Reumafen

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Reumafen

Property Description
Active Ingredient Ibuprofen
Pharmacological Class Nonsteroidal Anti-inflammatory Drug (NSAID)
Common Therapeutic Purpose Symptomatic relief of pain, inflammation, and fever
Origin Synthetic compound (Propionic acid derivative)
Primary Forms Tablet, Capsule, Oral suspension

What Type of Medicine is Reumafen (Ibuprofen)?

Reumafen is a medicinal product defined by its sole active ingredient, Ibuprofen, which firmly establishes it within the core pharmacological class of Nonsteroidal Anti-inflammatory Drugs (NSAIDs). This classification denotes that Reumafen functions as a multifaceted anti-inflammatory agent, simultaneously delivering analgesic (pain-relieving) and antipyretic (fever-reducing) effects. As an NSAID, Ibuprofen is utilized for its effects on pain and inflammation, belonging to a widely used group of substances that is clinically recognized for its broad application in managing general discomfort.

Composition, Origin, and Available Forms

Ibuprofen, the active constituent, is a synthetic compound that belongs to the propionic acid derivative chemical family. For oral administration, Reumafen is presented in multiple common dosage forms, including the standard tablet, the film-coated tablet, the capsule, and a liquid oral suspension. The active substance Ibuprofen is available in various immediate-release oral forms for systemic absorption. This range of pharmaceutical preparations ensures that the single-ingredient product is accessible to different target audiences, including those requiring the oral suspension form.

General Purpose and Core Therapeutic Action

The fundamental general purpose of Reumafen is the symptomatic treatment of pain, inflammation, and fever by interrupting a key biochemical pathway. The drug achieves its effect by inhibiting the activity of specific enzymes, thereby suppressing the synthesis of prostaglandins, which are local hormones that trigger pain and swelling. By modulating the chemical signals responsible for the inflammatory response, Reumafen helps to reduce the sensation of pain, mitigate associated inflammation, and lower an elevated fever.

Regulatory References

  1. U.S. National Library of Medicine

What side effects are possible with Reumafen?

Possible Side Effects and Safety Information

The safety profile of Reumafen, which contains Ibuprofen, is characterized by classifications and constraints established in official regulatory documents. Adverse reactions are grouped by the affected System-Organ-Class (SOC), including Gastrointestinal, Nervous System, Skin, and Cardiovascular Disorders.


The regulatory frequency framework classifies potential effects to establish expected occurrence rates:

  • Common Reactions (affecting up to 1 in 10 patients) include Gastrointestinal symptoms like dyspepsia, nausea, vomiting, and abdominal pain, as well as Headache and Dizziness.
  • Uncommon Reactions may include hypersensitivity reactions (e.g., urticaria) or gastrointestinal ulceration.
  • Rare and Very Rare classifications cover less frequent but potentially significant reactions, such as severe cutaneous adverse reactions (like Stevens-Johnson syndrome), acute renal failure, and severe hepatic dysfunction.

Serious Adverse Reactions and Safety Constraints

The official labeling documents potential Serious Adverse Reactions, most notably Serious Cardiovascular Thrombotic Events (such as myocardial infarction and stroke) and severe Gastrointestinal Events (including bleeding and perforation), which can be fatal. The risk of these serious events is officially stated to increase with higher doses and longer durations of use.

Population-Specific Safety: Older adults are documented to have an increased frequency of adverse reactions, particularly serious gastrointestinal bleeding. Furthermore, the medicine is formally contraindicated for the management of peri-operative pain in the setting of Coronary Artery Bypass Graft (CABG) surgery, reflecting specific regulatory limitations on its use.

Overdose and Emergency Response

Reumafen Overdose and When to Seek Help

The official regulatory profile for Reumafen (Ibuprofen) overdose outlines specific clinical manifestations and mandated emergency actions. Overdose is officially documented to range from mild symptoms to severe, life-threatening outcomes.

