Revoxin

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Revoxin

Quick Facts

Property Description
Active Ingredient Piroxicam
Pharmacological Class Oxicam-Type Nonsteroidal Anti-Inflammatory Drug (NSAID)
Common Forms Capsule, Tablet, Gel/Cream
Origin Synthetic (Small Molecule)
Key Differentiating Feature Long duration of action

What is Revoxin?

Revoxin is the proprietary name for a single-ingredient medicine containing the active substance piroxicam, which belongs to the class of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). As a pharmaceutical product, Revoxin is synthetic in origin, designed to provide relief from pain, swelling, and stiffness by controlling the body’s inflammatory response.


What Type of Medicine is Revoxin?

Piroxicam is categorized as an oxicam-type NSAID, a distinction that is clinically recognized for its extended half-life compared to many other conventional NSAIDs. This feature allows the medication to maintain stable concentrations over a longer period, supporting its use for sustained relief of chronic discomfort. Piroxicam works by inhibiting the biosynthesis of prostaglandins, leading to potent anti-inflammatory effects.


What Forms is Revoxin Available In?

Revoxin is available for both oral administration, typically as a capsule or tablet, and for topical use, such as a gel or cream. The oral forms are used when systemic action is necessary to address widespread inflammation throughout the body. Conversely, topical preparations allow the active ingredient to be delivered locally to the site of discomfort, such as an affected joint or area of swelling. Piroxicam is utilized in these varied dosage forms to meet diverse patient needs. This flexibility allows the medication to target pain and swelling either systemically or directly where needed.

Regulatory References

  1. Piroxicam Summary

What side effects are possible with Revoxin?

Revoxin: Possible side effects and safety information

Official government regulatory bodies classify the safety profile of Piroxicam (Revoxin) with mandatory warnings regarding serious adverse reactions, primarily affecting the cardiovascular and gastrointestinal systems. These warnings underscore the potential for serious, potentially fatal, cardiovascular thrombotic events (including myocardial infarction and stroke) and severe gastrointestinal events (including bleeding, ulceration, and perforation). The risk of cardiovascular events may increase with the duration of use, while serious gastrointestinal events can occur at any time during treatment.

Adverse reactions are formally categorized by their frequency and the system or organ affected.

Common reactions, affecting 1 to 10 users in 100, generally involve Gastrointestinal Disorders such as dyspepsia, nausea, vomiting, abdominal pain, and constipation, as well as Nervous System Disorders like headache and dizziness. Rare reactions, affecting fewer than 1 in 1,000 users, include severe skin reactions (such as Stevens-Johnson syndrome) and acute organ failures (such as acute renal failure).

Specific safety considerations are documented for certain populations. Older adults are officially noted to be at a greater risk for serious gastrointestinal adverse events. Furthermore, the medicine is contraindicated in individuals with severe, pre-existing heart failure and during the third trimester of pregnancy. Its use is also restricted in the setting of peri-operative pain for coronary artery bypass graft (CABG) surgery.

Overdose and Emergency Response

The regulatory descriptions of overdose for Revoxin (Piroxicam) primarily focus on acute, serious systemic manifestations. Documented clinical signs often involve the gastrointestinal system, presenting as nausea, vomiting, abdominal pain, and potentially serious findings like gastrointestinal bleeding or peptic ulceration. Central nervous system (CNS) effects are also noted, including drowsiness, confusion, headache, and—in severe cases—convulsions or coma. Other officially documented outcomes include hypotension (shock), little to no urine production, and respiratory changes.

When to Seek Urgent Help

Official guidance mandates that individuals must seek immediate medical attention following any suspected overexposure. Emergency services must be contacted immediately if the person is collapsed, having a seizure, experiencing trouble breathing, or cannot be awakened.

Official Management Protocols

Management detailed in regulatory labeling is symptomatic and supportive, as no specific antidote is known for Piroxicam. Procedural interventions may include administering activated charcoal and performing gastric lavage. Overdose requires hospital observation and continuous monitoring, including checking vital signs, conducting blood and urine tests, and performing an ECG (heart tracing). The risk for serious GI complications is noted to increase in the elderly population.

