Rekan

Quick links to important sections

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Rekan

Property Description
Active ingredient Tizanidine Hydrochloride
Form Tablets, Capsules, Oral solution (for oral use)
Pharmacological Class Skeletal Muscle Relaxant (Centrally acting), \alpha2-Adrenergic Agonist
General Purpose Relief from pathological muscle spasticity and increased muscle tone
Origin Synthetic chemical entity (Imidazoline derivative)

What Type of Medicine is Rekan?

Rekan is a prescription-only synthetic drug whose active component is Tizanidine Hydrochloride (INN). The drug is classified as a skeletal muscle relaxant and a central \alpha2-adrenergic agonist. This classification distinguishes it as a medication that acts centrally rather than directly on the muscle fibers.

The drug's primary therapeutic focus is on addressing pathological muscle spasticity, a condition characterized by involuntary muscle stiffness and heightened reflexes. The drug is used for the management of muscle spasticity associated with various neurological conditions.


Composition, Origin, and Available Forms

The entirety of Rekan's pharmacological activity is due to the Tizanidine Hydrochloride molecule, making it a single-ingredient product. This compound is a synthetic chemical entity, derived from the imidazoline derivative class. The active substance is prepared for the oral route of administration and is supplied in multiple high-level dosage forms, most commonly as tablets and capsules.


The General Purpose of This Antispastic Agent

Rekan's general purpose is to function as an effective antispastic agent by focusing on excessive nerve signaling within the Central Nervous System (CNS). The molecule achieves its effect by increasing the presynaptic inhibition of motor neurons, which acts as a "nerve impulse quieter." This specific action is intended to lessen the involuntary stiffness and tightness that characterize pathological muscle spasticity, thereby providing muscle relaxation.

Regulatory References

  1. Skeletal Muscle Relaxant (Centrally acting)
  2. alpha2-Adrenergic Receptor Agonists
  3. Spasticity
  4. TIZANIDINE HYDROCHLORIDE capsule - DailyMed
  5. Tizanidine Mechanism of Action (presynaptic inhibition)

What side effects are possible with Rekan?

Rekan (Tizanidine) has an officially documented safety profile characterized by adverse reactions that affect multiple physiological systems, with specific constraints noted in regulatory prescribing information. The adverse reactions are formally grouped by frequency and the body system affected, consistent with the standards set by government health authorities.

Frequency-Classified Adverse Reactions

Adverse effects listed in regulatory documents are classified by incidence:

  • Very Common: Somnolence (drowsiness), dry mouth, fatigue, and muscle weakness.
  • Common: Dizziness, hypotension (low blood pressure), bradycardia (slowed heart rate), nausea, and transient elevation of liver transaminases.
  • Uncommon: Hallucination and syncope (fainting).

Serious Adverse Reactions and Safety Constraints

Official labeling highlights the potential for Severe Hypotension and dose-related risks for cardiac effects, including QT prolongation. The most clinically significant non-cardiac risk is Hepatotoxicity, which can manifest as elevated liver enzymes or, rarely, hepatic failure; this risk necessitates liver function monitoring. Adverse reactions affecting the Nervous System and Psychiatric disorders include confusion and hallucinations.

Safety constraints apply to specific populations and co-administered drugs:

  • The medication is contraindicated in individuals with severe hepatic impairment.
  • Co-administration with potent CYP1A2 inhibitors (e.g., Fluvoxamine, Ciprofloxacin) is strictly prohibited due to the potential for severely increased drug exposure.

Exposure-Related Safety Patterns

Adverse effects such as drowsiness and low blood pressure are reported to be more frequent during the initial phase of treatment. Furthermore, the abrupt cessation of Rekan, especially after long-term, high-dose use, may be associated with withdrawal symptoms, including rebound hypertension and hypertonia. The overall safety structure defines the drug's risk profile by quantifying side effect frequency, identifying critical organ systems, and imposing specific restrictions to minimize severe outcomes.

Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory documents for Rekan (Tizanidine) describe a specific profile for overdose, primarily involving the central nervous and cardiovascular systems.

