Components:
Medically reviewed by Fedorchenko Olga Valeryevna, PharmD. Last updated on 26.06.2023
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Oral
Adjunct in partial seizures
Adult: Initially, 300 mg daily for 1 wk; thereafter, the total daily dose is adjusted by max wkly increments of 150 mg, according to response and tolerability, to a usual maintenance dose of 600-1,200 mg daily. Doses are to be given in 3 divided doses daily.
Elderly: ≥65 yr Initially, 150 mg daily, followed by max wkly increments of 150 mg to a max maintenance of 900 mg daily.
Max total daily starting dose: 300 mg (100 mg tds). Thereafter, the total daily dose is increased by max of 150 mg every wk. Maintenance dose: 600-1,200 mg daily (max). Elderly Total daily starting dose: 150 mg, increased by a max of 150 mg every wk. Max: 750 mg/day (250 mg tds). Moderate or severe renal & hepatic impairment Total daily starting dose 150 mg, increased by 50 mg every wk. Max: 600 mg/day. All doses are to be taken in 3 divided doses each day.
Hypersensitivity.
Decreased Retigabine systemic exposure w/ phenytoin, carbamazepine. May increase duration of anaesth induced by some anaesth eg, thiopental Na. Ethanol may result in increase visual blurring. Falsely elevated readings of clinical laboratory assays of both serum & urine bilirubin.
Dizziness, somnolence, fatigue, confusional state, aphasia, abnormal coordination, tremor, balance disorder, memory impairment, gait disturbance, blurred vision, constipation, anxiety, psychotic disorders, paraesthesia, wt gain, nausea, dyspepsia, urinary retention and hesitation, dysuria; discolouration of ocular tissues (including the retina), skin, lips, and nails; prolongation of QT interval.