Therapeutic Uses of Revoxin

What Revoxin Treats: Main Uses and Benefits

Revoxin is generally applied across therapeutic domains involving symptoms related to inflammatory or irritative states. It is used for easing symptoms related to physical discomfort. The medication may assist with managing symptom clusters associated with conditions involving inflammatory or irritative processes, such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is also relevant in conditions characterized by periods of heightened symptoms, such as acute gouty arthritis flare-ups, acute musculoskeletal disorders, and primary dysmenorrhea.

The core benefit is addressing symptom clusters such as persistent joint pain, swelling, and stiffness. This supports patients during difficult episodes by easing distress and may help maintain a sense of stability when symptoms are more noticeable.

“This approach is relevant when supportive symptom management is appropriate, assisting patients during difficult episodes by easing distress.”

The medication is applied in scenarios where additional management of discomfort is required, such as non-articular settings, or during phases when symptoms become more noticeable, including post-operative or post-childbirth pain. This offers symptomatic relief that helps patients cope more steadily with symptom fluctuations and assists with maintaining functional stability.

Symptomatic Support Focus
Symptom Goal Easing pain, swelling, and stiffness
Primary Domain Chronic and acute inflammatory conditions
Key Benefit Helps maintain a sense of stability when symptoms are more noticeable

Regulatory References

  1. NIH MedlinePlus Drug Information on Piroxicam

Eligibility and Restrictions for Use

Eligibility Profile: Who Can and Cannot Use Revoxin

Revoxin (piroxicam) use is strictly defined by regulatory eligibility criteria, focusing on population-specific exclusions and restrictions. The medicine is primarily intended for adults (18 years and older) with approved chronic inflammatory conditions.

Populations for Whom Use is Contraindicated

Use is contraindicated in patients with a known hypersensitivity to piroxicam or other Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), as well as those with a history of severe allergic skin reactions (e.g., Stevens-Johnson syndrome). Absolute bans include individuals with active gastrointestinal ulceration, severe heart failure, or immediately following coronary artery bypass graft (CABG) surgery.

Age and Condition Restrictions

Safety and effectiveness are not established for the pediatric population (under 18 years). Use should generally be avoided in older adults over 80 years. During pregnancy, Revoxin is contraindicated from 30 weeks gestation onward. Special caution and monitoring are required for patients with advanced renal disease, hepatic impairment, or established cardiovascular conditions.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Revoxin’s official interaction profile is defined by specific administration constraints and documented pharmacokinetic and pharmacodynamic outcomes.


Official Restrictions and Contraindications

Co-administration is contraindicated for the management of pain in the perioperative setting of Coronary Artery Bypass Graft (CABG) surgery. Official documentation also advises prohibiting co-use with other systemic Non-Aspirin NSAIDs and with analgesic doses of Aspirin due to the officially recognized risk of additive gastrointestinal adverse events.


Pharmacokinetic and Exposure Interactions

The medicine's elimination pathway involves hepatic metabolism, specifically as a substrate of the CYP2C9 enzyme. This established metabolic route means that individuals classified as intermediate or poor CYP2C9 metabolizers will have a pharmacokinetically documented risk of higher systemic exposure to Revoxin. Furthermore, Revoxin can affect the clearance of co-administered medicines, increasing the plasma concentrations of drugs such as Lithium and Digoxin.


Pharmacodynamic and Substance Interactions

In terms of pharmacodynamic interactions, co-administration with agents that interfere with hemostasis, including Warfarin, SSRIs, or SNRIs, is officially associated with an increased regulatory risk of serious bleeding complications. The medicine also has a documented interaction that may diminish the antihypertensive effect of ACE Inhibitors, ARBs, and Diuretics. This pharmacodynamic outcome is of heightened concern in the elderly, volume-depleted, or renal-impaired populations. Finally, consumption of Alcohol is noted in regulatory information to increase the risk of gastrointestinal bleeding.