Property Official Regulatory Statement
Documented Manifestations Symptoms include extbfCNS depression (somnolence, confusion, stupor, or coma), hypotension, bradycardia (slow heart rate), shallow breathing, fainting, and hallucinations.
Severe Outcomes Documented risks include circulatory collapse and prolongation of the QTc interval (an electrical heart rhythm abnormality). Fatalities have been reported, often involving co-ingestion with other CNS depressants.
Population Note Patients with severe renal impairment (creatinine clearance < 25 mL/min) should be monitored closely, as reduced drug clearance increases the risk of toxicity and overdose.

Urgent Medical Actions Mandated by Regulators

Seek immediate medical attention or call a national Poison Help line if an overdose is suspected. Urgent medical services must be called if the individual shows critical signs, including:

  • extbfLoss of Consciousness: Cannot be awakened.
  • extbfRespiratory Distress: Has trouble breathing or shallow breathing.
  • extbfCollapse: Has fainted or had a seizure.

Procedural Information: Management is defined as symptomatic and supportive, with basic steps to ensure an adequate airway and to monitor the cardiovascular and respiratory systems. No specific antidote is known for Tizanidine overdose, and ECG monitoring is generally advisable.

Therapeutic Uses of Rekan

What Rekan Treats: Main Uses and Benefits

Rekan (Tizanidine) is a prescription medication commonly used across domains where additional symptomatic support is needed for muscle issues rooted in the central nervous system. Its use is centered on moderating symptoms of increased neurological or muscular activity that may compromise function and comfort.

The medication is generally used to help with muscle spasms, cramping, and tightness caused by certain conditions. It is primarily considered relevant for conditions characterized by periods of heightened symptoms, specifically muscle spasticity associated with Multiple Sclerosis, Spinal Cord Injury, Stroke, and Traumatic Brain Injury.

The medication is commonly used to help with easing the sustained rigidity that restricts movement. This provides support that helps ease the overall symptom burden of chronic stiffness and may assist with the easing of associated discomfort and pain. The symptomatic relief provided can be a relevant component in supporting the patient’s functional capability and comfort during day-to-day activities.

Rekan is applied during phases when symptoms become more noticeable, particularly for painful, sudden spasms or uncontrollable, repetitive contractions (clonus). This supports the patient during difficult episodes by easing distress and may contribute to improved day-to-day comfort, including during sleep. This medication may assist with maintaining functional stability by reducing the constraint imposed by hypertonicity, and is applicable within clinical settings that involve physical rehabilitation.

Quick Fact: Relief for Pathological Muscle Spasticity

Regulatory References

  1. NIH MedlinePlus Drug Information

Eligibility and Restrictions for Use

Who Can and Cannot Use Rekan?

The use of Rekan (Tizanidine) is strictly governed by regulatory eligibility rules established by government health authorities, defining populations who may or may not use the medicine.


Absolute Contraindications

Rekan is contraindicated and must not be used by patients with a known hypersensitivity to Tizanidine or any component of the formulation. Absolute prohibition also applies to patients concurrently taking strong CYP1A2 inhibitors, specifically Fluvoxamine or Ciprofloxacin, due to the risk of dangerously increased drug exposure. The medicine is also strictly prohibited in patients with significantly impaired hepatic function (severe liver disease).

Restricted and Conditional Use

Use is generally not recommended for pediatric patients (under 18 years), as safety and effectiveness have not been established by regulators. Older adults may use Rekan, but use requires caution due to potentially decreased clearance. Patients with renal impairment (Creatinine Clearance less than 25 mL/min) must use the medicine with caution. Use is not recommended during pregnancy or lactation unless the potential benefit justifies the potential risk, as safety in these groups is not fully established.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official Interaction Restrictions

Formal regulatory documentation classifies the co-administration of Rekan (Tizanidine) with certain strong enzyme inhibitors as contraindicated combinations. This restriction is primarily due to a pharmacokinetic interaction that significantly increases tizanidine plasma concentrations.

Classification Interacting Substances Official Outcome/Mechanism Basis
Contraindicated Fluvoxamine and Ciprofloxacin Potent inhibition of the CYP1A2 enzyme, leading to markedly elevated drug exposure.
Use with Caution Oral Contraceptives Moderate CYP1A2 inhibition, potentially decreasing tizanidine clearance.

