Progevera

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Progevera

Property Description
Active Ingredient Medroxyprogesterone Acetate (MPA)
Forms Oral Tablets, Injectable Suspension
Pharmacological Class Progestin (Synthetic Progestogen)
General Purpose Hormone balance and uterine lining regulation
Origin Synthetic Steroid (Pregnane Derivative)

What is Progevera and its Pharmacological Class?

Progevera is a prescription-only medication based on the active ingredient Medroxyprogesterone Acetate (MPA), which is classified as a progestin. This medicine belongs to the Pharmacological Class of synthetic progestogens, meaning it is a man-made hormone that mimics the actions of the natural hormone progesterone. Medroxyprogesterone Acetate is a synthetic steroid—specifically a pregnane derivative—with a stable steroidal structure. The compound is an acetate ester resulting from a chemical modification of the progesterone molecule, granting it increased potency and stability compared to its natural counterpart. Progestins are used to replace the body's natural hormone when it is no longer being produced, such as in certain hormone therapies. This synthetic identity is crucial for ensuring a reliable and predictable source of progestational activity, which is clinically recognized for its systemic hormonal effects.


Progevera Composition, Forms, and General Purpose

Progevera is typically provided as oral tablets, where the Medroxyprogesterone Acetate is compounded with solid excipients. The MPA substance itself is active by both the oral and parenteral routes of administration. While the oral tablets are used for daily systemic action, MPA is also formulated as an injectable suspension suspended in an aqueous vehicle for longer-acting effects. The general purpose of this hormone substitute is to establish hormonal balance by acting as a powerful Progesterone Receptor Agonist. Medroxyprogesterone is established as an effective agent for maintaining endometrial health. This function allows it to regulate and stabilize the growth of the uterine lining (endometrium), providing support for individuals requiring controlled hormonal intervention, such as supporting the uterus during Hormone Replacement Therapy (HRT) or for managing certain gynecological disorders.

Regulatory References

  1. Medroxyprogesterone: MedlinePlus Drug Information

What side effects are possible with Progevera?

Possible side effects and safety information

The safety profile for Medroxyprogesterone Acetate (Progevera) is officially classified by frequency and categorized by System-Organ Class (SOC) in regulatory documents. This structure defines the documented risk profile without providing clinical advice or usage instructions.

Documented Adverse Reactions

Adverse reactions are formally listed, with menstrual irregularities (e.g., irregular bleeding, spotting, amenorrhea) and headache being classified as Very Common in regulatory labeling. Other Common effects include depression, insomnia, dizziness, acne, alopecia, and weight increase. These reactions are primarily mapped to the Reproductive system, Nervous system, and Metabolism SOC categories.

Serious Safety Considerations

Regulatory documents highlight several serious adverse reactions. These include a risk of Thromboembolic Disorders (e.g., Deep Vein Thrombosis, Pulmonary Embolism, Stroke), and significant Loss of Bone Mineral Density (BMD), with the latter being greater with long-term use. Cases of Meningioma have also been reported in association with prolonged therapy of several years. Furthermore, hypersensitivity reactions such as Anaphylaxis and Angioedema are documented.

Population and Duration Safety Notes

Safety characteristics are also tied to duration and specific populations. The BMD loss concern is particularly noted for adolescents and young adults as it relates to peak bone mass accrual. Long-term exposure (over two years) may be restricted for certain indications due to the BMD risk. Absolute safety restrictions (Contraindications) apply to individuals with undiagnosed uterine bleeding, a history of thromboembolic events, known hormone-dependent malignancy, or severe hepatic disease.

Overdose and Emergency Response

Overdose and when to seek help

The regulatory description of an overdose involving Progevera (medroxyprogesterone acetate) focuses on officially documented acute signs and symptoms. The clinical manifestations of overexposure may include non-life-threatening effects on several physiological systems. Documented overdose presentations include nausea and vomiting affecting the gastrointestinal tract, central nervous system effects such as dizziness and drowsiness/fatigue, and hormone-related changes like breast tenderness and withdrawal bleeding in women. These effects define the recognized symptom cluster following overdosage as described in government prescribing information.

For all suspected or confirmed cases of overdosage, regulatory authorities mandate specific emergency actions. Immediate medical help is required in all circumstances. The official instruction is to seek medical help or contact a Poison Control Center right away.