Mechanism of Action

️ How Revoxin Works

Revoxin's mechanism is based on targeted intervention within signaling systems that govern processes associated with inflammation and elevated body temperature. Its action is strictly defined by inhibiting specific enzymes and modulating the downstream biochemical cascade.


Non-Selective Inhibition of COX Enzymes

Revoxin's active ingredient is a reversible competitive inhibitor of both the Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2) enzymes. This dual action constitutes the molecular foundation of the drug, blocking the initial enzymatic step in the Arachidonic Acid Cascade.


Modulation of Prostaglandin Biosynthesis

By inhibiting the COX enzymes, the drug prevents the subsequent biosynthesis and release of various prostaglandins—chemical mediators that sensitize nerves and reset the body's core temperature set-point. This cascade results in the physiological dampening of nociceptive signaling and the modulation of the signaling that controls the body's thermoregulatory set-point.


Dual Physiological Constraints

The non-selective action on COX enzymes leads to dual physiological consequences. While inhibition of COX-2 modulates signaling associated with physiological responses, the simultaneous inhibition of constitutive COX-1 interferes with the production of prostaglandins necessary for gastrointestinal mucosal maintenance and the prostaglandins involved in renal blood flow autoregulation.

Dosage and Administration Information

How Revoxin is Used

Revoxin (piroxicam) is utilized according to administration principles aligned with its long plasma half-life. The primary goal of usage is to maintain the lowest effective dosage for the shortest duration.


Official Routes, Dosing, and Frequency

Category Usage Principle
Administration Routes Oral (Capsule/Tablet) and Topical (Gel/Cream) are the standard routes. The Intramuscular (IM) Injection route is also approved, but its use is strictly limited to a maximum of 2 to 3 days when oral administration is not possible.
Maintenance Dosing (OA/RA) For chronic conditions like osteoarthritis and rheumatoid arthritis, the standard maintenance range is 10 mg to 20 mg per day. The maximum recommended daily dose for long-term use is 20 mg.
Dosing Frequency The standard regimen is once daily (qD), reflecting the drug's extended duration of action. The 20 mg daily dose may be given in divided doses (10 mg twice daily).

Administration Conditions and Adjustments

Oral formulations of Revoxin are to be taken preferably with or after food to aid gastrointestinal tolerability. Due to the drug's pharmacokinetics, the full effect of any dosage adjustment on chronic regimens should not be assessed until two weeks of consistent use have passed, as this time is needed to reach steady-state plasma concentrations.

In specific populations, lower doses and close monitoring are indicated. This includes older adults and individuals identified as CYP2C9 poor metabolizers, who may require a dose reduction due to impaired clearance and elevated plasma levels. If a scheduled dose is missed, the standard procedure is to skip the missed dose and resume the normal schedule if the next dose is due shortly, without doubling the dose.

Recent Clinical Evidence

Research evidence / Overview of Studies for Revoxin (Piroxicam)


Evidence for Symptom Management in Osteoarthritis and Rheumatoid Arthritis

The research for Revoxin in chronic inflammatory conditions like osteoarthritis (OA) and rheumatoid arthritis (RA) involves controlled clinical trials and large analyses that combine data from multiple studies. Research explored whether symptoms changed over time in adults diagnosed with these conditions. Short-term Randomized Controlled Trials (RCTs) were conducted, exploring outcomes related to physical discomfort. These studies primarily monitored outcomes such as pain intensity, joint stiffness, and outcomes reflecting daily functioning or activity level, as reported by patients. The evidence for these indications is generally drawn from the volume of controlled trials. However, the follow-up durations were limited in most core controlled research, meaning there is limited information for long-term outcomes regarding the observed effects on functional imbalance.


