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Medically reviewed by Oliinyk Elizabeth Ivanovna, PharmD. Last updated on 31.04.2022
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Pimplex Lotion is indicated for the topical treatment of acne vulgaris in patients 12 years and older.
Treating severe acne. It may also be used for other conditions as determined by your doctor.
Pimplex cream is a retinoid-like compound. The exact way Pimplex cream works is unknown. However, it helps the skin cells renew quicker and decreases blackhead formation.
Usual Adult Dose for Acne
Pimplex
Topical 0.1% cream, 0.1% gel, 0.3% gel
Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes.
Lotion: Apply a thin film of lotion to the entire face and other affected areas of the skin once daily, after washing gently with a mild soapless cleanser. Dispense a nickel size amount of lotion (3 to 4 actuations of the pump) to cover the entire face. Avoid application to the areas of skin around eyes, lips and mucous membranes.
Usual Pediatric Dose for Acne
Pimplex
Topical 0.1% cream, 0.1% gel, 0.3% gel
11 years or less: Safety and efficacy have not been established.
12 to 18 years: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes.
Safety and effectiveness of the lotion formulation in pediatric patients under the age of 12 have not been established.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
Pimplex should not be applied to skin with cuts, abrasions, eczema, or sunburn.
Patients should minimize exposure to sunlight, including sunlamps, and use sunscreens and other protection whenever prolonged exposure is unavoidable. Therapy should be discontinued if sunburn develops, and not resumed until the skin fully recovers. Patients may also have a heightened susceptibility to irritation due to weather extremes (wind or cold).
Pimplex may cause erythema, dryness, scaling, burning, and itching, which usually begin the first 2 to 4 weeks of therapy but diminish with continued use. Patients who develop excessive irritation should use the medication less frequently, interrupt treatment briefly, or discontinue use totally.
Pimplex therapy may render the skin more vulnerable to the irritating effects of astringents, abrasive soaps, skin cleansers, and other facial chemicals and cosmetics that contain alcohol or have a strong drying effect. Concomitant use of these agents with Pimplex should be approached with caution. Products containing alpha hydroxy or glycolic acids should be avoided.
Pimplex should not be used around the eyes, mouth, angles of the nose, mucous membranes, or on cut, abraded, or eczematous skin. Contact with the eye may cause an ocular reaction such as swelling, conjunctivitis, and irritation.
Wax epilation should not be performed on Pimplex-treated skin.
Safety and effectiveness in pediatric patients under the age of 12 years has not been established.
Dialysis
Data not available
Other Comments
Initially, an apparent exacerbation of acne may appear within the first few weeks of treatment due to the action of Pimplex topical on previously unseen lesions. Therapeutic results are typically noticed after 8 to 12 weeks of treatment.
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What is the most important information I should know about Pimplex?
Avoid getting this medication in your eyes, in the creases of your nose, or on your lips. If it does get into any of these areas, wash with water. Do not use Pimplex topical on sunburned, windburned, dry, chapped, irritated, or broken skin. Also avoid using this medication in wounds or on areas of eczema. Wait until these conditions have healed before using Pimplex topical.
Do not use skin products that contain alpha hydroxy or glycolic acid while you are also using Pimplex topical.
Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medication skin products unless your doctor has told you to.
Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Pimplex topical can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.
Use Pimplex cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Pimplex cream. Talk to your pharmacist if you have questions about this information.
- Do not use other medicines on your skin without first discussing it with your doctor.
- Pimplex cream is for external use only. Avoid contact with the eyes, lips, angles of the nose, and mucous membranes. Exposure of Pimplex cream to the eye may cause swelling, redness, and irritation.
- Do not apply Pimplex cream to cuts, abrasions, eczematous skin, or sunburned skin.
- Use Pimplex cream in the evening before bedtime unless directed otherwise by your doctor.
- Before applying Pimplex cream, clean the area to be treated with mild soap or soapless cleanser and gently dry.
- Apply a thin film of Pimplex cream to the affected and surrounding area. Rub in gently. Wash your hands immediately after using Pimplex cream.
- A mild sensation of warmth or slight stinging may occur shortly after using Pimplex cream.
- If you miss a dose of Pimplex cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. If several applications are missed, contact your doctor or pharmacist.
Ask your health care provider any questions you may have about how to use Pimplex cream.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.This medication is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Pimplex belongs to a class of medications called retinoids. It works by affecting the growth of cells and decreasing swelling and inflammation.
How to use Pimplex topical
Wash your hands before applying this medication. Gently clean the affected skin with a mild or soapless cleanser and pat dry. Use your fingertips to apply a small amount of medication in a thin layer, usually once daily at bedtime, or as directed by your doctor. A gauze pad or cotton swab can be used to apply the solution.
Use this medication on the skin only. Do not apply to the inner lip area or inside the nose/mouth. Do not apply to cut, scraped, sunburned, or eczema-affected skin.
Avoid getting this medication in your eyes. If this medication gets into your eyes, flush with large amounts of water. Call your doctor if eye irritation develops. Wash your hands after using the medication to avoid accidentally getting it in your eyes.
During the first few weeks of using Pimplex, your acne might appear worse because the medication is working on pimples forming inside the skin. It may take up to 8-12 weeks to notice results from this medication.
Use it regularly in order to get the most benefit from it. To help you remember, use it at the same time each day. Do not use a larger amount or use it more frequently than recommended. Your skin will not improve any faster, and it will increase the risk of developing redness, peeling and pain.
This medication is available in different strengths and forms (e.g., gel, cream, solution). The best type of medication for you to use will depend on the condition of your skin and your response to therapy. Inform your doctor if your condition persists or worsens.
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What other drugs will affect Pimplex?
As DIFFERIN® (Pimplex gel) Gel has the potential to produce local irritation in some patients, concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices, or lime) should be approached with caution. Particular caution should be exercised in using preparations containing sulfur, resorcinol, or salicylic acid in combination with DIFFERIN® (Pimplex gel) Gel. If these preparations have been used, it is advisable not to start therapy with DIFFERIN® (Pimplex gel) Gel until the effects of such preparations in the skin have subsided.
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What are the possible side effects of Pimplex?
In controlled clinical trials, local cutaneous irritation was monitored in 285 acne patients who used Pimplex Cream once daily for 12 weeks. The frequency and severity of erythema, scaling, dryness, pruritus and burning were assessed during these studies. The incidence of local cutaneous irritation with Pimplex Cream from the controlled clinical studies is provided in the following table:
Other reported local cutaneous adverse events in patients who used Pimplex Cream once daily included: sunburn (2%), skin discomfort-burning and stinging (1%) and skin irritation (1%). Events occurring in less than 1% of patients treated with Pimplex Cream included: acne flare, dermatitis and contact dermatitis, eyelid edema, conjunctivitis, erythema, pruritus, skin discoloration, rash, and eczema.
Pimplex is a topical retinoid primarily used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. It is currently marketed by Galderma under the trade names Differin in some countries, and Pimplex in India. [Wikipedia]