Procodine

Coughs due to colds as well as coughs and congestive symptoms associated with upper respiratory tract infections such as tracheobronchitis or laryngobronchitis, croup, pharyngitis, allergic bronchitis, and infectious bronchitis, when accompanied by disturbing and fatiguing cough

Adult 1-2 tsp tds-qds. Childn 6-12 yr 2.5-5 mL tds, 2-5 yr 1.6 mL tds.

Contra-indicated in respiratory depression, acute alcoholism, head injuries and conditions in which intracranial pressure is raised.

this medicine should not be given to patients receiving mono-amine oxidase inhibitors or within 14 days of its termination.

It should also not be given to premature infants or neonates.

It is contra-indicated during acute attacks of asthma and in heart failure secondary to chronic lung disease

Safety in pregnancy has not been established

Codeine (Procodine):

In patients receiving MAO inhibitors, an initial small test dose is advisable to allow observation of any excessive narcotic effects or MAOI interaction.

Promethazine (Procodine)

CNS Depressants —Promethazine (Procodine) may increase, prolong, or intensify the sedative action of other central-nervous system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricylic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving Promethazine (Procodine) HCl. When given concomitantly with Promethazine (Procodine), the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Dosage must be individualized. Excessive amounts of Promethazine (Procodine) HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain.

Epinephrine —Because of the potential for Promethazine (Procodine) to reverse epinephrine

The only significant untoward effects that have occurred are mild anorexia and an occasional tendency to constipation. However, discontinuance of this medicine has seldom been required. Mild drowsiness occurs in some patients but, when cough is relieved, the quieting effect of this medicine is considered beneficial in many instances. Because of its iodide content, this medicine may cause elevation of the protein-bound iodine. Adverse reactions to Codeine (Procodine) include: Central Nervous System: Sedation, drowsiness, mental clouding, dizziness, lethargy, impairment of mental and physical performance, anxiety, convulsions, fear, miosis, dysphoria, psychic dependence, mood changes, and respiratory depression. Gastrointestinal System: Nausea, vomiting, increased pressure in the biliary tract, and constipation. Cardiovascular System: Orthostatic hypotension, fainting, and tachycardia. Genitourinary System: Ureteral spasm, spasm of vesical sphincters and urinary retention have been reported. Other: Flushing, sweating, pruritus, allergic reactions, and suppressed cough reflex. Adverse reactions to phenylephrine hydrochloride include headache, reflex bradycardia, excitability, restlessness, and, rarely, arrhythmias.

Adverse reactions to chlorpheniramine maleate include slight to moderate drowsiness. Other possible side effects common to antihistamines in general include: General: Urticaria, drug rash, anaphylactic shock, photosensitivity, excessive perspiration, chills, dryness of mouth, nose, and throat. Cardiovascular System: Hypotension, headache, palpitations, tachycardia, and extrasystoles. Hematologic System: Hemolytic anemia, thrombocytopenia, and agranulocytosis. Nervous System: Sedation, dizziness, disturbed coordination, fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, euphoria, paresthesias, blurred vision, diplopia, vertigo, tinnitus, acute labyrinthitis, hysteria, neuritis, and convulsions. Gastrointestinal System: Epigastric distress, anorexia, nausea, vomiting, diarrhea, and constipation. Genitourinary System: Urinary frequency, difficult urination, urinary retention, and early menses. Respiratory System: Thickening of bronchial secretions, tightness of chest and wheezing, and nasal stuffiness.