Evidence for Acute and Intermittent Conditions

Revoxin was also evaluated in studies focusing on episodes where symptoms become more noticeable, such as acute gouty arthritis, specific musculoskeletal disorders, and primary dysmenorrhea. The studies conducted were often very short-term RCTs, focusing on outcomes related to episodic or acute changes. Findings for acute musculoskeletal disorders reported outcomes related to physical discomfort and functional status over the short term. Studies explored symptom intensity or variability over a single episode of primary dysmenorrhea. The quality of the evidence varies across studies and is generally categorized as moderate. The key limitation is that follow-up durations were strictly limited to the acute episode.


Evidence Gaps and Areas of Research Uncertainty

Studies describe group patterns, not personal outcomes, and research outlines what is known—and what is still uncertain. One major gap is the lack of extensive, continuous, controlled trials exploring outcomes over long periods in daily-life functioning. Follow-up durations were limited across many key studies, meaning the data available for long-term outcomes are still emerging. Comparative evidence is also lacking in some areas, particularly concerning current protocols for acute episodic conditions. Subgroup findings are uncertain, and data for certain high-risk or specific comorbidity groups remain insufficient, meaning results apply only to the populations studied in the trials.

Key Studies & References

  1. Efficacy and safety of piroxicam revisited: a global meta-analysis of randomised clinical trials

Frequently Asked Questions (FAQ)

Common questions about Revoxin (FAQ)

Q: How quickly does Revoxin usually start to work?

According to official product information, the concentration of the active ingredient in the bloodstream typically peaks within three to five hours after a person takes an oral dose. Clinical studies report that therapeutic effects may be evident early in the treatment course.

Q: How long does the effect of Revoxin last?

The active ingredient in Revoxin has a relatively long half-life of approximately 50 hours. This prolonged duration of action is the reason why the medicine is typically prescribed for a once-daily dosing regimen.

Q: Does Revoxin affect blood pressure?

Official warnings state that Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), the class of medicine Revoxin belongs to, can potentially cause new high blood pressure or worsen existing high blood pressure. This is a factor that is often monitored during use.

Q: What kind of monitoring is typically done when taking Revoxin?

Regulatory documents advise that certain factors be checked while taking the medicine. This may involve monitoring blood pressure, assessing kidney function, and checking blood levels such as hemoglobin or hematocrit, particularly for patients with certain risk factors.

Q: Does Revoxin cause weight gain?

Official data reports that weight changes have been included in the adverse reaction profile. Rapid weight gain has been noted among the rare events reported.

Q: What is the black box warning associated with Revoxin, if any?

Yes, official FDA labeling includes a Boxed Warning. This warning highlights the potential risks of serious cardiovascular thrombotic events (like heart attack and stroke) and serious gastrointestinal events (including bleeding, ulceration, and perforation).

Q: What is the purpose of the 'inactive ingredients' in Revoxin?

The inactive ingredients, or excipients, are listed in the official formulation details. These components are essential for manufacturing and delivering the medicine, providing structure, stability, and helping to ensure the active substance is properly absorbed.

Q: What's the difference between Revoxin and [Similar Drug Name]?

The active ingredient in Revoxin, piroxicam, belongs to the oxicam class of NSAIDs. It is officially distinguished from many other conventional NSAIDs by its extended plasma half-life of approximately 50 hours.

Q: Can Revoxin make you feel tired?

Regulatory documents report that side effects under the Nervous System category have included fatigue and general unusual tiredness or weakness in some users.

Q: Is hair loss a possible side effect of Revoxin?

The full list of reported adverse reactions indicates that hair loss or thinning of the hair has been noted as a less common event in the clinical data.

Q: Does Revoxin interact with common painkillers like ibuprofen?

Official documentation advises against the co-administration of this medicine with other Non-Aspirin NSAIDs, a category that includes painkillers such as ibuprofen. This is due to an established increased risk of serious gastrointestinal adverse events when these drugs are co-administered.

Q: Are there any foods or drinks that should be avoided when using Revoxin?

Regulatory information specifically notes that consuming alcohol is associated with an increased risk of gastrointestinal bleeding while using this medicine. No other specific foods or non-alcoholic drinks are listed in the official warnings.