Management protocols documented in the official labeling specify that treatment consists of discontinuation of the medication regimen. Following discontinuation, the management of overdosage requires the institution of appropriate symptomatic care. No specific antidote for Medroxyprogesterone Acetate is explicitly documented in the overdosage section of regulatory labels. Mandatory hospital monitoring or observation requirements beyond general symptomatic care are not specifically detailed in the official overdosage text.

Therapeutic Uses of Progevera

What Progevera Treats: Main Uses and Benefits

Progevera is commonly used to help with symptoms related to systemic imbalance, including secondary amenorrhea (absence of periods) and abnormal uterine bleeding characterized by disruptive blood loss. It helps address symptom clusters that interfere with daily functioning and supports the management of bleeding.


The medication is considered relevant for non-hysterectomized postmenopausal women undergoing Estrogen Hormone Replacement Therapy (HRT) for conditions associated with increased physiological stress. This use assists with maintaining functional stability and supports the patient by easing the overall symptom load. The therapeutic domains include managing dysfunctional uterine bleeding, amenorrhea, endometrial hyperplasia risk, and symptomatic management of endometriosis.

“This therapy contributes to improved comfort during symptomatic periods and supports patients during episodes of heightened discomfort.”

Progevera may be part of symptomatic management for endometriosis, helping to address symptoms related to physical discomfort and associated functional strain. Furthermore, it is considered relevant in conditions involving hormone-sensitive malignancies, where it is applied in clinical settings that involve acute or unstable symptom patterns.


Quick Fact: Support for Irregular Bleeding and Endometrial Risk Management


Regulatory References

  1. NIH MedlinePlus overview

Eligibility and Restrictions for Use

Eligibility Map: Who Can and Cannot Use Progevera

The eligibility criteria for using Progevera (Medroxyprogesterone Acetate) are strictly defined by regulatory documents, emphasizing patient safety through absolute prohibitions and conditional use rules.


Contraindicated Populations (Absolute Non-Eligibility)

Use of Progevera is CONTRAINDICATED (must not be used) in patients with the following conditions:

  • Known or Suspected Pregnancy or Missed Abortion.
  • Undiagnosed Abnormal Genital Bleeding (until malignancy is excluded).
  • History of Breast Cancer or other Hormone-Dependent Neoplasia.
  • Active or History of Thromboembolic Disorders (e.g., DVT, PE, Stroke, or Myocardial Infarction).
  • Severe Liver Impairment or active liver disease.

Age and Condition-Based Restrictions

Population Group Regulatory Status
Pediatric Population Use is not indicated or not established (specifically before menarche).
Geriatric Population (ge 65) Not recommended for the prevention of dementia (when combined with estrogen).
Diabetic Patients Require careful observation due to a potential decrease in glucose tolerance.
Renal Impairment Caution is required due to risk of fluid retention; pharmacokinetics are not established.

What should I know about interactions with other medicines?

Progevera Interactions with other medicines and products

Medroxyprogesterone acetate (the active ingredient in Progevera) can interact with several types of medications, potentially altering the effectiveness of either Progevera or the co-administered drug. Always inform your healthcare provider of all prescription drugs, non-prescription medicines, and herbal supplements you are taking.

Medications that may affect Progevera’s effectiveness

Certain medicines can increase the metabolism of Progevera in the liver, which may reduce its concentration in the blood and consequently decrease its effectiveness. These include:

Category Examples
Anticonvulsants Phenytoin, Carbamazepine, Phenobarbital
Antibiotics Rifampicin
HIV/Hepatitis C drugs Certain protease inhibitors (e.g., Darunavir, Ritonavir) and non-nucleoside reverse transcriptase inhibitors (e.g., Efavirenz, Etravirine)
Herbal supplements St. John’s wort (used for depression)

Other important interactions

Progevera may affect the action of other medicines and laboratory tests:

  • Anticoagulants: When taken with oral anticoagulants, such as Warfarin, close monitoring may be required as Progevera may alter their blood-thinning effect.
  • Antidiabetic drugs: Progevera may potentially decrease the therapeutic effect of medications used to manage diabetes, requiring dosage adjustment by your doctor.
  • Corticosteroids and Thyroid hormones: Progevera may interfere with the results of certain laboratory tests, including measurements of cortisol (due to its own inherent glucocorticoid-like activity) and thyroid hormones, leading to decreased plasma levels. Be sure to inform laboratory personnel that you are taking this medication.

