Pcm

Temporary relief of runny nose, sneezing, and itchy, watery eyes due to hay fever (allergic rhinitis); temporary relief of cough due to minor bronchial irritation and nasal congestion caused by common cold; temporary relief of sinus congestion and pressure.

Chlorpheniramine (Pcm) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Methscopolamine (Pcm) reduces the secretions of certain organs in the body.

Phenylephrine (Pcm) is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Chlorpheniramine (Pcm), Methscopolamine (Pcm), and Phenylephrine (Pcm) is a combination medicine used to treat runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

Chlorpheniramine (Pcm), Methscopolamine (Pcm), and Phenylephrine (Pcm) may also be used for purposes not listed in this medication guide.

Adults and children 12 years of age and older: 1-2 teaspoonfuls (5-10 mL) every 4 to 6 hours, not to exceed

8 teaspoonfuls in 24 hours.

Children 6 to under 12 years of age: 1 teaspoonful (5 mL) every 4 to 6 hours, not to exceed

4 teaspoonfuls in 24 hours.

Pcm Syrup is not recommended for children under 6 years of age.

Note: Geriatric patients may be more sensitive to the effects of the usual adult dose. Adjust adult dose accordingly.

See also:
What is the most important information I should know about Pcm?

This product is contraindicated in patients with hypersensitivity or idiosyncrasy to any of its ingredients. It is also

contraindicated in women who are pregnant or nursing. This product is contraindicated in children under six years

of age, because this age group is sensitive to the effects of sympathomimetic amines.

It is also contraindicated in newborn or premature infants, because this age group has an increased susceptibility

to the anticholinergic side effects of Chlorpheniramine (Pcm) maleate. Geriatric patients may be more sensitive to the

effects of this medication.

Risk-benefit should be considered when the following conditions exist: Acute asthma; Bladder neck obstruction;

Brain damage in children; Cardiac disease, especially cardiac arrhythmias, congestive heart failure, coronary artery

disease, and mitral stenosis; Cardiovascular disease; Diabetes Mellitus; Down's Syndrome; Esophagitis, reflux;

Narrow angle glaucoma; Acute hemorrhage with unstable cardiovascular status; Hepatic function impairment; Hernia;

Hypertension; Hyperthyroidism; Intestinal atony in the elderly or debilitated patient; Chronic lung disease; Myasthenia

gravis; Autonomic neuropathy; Paralytic ileus; Prostatic hypertrophy; Psychiatric disorders; Pyloric obstruction; Renal

function impairment; Spastic paralysis, in children; Tachycardia; Toxemia of pregnancy; Ulcerative colitis; Urinary

retention, or predisposition to; Urothopy; Xerostomia.

Use Chlorpheniramine (Pcm)/Methscopolamine (Pcm)/Phenylephrine (Pcm) suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Chlorpheniramine (Pcm)/Methscopolamine (Pcm)/Phenylephrine (Pcm) suspension by mouth with or without food.
• Shake well before each use.
• Do not take Chlorpheniramine (Pcm)/Methscopolamine (Pcm)/Phenylephrine (Pcm) suspension at the same time as antacids, certain medicines for diarrhea (eg, kaolin, pectin, attapulgite, bismuth), or ketoconazole. Take these medicines 2 or 3 hours before or after you take Chlorpheniramine (Pcm)/Methscopolamine (Pcm)/Phenylephrine (Pcm) suspension.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you miss a dose of Chlorpheniramine (Pcm)/Methscopolamine (Pcm)/Phenylephrine (Pcm) suspension and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Chlorpheniramine (Pcm)/Methscopolamine (Pcm)/Phenylephrine (Pcm) suspension.

This medication is used for the temporary relief of runny/stuffy nose, watery/itchy eyes, and itchy throat caused by allergies, hay fever, the common cold, and other breathing illnesses. This product is usually not used for ongoing cough from smoking or long-term breathing problems (such as chronic bronchitis, emphysema) unless directed by your doctor. The decongestant treats nasal congestion by narrowing the blood vessels in the nose. The antihistamine relieves itchy/watery eyes and itchy throat by blocking a substance (histamine) released by allergies. The anticholinergic dries up a runny nose and the fluid that runs down your throat causing itching/irritation.

Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.

These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).

How to use PCM

Take this medication by mouth with a full glass of water unless otherwise directed by your doctor. Since dosing recommendations may vary, carefully follow your doctor's directions for taking this medication. This medication may be taken with food or milk if stomach upset occurs. To prevent trouble sleeping, do not take this medication close to bedtime. If you are uncertain about any of the information, ask your doctor or pharmacist.

Dosage is based on the product you are taking and on your age, medical condition, and response to treatment. Do not increase your dose or take this drug more often than directed.

If you are using a liquid form, carefully measure your prescribed dose using a medication-measuring device or spoon. Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle well before each dose.

Swallow extended-release capsules whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

Chewable forms of this medication should be chewed thoroughly before swallowing.

Caffeine can increase the side effects of this medication. Avoid drinking large amounts of beverages containing caffeine (coffee, tea, colas), eating large amounts of chocolate, or taking nonprescription products that contain caffeine.

Tell your doctor if your condition is accompanied by fever, severe sore throat, rash, persistent headache, or if it persists, returns, or worsens after 7 days. These may be signs of a serious medical problem.

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What other drugs will affect Pcm?

With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Pcm.

With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.

With the simultaneous use of anticholinergics may decrease absorption of Pcm.

With the simultaneous use of oral contraceptives accelerated excretion of Pcm from the body and may reduce its analgesic action.

With the simultaneous use with urological means reduced their effectiveness.

With the simultaneous use of activated charcoal reduced bioavailability of Pcm.

When PCM Intas Pharmaceuticals applied simultaneously with diazepam may decrease excretion of diazepam.

There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Pcm. A case of severe toxic liver injury.

Described cases of toxic effects of Pcm, while the use of isoniazid.

When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Pcm, which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Pcm and phenobarbital.

In applying cholestyramine a period of less than 1 h after administration of Pcm may decrease of its absorption.

At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.

With the simultaneous use of metoclopramide may increase absorption of Pcm and its increased concentration in blood plasma.

When applied simultaneously with probenecid may decrease clearance of Pcm, with rifampicin, sulfinpyrazone - may increase clearance of Pcm due to increasing its metabolism in the liver.

At simultaneous application of PCM Intas Pharmaceuticals with ethinylestradiol increases absorption of Pcm from the gut.

Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).

See also:
What are the possible side effects of Pcm?

Drowsiness, dizziness, dry mouth, blurred vision, headache, stomach upset, and constipation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: fast heartbeat, mental/mood changes (such as nervousness, excitement, irritability), trouble sleeping, shaking (tremors), difficult/painful urination.

Get medical help right away if you have any very serious side effects, including: fainting, very fast/pounding/irregular heartbeat, severe mental/mood changes (such as confusion, hallucinations), seizures, eye pain/swelling/redness, vision changes (such as seeing rainbows around lights at night).

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.