Релиум

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Релиум

Quick Facts

Property Description
Active ingredient Diazepam (C16H13ClN2O)
Form Tablets, Injection solution, Oral solution
Pharmacological class Benzodiazepine derivative, Anxiolytic agent
Common purpose Relieves anxiety, muscle spasm, and convulsive states
Origin Synthetic compound

What Type of Medicine is Релиум (Diazepam)?

Релиум is the established trade name for a prescription-only medicine containing the active substance Diazepam. This compound is a synthetic compound classified within the benzodiazepine derivative family. The core chemical entity is defined by the formula C16H13ClN2O, confirming its structure as a 2H-1,4-Benzodiazepin-2-one derivative. The substance's profile is clinically recognized for its utility as a foundational anxiolytic agent for managing acute states.

Physical Forms and General Therapeutic Purpose

Релиум is provided across multiple pharmaceutical preparations, specifically including solid Tablets, a liquid Oral solution, and a sterile Injection solution supplied in ampoules. This versatility in dosage form(s) is a critical feature, allowing administration via oral, intravenous (IV), and intramuscular (IM) route(s) of administration.

The overall therapeutic purpose of this substance is rooted in its ability to achieve broad central nervous system (CNS) depression by enhancing the activity of the inhibitory neurotransmitter GABA. This mechanism results in significant utility across three primary general functions: acting as a strong sedative-hypnotic agent, serving as an effective anticonvulsant to control excessive electrical activity, and functioning as a skeletal muscle relaxant to alleviate muscle rigidity and spasm.

Regulatory References

  1. NIH DailyMed: Diazepam Label
  2. MedlinePlus: Diazepam Drug Information

What side effects are possible with Релиум?

The safety profile of Релиум (Diazepam) is defined by classifications and statements documented in official government regulatory texts, such as those published by the FDA and EMA. Adverse reactions are grouped by the affected System Organ Class and the estimated frequency of occurrence.

Frequency Classification and Systems

Side effects related to the central nervous system (CNS) depressant activity are commonly documented:

Classification Examples of Documented Adverse Reactions
Common Drowsiness, fatigue, muscle weakness, and ataxia (impaired co-ordination). These effects are more frequently observed at the start of treatment or following a dose increase.
Uncommon/Rare Respiratory depression, paradoxical reactions (e.g., agitation, hostility), memory impairment (anterograde amnesia), and slurred speech (dysarthria).

Serious Safety Considerations

Official labeling addresses specific, clinically significant risks. Respiratory depression is a serious adverse reaction, particularly with rapid intravenous administration or in individuals with pre-existing respiratory issues. The risk of developing physical and psychological dependence and subsequent withdrawal syndrome is a critical safety concern documented with prolonged and continuous use.

Safety Considerations for Special Populations

Regulatory texts mandate specific caution for certain groups. Older adults exhibit an officially documented increased sensitivity to CNS effects, which may increase the risk of falls. The use of Diazepam is contraindicated in individuals with severe hepatic insufficiency due to the potential for precipitating hepatic coma, as noted in authoritative product information.

Overdose and Emergency Response

Overdose and When to Seek Help

Officially documented information indicates that overdose with Релиум (Diazepam) results primarily from Central Nervous System (CNS) depression. Manifestations typically begin with mild signs such as somnolence, lethargy, ataxia, and diminished reflexes. The severity can range up to life-threatening outcomes, which are associated with high dosage, particularly when combined with other CNS depressants.

Severity Classification Documented Outcomes
Severe/Life-Threatening Profound sedation, coma, respiratory depression, cardiovascular collapse, and death.
Risk Factors Highest risk is noted with high dosage, particularly when combined with other CNS depressants, including alcohol.

Mandatory Emergency Actions

Immediate medical attention is officially required upon suspected overdose or the manifestation of severe symptoms like profound sedation, respiratory compromise, or loss of consciousness. Emergency services must be contacted immediately in such scenarios. The regulatory management protocol emphasizes symptomatic and supportive treatment, requiring continuous cardiorespiratory monitoring and supportive care to maintain the airway, breathing, and circulation. Although Flumazenil is described as an available antagonist, regulatory documents caution that it is not routinely recommended for reversal due to the risk of precipitating seizures. Specific populations, including the elderly and debilitated patients, are also documented as having an increased risk for severe CNS and respiratory effects.