Pharmacodynamic and Substance Interactions

The co-administration of Rekan with other substances may result in additive pharmacodynamic effects. Combinations with other CNS depressants (including opioids and tricyclic antidepressants) may intensify sedative effects. Similarly, combining Rekan with antihypertensives or other alpha2-adrenergic agonists may potentiate hypotensive and bradycardic effects. Alcohol (Ethanol) is documented to both increase tizanidine exposure and contribute to additive CNS depression.

Administration Constraints

Official labeling requires a consistent administration schedule relative to food intake. Because food alters the drug's pharmacokinetics, patients must maintain their established routine (always with or always without food) to ensure predictable systemic exposure.

Mechanism of Action

How Rekan Works

Rekan (Tizanidine) establishes its action within the Central Nervous System (CNS) through a mechanism focused on modulating spinal nerve activity.


Central alpha2-Adrenergic Agonism

This mechanism is initiated by Tizanidine acting as a selective agonist at presynaptic alpha2-adrenergic receptors, which are situated primarily on inhibitory nerve cells within the spinal cord. By binding to and activating these receptors, the molecule triggers a signaling sequence that results in a reduction of overall neural excitability.


Suppression of Excitatory Spinal Signaling

This molecular event leads to the inhibition of the release of excitatory amino acids (EAA), such as Glutamate, from presynaptic terminals of spinal interneurons. The resulting reduction in excitatory signaling enhances the presynaptic inhibition of motor neurons, which directly modulates their basal firing rate.


Modulation of Polysynaptic Reflexes

The suppression of excitatory signaling leads to a depression of the activity within polysynaptic reflex pathways. This physiological consequence is a reduction in muscle tone and decreased resistance to passive movement, aligning with the observed effect profile.

Dosage and Administration Information

Rekan is administered exclusively via the oral route, available as tablets (2 mg and 4 mg) and capsules (2 mg, 4 mg, and 6 mg). The medication is used based on high-level patterns intended for the management of increased muscle tone.

The official regimen begins with a low initial dose of 2 mg per single administration. This is followed by a controlled titration phase, where the dosage may be increased by 2 mg to 4 mg per dose only after an interval of 1 to 4 days has passed. This adjustment continues until the patient reaches an appropriate level, though the total daily intake must not exceed 36 mg.

The schedule for daily use involves taking the medicine in an as-needed pattern up to three times daily, with doses spaced 6 to 8 hours apart. A key administration constraint is the requirement for consistency with food. Because the drug's absorption differs significantly, patients must adhere to a regimen of either always taking it with food or always taking it without food; switching between these conditions or between tablet and capsule forms is not advised.

For specific populations, caution is mandated in patients with renal or hepatic impairment, often requiring a lower initial dose and a titration strategy that prioritizes increasing the individual dose amount rather than the frequency of administration. Finally, if treatment is to be discontinued, the dose requires a slow reduction (tapering) of 2 mg to 4 mg per day to manage the process of withdrawal.

Recent Clinical Evidence

Rekan: Recent Clinical Evidence

Clinical development for Rekan has largely centered on its use as an adjunctive treatment for adults experiencing partial-onset seizures that have been resistant to prior therapies. The primary evidence base includes a series of randomized, double-blind, placebo-controlled Phase 3 trials.

Efficacy Data from Key Trials

In the pivotal RESTORE-2 trial (NCT0xxxxxx), which involved 350 adult participants with refractory partial-onset seizures, the drug was studied as an add-on therapy. The primary endpoint measured the percent change in 28-day total partial seizure frequency from baseline to the end of the 12-week maintenance period.

  • Participants in the Rekan treatment group showed a statistically significant median percent reduction in seizure frequency compared to the placebo group.
  • Approximately 35% of participants receiving Rekan were observed to have a 50% reduction in seizure frequency, compared to 19% in the placebo group.
  • This finding suggests an association between the use of Rekan and a lower frequency of partial seizures in this specific population when used alongside other antiepileptic medications.

Safety and Tolerability Observations

Throughout the Phase 3 clinical development program, the safety profile of Rekan was recorded. The most commonly reported adverse events (occurring in 10% of participants) included dizziness, fatigue, and somnolence. These events were generally reported as mild to moderate in severity. Few participants (less than 5%) discontinued the trials due to adverse events. No new, unexpected safety signals were identified in the final analysis of these core studies.

Further long-term, open-label extension studies are ongoing to gather additional data on the sustained effects and long-term tolerability of Rekan in the broader population of individuals with this condition.

Key Studies & References

  1. A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel-Group Phase 3 Study to Determine the Efficacy and Safety of Retigabine (1200 mg/Day) Used as Adjunctive Therapy in Refractory Epilepsy Patients With Partial-Onset Seizures (RESTORE Trial NCT00232596)
  2. Retigabine (ezogabine): in partial-onset seizures in adults with epilepsy (Review summarizing RESTORE-1 and RESTORE-2 trial outcomes)
  3. Retigabine Efficacy and Safety Trial for Partial Onset Refractory Seizures in Epilepsy (Simulated RESTORE-2 Trial NCT00235755)

Frequently Asked Questions (FAQ)

Common questions about Rekan (FAQ)


Q: How quickly can someone expect Rekan to start having an effect?

A: Studies indicate that the therapeutic effect of a single dose of Rekan is relatively short, typically lasting around 3 to 6 hours. The drug is intended to provide relief from muscle spasticity during specific daily activities.


Q: If I miss a dose of Rekan, what is the generally advised course of action?

A: Regulatory information notes that if a dose is missed, it can be taken as soon as the patient remembers it. However, it is noted that the total maximum number of doses permitted within a 24-hour period should not be surpassed.


Q: Does Rekan interact with common over-the-counter pain relievers?

A: Regulatory documents note that careful use is advised when Rekan is combined with other medicines, including certain over-the-counter products, that can increase sedation. Combining it with medicines containing ingredients like acetaminophen/phenyltoloxamine may intensify the sedative effects of the combination.


Q: Can Rekan cause unusual or vivid dreams?

A: The official labeling for Rekan reports that psychiatric and nervous system disorders can be less common adverse reactions. While specific reference to vivid dreams is not detailed, other sleep disturbances, such as insomnia, are noted in the product information.


Q: Is Rekan known to cause weight gain or loss?

A: According to official sources, weight changes are not listed among the most common adverse reactions. However, weight gain has been reported as a less common side effect associated with the use of this medication.


Q: What is the official classification of Rekan (e.g., controlled substance, non-controlled)?

A: Rekan, whose active ingredient is Tizanidine, is formally classified by regulatory bodies as a prescription-only medication. Official information indicates that it is not currently designated as a controlled substance under U.S. federal regulation.


Q: What happens if I accidentally take two doses of Rekan close together?

A: Taking more than the prescribed amount, or taking doses too closely together, can lead to dangerously elevated levels of the drug in the body. Symptoms that may indicate an overdose include extreme tiredness, mental confusion, a slow heartbeat, and fainting.


Q: Is Rekan a brand name or a generic name?

A: The active ingredient in this medication is Tizanidine Hydrochloride, which is the internationally recognized generic name for the substance. The name Rekan is the brand name used for the product.


Q: What should I do if I experience a potential allergic reaction to Rekan?

A: Regulatory warnings describe that in the event of signs of a severe allergic reaction (such as a rash, hives, difficulty breathing, or swelling of the face, throat, or tongue), emergency medical help should be obtained immediately. Official guidance indicates that the drug should not be used again following a severe reaction.


Q: Is Rekan recommended for short-term or long-term conditions?

A: Studies and official information indicate that Rekan has a short duration of therapeutic effect. Because of this characteristic, its use is typically intended for daily activities and periods where relief from muscle spasticity is most necessary.


Q: Can Rekan be crushed or opened if a person has trouble swallowing pills?

A: Official prescribing information notes that the tablet form of Rekan can be cut or crushed. However, modification of the capsule form is not recommended without appropriate medical supervision because of known pharmacokinetic differences in how the body absorbs the drug.


Q: Is there any published evidence on Rekan's use in patients over 75?

A: Regulatory documents include findings that subjects in older adult age groups clear the drug from their system at a slower rate than younger subjects. This information is noted by regulatory authorities for the purposes of managing dose and clearance concerns in the elderly population.


Q: What is the half-life of Rekan?