Documented manifestations commonly include gastrointestinal effects such as nausea, vomiting, and epigastric pain. Central Nervous System (CNS) effects are also listed, including drowsiness, lethargy, headache, and confusion. Severe outcomes are documented to potentially include convulsions, coma, metabolic acidosis, acute renal failure, and respiratory depression.

Immediate medical attention must be sought for suspected overdose, especially if severe manifestations are present. This urgent action is required because no specific antidote is known according to regulatory information. Management is stated to be symptomatic and supportive, and may involve procedures such as activated charcoal or gastric lavage under professional guidance.

The official label notes specific considerations, including an increased risk of CNS depression in children and a higher risk of acute renal failure in patients with pre-existing renal or hepatic impairment. Continuous hospital monitoring of vital signs, renal function, and serum electrolytes may be required.

Therapeutic Uses of Reumafen

What Reumafen Treats: Main Uses and Benefits

The therapeutic application of Reumafen is centered on providing supportive relief across key symptomatic domains, and supports patients during difficult episodes by easing distress. The medicine is relevant for easing pain, inflammation, and fever.

The medication is commonly used to help with symptoms related to physical discomfort and systemic imbalance across conditions such as headache, toothache, primary dysmenorrhea (menstrual cramps), and joint pain associated with conditions like Osteoarthritis and Rheumatoid Arthritis. It is applied in addressing symptoms related to inflammatory or irritative states and is relevant for controlling elevated body temperature (fever) during acute episodes, such as those accompanying colds and influenza.

“The primary goal is symptomatic management, providing support that helps ease the overall symptom burden when symptoms become more noticeable.”

This short-term symptomatic assistance helps improve day-to-day comfort during symptomatic periods and may help patients cope more steadily with symptom fluctuations.


Quick Fact: Relief for Inflammation Reumafen assists with maintaining functional stability by addressing the swelling and stiffness often associated with musculoskeletal conditions and minor sprains or strains.

Regulatory References

  1. U.S. FDA official indications for Ibuprofen

Eligibility and Restrictions for Use

Who Can and Cannot Use Reumafen?

This section outlines the official population eligibility and contraindications for Reumafen (Ibuprofen), based strictly on government regulatory documents.


Contraindicated Populations (Must Not Use)

Condition/Population Restriction Type
Aspirin/NSAID Hypersensitivity Absolute Contraindication
Active or Recurrent Peptic Ulcers/GI Bleeding Absolute Contraindication
Severe Heart, Liver, or Renal Failure Absolute Contraindication
Coronary Artery Bypass Graft (CABG) Surgery Contraindicated (Peri-operative pain)
Third Trimester of Pregnancy Absolute Contraindication

Restricted and Conditional Use

Age Group/Condition Official Status
Infants under 6 months of age Use Not Established
Older Adults (Geriatric) Use with Caution (Increased risk of adverse reactions)
Mild to Moderate Organ Impairment Use with Caution (Lowest effective dose)
First and Second Trimester of Pregnancy Not Recommended (Unless necessary)

Adults and children aged 6 months and older who do not possess any of the specified contraindications or limiting risk factors are eligible for use under standard labeled conditions. The medicine may also impair female fertility and is therefore not recommended for women attempting to conceive. Use during lactation is generally considered permissible due to minimal transfer into breast milk.

What should I know about interactions with other medicines?

Reumafen (Ibuprofen) exhibits officially documented interaction patterns primarily through Pharmacodynamic (PD) and Pharmacokinetic (PK) mechanisms, as outlined in government regulatory labeling. The co-administration with other medicinal products may result in altered drug exposure or enhanced risk of specific adverse effects.

Documented Interaction Patterns

Interaction Type Interacting Substances Regulatory Outcome Statement
PK Interaction Lithium, Methotrexate Decreased renal clearance results in increased plasma concentration of the co-administered drug.
PK Interaction CYP2C9 Inhibitors (e.g., Fluconazole) Co-administration may increase Ibuprofen exposure.
PD Interaction Anticoagulants (e.g., Warfarin) Potentiation of the anticoagulant effect, increasing bleeding risk.
PD Interaction Diuretics, ACE Inhibitors Diminution of the antihypertensive and diuretic effects.
Additive Risk Corticosteroids, SSRIs Officially documented increased risk of gastrointestinal bleeding.

Administration Restrictions

Contraindicated Combinations formally include other Nonsteroidal Anti-inflammatory Drugs (NSAIDs) and high-dose Acetylsalicylic Acid (Aspirin). For patients co-administering immediate-release low-dose Aspirin, the regulatory label specifies a timing separation rule: Reumafen must be administered at least eight hours before or thirty minutes after the Aspirin dose to avoid interference with its antiplatelet effect. The official label also notes that co-administration with alcohol or the herbal product Ginkgo biloba is associated with an increased bleeding risk. Elderly patients are classified as having an increased risk for serious GI events and renal dysfunction when combined with interacting drugs.

Mechanism of Action

How Reumafen Works

Blocking the Synthesis of Prostaglandin Mediators

The drug's mechanism involves the reversible, non-selective inhibition of the Cyclooxygenase (COX) enzymes, both COX-1 and COX-2. By limiting the enzymes' ability to convert arachidonic acid, Reumafen suppresses the synthesis of prostaglandins, which are powerful lipid mediators associated with nociceptor sensitization and local vascular and cellular responses.

Modulating Peripheral and Central Signaling

The suppression of prostaglandins results in a dual physiological effect: peripheral desensitization of pain-sensing nerve endings (nociceptors) and a central reset of the body's thermoregulatory set-point in the hypothalamus. This concerted action reflects the mechanism's influence on the chemical drivers of sensitization and temperature dysregulation, resulting in the adjustment of the elevated thermoregulatory set-point.

Mechanistic Constraints

The mechanism is functionally restricted to physiological responses mediated by prostaglandin activity; consequently, it is irrelevant for signaling mediated by activated nociceptors arising from prostaglandin-independent pathways, such as purely neuropathic signaling. The degree of COX inhibition also imposes a ceiling effect, limiting the maximal possible alteration of pathway activity irrespective of dosage changes.

Dosage and Administration Information

How to Use Reumafen

The usage of Reumafen is defined by administration parameters across its various forms. The medication is available for oral administration as tablets, capsules, and an oral suspension, and also as a solution for intravenous infusion in controlled clinical settings.

For acute, symptomatic relief in adults, a standard single oral dose ranges from 200 mg to 400 mg, typically taken every 4 to 6 hours as needed. The total consumption must not exceed the non-prescription maximum of 1,200 mg in a 24-hour period. When utilized for chronic inflammatory conditions, such as certain forms of arthritis, the total daily dose is administered in divided doses and may range up to the maximum of 3,200 mg.

Labels advise that oral forms may be taken with food or milk to help ease gastrointestinal administration. If using the liquid oral suspension, the bottle must be shaken well, and the dose must be measured precisely using the calibrated device provided. Dosing for pediatric patients follows a weight-based calculation (mg/kg). For older adults and patients with known mild to moderate renal or hepatic impairment, labels generally direct the use of the lowest effective dose for the shortest duration necessary. If a scheduled dose is missed, particularly for intermittent use, it should be skipped if the next dose is due shortly; taking two doses at once to compensate is not an authorized procedure.

Recent Clinical Evidence

Research evidence / Overview of studies for Reumafen

Evidence for Short-Term Pain Relief (Acute Mild-to-Moderate Pain)

This section summarizes the structure of Randomized Controlled Trials (RCTs) and meta-analyses that form the primary research base for Reumafen in acute contexts, such as headache, dental pain, and minor injuries. The focus is on the study designs used to measure short-term changes in pain intensity.

Research was evaluated in trials assessing short-term or episodic symptom patterns. Studies monitored changes in pain intensity using standardized scales, and research highlights changes measured during the study period, tracking the proportion of participants who met pre-defined relief criteria. Findings describe patterns observed in the studies related to a defined dose point, suggesting that beyond a certain single dose amount, measurements did not report further increases in measured pain outcomes (referred to in literature as a dose ceiling).


Evidence for Fever Reduction (Antipyresis)

This section describes the clinical trial landscape that examines the research that evaluates elevated body temperature. It specifically addresses the types of comparative studies conducted in both adults and children, and the duration of observation periods.

Research monitored outcomes linked to inflammatory or irritative states, specifically measuring the change in body temperature from the starting point and the duration of the temperature-reducing effect. Research describes that studies monitored responses over defined time intervals that were typically short-term, such as a single administration or up to a few days. While research reports how symptoms evolved in the observed populations, most trials focused on otherwise healthy individuals experiencing acute fever.


Evidence for Symptom Studies in Chronic Conditions

This part overviews the research structure, including long-term RCTs and observational studies, related to the use of Reumafen for symptom studies in chronic inflammatory and rheumatic conditions, such as Osteoarthritis. The summary details the functional and activity-level outcomes that were monitored in these studies.

Studies monitored patient-reported outcomes describing perceived discomfort in Adults with conditions marked by functional limitations, such as Osteoarthritis. The research examined outcomes reflecting daily functioning or activity level, such as changes in stiffness and recorded measurements on functional scales that track joint mobility. The studies were designed to monitor symptom change and function, and research does not determine whether the medicine affects the underlying disease process itself.


Research Gaps and Unanswered Questions

This final section synthesizes the main evidence gaps and areas identified by regulators and peer-reviewed literature where data remains limited or uncertain.

There is limited information for long-term outcomes when considering continuous administration for periods exceeding six months to a year. Follow-up durations were limited in many acute studies, and research does not determine the specific outcomes for an individual based on the group patterns reported in studies. Furthermore, research has observed that the analgesic ceiling dose may lead to additional doses taken at once not reporting further increases in measured pain outcomes.

Frequently Asked Questions (FAQ)

Common questions about Reumafen (FAQ)

Q: What is the main purpose of Reumafen, outside of the conditions listed in the core text?

Official documents indicate that the general purpose of Reumafen is the symptomatic relief of pain, fever, and inflammation. In addition to treating chronic conditions like arthritis, the medication is also sometimes specifically listed as an indication for acute uses such as painful menstrual periods or migraine headaches.

Q: Does Reumafen work for different types of pain, such as nerve pain or headache?

Regulatory information states that this medicine is indicated for the relief of mild to moderate pain, which includes acute pain like headaches. Its mechanism works by blocking chemical mediators called prostaglandins. Because of this, it is generally considered ineffective for pain driven by other pathways, such as purely neuropathic (nerve) pain.

Q: Is Reumafen known to affect blood pressure?

Official product information notes that high blood pressure, known as hypertension, and salt and fluid retention are potential adverse effects of this medication. Furthermore, it may reduce the blood pressure-lowering effect of certain other medicines used to treat hypertension.

Q: How quickly does Reumafen start to take effect for pain or fever?

According to official pharmacokinetic data, the drug typically reaches its maximum concentration in the blood within one to two hours after taking an oral dose. This peak plasma concentration generally correlates with the onset of the medicine's effects on pain or fever.

Q: If I take Reumafen regularly, how long should it take to feel the full effects?

For individuals using the drug to manage severe or continuing conditions such as certain types of arthritis, regulatory information indicates that the full beneficial effects may take longer to feel. It is described that a period of up to two weeks or more may be required to reach the full therapeutic effect.

Q: What is the general duration of Reumafen's action after a single dose?

The effective duration of the drug's action is suggested by the recommended dosing interval provided in the official guidance. For pain and fever, the drug is typically administered every four to six hours as needed.

Q: Can Reumafen interact with common over-the-counter pain relievers or cold medicines?

The use of Reumafen is contraindicated with other Nonsteroidal Anti-inflammatory Drugs, including other products containing ibuprofen or high-dose aspirin. Due to the wide variety of ingredients in cold medicines and combination products, interaction guidance should be sought from a qualified healthcare provider.

Q: Are there any specific food or beverage interactions to know about when taking Reumafen?

Official product labels specifically note that co-administration with alcohol is associated with an increased risk of gastrointestinal bleeding. Additionally, oral forms of the medicine may be taken with food or milk, which can help to reduce the chance of experiencing stomach discomfort.

Q: Is Reumafen a common medication prescribed for children, and if so, for what uses?

According to regulatory guidelines, Reumafen is indicated for the temporary reduction of fever and for the relief of pain in children aged six months and older. Administration amounts for pediatric patients are calculated based on the child’s body weight.

Q: Are there different forms of Reumafen available (e.g., tablet, capsule, suspension, topical gel)?

Widely approved oral dosage forms include tablets, capsules, and the liquid oral suspension. While topical ibuprofen products exist, the U.S. Food and Drug Administration (FDA) has not approved over-the-counter topical versions for general marketing in the U.S.

Q: Why do official documents sometimes mention blood monitoring while taking Reumafen?

For individuals undergoing long-term therapy with this medication, periodic laboratory monitoring may be recommended by official documents. This monitoring often involves blood tests to check for potential adverse effects on the kidneys, which could lead to renal failure, and to check blood counts for signs of anemia.

Q: What is the general information about Reumafen use if a person has systemic lupus erythematosus (SLE)?

Official safety warnings indicate that a rare side effect called aseptic meningitis has been observed in some patients using this medicine. This specific reaction is noted as being more likely to occur in patients who have systemic lupus erythematosus (SLE) or related connective tissue diseases.

Q: Can Reumafen cause problems with fluid retention or swelling in the ankles?

Fluid retention and swelling, medically known as edema, are listed as potential adverse reactions in the official labeling. Regulatory documents state a need for caution in populations with fluid retention or heart failure.

Q: What information is available about Reumafen's effect on hearing or causing ringing in the ears?

Official reports of potential adverse reactions include ringing in the ears, known as tinnitus, in association with the drug's use. Cases of hearing loss have also been reported in product information summaries.

Q: Can taking Reumafen increase sensitivity to sunlight?

Regulatory documents have reported that photosensitivity reactions, which involve an increased sensitivity to sun or UV light, may occur. These types of skin reactions are generally classified as uncommon or rare events.

Q: Why is Reumafen sometimes associated with changes in ocular (eye) function?

Visual disturbances are cited as reported adverse effects in the official labeling documents. These ocular (eye) changes can include temporary blurred vision, a reduction in visual clarity, or changes in how colors are perceived.

Q: What kind of monitoring is typically done by doctors for patients on long-term Reumafen therapy?

For patients receiving chronic treatment, regulatory warnings advise that regular monitoring of several key physiological systems may be necessary. This typically includes the gastrointestinal tract, blood pressure, heart function, and renal (kidney) function.

Q: Is Reumafen ever used to treat gouty arthritis?

According to official medical guidelines, this non-steroidal anti-inflammatory drug (NSAID) is often cited as a treatment option for the pain and inflammation related to acute gout attacks. While not listed as a primary indication on all regulatory documents, this anti-inflammatory action is often cited in medical guidelines for acute gout.

Q: Are there specific symptoms that require immediately stopping Reumafen and seeking medical attention?

Official patient information leaflets detail symptoms of a serious adverse event that warrant immediate evaluation. These may include chest pain, difficulty breathing, slurring of speech, sudden weakness, or signs of internal bleeding such as black, tarry stools or vomiting blood.

How should Reumafen be stored and disposed of?

Official Storage and Disposal Instructions

Reumafen, containing ibuprofen, must be stored according to regulatory requirements to ensure its stability. The medicine should be kept at Controlled Room Temperature, typically ranging from 20 C to 25 C (68 F to 77 F). The product must be protected from excessive heat, moisture, and direct sunlight. Always store the medication in its original container with the lid tightly closed.

For liquid forms, it is specified that the product must not freeze. It is a mandatory requirement to keep all medicines out of the sight and reach of children.

Unused or expired Reumafen should be disposed of via a drug take-back program if available. If not, follow the official instructions to mix the medicine with an undesirable substance before discarding it in the household trash. The medication must not be flushed down the toilet or poured down the sink.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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