Циклодинон

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Циклодинон

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Циклодинон

What is Cyclodynon?

Here is a quick overview of Cyclodynon:

Property Description
Active ingredient Dry extract of Vitex agnus-castus (Chasteberry) fruit
Form Film-coated tablets or oral solution (drops)
Pharmacological class Gynecological medicinal product/Herbal medicine
Common use Treatment of menstrual cycle disorders and PMS symptoms
Origin Plant-based (Phytomedicine)

The Natural Essence and Cyclodynon's Composition

Cyclodynon is a recognized herbal medicinal product or phytomedicine, which distinguishes it by being a non-synthetic therapeutic option derived from a plant source. The medication's active agent is a standardized dry extract obtained from the fruits of the Chasteberry tree (Vitex agnus-castus). This plant has been used for centuries in traditional medicine and is utilized in modern pharmacology. The standardization process ensures that each tablet or dose of drops contains a reliable and consistent concentration of key active compounds.


Pharmacological Classification and General Therapeutic Purpose

Clinically, Cyclodynon is categorized as a medicinal product for gynecological use aimed at managing menstrual cycle disorders and the various symptoms of premenstrual syndrome (PMS). Its general therapeutic purpose is to promote a more stable hormonal environment.

The mechanism of action is linked to dopaminergic activity. This effect is thought to modulate the balance of pituitary hormones, which in turn helps to correct the imbalances that lead to symptoms like cyclic mastalgia (breast tenderness) and irregular periods. This action is associated with the drug’s role in promoting a more regulated and comfortable menstrual cycle.

What side effects are possible with Циклодинон?

Possible Side Effects and Safety Information

The official safety information for medicinal products containing Vitex agnus-castus (the active ingredient in Циклодинон) describes documented adverse reactions based on reports from clinical use and post-marketing surveillance. Regulatory authorities classify the frequency of these reactions as Not Known, meaning the rate cannot be accurately estimated from the available data.

Reported adverse effects are categorized by the systems affected, as outlined in official labeling:

System-Organ Class Documented Adverse Reactions
Immune System Severe allergic reactions, including face swelling, difficulty breathing (dyspnoea), and swallowing difficulties.
Skin Allergic skin reactions, such as rash and urticaria (hives); acne.
Nervous System Headache and dizziness.
Gastrointestinal Nausea and abdominal pain.
Reproductive System Menstrual disorders.

The severe allergic reactions listed are considered serious adverse reactions documented in the safety profile.


Safety Considerations and Restrictions

The product label includes explicit restrictions for certain populations and pre-existing conditions:

  • Contraindications: Use is prohibited in cases of known hypersensitivity to the active substance, a current pituitary disorder, or during pregnancy and lactation. Caution is also advised regarding a history of oestrogen-sensitive cancer.
  • Pediatric Use: Safety has not been established for use in children and adolescents under 18 years of age.

Due to the medicine's pharmacological properties, high-level safety consequences from co-administration with dopamine agonists/antagonists and oestrogens/antioestrogens cannot be excluded from the official safety profile.

Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory documents regarding the Циклодинон (Vitex agnus-castus extract) overdose profile are based on the available safety data, which is common for established herbal medicines. The analysis below reflects information strictly found in government-authorized prescribing information.


Documented Overdose Manifestations

Regulatory records indicate that no specific cases of overdose have been reported for the active ingredient itself. Therefore, formal descriptions of typical clinical signs or symptoms related to an overdose of the Vitex agnus-castus extract are absent from official prescribing information.

A specific concern relates to the excipient in the oral drop formulation, which contains ethanol. Consequently, ingestion of a quantity greatly exceeding the recommended dose may result in signs of alcohol intoxication.


Mandated Emergency Actions and Management

In the event that an overdose is suspected, or if any unexpected symptoms occur after taking an excessive amount, regulatory authorities advise the immediate step of contacting a doctor, pharmacist, or healthcare professional. This guidance emphasizes the need for professional evaluation following any suspected excessive ingestion.

Should symptoms develop, the official management strategy described in product labeling is to initiate symptomatic treatment. This means that care would be directed toward relieving the specific discomfort or manifestations experienced by the patient. No specific antidote is listed as being known or available in the regulatory documentation for the active extract.

Therapeutic Uses of Циклодинон

Quick Facts

  • May assist in the management of premenstrual syndrome (PMS).
  • Can support the relief of minor symptoms associated with the days before menstruation.
  • Used traditionally to help stabilize menstrual cycle irregularities.

Циклодинон (Cyclodynon), which contains an extract derived from Vitex agnus-castus fruit (Chaste Tree fruit), may be considered for the management of certain female health concerns related to the menstrual cycle. The medication is utilized to support the relief of symptoms associated with premenstrual syndrome (PMS).

This extract is used for addressing minor physical and emotional discomforts that may occur in the days preceding menstruation. Such symptoms can include headaches, breast tenderness, and mood lability. It is also used traditionally to assist in the stabilization of menstrual cycle irregularities.

This herbal preparation is used for the relief of minor premenstrual symptoms based on long-standing use. Use of this medication should be discussed with a qualified healthcare professional.

Eligibility and Restrictions for Use

Official Eligibility and Restrictions for Cyclodynon

Regulatory documentation defines specific populations who are eligible to use Циклодинон (Vitex agnus-castus extract) and those for whom its use is strictly restricted or contraindicated.

Eligibility Status Population Group Regulatory Classification
Allowed Use Adult women 18 years of age and over. Indicated/Established Use
Contraindicated Women who are pregnant or breastfeeding (lactation). Prohibited Use
Contraindicated Patients with a known pituitary disorder or hypersensitivity to the ingredients. Absolute Non-Eligibility
Not Recommended Children and adolescents under 18 years of age. Safety/Efficacy Not Established

Use is contraindicated during both pregnancy and lactation due to established restrictions [4.5]. The medicine is not recommended for individuals under 18 because safety and efficacy have not been formally established in this age group [4.4, 4.5]. Furthermore, patients with a history of estrogen-sensitive cancer must exercise caution and seek professional consultation prior to use [1.1, 4.5]. These rules strictly define the population allowed to use the product.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official regulatory profile for Циклодинон (containing Vitex agnus-castus extract) primarily identifies potential interaction patterns within the realm of pharmacodynamics, focusing on the active substance's possible influence on the body's hormonal systems.

Documented Pharmacodynamic Interactions

Due to the officially described possible dopaminergic and oestrogenic effects of the extract, regulatory documentation highlights potential interaction risks with specific classes of medicinal products. The following combinations are officially noted where interactions cannot be excluded:

Interacting Substance Class Regulatory Rationale
Dopamine Agonists & Antagonists Potential alteration of effects due to the extract’s dopaminergic activity.
Oestrogens (Estrogens) & Antioestrogens Potential alteration of hormonal balance due to the extract’s oestrogenic effects.

These statements establish a formal restriction that necessitates caution regarding concomitant use with medicinal products that modulate either the dopaminergic or oestrogenic axes.

Undocumented Interaction Categories

The official regulatory documents do not formally report clinical data or restrictions concerning several other potential interaction categories. These are not documented in the interaction sections of the prescribing information:

  • Pharmacokinetic Interactions: No explicit interactions related to CYP enzymes or drug transporters (e.g., P-gp) are reported.
  • Food and Timing: No specific interactions with food, alcohol, or other herbal products are listed, and no mandatory separation of administration timing is required.

Mechanism of Action

Циклодинон (Cyclodynon) operates via the pharmacologically active compounds, primarily diterpenes, derived from Vitex agnus-castus fruit extract, which is its basis. The primary biological target is the Dopamine D2 receptor ( D2R), a Gi/ Go-protein coupled receptor, located prominently on lactotroph cells in the anterior pituitary gland. The diterpenes function as agonists at the D2R.

The molecular interaction leads to the activation of the Gi subunit, initiating an intracellular cascade that results in the inhibition of adenylyl cyclase activity. This inhibition consequently causes a decrease in the intracellular concentration of cyclic adenosine monophosphate (cAMP). The reduction in cAMP levels results in the downregulation of prolactin gene expression and modification of ion channel activity, specifically the inhibition of voltage-gated calcium channels and activation of potassium channels.

The resulting hyperpolarization and reduced intracellular calcium concentration ultimately inhibits the exocytosis and secretion of the hormone prolactin ( PRL) from the lactotroph cells. This suppression of PRL release constitutes the systemic physiological consequence.

Dosage and Administration Information

How to Use Циклодинон (Administration Guidelines)

The usage of Циклодинон (containing Vitex agnus-castus extract) is governed by standardized instructions defining the route, dose, frequency, and duration of the treatment course. These guidelines ensure consistent administration as outlined in available prescribing information.

Administration Scope

Instruction Parameter Guideline
Route of administration Oral (via the mouth), for both tablet and liquid forms.
Dosing schedule (Adults) One film-coated tablet daily or 40 drops of the oral solution daily.
Timing Administered once daily and advised to be taken at the same time each day.
Preparation Tablets must be swallowed whole with liquid; drops are taken directly. Chewing the tablets is not permitted.
Age-group rules Not recommended for use in patients under 18 years due to insufficient clinical data in this age group.
Missed-dose rule Do not take a double dose to compensate for a forgotten one; continue with the next scheduled dose.

Treatment Course and Duration

The administration pattern for this extract requires a long-term commitment. The treatment course should be continued daily and without interruption for a minimum duration of three months to align with the usage protocol, a practice which must be sustained even during menstruation.


Procedural Summary

The procedural structure establishes a fixed, once-daily oral administration framework. This is coupled with a three-month minimum duration requirement, defining a continuous and structured use protocol. This approach is intended to standardize use according to the drug's profile.

Recent Clinical Evidence

Recent Clinical Evidence

Clinical evidence regarding the use of standardized extracts of Vitex agnus-castus (the active component in Cycodynon) focuses primarily on conditions related to menstrual cycle disorders (MCDs), including Premenstrual Syndrome (PMS) and cyclic breast tenderness (mastodynia).


Efficacy Studies in PMS and PMDD

  • PMS Symptom Assessment: Multiple randomized, placebo-controlled trials have been conducted to evaluate the effects of Vitex agnus-castus extracts on premenstrual symptoms such as irritability, mood changes, headache, bloating, and breast tenderness. Systematic reviews indicate that, overall, these extracts are often associated with a greater reduction in total premenstrual symptoms compared to a placebo.
  • Comparison to Active Agents: In some studies evaluating Premenstrual Dysphoric Disorder (PMDD), the effect of the extract was reported as being similar to that of certain antidepressants (SSRIs) on overall symptoms, although the antidepressant may show a greater effect on psychological symptoms, while the extract may show a greater effect on physical symptoms.

Clinical Findings on Menstrual Cycle Disorders

Observational studies involving large cohorts of women with menstrual cycle disorders, including dysmenorrhea and mastodynia, have investigated the use of Vitex agnus-castus products. Data from a retrospective longitudinal cohort study on over 1,700 women reported that a three-month period of use was associated with decreased percentages of patients with irregular cycles and breast tenderness. Improvements in bleeding intensity, frequency, and menstrual pain were noted by a high proportion of participants.


Safety and Tolerability Profile

Vitex agnus-castus extracts are generally regarded as well tolerated in clinical trials. Reported adverse events are typically mild and infrequent, with the most commonly mentioned side effects including headache, gastrointestinal discomfort (e.g., nausea), and dizziness. No evidence of severe safety concerns has been consistently demonstrated across major clinical reviews.

Frequently Asked Questions (FAQ)

Common questions about Циклодинон (FAQ)


Q: Is Циклодинон also intended for issues related to menopause or perimenopause?

According to official regulatory documents, the medicine's indications specify its use for premenstrual syndrome and minor symptoms that occur before menstruation. Official product information does not list menopause or perimenopause as formal indications.


Q: How long does it typically take to notice the expected effects of Циклодинон?

To achieve the optimal effect observed in clinical studies, regulatory guidelines recommend continuous, daily use for a minimum duration of three months. This reflects the period over which the extract's action is typically assessed.


Q: Is it common for my period to change (shorter, longer, heavier) after starting Циклодинон?

Changes to the menstrual pattern have been reported during use. The official safety information lists menstrual disorders as a documented adverse reaction. Official regulatory information advises consulting with a healthcare professional if symptoms or changes persist or worsen.


Q: Can Циклодинон be used by patients with a history of liver disease?

Official regulatory documents define specific contraindications, such as a known pituitary disorder or use during pregnancy/lactation. A history of liver disease is not explicitly listed as a formal contraindication for use.


Q: Are there any specific safety warnings for people with conditions like endometriosis or uterine fibroids?

Official safety considerations advise caution regarding a history of oestrogen-sensitive cancer due to the product’s pharmacological properties. Endometriosis and uterine fibroids are not explicitly named as restrictions in the regulatory documentation.


Q: Do experts recommend taking breaks from Циклодинон, or is it intended for continuous use?

The official protocol establishes that the treatment course should be continued daily and without interruption for a minimum duration of three months. This standardized approach is consistent with the regulatory profile of the extract.


Q: Can Циклодинон be taken with vitamins or other dietary supplements?

Official regulatory documents identify potential interactions with prescription medicines such as dopamine agonists/antagonists and oestrogens/antioestrogens. Explicit interaction warnings with general vitamins or other dietary supplements are not specifically documented in the product information.


Q: What should I do if my menstrual symptoms worsen after starting Циклодинон?

Official regulatory information states that if symptoms worsen or continue while taking the medicine, a healthcare practitioner should be consulted. This ensures that persistent changes are professionally reviewed.


Q: Can using Циклодинон affect the risk of getting pregnant?

The product’s pharmacological properties are known to influence hormone levels. Because of this, its use is contraindicated and should be avoided during pregnancy.


Q: What is the general safety profile of the active ingredient for long-term use?

The official protocol requires a minimum treatment duration of three months. Reported adverse events are generally mild and infrequent, but official safety profiles typically focus on the standard duration of use and do not typically summarize extensive data for continuous use exceeding this period.


Q: Can Циклодинон be used alongside medicines for thyroid issues?

The official interaction profile identifies potential risks with medicines that affect the dopamine and oestrogen axes. Interactions with specific thyroid medications are not explicitly documented in the regulatory information.


Q: Is there a maximum length of time that a patient can safely take Циклодинон?

The official prescribing information defines a minimum treatment duration of three months for an optimal effect. The regulatory documents do not specify a maximum length of time for continuous use.


Q: Can Циклодинон cause acne or make existing acne worse?

The official safety profile lists acne as a documented allergic skin reaction with an unknown frequency. Official documentation lists this adverse reaction but does not contain specific information about the risk of exacerbating existing acne.


Q: What is the difference between Циклодинон and other Vitex agnus-castus products?

Циклодинон is defined as a standardized dry extract of Vitex agnus-castus fruit. Official documents state that the standardization process is intended to ensure a reliable and consistent concentration of the active components in each dose, which can vary across different preparations.


Q: Is dizziness or fatigue a common side effect of Циклодинон?

The official safety profile lists dizziness as a documented adverse reaction in the nervous system. Fatigue is not explicitly listed among the documented side effects found in the official safety profile.


Q: Why is it described as having a dopaminergic activity?

The active component is described in official documents as acting on the Dopamine D2 receptor (a dopaminergic effect), which leads to the inhibition of prolactin release from the pituitary gland.


Q: Does Циклодинон affect the level of the hormone prolactin?

The official mechanism of action is linked to the inhibition of prolactin secretion from the pituitary gland. This action is considered the systemic physiological consequence of the product's activity.


Q: Does Циклодинон have any known interactions with oral contraceptive pills?

The official regulatory profile highlights potential interaction risks with medicines that contain oestrogens (estrogens) and antioestrogens. This is due to the extract's documented pharmacological properties.


Q: What is the interaction profile of Циклодинон with other hormone-based medications?

The officially documented interaction profile highlights potential risks with two main classes of medicines: Dopamine Agonists/Antagonists and Oestrogens (Estrogens)/Antioestrogens. The product's effects are tied to these specific hormonal axes.


Q: Are there any potential effects of Циклодинон on mood or anxiety?

Clinical studies have examined the extract in relation to premenstrual symptoms like irritability and mood changes. The official adverse reaction list for the nervous system includes headache and dizziness, but anxiety or mood disorders are not listed as documented side effects.


Q: Can Циклодинон be used by individuals with Parkinson's disease?

Official regulatory documentation states that the product's dopaminergic activity may alter the effects of Dopamine Agonists and Antagonists, which are used to manage certain conditions. This documented interaction requires caution regarding concomitant use.

How should Циклодинон be stored and disposed of?

Storage and Disposal of Cyclodynon (Циклодинон)

The official regulatory profile defines specific requirements for storing and discarding Cyclodynon.


Storage Requirements

Item Requirement
Temperature Does not require any special storage conditions regarding temperature.
Protection Must be kept in the original packaging to protect it.
Safety Store out of the reach and sight of children at all times.
Stability Must not be used after the expiry date printed on the packaging.

Disposal Instructions

Medicines should not be disposed of via wastewater or household waste. The proper method for discarding unused or expired Cyclodynon is to return the product to a pharmacy for safe disposal, in accordance with local pharmaceutical waste regulations.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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