Q: Is Revoxin safe for children to use?

Official documents clearly state that the safety and effectiveness of the medicine have not been established for the pediatric population, which includes individuals under 18 years of age.

Q: Is Revoxin used for conditions other than [Main Use]?

The medicine is officially indicated for the relief of the signs and symptoms of osteoarthritis and rheumatoid arthritis. It has also been studied for acute conditions such as gout and specific musculoskeletal disorders as defined by its regulatory approvals.

Q: Is it normal to feel a mild headache when starting Revoxin?

Headache is listed in regulatory documents as a common side effect. This means it has been reported to occur in a statistically higher number of users (between 1 and 10 out of every 100) and is a known possibility when starting the medicine.

Q: Can Revoxin cause dry mouth?

The adverse event profile includes dry mouth as an effect that has been occasionally reported in patients using the active substance.

Q: Does Revoxin cause sun sensitivity?

Sun sensitivity, also known as photosensitivity, has been reported as a possible adverse reaction associated with the use of the medicine, and official safety information advises caution regarding sun exposure.

Q: Can men and women use Revoxin for the same conditions?

Regulatory documents list the official indications for this medicine, such as osteoarthritis and rheumatoid arthritis, generally for use in adults. The approved conditions are not differentiated or restricted based on the user's sex.

Q: Are there long-term side effects associated with Revoxin use?

Official warnings explicitly indicate that the risk of serious adverse reactions, particularly serious cardiovascular thrombotic events and gastrointestinal events, may increase with the duration of use of this class of medicine.

Q: Is it possible to become dependent on Revoxin?

The active ingredient, piroxicam, is a Nonsteroidal Anti-Inflammatory Drug (NSAID). There are no official regulatory warnings or indications that the medicine carries a risk of dependence or has potential for abuse.

Q: What are the contraindications listed for Revoxin?

The medicine is officially contraindicated in several situations. These include known hypersensitivity to the active ingredient or other NSAIDs, a history of allergic-type reactions (like asthma or hives) to NSAIDs, and use in the setting of coronary artery bypass graft (CABG) surgery.

Q: Can Revoxin be taken while breastfeeding?

Regulatory information indicates that the active ingredient is excreted into human milk. Official guidance advises against the use of the medicine in nursing mothers, particularly when nursing a newborn or preterm infant, as clinical safety has not been fully established.

Q: Why does the packaging of Revoxin say 'may cause drowsiness'?

Drowsiness is listed in the official adverse reaction data under the Nervous System effects category. Regulatory bodies require that this possible side effect be noted on the packaging to inform patients of the risk.

Q: Does Revoxin contain gluten or lactose?

Official excipient lists for some formulations of the capsule or tablet show the inclusion of lactose as an inactive ingredient. Patients with dietary restrictions should refer to the specific ingredients list for their prescribed formulation.

Q: When was Revoxin first approved for use?

The active ingredient (Piroxicam) was first approved for medical use by the U.S. Food and Drug Administration (FDA) on April 6, 1982.

Q: Is it common for doctors to start on a low dose of Revoxin?

Official guidelines mandate that this type of medicine must be used at the lowest effective dosage for the shortest duration consistent with individual patient goals. This establishes the regulatory principle governing the initiation of therapy.

How should Revoxin be stored and disposed of?

The official storage and disposal guidelines for Revoxin (Piroxicam) are structured to maintain the product's quality and ensure environmental compliance.


Storage Requirements

Condition Official Mandate
Temperature Store at controlled room temperature (20 C to 25 C), permitting excursions between 15 C and 30 C.
Protection Protect from light and moisture and store the medicine away from excessive heat.
Packaging Keep the product in the original, tightly closed container.

Disposal and Safety

Official labeling mandates that the medicine be kept out of the sight and reach of children.

For disposal, unused or expired product must be discarded in accordance with local regulations.

Regulators instruct against disposing of medicines via wastewater or household waste, emphasizing that disposal should occur through approved collection programs or regulated waste procedures.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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