Therapeutic Uses of Релиум

What Релиум Treats: Main Uses and Benefits

Релиум is commonly used to provide supportive, short-term symptomatic relief across certain domains involving symptoms of increased neurological or muscular activity. It is applied in clinical settings marked by temporary physiological imbalance. The medication is considered relevant for symptomatic support across several key therapeutic areas where symptoms may intensify.

The medication is considered relevant for addressing symptoms that create noticeable physiological strain, particularly those associated with acute anxiety, convulsive disorders, muscle spasms, and severe manifestations of alcohol withdrawal syndrome. It is relevant for easing symptomatic assistance when symptoms become temporarily overwhelming.

Domains of Symptomatic Support

Domain Focus of Symptomatic Support
Neurological Applied in situations involving acute or unstable seizure patterns
Muscular Contributes to easing pathological hypertonia and rigidity
Emotional/Autonomic Relevant for managing acute tension, fear, and excitation in crisis

The application of this medication helps maintain a sense of stability when symptoms are more noticeable, assisting with maintaining functional stability during periods of heightened discomfort. It contributes to improved day-to-day comfort and helps patients cope more steadily with symptom fluctuations.

Eligibility and Restrictions for Use

The eligibility profile for Релиум (Diazepam) is strictly governed by regulatory documentation, establishing clear criteria for use. The medicine is generally approved for adults and children 6 months of age and older under standard labeled conditions.

However, its use is absolutely contraindicated in several populations. These formal prohibitions include patients with a known hypersensitivity to the drug, myasthenia gravis, sleep apnoea syndrome, or severe hepatic and respiratory insufficiency. The label also prohibits the use of oral forms in pediatric patients under six months of age.

Eligibility is further restricted based on age and health status. Older adults must be prescribed a lower starting dose due to increased risk of accumulation and potential for central nervous system effects. Caution and dose reduction are mandated for patients with chronic respiratory insufficiency or mild to moderate liver impairment. Use is officially restricted or not recommended for pregnant and breastfeeding women, with the substance being excreted into breast milk. Patients with a history of substance abuse also require extreme caution due to the documented risk of dependence.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official regulatory documentation for Релиум (diazepam) highlights two primary interaction concerns: potentiation of Central Nervous System (CNS) depression and interference with metabolism by liver enzymes.

  • Opioids and CNS Depressants: Co-administration with opioids (such as oxycodone or hydrocodone) carries the most severe official warning, involving the risk of profound sedation, respiratory depression, coma, and death. This combination should be restricted only to patients when alternative treatments are inadequate, using the lowest effective dosages and minimum durations. The concurrent use of alcohol and other CNS depressants, including certain antipsychotics, muscle relaxants, and sedative antihistamines, is advised against due to additive depressant effects.

  • Inhibitors of Metabolism: Multiple medicines can increase and prolong the effects of diazepam by interfering with its breakdown by the hepatic enzymes CYP3A4 and CYP2C19. Explicitly listed inhibitors include certain antifungal agents (like ketoconazole), some antidepressants (e.g., fluvoxamine, fluoxetine), and stomach acid reducers (cimetidine, omeprazole). When these agents are co-administered, a lower dose of diazepam may be required. Conversely, enzyme inducers (e.g., carbamazepine, phenytoin) may decrease diazepam levels, potentially reducing its efficacy.

  • Food/Beverage Interaction: Consumption of grapefruit or large amounts of grapefruit juice is noted in official labeling as a risk factor, as it can inhibit the CYP3A4 enzyme and increase the systemic exposure and side effects of diazepam.

Mechanism of Action

The mechanism of Релиум (Diazepam) involves the precise modulation of the Central Nervous System ( CNS) by targeting key inhibitory pathways and modulating neuronal membrane potential.

Positive Modulation of the GABA A Receptor

The primary action is a molecular-level engagement with the GABA A receptor complex, where the drug acts as a Positive Allosteric Modulator (PAM) to increase the efficacy of the body's main inhibitory neurotransmitter, GABA. This interaction forces the receptor's intrinsic chloride ion channel to open more frequently, allowing chloride ion influx into the postsynaptic cell.

The Mechanism of Neuronal Hyperpolarization

The influx of chloride ions drives the nerve cell membrane into a state of hyperpolarization, displacing the membrane potential toward the Cl^- reversal potential. This generalized dampening of neuronal excitability is the core physiological effect. This inhibitory action propagates through central structures, including those associated with limbic system function.

Modulation of Spinal Reflex Arcs

Beyond the cortical and limbic systems, the enhanced inhibition extends to the neural circuits in the spinal cord and brainstem that govern motor function. By suppressing the polysynaptic reflex pathways, the drug dampens the activity of motor control pathways, resulting in a reduction of afferent and efferent signal transmission.

Dosage and Administration Information

How to Use Релиум: Official Administration Guidelines

The use of Релиум, which contains the active substance Diazepam, is strictly defined by regulatory documents regarding its route, dosage, frequency, and duration. The medication is officially available for oral intake (as tablets or solution), and for parenteral use via intravenous (IV) or intramuscular (IM) injection. For specific acute episodes, it is also approved for administration via the rectal gel and intranasal spray routes.

Dosing and Administration Patterns

Official adult oral dosing for conditions like anxiety or muscle spasm typically involves doses ranging from 2 mg to 10 mg, administered in divided doses 2 to 4 times per day. The use of oral forms is generally limited to short-term relief only. For parenteral use in acute situations, initial doses are often 5 mg to 10 mg. For treatment of severe convulsive states, the total IV dose is limited to a maximum of 30 mg, with doses repeated at specific intervals, such as every 10 to 15 minutes, under close supervision.

Procedural and Population Requirements

Specific administration rules apply to ensure proper use. The intravenous solution must be injected slowly, generally at a rate no faster than 5 mg per minute, and must not be mixed with other solutions in the syringe. The oral concentrate must be diluted in a liquid before consumption. For older adults and certain other populations, a significantly lower initial dose (e.g., 2 mg to 2.5 mg oral) is utilized compared to the standard adult regimen. Furthermore, forms intended for intermittent acute use are subject to strict official constraints, such as limiting administration to no more than two doses per single acute episode.

Recent Clinical Evidence

Research evidence / Overview of Studies for Релиум (Diazepam)

This section summarizes the structure of clinical research evidence for Релиум (Diazepam) as documented in regulatory filings and major scientific literature. It focuses exclusively on the types of studies conducted, the populations included, and what outcomes researchers formally investigated, without providing clinical advice or treatment interpretation.

Evidence for Acute Anxiety Symptoms

Research exploring the use of this compound for acute anxiety symptoms has primarily involved short-term Randomized Controlled Trials (RCTs) and systematic reviews. The compound was evaluated in research exploring how symptoms change over time, typically including adult participants experiencing periods of heightened symptoms of fear, tension, and excitation. Findings described patterns observed in the studies, reporting short-term changes in the measured intensity of anxiety symptoms over durations usually no more than four weeks. However, the evidence is limited regarding sustained symptom management, and long-term effects are not fully established.

Evidence for Acute Convulsive Disorders

The use of this compound in managing acute seizure states, such as Status Epilepticus, was evaluated in clinical trials, often comparing it against other established anti-seizure medications. These studies were applied to populations including both adults and pediatric patients (starting from age six months). Studies monitored episodic or acute changes by measuring the specific time interval required for seizure activity to cease following administration. Research describes the outcomes related to the need for additional rescue medications if seizure activity persisted. Data for certain subgroups of pediatric patients remain insufficient, with research ongoing.

Long-Term Studies and Evidence Gaps

The available research primarily explores short-term symptom changes, focusing on temporary physiological imbalance and acute relief. Follow-up durations were limited in most studies, and therefore, certainty remains low regarding the effects of using the compound over extended periods. Long-term effects are not fully established for any of the conditions studied, and the evidence base is largely focused on providing context for acute or episodic use.

Key Studies & References

  1. Efficacy of diazepam as an anti-anxiety agent: meta-analysis of double-blind, randomized controlled trials
  2. Alcohol withdrawal syndrome in medical patients (Review)

Frequently Asked Questions (FAQ)

Common questions about Релиум (FAQ)


Q: What kind of effects should I generally expect from Релиум?

A: The official purpose of Релиум is to provide relief from anxiety, muscle spasms, and certain convulsive states. The drug's mechanism of action is designed to produce anxiolytic and muscle-relaxant effects. Common side effects documented in regulatory reports include drowsiness, fatigue, muscle weakness, and impaired coordination (ataxia), particularly when treatment is initiated.

Q: Has Релиум been studied in children?

A: According to official product information, Релиум is approved for use in children aged 6 months and older for specific indications. Research has included pediatric patients in studies focused on managing acute seizure states. Regulatory guidelines establish specific parameters for use in pediatric patients.

Q: Is Релиум safe for older adults (the elderly)?

A: Official documents note that older adults exhibit an increased sensitivity to the medication's central nervous system effects. Caution is required because this population has an increased risk of side effects, such as sedation, which can lead to falls. For this reason, official prescribing information requires a significantly lower initial dose compared to the general adult regimen.

Q: Can Релиум be used during pregnancy?

A: Official regulatory texts indicate that use during pregnancy is generally restricted or not recommended. Safety data points to a potential risk of congenital malformations if the drug is used during the first trimester. Furthermore, there is a documented risk of withdrawal symptoms for the newborn if the drug is used later in the pregnancy.

Q: How do I know if I am eligible to use Релиум?

A: The official eligibility profile is defined by specific conditions called contraindications, such as myasthenia gravis, sleep apnoea, or severe liver and respiratory problems, that formally prohibit its use. Other patient factors, including age or a history of substance abuse, also require caution and specific prescription conditions. Official product information emphasizes that eligibility is determined by careful evaluation against these criteria.

Q: Does Релиум affect memory?

A: Official reports list memory impairment as an uncommon adverse reaction. This may involve anterograde amnesia, which is difficulty forming new memories after taking the medication. This effect is listed in regulatory data along with other uncommon side effects.

Q: Does taking Релиум with food change its effect?

A: Pharmacokinetic data suggests that taking the medicine with food may slightly delay how quickly it reaches its maximum concentration in the blood. However, this does not typically affect the overall amount of the drug the body absorbs. Specific exceptions, such as grapefruit, are noted in official warnings.

Q: Is Релиум the same as other medicines for anxiety?

A: Релиум contains the active substance Diazepam, which is part of the benzodiazepine class of medicines. Regulatory information confirms that this is only one type of medicine used for anxiety, as many other anxiety treatments belong to different pharmacological groups and have distinct mechanisms of action.

Q: Does Релиум work right away, or does it take time?

A: When the medicine is taken by mouth, effects typically begin to be noticeable within 15 to 60 minutes. For acute medical situations, administration via injection or nasal spray is known to result in a much more rapid onset of effect.

Q: How long does the effect of Релиум typically last?

A: The immediate effects felt from a single dose typically last up to several hours. The drug is metabolized into active substances that have a long elimination half-life, meaning the drug's byproducts stay in the body for an extended period. This half-life typically ranges from 18 to 25 hours.

Q: Can I use Релиум if I am taking over-the-counter pain relievers?

A: Combining the medicine with certain over-the-counter pain relievers, particularly those containing other sedating ingredients like some antihistamines, can increase side effects. This includes heightened drowsiness, dizziness, and difficulty concentrating due to the risk of additive central nervous system depressant effects. Official warnings highlight these types of interactions.

Q: Is it safe to drink coffee while using Релиум?

A: Regulatory data suggests that consuming caffeine, such as in coffee or energy drinks, may interfere with the drug’s intended action. Caffeine may reduce the concentration of the medicine in the blood, which could potentially make the medication less effective.

Q: Can Релиум affect my ability to drive or operate machinery?

A: Official patient information warns that common side effects, including drowsiness, dizziness, and impaired coordination, can affect alertness. Due to these potential effects, regulatory bodies strongly caution against driving a car or operating heavy machinery.

Q: Are there certain foods or drinks that should be avoided with Релиум?

A: Official regulatory documents advise against the consumption of alcohol and grapefruit products, including juice. Both substances can significantly increase the risk of serious adverse effects, such as profound sedation and dangerous respiratory depression.

Q: What happens if I forget to take Релиум?

A: Official administration guidance generally recommends that if a dose is missed, it can be taken as soon as it is remembered. However, if it is near the time for the next scheduled dose, the missed dose should be skipped to avoid taking too much medicine. It is advised never to take a double dose to compensate for a missed dose.

Q: Do studies support the use of Релиум for muscle spasms?

A: The medicine is officially approved for the management of muscle spasms. Its use is based on its ability to suppress certain nerve pathways that govern motor function in the central nervous system. This action helps to alleviate spasm and rigidity.

Q: Can Релиум cause changes in mood?

A: The official label warns that abnormal changes in thinking and behavior, including paradoxical reactions such as agitation and hostility, have been reported. The medication may also cause or worsen existing symptoms of mental depression, and caution is advised.

Q: Is Релиум used before surgery sometimes?

A: Yes, the drug is formally indicated for use before certain medical or surgical procedures. Its purpose in this context is to induce sedation, relieve anxiety (anxiolysis), and help diminish the patient's recall of the event.

Q: Does Релиум show up on drug tests?

A: Yes, the active substance, Diazepam, is commonly detectable in urine toxicology screens. Toxicology screens commonly look for the presence of the drug's three active metabolites, which are known to remain in the body for an extended period after use.

Q: Can Релиум make existing depression worse?

A: Regulatory product information warns that the drug can cause or worsen symptoms of mental depression. The official product label advises caution when the medicine is prescribed to patients who have a history of depression or other psychiatric conditions.

Q: Is it normal to feel a metallic taste after taking Релиум?

A: Abnormal changes in taste sensation, such as a metallic taste, have been reported as an adverse reaction in some regulatory data. However, the exact frequency of this specific side effect is generally not known or is considered rare.

Q: Are there any reported interactions with herbal supplements and Релиум?

A: Official interaction warnings note that certain herbal supplements, such as St. John's Wort, can potentially interfere with how the drug is metabolized in the liver. This interference can increase the central nervous system depressant effects of the medication.

Q: Can people with kidney problems use Релиум?

A: Caution is advised when the medicine is used in the presence of compromised kidney function. Regulatory documents suggest that monitoring kidney function during treatment may be necessary to help prevent the accumulation of the drug's byproducts (metabolites) in the body.

Q: What should I do if I suspect an interaction between Релиум and another medicine?

A: Official guidance recommends that if a potential drug interaction or unusual symptom is suspected, a doctor, pharmacist, or other healthcare professional should be contacted immediately. This ensures the interaction can be discussed based on the individual's full medical profile and current regimen.

Q: Is Релиум a controlled substance?

A: Yes, the active substance Diazepam is regulated as a controlled substance, typically classified as Schedule IV in the US. This classification is assigned due to its documented potential for misuse, physical dependence, and psychological dependence.

Q: What is the half-life of Релиум?

A: The terminal elimination half-life, which measures the rate at which the substance is eliminated from the body, is considered long. For the drug's active metabolites, this period typically ranges from 18 to 25 hours.

Q: Can Релиум cause strange dreams?

A: Reports of strange dreams, nightmares, and other sleep disturbances are documented in patient data. These effects are often associated with the process of stopping the medication, forming part of a documented withdrawal syndrome.

Q: Are there different strengths of Релиум available?

A: Yes, the drug is available in multiple pharmaceutical preparations. These include various tablet strengths, such as 2 mg, 5 mg, and 10 mg, as well as oral and injectable liquid solutions.

Q: Can Релиум be used for acute panic attacks?

A: The medication is officially indicated for the management of anxiety disorders. In medical practice, it is sometimes used to help manage the acute symptoms associated with panic attacks.

Q: Is it common to have dizziness with Релиум?

A: Dizziness and feeling less alert are documented as reported side effects. These effects are connected to the drug's overall depressant action on the central nervous system. This action can also lead to common effects like impaired coordination (ataxia).

How should Релиум be stored and disposed of?

How to Store and Dispose of Relium

Relium (diazepam) must be stored under specific environmental conditions to maintain its stability and effectiveness, as mandated by regulatory authorities.

Storage Requirements

Condition Requirement
Temperature Controlled room temperature, between 20 C and 25 C (68 F and 77 F).
Protection The product must be protected from light and kept in its original container.
Container The oral solution bottle must be kept tightly closed.
Safety Store all forms of the medication out of the sight and reach of children.

Disposal Instructions

Unused or expired Relium should be disposed of according to local regulations for pharmaceutical waste. Patients must consult with a pharmacist or local waste disposal company about proper methods, such as a medicine take-back program. It is generally advised not to dispose of this medicine by flushing it down the toilet or placing it in household trash.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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