Эскапел typically last?

A: Official patient information often describes common side effects such as headache, nausea, and dizziness as generally mild and temporary. These effects typically begin to resolve within a few days after the tablet is taken.


Q: Can taking Эскапел affect the next menstrual period?

A: Yes, regulatory documents indicate that the medicine may alter the timing and nature of the next period. It is possible for the period to be delayed by a few days, or in some cases, it may occur earlier than expected.


Q: Is it common for bleeding or spotting to occur after using Эскапел?

A: According to official product information, it is listed as a very common side effect to experience irregular bleeding or spotting between the time the drug is taken and the next expected period.


Q: Are there any common medicines that are known to interact with Эскапел?

A: Yes. Regulatory sources note that medicines and supplements that induce liver enzymes (which speed up the clearance of the drug) can reduce its effectiveness. This includes certain antiepileptics, anti-infectives like rifampicin, and the herbal product St. John's wort.


Q: Does alcohol consumption affect how Эскапел works?

A: Official regulatory documents and patient instructions do not provide specific instructions or warnings concerning the consumption of alcohol and its potential effect on the efficacy of the medicine.


Q: Can a woman who is breastfeeding use Эскапел?

A: The active ingredient, levonorgestrel, is secreted into breast milk. Regulatory information typically discusses strategies to minimize infant exposure, such as taking the tablet immediately after a feed and then taking a break from breastfeeding, with guidance from a healthcare provider.


Q: Are there any known issues with using Эскапел for women with a history of liver conditions?

A: Official warnings state that the drug is generally not recommended for women with severe liver disease or severe hepatic dysfunction. This is because these conditions may impair the body's ability to process and clear the active substance.


Q: What are the most commonly reported side effects of Эскапел?

A: Official documents list very common side effects as including headache, nausea, fatigue (tiredness), lower abdominal pain, and menstrual disturbances (irregular bleeding).


Q: Is abdominal pain a common experience after taking Эскапел?

A: Yes, lower abdominal pain is classified in official regulatory documents as a very common side effect, meaning it may affect more than 1 in 10 people.


Q: Can Эскапел cause changes in mood or feelings?

A: Yes, official reports, including post-marketing experience data, have noted changes such as mood alterations and reports of depressed mood as possible adverse reactions.


Q: Is there any research about the long-term effects of using Эскапел repeatedly?

A: Regulatory documents state that this drug is not intended for routine use as a primary contraceptive method. Therefore, there is limited data and official guidance on the safety themes or effects related to the long-term or repeated use of this medicine.


Q: Does Эскапел protect against sexually transmitted infections?

A: No. Official documents contain a clear statement that the drug does not protect against HIV/AIDS or other sexually transmitted infections.


Q: Is it still appropriate to use Эскапел if there is uncertainty about the timing of the last period?

A: The medicine is contraindicated (should not be used) if a woman has a known or suspected pregnancy. Official guidance emphasizes that if the menstrual period is overdue, pregnancy must be ruled out before the tablet is taken.


Q: Can taking Эскапел affect fertility in the future?

A: The medicine works acutely to delay or inhibit ovulation. Official regulatory information states there is no known long-term data to suggest that taking this emergency contraceptive has any impact on a person's future fertility.


Q: What are the reasons someone might not be able to use Эскапел?

A: Official contraindications generally include a known or suspected pregnancy or a known hypersensitivity (allergy) to levonorgestrel or any of the inactive ingredients in the product.


Q: Can Эскапел be bought without a prescription in some places?

A: The availability of the drug depends on local regulatory jurisdiction. In many countries, the active substance is available as an over-the-counter (OTC) medicine without a prescription, though it may be subject to minimum age requirements.


Q: How should Эскапел be stored to maintain its quality?

A: Official storage instructions typically advise keeping the medicine below a specific temperature (often 25 C or 30 C), protecting it from light, and storing it in its original packaging.


Q: Is it possible for Эскапел to fail to work?

A: Yes, official clinical efficacy data indicates the drug will not prevent pregnancy in every instance. The medicine is not 100% effective, and its potential effectiveness decreases the longer the time interval is after unprotected intercourse.


Q: Can using Эскапел cause a headache?

A: Yes, headache is listed as a very common side effect in official regulatory documents.


Q: Are there any known interactions between Эскапел and herbal supplements?

A: Yes, the herbal product St. John's wort (Hypericum perforatum) is specifically documented in regulatory warnings as an enzyme inducer that can potentially reduce the concentration and effectiveness of the drug.


Q: What should be expected from the next period after using Эскапел?

A: The next period is usually expected around the normal time, but it may occur earlier or later than usual. Official guidance notes that if the period is delayed by more than 7 days or is unusually light or heavy, this is a trigger for seeking medical evaluation.


Q: What are the contraindications for using Эскапел?

A: Contraindications, as listed in official documentation, include a known or suspected pregnancy and known hypersensitivity (allergy) to the active substance (levonorgestrel) or any of the excipients.


Q: Is it normal to feel tired or dizzy after using Эскапел?

A: Yes. Fatigue (tiredness) is officially listed as a very common side effect, and dizziness is listed as a common side effect in regulatory documents.


Q: Can Эскапел be used by women under the age of 18?

A: Regulatory access rules vary by country. In some regions, the drug is available over-the-counter (OTC) for all women of childbearing potential, while in other regions, prescription requirements or age limits may apply to those under 18.


Q: What if a user is taking regular medication for epilepsy—can they still use Эскапел?

A: Official documents warn that certain antiepileptic medicines (anticonvulsants) are known enzyme-inducers that can reduce the drug's effectiveness. The use of these medicines may require alternative emergency contraceptive methods or dose adjustments, as noted in official prescribing information for users of enzyme-inducing agents.


Q: Can Эскапел interfere with the effectiveness of long-term contraceptives?

A: After taking emergency contraception, a woman can generally continue to use her regular hormonal contraception. Official guidance mentions that a barrier method (such as a condom) may be needed until the next period, as the medicine does not offer continuous protection.


Q: What regulatory bodies have approved the use of Эскапел?

A: The active substance, levonorgestrel (1.5 mg), is approved by numerous government drug agencies worldwide, including the EMA (European Medicines Agency) and the FDA (U.S. Food and Drug Administration), among other national bodies.


Q: Does Эскапел affect hormonal balance in the long term?

A: The medicine is a single, acute dose and is not intended for routine use. Regulatory information does not contain long-term safety data to assess the effects of repeated use on hormonal balance.


Q: Are there any warnings about allergic reactions to Эскапел?

A: Yes. Known hypersensitivity (allergy) to the active substance or any of the product's ingredients is listed as a contraindication. Allergic reactions have also been noted in official post-marketing reports.


Q: How long does the active ingredient of Эскапел stay in the body?

A: Pharmacokinetic data available in official product information shows that the active substance, levonorgestrel, has an elimination half-life that is officially cited as being approximately 24 to 26 hours.


Q: Can Эскапел interact with antibiotics?

A: Official documents warn that certain anti-infective agents, such as the antibiotic Rifampicin, can significantly reduce the effectiveness of the drug due to liver enzyme induction.


Q: Is there a maximum number of times Эскапел can be used in a year?

A: The medicine is an acute emergency measure. Regulatory documents state it is not intended for routine use and repeated administration within a single cycle is generally not advisable due to the potential for cycle disturbance. No specific annual limit is defined in official documents.


Q: What kind of research supports the safety profile of Эскапел?

A: The safety profile is supported by clinical trials that monitor adverse effects and by official post-marketing surveillance data. This evidence demonstrates that the drug is generally well-tolerated and that serious adverse effects are rare.


Q: Does the packaging of Эскапел include any patient information leaflets?

A: Yes. In line with regulatory requirements in most jurisdictions, the product is packaged with a patient information leaflet (or Summary of Product Characteristics) that includes instructions, important safety warnings, and lists of possible side effects.

How should Эскапел be stored and disposed of?

Official Storage and Disposal Requirements

Escapelle (Levonorgestrel) must be stored under specific conditions to maintain product stability, as stated in regulatory documents.

Storage Requirement Official Condition
Temperature Store below 25 C (77 F).
Protection Store in the original package to protect from light.
Child Safety Keep out of the sight and reach of children.

All unused or expired Escapelle tablets, or any associated waste material, must be handled and disposed of in accordance with local requirements. There are no specific additional requirements detailed in the official prescribing information for the disposal of this product.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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