Mechanism of Action

Progevera (medroxyprogesterone acetate) functions primarily as a synthetic progestin, exerting its effects by engaging with and modulating specific hormone-dependent signaling pathways. Its mechanism of action involves interacting with biological systems that regulate reproductive and endocrine functions, leading to physiological adjustments.


Regulation of Progesterone Receptor Signaling

Progevera acts within domains involving receptor-mediated signaling by binding to and activating intracellular progesterone receptors. This initiates or suppresses gene expression sequences that control various downstream molecular and cellular effects. This mechanism is central to its effects on hormone-responsive tissues, modulating activity within targeted pathways.


Modulation of Hypothalamic-Pituitary-Ovarian (HPO) Axis

The drug modulates key pathways associated with physiological responses by influencing the hypothalamic-pituitary-ovarian (HPO) axis. This engagement affects the release of gonadotropins (Luteinizing Hormone and Follicle-Stimulating Hormone), which in turn modifies early molecular steps that shape systemic physiological outcomes. This mechanism involves altering the activity level of mediators in the endocrine system, influencing the magnitude of specific physiological responses.


Impact on Endometrial Cell Differentiation

Progevera engages mechanisms that regulate processes within the endometrium. It affects the regulation of processes driven by distinct signaling patterns, primarily by inducing secretory changes in the proliferative endometrium. This results in physiological adjustments via effects on systems where specific transmitters or mediators dominate, resulting in structural changes in the uterine lining.

Dosage and Administration Information

How to use Progevera

Progevera (medroxyprogesterone acetate or MPA) is administered through distinct routes, which determine the dosage form, frequency, and required administration setting. The medicine is available as oral tablets (2.5 mg, 5 mg, 10 mg) for daily or cyclic use and as sterile injectable suspensions for parenteral (IM or SC) administration.

Labeled Dosing and Schedule

For most gynecological conditions requiring cyclic therapy, the oral dose ranges from 5 mg to 10 mg daily, taken for 5 to 10 consecutive days per course. Oral tablets can be administered with or without food. When used for endometrial protection during estrogen therapy, the typical oral dose is 2.5 mg to 5 mg daily for 12 to 14 consecutive days each month.

The long-acting injectable forms follow a strict, less frequent dosing schedule. The 150 mg Intramuscular (IM) suspension is administered by a healthcare professional every 13 weeks (3 months), while the 104 mg Subcutaneous (SC) suspension is given every 12 to 14 weeks. Prior to use, the injectable suspensions must be shaken vigorously to ensure the active ingredient is properly mixed.

Procedural Structure

Adherence to the prescribed administration interval is necessary to maintain effect. If an oral dose is missed, standard instructions advise taking it as soon as remembered, but caution against doubling the dose. If the interval for an injection exceeds the recommended period, confirmation that the patient is not pregnant is required before the next dose is administered. The injectable forms are not indicated for use before menarche (the onset of menstruation).

Recent Clinical Evidence

Research evidence / Overview of studies for Progevera


Evidence for Preventing Changes to the Uterine Lining (Endometrial Hyperplasia)

Research focuses on large-scale Randomized Controlled Trials (RCTs) of Medroxyprogesterone Acetate (MPA) in postmenopausal women receiving estrogen therapy. Studies monitored the measured incidence of uterine lining changes (hyperplasia and carcinoma) and the effect on certain systemic biomarkers. Further research is required to fully characterize the effects of different progestin dosages on these systemic biomarkers.


Evidence for Managing Irregular Menstrual Cycles

MPA was studied in the context of secondary amenorrhea and Abnormal Uterine Bleeding (AUB) caused by hormonal imbalance. Evidence relies heavily on retrospective observational studies, examining whether treatment was associated with the re-establishment of a withdrawal bleed and changes in unscheduled bleeding patterns. Comparative evidence against all modern standard-of-care agents may be lacking.


Evidence for Other Hormone-Sensitive Conditions

The evidence base extends to research exploring symptomatic patterns related to endometriosis using comparative trials. MPA was also evaluated in oncology settings using high-dose protocols for specific hormone-sensitive malignancies (endometrial and renal carcinoma), with studies examining tumor response and progression-free survival.


Long-Term Studies and Follow-Up

Research includes long-term observational follow-up, where outcomes were tracked for many years in specific RCTs related to hormone therapy. Conversely, for shorter-term gynecological indications, long-term effects regarding the persistence of cycle regularity or other outcomes are not fully established.


Evidence in Specific Patient Contexts

Studies explored specific high-dose protocols for patients with endometrial and renal carcinoma. However, data for certain groups remain insufficient, and subgroup findings are uncertain for patients with specific comorbidities or those at the extremes of the age range.


What Remains Uncertain About Progevera Research

A significant limitation is that the evidence quality varies across studies; some indications rely on retrospective data rather than recent large-scale trials. Limited information for long-term outcomes is available, and comparative evidence against all contemporary treatments is not fully available across the board.

Key Studies & References

  1. Hormone Therapy for Endometrial Cancer (American Cancer Society): Use of progestins in malignancies
  2. Management of Endometrial Hyperplasia (Royal College of Obstetricians and Gynaecologists - RCOG Guideline)
  3. Evaluation of Amenorrhea, Anovulation, and Abnormal Bleeding (Endotext - NIH): Use of MPA in diagnostic and therapeutic protocols

Frequently Asked Questions (FAQ)

Common questions about Progevera (FAQ)


Q: How long does Progevera usually stay in your system?

The length of time Progevera stays in the body is influenced by the specific form of the medicine used, as reflected in the different administration schedules. For the long-acting injectable form, the prescribed schedule is typically every 12 to 13 weeks, indicating a prolonged duration of effect. The body metabolizes the medicine, and trace amounts may persist.


Q: What can happen if I miss a scheduled time to take Progevera?

Regulatory documents indicate that breakthrough bleeding or spotting is a possible consequence of a missed dose. Official materials emphasize that the medicine's effectiveness relies on adherence to the prescribed dosage schedule.


Q: How does Progevera differ from other progesterone medicines?

Progevera's active ingredient, medroxyprogesterone acetate, is classified as a synthetic progestin, meaning it is a man-made hormone that mimics natural progesterone. Due to its specific chemical structure, it is often classified in official product information as having enhanced stability compared to natural progesterone.


Q: Is it common to feel tired while taking Progevera?

Official regulatory documents list fatigue and general tiredness among the documented adverse reactions associated with Progevera. This information is classified by frequency in the official safety profile of the medicine.


Q: Do most people experience weight changes with Progevera?

Official labeling states that change in weight (either increase or decrease) is a documented adverse reaction. This effect is listed in the medicine's safety profile as a documented reaction.


Q: Does Progevera cause mood swings or emotional changes?

Regulatory documents list side effects related to the nervous system, including depressed mood, depression, and nervousness. Official materials advise patients to contact their medical practitioner if they notice significant mood changes.


Q: What should I watch out for regarding liver health while on Progevera?

Official warnings state that discontinuation of the medication is a measure to be taken if signs of jaundice (yellowing of the skin or eyes) or other serious disturbances of liver function develop. Regulatory information identifies severe liver impairment as a condition that prevents the use of Progevera.


Q: Are there any common supplements or vitamins that interact with Progevera?

The herbal supplement St. John's wort is officially listed as a known interaction. Official guidance advises that insufficient information is available to confirm the safety of many other common supplements and herbal remedies when taken with Progevera.


Q: Can women who are past menopause still use Progevera for certain conditions?

Yes, regulatory documents describe Progevera's use for certain indications in postmenopausal women. It is often used in combination with estrogen therapy to help protect the uterine lining (endometrium) from specific changes.


Q: Why is Progevera often prescribed in a cyclical pattern?

The cyclical pattern is described in official documents as a method to help oppose the effects of estrogen on the uterine lining (endometrium). This controlled use results in an expected withdrawal bleed.


Q: What should I know about the safety classification of Progevera?

Official documents state that Progevera is contraindicated in known or suspected pregnancy, meaning it must not be used. Information is also available regarding its use during breastfeeding, which should be discussed with a healthcare provider.


Q: Is Progevera used for fertility treatments?

Regulatory documents in some regions list Progevera's use for treating certain conditions that cause infertility related to luteal insufficiency (a hormonal imbalance). It may also be used for specific timing related to ovulation during controlled ovarian stimulation.


Q: Can I take Progevera if I am lactose intolerant?

Official product documents state that Progevera oral tablets contain lactose monohydrate (a type of sugar) as an excipient. This is a factual component of the medicine's composition.


Q: Do lifestyle factors like smoking or alcohol affect Progevera?

Official warnings note that the documented risk of bone loss (a side effect of long-term use) may be increased by smoking. Consuming small amounts of alcohol is generally not described in official information as affecting the medicine's safety or usefulness.


Q: What is the active ingredient's role in the body when taking Progevera?

Official descriptions explain that Progevera's active ingredient engages and activates the progesterone receptors in the body. This process primarily influences hormonal signals that regulate the growth and shedding of the uterine lining (endometrium).


Q: Is there a known link between Progevera and breast tenderness?

Breast tenderness and breast pain are documented adverse reactions listed in the official safety information. Breast enlargement has also been reported, particularly when Progevera is used in combination with estrogen.


Q: Why must I inform my healthcare provider about all my current medications before starting Progevera?

This information is required because other medicines, including supplements, can potentially alter the blood concentration of Progevera. These interactions may either decrease the medicine's effectiveness or increase the risk of side effects.


Q: What does the patient information leaflet say about driving while taking Progevera?

Official labeling advises caution regarding driving or operating machines because some common side effects, such as dizziness or headache, may affect concentration. It is advised to monitor how the medicine affects you before engaging in these activities.


Q: Can Progevera be used by people with a history of depression?

Official warnings advise that patients with a history of depression should be carefully monitored while using Progevera. Discontinuation of the medicine should be considered if depression recurs to a serious degree.


Q: Are there specific instructions for what to do before a planned surgery while taking Progevera?

Due to the documented risk of thromboembolic events (blood clots), official guidance advises that discontinuation of Progevera 4 to 6 weeks before major elective surgery should be considered. This precaution applies especially if prolonged immobilization is likely after the procedure.


Q: Is Progevera a controlled substance?

Progevera (medroxyprogesterone acetate) is generally not classified as a controlled substance by drug regulatory agencies. It is a prescription-only medication.


Q: Does the time of day I take Progevera matter?

Official instructions advise that if the tablet is taken once daily, it can be taken at any time of day. However, taking it at the same time each day is advised to help maintain consistent levels of the medicine in the body.


Q: What happens when I stop taking Progevera?

When a course of Progevera is stopped, a progestin withdrawal bleeding event (similar to a menstrual period) is typically expected to occur within a few days. This outcome is described in official product information as the expected physiological response following the end of certain treatment regimens.


Q: What kind of monitoring is typically required while taking Progevera?

Specific monitoring is advised for patients with certain pre-existing conditions. This includes careful monitoring for patients with diabetes (due to a potential decrease in glucose tolerance) or those with a strong family history of breast cancer.


Q: Does Progevera have an impact on cholesterol levels?

Studies have examined the effect of Progevera on lipid metabolism and certain blood fat levels, such as cholesterol. Regulatory information advises caution and careful observation for patients with existing high cholesterol or triglyceride levels.


Q: How is Progevera eliminated from the body?

Official regulatory documents explain that the active ingredient is primarily metabolized by the liver. It is then eliminated from the body as various metabolites, mostly through the urine and feces.

How should Progevera be stored and disposed of?

How to Store and Dispose of Provera (Medroxyprogesterone Acetate Tablets)

The storage and disposal of Provera must strictly follow regulatory guidance to ensure product stability and safety. The tablets must be stored at Controlled Room Temperature, which is defined between 20 C and 25 C (68 F and 77 F).


Storage Requirements

  • Temperature: Store at Controlled Room Temperature, avoiding excess heat and moisture.
  • Container Integrity: Keep the medicine in its original container and ensure it is tightly closed.
  • Child Safety: The product must be stored out of the reach of children.

Disposal Instructions

Unused or expired Provera should be disposed of via a drug take-back program when available. If a take-back program is not accessible, the product may be disposed of in the household trash by mixing the tablets with an undesirable substance (such as coffee grounds or kitty litter) and placing the mixture in a sealed container. Provera is not on the list of medicines recommended for flushing.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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