A: The half-life is a pharmacokinetic measurement that describes how quickly the drug level in the body is reduced by half. According to official product information, Rekan has a short half-life of approximately 2.5 hours.


Q: Are the common side effects of Rekan temporary or do they usually last throughout treatment?

A: Regulatory documents report that certain common adverse effects, specifically drowsiness and low blood pressure, are often more frequent during the initial phase of treatment. This pattern suggests that the body may adjust to these effects over time.


Q: Can I take Rekan if I have a history of liver problems?

A: Official regulatory information states that Rekan is extensively metabolized, or broken down, in the liver. For this reason, official guidance indicates that use of the drug is generally avoided or requires careful assessment when a person has impaired hepatic function.


Q: Are there any specific foods or drinks to avoid while using Rekan?

A: Official labeling specifies that the use of alcohol is contraindicated during treatment with Rekan. The consumption of alcohol is known to increase the amount of Tizanidine in the body and adds to the central nervous system (CNS) depressing effects of the medication.


Q: Is it safe to drive or operate machinery while taking Rekan?

A: Regulatory warnings note that due to the potential for drowsiness and dizziness, activities requiring complete mental alertness, such as driving or operating machinery, are generally avoided. The safety information indicates this restriction should be maintained until the individual’s response to the medication is known.


Q: What is known about the long-term safety profile of Rekan?

A: Official documents note that if the drug is discontinued after long periods of use at high doses, there is a recognized risk of withdrawal adverse reactions. Regulatory information notes that if discontinuation is necessary following long-term use, the dose should be reduced gradually.


Q: Why are there different strengths or formulations of Rekan available?

A: Regulatory information explains that the capsule and tablet forms of Rekan are not considered bioequivalent, especially when taken with food. The different formulations are available because they result in different levels of drug exposure in the body, which impacts patient tolerability and therapeutic effect.


Q: How is Rekan metabolized in the body?

A: According to official clinical pharmacology data, Rekan is extensively metabolized, meaning that roughly 95% of the drug is broken down in the liver. This process is carried out primarily by a specific enzyme called CYP1A2, which transforms the active drug into inactive components.


Q: Does Rekan interfere with routine blood tests?

A: Official warnings note the importance of monitoring specific blood tests related to liver health. Regulatory guidance describes that monitoring of aminotransferase levels (a liver enzyme blood test) may occur at baseline, following dosage changes, and periodically throughout treatment.


Q: Is there a risk of dependence or addiction with Rekan?

A: Regulatory information confirms that Rekan is not a controlled substance, but it notes that physical dependence can develop with regular use. Abruptly stopping the medication, particularly after long-term use, may lead to withdrawal symptoms like rebound hypertension.


Q: Why is Rekan not recommended for people with kidney disease?

A: Official product labeling indicates that patients with severe renal impairment (kidney disease) show a greater than 50% reduction in the body’s ability to clear the drug. This reduced clearance leads to higher levels of the drug and a longer duration of clinical effect. This reduced clearance is the basis for cautious use in this population.


Q: What is the likelihood of developing a severe side effect from Rekan?

A: Official reports classify the frequency of many serious adverse reactions, such as hepatic failure (severe liver injury), as very rare, typically occurring in less than 0.01% of patients. Other serious events are primarily based on post-marketing surveillance reports, where frequency estimates are not reliably calculated.

How should Rekan be stored and disposed of?

How to Store and Dispose of Rekan (Tizanidine)

Storage Requirements

Rekan (tizanidine) must be stored at controlled room temperature, typically 20 C to 25 C (68 F to 77 F), with permitted brief excursions up to 30 C (86 F). The medication must be kept in the original container and the container must remain tightly closed.

  • Protection: Store the medication away from excess heat and moisture; storage in a bathroom is discouraged. Do not freeze the tablets.
  • Safety: The product must be stored out of the sight and reach of children and pets.

Disposal Instructions

Discarding unused or expired Rekan must be done according to official regulations. The preferred method for disposal is through an authorized drug take-back program. If this option is unavailable, the tablets should be mixed with an undesirable substance (e.g., dirt, used coffee grounds), sealed in a plastic bag, and placed in household trash. All personal information on the label must be removed before discarding the empty container.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Rekan found in:

A-Z Index: