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Medically reviewed by Fedorchenko Olga Valeryevna, PharmD. Last updated on 16.04.2022
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When oral therapy is not feasible, and the strength, dosage form, and route of administration of the drug reasonably lend the preparation to the treatment of the condition, the intravenous or intramusculat use of Solu-Hydrocortisone (Pigmanorm Widmer) Sterile Powder is indicated as follows:
Allergic states
Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions.
Dermatologic diseases
Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome).
Endocrine disorders
Primary or secondary adrenocortical insufficiency (Hydrocortisone (Pigmanorm Widmer) or cortisone is the drug of choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy, mineralocorticoid supplementation is of particular importance), congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis.
Gastrointestinal diseases
To tide the patient over a critical period of the disease in regional enteritis (systemic therapy) and ulcerative colitis.
Hematologic disorders
Acquired (autoimmune) hemolytic anemia, congenital (erythroid) hypoplastic anemia (Diamond Blackfan anemia), idiopathic thrombocytopenic purpura in adults (intravenous administration only; intramuscular administration is contraindicated), pure red cell aplasia, select cases of secondary thrombocytopenia.
Miscellaneous
Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy.
Neoplastic diseases
For the palliative management of leukemias and lymphomas.
Nervous System
Acute exacerbations of multiple sclerosis; cerebral edema associated with primary or metastatic brain tumor, or craniotomy.
Ophthalmic diseases
Sympathetic ophthalmia, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids.
Renal diseases
To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome, or that due to lupus erythematosus.
Respiratory diseases
Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis.
Rheumatic disorders
As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in acute gouty arthritis; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy). For the treatment of dermatomyositis, temporal arteritis, polymyositis, and systemic lupus erythematosus.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.ALPHAQUIN HP 4% CREAMNUQUIN HP 4% CREAM, NUQUIN HP 4% GEL, MELPAQUE HP 4% CREAM, MELQUIN HP 4% CREAM and Hydroquinone (Pigmanorm Widmer) (Hydroquinone (Pigmanorm Widmer) 3% topical solution) are indicated for the gradual bleaching of hyperpigmented skin conditions such as chloasma, melasma, freckles, senile lentigines and other undesired areas of melanin hyperpigmentation.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.(To understand fully the indication for this product, please read the entire INDICATIONS AND USAGE section of the labeling.)
Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) 0.05% is indicated as an adjunctive agent for use in the mitigation (palliation) of fine wrinkles, mottled hyperpigmentation, and tactile roughness of facial skin in patients who do not achieve such palliation using comprehensive skin care and sun avoidance programs. COMPLEX A™ Tretinoin (Pigmanorm Widmer) CREAM, USP (EMOLLIENT) DOES NOT ELIMINATE WRINKLES, REPAIR SUN-DAMAGED SKIN, REVERSE PHOTOAGING, or RESTORE A MORE YOUTHFUL or YOUNGER DERMAL HISTOLOGIC PATTERN. Many patients achieve desired palliative effects on fine wrinkling, mottled hyperpigmentation, and tactile roughness of facial skin with the use of comprehensive skin care and sun avoidance programs including sunscreens, protective clothing, and emollient creams NOT containing Tretinoin (Pigmanorm Widmer).
- Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) 0.05% has demonstrated NO MITIGATING EFFECT on significant signs of chronic sun exposure such as coarse or deep wrinkling, skin yellowing, lentigines, telangi-ectasia, skin laxity, keratinocytic atypia, melanocytic atypia, or dermal elastosis.
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Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) 0.05% should be used under medical supervision as an adjunct to a comprehensive skin care and sun avoidance program that includes the use of effective sun-screens (minimum SPF of 15) and protective clothing when desired results on fine wrinkles, mottled hyperpigmentation, and roughness of facial skin have not been achieved with a comprehensive skin care and sun avoidance program alone.
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The effectiveness of Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) 0.05% in the mitigation of fine wrinkles, mottled hyperpigmentation, and tactile roughness of facial skin has not been established in people greater than 50 years of age OR in people with moderately to heavily pigmented skin. In addition, patients with visible actinic keratoses and patients with a history of skin cancer were excluded from clinical trials of Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) 0.05%. Thus the effectiveness and safety of Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) 0.05% in these populations are not known at this time.
- Neither the safety nor the effectiveness of Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) for the prevention or treatment of actinic keratoses or skin neoplasms has been established.
- Neither the safety nor the efficacy of using Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) 0.05% daily for greater than 48 weeks has been established, and daily use beyond 48 weeks has not been systematically and histologically investigated in adequate and well-controlled trials.
See also: Entyvio
Hydrocortisone (Pigmanorm Widmer) is a steroid medicine that is used in the treatment of many different conditions, including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, multiple sclerosis, or lung disorders.
Hydrocortisone (Pigmanorm Widmer) is also used to replace steroids in people with adrenal insufficiency (decreased production of natural steroids by the adrenal glands).
Hydrocortisone (Pigmanorm Widmer) affects your immune system and is often used to treat certain blood cell disorders such as anemia (low red blood cells) or thrombocytopenia (low platelets).
Hydrocortisone (Pigmanorm Widmer) is also used in the treatment of certain cancers such as leukemia, lymphoma, and multiple myeloma.
Hydrocortisone (Pigmanorm Widmer) may also be used for purposes not listed in this medication guide.
Hydroquinone (Pigmanorm Widmer) decreases the formation of melanin in the skin. Melanin is the pigment in skin that gives it a brown color.
Hydroquinone (Pigmanorm Widmer) topical (for the skin) is used to lighten areas of darkened skin such as freckles, age spots, melasma (sun damage), or chloasma (darkened skin caused by hormonal changes).
Hydroquinone (Pigmanorm Widmer) topical may also be used for purposes not listed in this medication guide.
Tretinoin (Pigmanorm Widmer) is used to treat acne. It works partly by keeping skin pores clear.
One of the Tretinoin (Pigmanorm Widmer) creams is used to treat fine wrinkles, dark spots, or rough skin on the face caused by damaging rays of the sun. It works by lightening the skin, replacing older skin with newer skin, and by slowing down the way the body removes skin cells that may have been harmed by the sun. Tretinoin (Pigmanorm Widmer) works best when used within a skin care program that includes protecting the treated skin from the sun. However, it does not completely or permanently erase these skin problems or greatly improve more obvious changes in the skin, such as deep wrinkles caused by sun or the natural aging process.
Tretinoin (Pigmanorm Widmer) may also be used to treat other skin diseases as determined by your doctor.
Tretinoin (Pigmanorm Widmer) is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, Tretinoin (Pigmanorm Widmer) is used in certain patients with the following medical conditions:
- Keratosis follicularis (skin disorder of small, red bumps)
- Verruca plana (flat warts)
The initial dosage of Hydrocortisone (Pigmanorm Widmer) Tablets may vary from 20 mg to 240 mg of Hydrocortisone (Pigmanorm Widmer) per day depending on the specific disease entity being treated. In situations of less severity lower doses will generally suffice while in selected patients higher initial doses may be required. The initial dosage should be maintained or adjusted until a satisfactory response is noted. If after a reasonable period of time there is a lack of satisfactory clinical response, Hydrocortisone (Pigmanorm Widmer) should be discontinued and the patient transferred to other appropriate therapy. IT SHOULD BE EMPHASIZED THAT DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATMENT AND THE RESPONSE OF THE PATIENT. After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reached. It should be kept in mind that constant monitoring is needed in regard to drug dosage. Included in the situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease process, the patient's individual drug responsiveness, and the effect of patient exposure to stressful situations not directly related to the disease entity under treatment; in this latter situation it may be necessary to increase the dosage of Hydrocortisone (Pigmanorm Widmer) for a period of time consistent with the patient's condition. If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually, rather than abruptly.
Multiple Sclerosis
In treatment of acute exacerbations of multiple sclerosis, daily doses of 200 mg of prednisolone for a week followed by 80 mg every other day for 1 month have been shown to be effective (20 mg of Hydrocortisone (Pigmanorm Widmer) is equivalent to 5 mg of prednisolone).
How supplied
Hydrocortisone (Pigmanorm Widmer) Tablets are available in the following strengths and package sizes:
5 mg (white, round, scored, imprinted Hydrocortisone (Pigmanorm Widmer) 5) Bottles of 50 NDC 0009-0012-01
10 mg (white, round, scored, imprinted Hydrocortisone (Pigmanorm Widmer) 10) Bottles of 100 NDC 0009-0031-01
20 mg (white, round, scored, imprinted Hydrocortisone (Pigmanorm Widmer) 20) Bottles of 100 NDC 0009-0044-01
Store at controlled room temperature 20° to 25°C (68° to 77°F).
Distributed by: Pharmacia & Upjohn Company, Division of Pfizer Inc., NY, NY 10017. Revised: Sep 2013
Generic name: Hydroquinone (Pigmanorm Widmer) 40mg in 1g
Dosage form: gel
See also:
- Glytone Clarifying Cream cream
- Glytone Clarifying Gel gel
- Glytone Skin Lightening Cream cream
Medically reviewed on August 11, 2018.
Hydroquinone (Pigmanorm Widmer) should be applied daily at night to affected areas and rubbed in well, or as directed by a physician. If no lightening effect is seen after 2 months of treatment, use of this product should be discontinued.
During the day, avoid sunlight exposure to treated areas by using an effective broad spectrum sunscreen (SPF 15 or higher) or by wearing sun-protective clothing.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
More about Glytone Skin Lightening (Hydroquinone (Pigmanorm Widmer) topical)
- During Pregnancy
- Dosage Information
- Drug class: topical depigmenting agents
Consumer resources
Other brands: Hydroquinone (Pigmanorm Widmer) and Sunscreen, Hydroquinone (Pigmanorm Widmer), Eldoquin, Esoterica,... +22 more
Professional resources
- Glytone Skin Lightening Cream (FDA)
- Hydroquinone (Pigmanorm Widmer) (FDA)
- Hydroquinone (Pigmanorm Widmer) (AHFS Monograph)
Related treatment guides
- Dermatological Disorders
- Do NOT use Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) if the patient is pregnant or is attempting to become pregnant or is at high risk of pregnancy
- Do NOT use Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) if the patient is sunburned or if the patient has eczema or other chronic skin condition(s)
- Do NOT use Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) if the patient is inherently sensitive to sunlight
- Do NOT use Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) if the patient is also taking drugs known to be photosensitizers (e.g., thiazides, tetracyclines, fluoroquinolones, phenothiazines, sulfonamides) because of the possibility of augmented phototoxicity.
Patients require detailed instruction to obtain maximal benefits and to understand all the precautions necessary to use this product with greatest safety. The physician should review the Patient Package Insert.
Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) should be applied to the face once a day before retiring, using only enough to cover the entire affected area lightly. Patients should gently wash their faces with a mild soap, pat the skin dry, and wait 20 to 30 minutes before applying Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient). The patient should apply a pea-sized amount of cream to cover the entire face lightly. Special caution should be taken when applying the cream to avoid the eyes, ears, nostrils, and mouth.
Application of Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) may cause a transitory feeling of warmth or slight stinging.
Mitigation (palliation) of facial fine wrinkling, mottled hyperpigmentation, and tactile roughness may occur gradually over the course of therapy. Up to six months of therapy may be required before the effects are seen. Most of the improvement noted with Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) 0.05% is seen during the first 24 weeks of therapy. Thereafter, therapy primarily maintains the improvement realized during the first 24 weeks.
With discontinuation of Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) 0.05% therapy, a majority of patients will lose most mitigating effects of Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) 0.05% on fine wrinkles, mottled hyperpigmentation, and tactile roughness of facial skin; however, the safety and effectiveness of using Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) 0.05% daily for greater than 48 weeks have not been established.
Application of larger amounts of medication than recommended may not lead to more rapid results or better results, and marked redness, peeling, or discomfort may occur.
Patients treated with Complex A™ Tretinoin (Pigmanorm Widmer) Cream, USP (Emollient) 0.05% may use cosmetics, but the areas to be treated should be cleansed thoroughly before the medication is applied.
See also:
What is the most important information I should know about Hydrocortisone (Pigmanorm Widmer)?
You should not use this medication if you are allergic to Hydrocortisone (Pigmanorm Widmer), or if you have a fungal infection anywhere in your body.
Before taking Hydrocortisone (Pigmanorm Widmer), tell your doctor about all of your medical conditions, and about all other medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids.
Your steroid medication needs may change if you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you during treatment.
Steroid medication can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.
Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.
Do not receive a "live" vaccine while you are taking Hydrocortisone (Pigmanorm Widmer). Vaccines may not work as well while you are taking a steroid.
Do not stop using Hydrocortisone (Pigmanorm Widmer) suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.
Carry an ID card or wear a medical alert bracelet stating that you are taking a steroid, in case of emergency.
See also:
What is the most important information I should know about Hydroquinone (Pigmanorm Widmer)?
Before using Hydroquinone (Pigmanorm Widmer) topical, tell your doctor if you are allergic to any drugs, or if you have liver or kidney disease.
Do not use Hydroquinone (Pigmanorm Widmer) topical on skin that is sunburned, windburned, dry, chapped, or irritated, or on an open wound. It could make these conditions worse. Wait until these conditions have healed before applying Hydroquinone (Pigmanorm Widmer) topical.
Avoid getting this medication in your mouth or eyes. If it does get into any of these areas, rinse with water.
Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.
Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Hydroquinone (Pigmanorm Widmer) topical can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.
See also:
What is the most important information I should know about Tretinoin (Pigmanorm Widmer)?
Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Tretinoin (Pigmanorm Widmer) topical can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.
Avoid getting this medication in your eyes, mouth, and nose, or on your lips. If it does get into any of these areas, wash with water. Do not use Tretinoin (Pigmanorm Widmer) topical on sunburned, windburned, dry, chapped, irritated, or broken skin. Also avoid using this medication in wounds or on areas of eczema. Wait until these conditions have healed before using Tretinoin (Pigmanorm Widmer) topical.
Use this medication for as many days as it has been prescribed for you even if you think it is not working. It may take weeks or months of use before you notice improvement in your skin. If you are using Tretinoin (Pigmanorm Widmer) topical to treat acne, your condition may get slightly worse for a short time when you first start using the medication. Call your doctor if skin irritation becomes severe or if your acne does not improve within 8 to 12 weeks.
Use Hydrocortisone (Pigmanorm Widmer) solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Hydrocortisone (Pigmanorm Widmer) solution is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Hydrocortisone (Pigmanorm Widmer) solution at home, a health care provider will teach you how to use it. Be sure you understand how to use Hydrocortisone (Pigmanorm Widmer) solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Hydrocortisone (Pigmanorm Widmer) solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Hydrocortisone (Pigmanorm Widmer) solution, contact your doctor right away.
Ask your health care provider any questions you may have about how to use Hydrocortisone (Pigmanorm Widmer) solution.
Use Hydroquinone (Pigmanorm Widmer) cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Before using Hydroquinone (Pigmanorm Widmer) cream for the first time, apply a small amount to an unbroken patch of skin and check in 24 hours for itching, blistering, or excessive redness or irritation. If these effects develop, contact your doctor as soon as possible and do not use Hydroquinone (Pigmanorm Widmer) cream on other areas.
- Wash and completely dry the affected areas. Gently rub the medicine in until it is evenly distributed. Wash your hands immediately after using Hydroquinone (Pigmanorm Widmer) cream, unless your hands are part of the treated area.
- If you miss a dose of Hydroquinone (Pigmanorm Widmer) cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Hydroquinone (Pigmanorm Widmer) cream.
Use Tretinoin (Pigmanorm Widmer) emollient cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Tretinoin (Pigmanorm Widmer) emollient cream. Talk to your pharmacist if you have questions about this information.
- Tretinoin (Pigmanorm Widmer) emollient cream is for external use only.
- Remove all cosmetics with a mild soap before applying Tretinoin (Pigmanorm Widmer) emollient cream. Gently dry the area. Wait 20 to 30 minutes to make sure that skin is completely dry.
- Squeeze a small amount (quarter inch or less) of the medicine onto the fingertip. This should be enough to cover the entire affected area. Wash your hands immediately after using Tretinoin (Pigmanorm Widmer) emollient cream.
- If you miss a dose of Tretinoin (Pigmanorm Widmer) emollient cream, skip the missed dose and go back to your regular dosing schedule.
Ask your health care provider any questions you may have about how to use Tretinoin (Pigmanorm Widmer) emollient cream.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Hydrocortisone (Pigmanorm Widmer) is a natural substance (corticosteroid hormone) made by the adrenal gland. It is used to treat conditions such as arthritis, blood/hormone/immune system disorders, skin and eye conditions, breathing problems, cancer, and severe allergies. It decreases your immune system's response to various diseases to reduce symptoms such as pain, swelling and allergic-type reactions.
Hydrocortisone (Pigmanorm Widmer) is also used to treat low Hydrocortisone (Pigmanorm Widmer) levels caused by diseases of the adrenal gland (such as Addison's disease, adrenocortical insufficiency). Corticosteroids are needed in many ways for the body to function well. They are important for salt and water balance and keeping blood pressure normal.
How to use Hydrocortisone (Pigmanorm Widmer)
Take this medication by mouth, with food or milk to prevent stomach upset, exactly as directed by your doctor. Take this medication with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise.
Follow the dosing schedule carefully. The dosage and length of treatment are based on your medical condition and response to treatment. Your doctor may direct you to take Hydrocortisone (Pigmanorm Widmer) 1 to 4 times a day or take a single dose every other day. It may help to mark your calendar with reminders or use a pill box.
Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.
If you have used Hydrocortisone (Pigmanorm Widmer) regularly for a long time or in high doses, you may have withdrawal symptoms if the drug is suddenly stopped. To prevent withdrawal symptoms (such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness), your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away. See also Precautions section.
Tell your doctor if your condition persists or worsens.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Hydroquinone (Pigmanorm Widmer) is used to lighten the dark patches of skin (also called hyperpigmentation, melasma, "liver spots," "age spots," freckles) caused by pregnancy, birth control pills, hormone medicine, or injury to the skin.
This medicine works by blocking the process in the skin that leads to discoloration.
How to use Hydroquinone (Pigmanorm Widmer) topical
Follow all directions on the product package, or use as directed by your doctor. Before using, apply a small amount of this medicine to an area of unbroken skin, and check the area within 24 hours for any serious side effects. If the test area is itching, red, puffy, or blistering, do not use this product and contact your doctor. If there is just mild redness, then treatment with this product may begin.
Apply this medication to the affected areas of skin, usually twice daily or as directed by your doctor. This medication is for use on the skin only. If it is used incorrectly, unwanted skin lightening may occur. Avoid getting this product in your eyes or on the inside of your nose or mouth. If you do get this medication in those areas, flush with plenty of water.
This medication may make the treated areas of skin more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing on the treated areas of skin when outdoors.
Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.
Inform your doctor if your condition persists or worsens after 2 months.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled Indications
Acute promyelocytic leukemia (remission induction): Induction of remission in patients with acute promyelocytic leukemia, French American British (FAB) classification M3 (including the M3 variant) characterized by t(15;17) translocation and/or PML/RARα gene presence
Off Label Uses
Acute promyelocytic leukemia (consolidation therapy)
Data from studies of combination chemotherapy in adults with acute promyelocytic leukemia (APL) support the use of Tretinoin (Pigmanorm Widmer) as part of the consolidation phase of treatment.
See also:
What other drugs will affect Hydrocortisone (Pigmanorm Widmer)?
With simultaneous use of Hydrocortisone (Pigmanorm Widmer) increases the toxicity of cardiac glycosides (because of the emerging hypokalemia increases the risk of arrhythmias); with acetylsalicylic acid - accelerates its excretion and reduces its concentration in blood plasma (with the abolition of Hydrocortisone (Pigmanorm Widmer) concentration of salicylates in the blood increases, and increases the risk of side effects); with paracetamol - increased risk of hepatotoxic action of paracetamol (induction of hepatic enzymes and formation of a toxic metabolite of paracetamol); with cyclosporine - increased side effects of Hydrocortisone (Pigmanorm Widmer) as a result of inhibition of its metabolism; with ketoconazole - increased side effects of Hydrocortisone (Pigmanorm Widmer) as a result of reduction of its clearance.
Hydrocortisone (Pigmanorm Widmer) Micronised Xepa-Soul Pattinson reduces the effectiveness of hypoglycemic; intensifies the effect of indirect anticoagulants of coumarin derivatives.
Hydrocortisone (Pigmanorm Widmer) reduces the effect of vitamin D on the absorption of calcium ions into the lumen of the intestine. Ergocalciferol and parathyroid hormone hinder the development of osteopathy caused by GCS.
Hydrocortisone (Pigmanorm Widmer) Micronised Xepa-Soul Pattinson increases the metabolism of isoniazid, meksiletina (especially in "fast acetylators"), which leads to a decrease in their plasma concentrations; increases (with prolonged therapy) the content of folic acid reduces the concentration of praziquantel in blood.
Hydrocortisone (Pigmanorm Widmer) in high doses reduces the effect somatropina.
Hypokalemia caused by GCS, may increase the severity and duration of muscle blockade on the background of muscle relaxants.
Antacids reduce the absorption of the GCS.
At simultaneous application with SCS thiazides, carbonic anhydrase inhibitors, other GCS, amphotericin B increase the risk of hypokalemia, drugs containing sodium ions - swelling and increase blood pressure.
NSAIDs and ethanol increases the risk of gastrointestinal ulcerations and bleeding, in combination with NSAIDs to treat arthritis may reduce the dose of GCS due to summation of therapeutic effect. Indomethacin displacing the SCS from its association with albumin, increases the risk of its side effects.
Amphotericin B and carbonic anhydrase inhibitors increase the risk of osteoporosis.
The therapeutic effect of GCS is reduced under the influence of inducers of microsomal liver enzymes (including phenytoin, barbiturates, ephedrine, theophylline, rifampin) due to increased rate of metabolism of these substances.
Inhibitors of the function of the adrenal cortex (including mitotan) may necessitate higher doses of GCS.
Clearance GCS increased against the background of preparations of thyroid hormones.
Immunosuppressants increase the risk of infection and lymphoma or other lymphoproliferative disorders associated with Epstein-Barr virus.
Estrogens (including oral contraceptives containing estrogen) reduce the clearance of GKS, lengthens T1/2 and their therapeutic and toxic effects. The appearance of hirsutism and acne promotes the simultaneous use of other steroid hormone funds - androgens, estrogens, anabolic steroids, oral contraceptives.
Tricyclic antidepressants may increase the severity of depression caused by GCS (not shown for the treatment of these side effects).
The risk of developing cataracts increases with the application against other GCS antipsychotic funds (neuroleptics), carbutamide and azathioprine. Simultaneous of Hydrocortisone (Pigmanorm Widmer) Micronised Xepa-Soul Pattinson with the appointment of m-cholinoblockers, as well as with means having m-anticholinergic action (including antihistamines, tricyclic antidepressants), with nitrates improves the intraocular pressure.
With simultaneous application of SCS with live vaccines and antiviral compared to other types of immunization increases the risk of activation of viruses and development of infections.
See also:
What other drugs will affect Hydroquinone (Pigmanorm Widmer)?
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.
Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.
Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
See also:
What other drugs will affect Tretinoin (Pigmanorm Widmer)?
Limited clinical data on potential drug interactions are available.
Drugs Metabolized By the Hepatic P450 System
As Tretinoin (Pigmanorm Widmer) (Tretinoin (Pigmanorm Widmer)) is metabolized by the hepatic P450 system, there is a potential for alteration of pharmacokinetics parameters in patients administered concomitant medications that are also inducers or inhibitors of this system. Medications that generally induce hepatic P450 enzymes include rifampicin, glucocorticoids, phenobarbital and pentobarbital. Medications that generally inhibit hepatic P450 enzymes include ketoconazole, cimetidine, erythromycin, verapamil, diltiazem and cyclosporine. To date there are no data to suggest that co-use with these medications increases or decreases either efficacy or toxicity of Tretinoin (Pigmanorm Widmer) (Tretinoin (Pigmanorm Widmer)).
Agents Known to Cause Pseudotumor Cerebri/Intracranial Hypertension (Such as Tetracyclines)
Tretinoin (Pigmanorm Widmer) (Tretinoin (Pigmanorm Widmer)) may cause pseudotumor cerebri/intracranial hypertension. Concomitant administration of Tretinoin (Pigmanorm Widmer) (Tretinoin (Pigmanorm Widmer)) and agents known to cause pseudotumor cerebri/intracranial hypertension as well might increase the risk of this condition.
Vitamin A
As with other retinoids, Tretinoin (Pigmanorm Widmer) (Tretinoin (Pigmanorm Widmer)) must not be administered in combination with vitamin A because symptoms of hypervitaminosis A could be aggravated.
Anti-fibrinolytic Agents (Such as Tranexamic Acid, Aminocaproic Acid, or Aprotinin)
Cases of fatal thrombotic complications have been reported rarely in patients concomitantly treated with Tretinoin (Pigmanorm Widmer) (Tretinoin (Pigmanorm Widmer)) and anti-fibrinolytic agents. Therefore, caution should be exercised when administering Tretinoin (Pigmanorm Widmer) (Tretinoin (Pigmanorm Widmer)) concomitantly with these agents.
Effect of Food
No data on the effect of food on the absorption of Tretinoin (Pigmanorm Widmer) (Tretinoin (Pigmanorm Widmer)) are available. The absorption of retinoids as a class has been shown to be enhanced when taken together with food.
See also:
What are the possible side effects of Hydrocortisone (Pigmanorm Widmer)?
Applies to Hydrocortisone (Pigmanorm Widmer) topical: topical application cream, topical application ointment
Other dosage forms:
- topical application cream
- topical application cream, topical application lotion, topical application ointment, topical application solution
- topical application cream, topical application foam, topical application gel/jelly, topical application kit, topical application liquid, topical application lotion, topical application ointment, topical application pad, topical application paste, topical application solution, topical application spray, topical application stick
In addition to its needed effects, some unwanted effects may be caused by Hydrocortisone (Pigmanorm Widmer) topical (the active ingredient contained in Hydrocortisone (Pigmanorm Widmer) with Aloe). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Hydrocortisone (Pigmanorm Widmer) topical:
More common:
- Skin rash, encrusted, scaly, and oozing
- stinging
- Burning, itching, redness, skin rash, swelling, or soreness at the application site
- cough or hoarseness
- dry skin
- fever or chills
- itching in the genital or other skin areas
- lower back or side pain
- painful or difficult urination
- rash
- rash with flat lesions or small raised lesions on the skin
- skin irritation
- Blistering, burning, crusting, dryness, or flaking of the skin
- itching, scaling, severe redness, soreness, or swelling of the skin
- redness and scaling around the mouth
- thinning of the skin with easy bruising, especially when used on facial or intertriginous areas
Minor Side Effects
Some of the side effects that can occur with Hydrocortisone (Pigmanorm Widmer) topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Less common:
- Diarrhea
- indigestion
- loss of appetite
- nausea or vomiting
- passing of gas
- stomach pain, fullness, or discomfort
- Acne or pimples
- burning and itching of the skin with pinhead-sized red blisters
- burning, itching, and pain in hairy areas, or pus at the root of the hair
- increased hair growth on the forehead, back, arms, and legs
- lightening of normal skin color
- lightening of treated areas of dark skin
- reddish purple lines on the arms, face, legs, trunk, or groin
- softening of the skin
See also:
What are the possible side effects of Hydroquinone (Pigmanorm Widmer)?
Mild burning, stinging, redness, and dryness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
If your doctor has prescribed this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Stop using Hydroquinone (Pigmanorm Widmer) and tell your doctor right away if any of these unlikely but serious side effects occur: blistering, skin cracking, blue-black darkening of the skin.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
See also:
What are the possible side effects of Tretinoin (Pigmanorm Widmer)?
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Clinical Trials in Subjects with Acne
In separate clinical trials for each concentration, acne subjects treated with Tretinoin (Pigmanorm Widmer) gel, USP (microsphere) 0.1% or 0.04%, over the twelve week period showed that cutaneous irritation scores for erythema, peeling, dryness, burning/stinging, or itching peaked during the initial two weeks of therapy, decreasing thereafter.
Approximately half of the subjects treated with Tretinoin (Pigmanorm Widmer) gel, USP (microsphere) 0.04% had cutaneous irritation at Week 2. Of those subjects who did experience cutaneous side effects, most had signs or symptoms that were mild in severity (severity was ranked on a 4-point ordinal scale: 0=none, 1=mild, 2=moderate, and 3=severe). Less than 10% of patients experienced moderate cutaneous irritation and there was no severe irritation at Week 2.
In trials of Tretinoin (Pigmanorm Widmer) gel, USP (microsphere) 0.04%, throughout the treatment period the majority of subjects experienced some degree of irritation (mild, moderate, or severe) with 1% (2/225) of subjects having scores indicative of a severe irritation; 1.3% (3/225) of subjects treated with Tretinoin (Pigmanorm Widmer) gel, USP (microsphere) 0.04%, discontinued treatment due to irritation, which included dryness in one patient and peeling and urticaria in another.
In trials of Tretinoin (Pigmanorm Widmer) gel, USP (microsphere) 0.1%, no more than 3% of subjects had cutaneous irritation scores indicative of severe irritation; 6% (14/224) of subjects treated with Tretinoin (Pigmanorm Widmer) gel, USP (microsphere) 0.1% discontinued treatment due to irritation. Of these 14 subjects, four had severe irritation after 3 to 5 days of treatment, with blistering in one subject.
In a double-blind trial with 156 acne subjects comparing 12 weeks of treatment with Tretinoin (Pigmanorm Widmer) gel, USP (microsphere) 0.04% or 0.1% (78 subjects each group), the most frequently-reported adverse events affected the skin and subcutaneous tissue (15.4% in the 0.04% group, and 20.5% in the 0.1% group). The most prevalent of the dermatologic adverse events in the 0.04% group was skin irritation (6.4%); and in the 0.1% group skin burning (7.7%), erythema (5.1%), skin irritation (3.8%), and dermatitis (3.8%). Most adverse events were of mild intensity (63.4%), and 34.4% were moderate. One subject in each group had adverse events characterized as severe, neither were dermatologic findings and neither was characterized as related to drug by the investigator.
Trials in Subjects Without Acne
In a half-face comparison trial conducted for up to 14 days in women with sensitive skin, but without acne, Tretinoin (Pigmanorm Widmer) gel, USP (microsphere) 0.1% was statistically less irritating than Tretinoin (Pigmanorm Widmer) cream, 0.1%. In addition, a cumulative 21 day irritation evaluation in subjects with normal skin showed that Tretinoin (Pigmanorm Widmer) gel, USP (microsphere) 0.1%, had a lower irritation profile than Tretinoin (Pigmanorm Widmer) cream, 0.1%. The clinical significance of these irritation trials for patients with acne is not established. Comparable effectiveness of Tretinoin (Pigmanorm Widmer) gel, USP (microsphere) 0.1% and Tretinoin (Pigmanorm Widmer) cream, 0.1%, has not been established. The lower irritancy of Tretinoin (Pigmanorm Widmer) gel, USP (microsphere) 0.1% in subjects without acne may be attributable to the properties of its vehicle. The contribution of decreased irritancy by the methyl methacrylate/glycol dimethacrylate crosspolymer porous microspheres has not been established. No irritation trials have been performed to compare Tretinoin (Pigmanorm Widmer) gel, USP (microsphere) 0.04%, with either Tretinoin (Pigmanorm Widmer) gel, USP (microsphere) 0.1%, or Tretinoin (Pigmanorm Widmer) cream, 0.1%.
Postmarketing Experience
The following adverse reactions have been identified during post-approval use of Tretinoin (Pigmanorm Widmer) gel, USP (microsphere). Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a casual relationship to drug exposure.
Temporary hyper- or hypopigmentation has been reported with repeated application of Tretinoin (Pigmanorm Widmer).
Solu-Hydrocortisone (Pigmanorm Widmer) 100 mg contains Hydrocortisone (Pigmanorm Widmer) sodium succinate equivalent to Hydrocortisone (Pigmanorm Widmer) 100 mg, monobasic sodium phosphate 1 mg, dibasic sodium 9 mg and sodium hydroxide 10%.
Solu-Hydrocortisone (Pigmanorm Widmer) 100 mg/2 mL contains Hydrocortisone (Pigmanorm Widmer) sodium succinate equivalent to Hydrocortisone (Pigmanorm Widmer) 100 mg/2 mL, monobasic sodium phosphate 1 mg, dibasic sodium 10 mg and sodium hydroxide 10%.
Solu-Hydrocortisone (Pigmanorm Widmer) 250 mg/2 mL contains Hydrocortisone (Pigmanorm Widmer) sodium succinate equivalent to Hydrocortisone (Pigmanorm Widmer) 250 mg/2 mL, monobasic sodium phosphate 2 mg, dibasic sodium phosphate 25 mg and sodium hydroxide 10%.
Solu-Hydrocortisone (Pigmanorm Widmer) 500 mg/4 mL contains Hydrocortisone (Pigmanorm Widmer) sodium succinate equivalent to Hydrocortisone (Pigmanorm Widmer) 500 mg/4 mL, monobasic sodium phosphate 5 mg, dibasic sodium phosphate 52 mg and sodium hydroxide 10%.
Hydrocortisone (Pigmanorm Widmer) sodium succinate or pregn-4-ene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy; monosodium salt,(11β) is an anti-inflammatory adrenocortical steroid. This highly water-soluble sodium succinate ester of Hydrocortisone (Pigmanorm Widmer) permits the immediate IV administration of high doses of Hydrocortisone (Pigmanorm Widmer) in a small volume of diluent and is particularly useful where high blood levels of Hydrocortisone (Pigmanorm Widmer) are required rapidly.
When necessary, the pH of Solu-Hydrocortisone (Pigmanorm Widmer) was adjusted with sodium hydroxide so that the pH of the reconstituted solution is within the USP specified range of 7-8.
Hydroquinone (Pigmanorm Widmer) is a topical lightening product found in OTC products, and is used to correct skin discoloration associated with disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots, and freckles. It can be used alone, but is more frequently found in combination with other agents such as alpha-hydroxy acids, corticosteroids, retinoids, or sunscreen. Hydroquinone (Pigmanorm Widmer) has come under scrutiny due to several complications associated with its use, including dermal irritation, exogenous onchronosis, and carginogenicity. As a result of these concerns, Hydroquinone (Pigmanorm Widmer) has been banned in the EU and UK.
Tretinoin (Pigmanorm Widmer), also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as Tretinoin (Pigmanorm Widmer) are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin (Pigmanorm Widmer) also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL).